公开(公告)号：US06989155B1

公开(公告)日：2006-01-24

申请号：US09857392

申请日：1999-12-09

申请人： David Ganderton ,  David Alexander Vodden Morton ,  Paul Lucas

发明人： David Ganderton ,  David Alexander Vodden Morton ,  Paul Lucas

IPC分类号： A61K9/14 ,  A61K9/50 ,  B32B15/02

CPC分类号： A61K9/0075 ,  A61K9/145 ,  Y10T428/2982

摘要： Particles of an amino acid such as leucine may be formed from an amino acid vapor, for example by aerosol condensation, or by spray drying. The amino acid particles have a bulk density of not more than 0.1 gcm−3 or have a mass median aerodynamic diameter of not more than 10 μm or are in the form of flakes having a thickness of not more than 100 μm. The inclusion of the particles of amino acid in powder for use in dry powder inhalers has been found to improve the respirable fraction of the active material in the powder.

摘要翻译： 氨基酸如亮氨酸的颗粒可以由氨基酸蒸气形成，例如通过气溶胶冷凝或通过喷雾干燥形成。 氨基酸颗粒的堆积密度不超过0.1g / cm3，或质量中值空气动力学直径不大于10um，或者为薄片形式，其厚度不大于 100个妈妈 发现将氨基酸颗粒包含在干粉吸入器中的粉末中可以改善粉末中活性物质的可呼吸分数。

公开(公告)号：US20080245138A1

公开(公告)日：2008-10-09

申请号：US12019076

申请日：2008-01-24

申请人： Paul Lucas ,  Alain Luinaud

发明人： Paul Lucas ,  Alain Luinaud

IPC分类号： G01M1/00

CPC分类号： F01D5/027 ,  F05D2260/80 ,  G01M1/24

摘要： A method of balancing a first turbomachine module (20), comprising along an axis of rotation a bearing plane (22) on one side and a junction plane (24) on the other, with respect to a rotor (1) comprising said module (20), in whichan equivalent complementary module is defined such that the two modules form a rotor equivalent to said rotor by assembling along the junction plane (24), the total unbalance of said equivalent rotor and the corresponding correction to be made to said module are determined, which method comprises the following steps: the concentricity deviation of the bearing (22) of the first module (20) with respect to the axis perpendicular to the junction plane (24) is determined; the theoretical geometric unbalance of said equivalent complementary module is calculated; a short journal (40) is mounted on the first module adjacent to the junction plane (24) to form a short rotor whose axis of rotation is substantially coincident with the axis of the module (20) and the unbalance of the short rotor is measured; and the total unbalance of said module is determined by adding to the unbalance of the short rotor a systematic unbalance corresponding to the geometric unbalance.

摘要翻译： 一种平衡第一涡轮机模块（20）的方法，所述第一涡轮机组件（20）相对于包括所述模块的转子（1）沿着旋转轴线包括一侧的支承平面（22）和另一侧的接合平面（24） 20），其中定义等效的互补模块，使得两个模块通过沿着接合面（24）组装形成与所述转子等效的转子，所述等效转子的总不平衡和对所述模块的相应校正 确定该方法，该方法包括以下步骤：确定第一模块（20）的轴承（22）相对于垂直于结面（24）的轴的同心度偏差; 计算所述等效补充模块的理论几何不平衡; 短路颈（40）安装在与接合面（24）相邻的第一模块上以形成短转子，其旋转轴线基本上与模块（20）的轴线重合，并测量短转子的不平衡 ; 并且通过增加短转子的不平衡来确定对应于几何不平衡的系统不平衡来确定所述模块的总体不平衡。

公开(公告)号：US07259011B2

公开(公告)日：2007-08-21

申请号：US11133596

申请日：2005-05-20

申请人： Paul Lucas ,  Sherri Schultz ,  Sharon P. Pine

发明人： Paul Lucas ,  Sherri Schultz ,  Sharon P. Pine

IPC分类号： C12N5/00 ,  C12N5/08 ,  C12N5/02

CPC分类号： C12N5/0607 ,  A61K35/12 ,  C12N2501/39

摘要： The invention relates to isolated human pluripotent adult stem cells which express CD13, CD34, CD56 and CD117, and which do not express CD1O, which are capable of differentiating in all three germ lineages and differentiated cells derived therefrom.

摘要翻译： 本发明涉及分离的人多能成体干细胞，其表达CD13，CD34，CD56和CD117，并且不表达CD1O，其能够在所有三种胚系和从其衍生的分化细胞中分化。

公开(公告)号：US20070088105A1

公开(公告)日：2007-04-19

申请号：US11394008

申请日：2006-03-30

申请人： Michael Shelton ,  Jessica Posey-Dowty ,  Luis Perdomo ,  Daniel Dixon ,  Paul Lucas ,  Alan Wilson ,  Kenneth Walker ,  Jonathan Lawniczak ,  Roy Foulk ,  Hieu Phan ,  Charlie Freeman ,  John Booton

发明人： Michael Shelton ,  Jessica Posey-Dowty ,  Luis Perdomo ,  Daniel Dixon ,  Paul Lucas ,  Alan Wilson ,  Kenneth Walker ,  Jonathan Lawniczak ,  Roy Foulk ,  Hieu Phan ,  Charlie Freeman ,  John Booton

IPC分类号： C08L1/00

CPC分类号： C08B3/18 ,  C08B3/16 ,  C08G18/6484 ,  C09D101/14 ,  C09D201/00 ,  C08L2666/02 ,  C08L2666/26

摘要： Cellulose mixed esters are disclosed having low molecular weights and low degrees of polymerization. These new cellulose mixed esters include cellulose acetate propionate and cellulose acetate butyrate. The esters exhibit solubility in a wide range of organic solvents with minimal viscosity increase, are compatible with a wide variety of resins, and are useful in coatings and inks compositions as binder resins and rheology modifiers.

摘要翻译： 公开了具有低分子量和低聚合度的纤维素混合酯。 这些新的纤维素混合酯包括乙酸丙酸纤维素和乙酸丁酸纤维素。 该酯在宽范围的有机溶剂中表现出溶解性，粘度增加最小，与多种树脂相容，并且可用作涂料和油墨组合物作为粘合剂树脂和流变改性剂。

公开(公告)号：US20050131875A1

公开(公告)日：2005-06-16

申请号：US10787714

申请日：2004-02-26

申请人： Fabio Riccardi ,  Paul Lucas ,  Daniela Florescu ,  Donald Kossmann ,  Till Westmann ,  Christopher Hillery

发明人： Fabio Riccardi ,  Paul Lucas ,  Daniela Florescu ,  Donald Kossmann ,  Till Westmann ,  Christopher Hillery

IPC分类号： G06F20060101 ,  G06F7/00 ,  G06F17/00 ,  G06F17/30

CPC分类号： G06F17/30932 ,  Y10S707/99932 ,  Y10S707/99933 ,  Y10S707/99934 ,  Y10S707/99943 ,  Y10S707/99945

摘要： Systems and methods in accordance with the present invention provide for an implementation of the XQuery standard, and such an implementation will be referred to herein as an XQuery (XML Query language) implementation. An XQuery implementation can be based on a token stream representation, which allows large XML documents to be processed without having to first read the entire document. An XQuery implementation can also utilize a streaming XQuery engine. A set of algorithms and a set of rewrite rules can be used for the implementation. Given a query, a set of rules can be applied to that query to transform the query into another query. Some of these rules allow the resulting query to be streamable. In other words, a query that would otherwise require an XML document to be read into memory can now be transformed into a query that can work on an XML stream. The type system of the XQuery language can be based on XML Schema, and the basic types of XML Schema can have derived types. The XQuery programs can execute in a context comprising of variable bindings, namespaces, operators, default parameters, etc. This description is not intended to be a complete description of, or limit the scope of, the invention. Other features, aspects, and objects of the invention can be obtained from a review of the specification, the figures, and the claims.

摘要翻译： 根据本发明的系统和方法提供了XQuery标准的实现，并且这种实现在这里将被称为XQuery（XML查询语言）实现。 XQuery实现可以基于令牌流表示，这允许处理大型XML文档，而不必首先读取整个文档。 XQuery实现也可以使用流XQuery引擎。 一组算法和一组重写规则可用于实现。 给定一个查询，一组规则可以应用于该查询以将查询转换为另一个查询。 这些规则中的一些允许生成的查询是可流式的。 换句话说，否则需要将XML文档读入内存的查询现在可以转换成可以在XML流上工作的查询。 XQuery语言的类型系统可以基于XML Schema，XML Schema的基本类型可以有派生类型。 XQuery程序可以在包括变量绑定，命名空间，操作符，默认参数等的上下文中执行。该描述不旨在是对本发明的完整描述或限制本发明的范围。 本发明的其它特征，方面和目的可以通过对说明书，附图和权利要求的评述来获得。

公开(公告)号：US20060010124A1

公开(公告)日：2006-01-12

申请号：US11004462

申请日：2004-12-03

申请人： Paul Lucas ,  Daniela Florescu ,  Fabio Riccardi

发明人： Paul Lucas ,  Daniela Florescu ,  Fabio Riccardi

IPC分类号： G06F17/30

CPC分类号： G06F8/31

摘要： The invention provides systems and methods for implementation of a computer language type system by augmenting finite state automata algorithms to accommodate symbols having both subtype relationships and nested types. To make the classical automata algorithms work for type system with subtypes, finite state automata for a data type is augmented by additional transitions that include secondary symbols, wherein secondary symbols are subtypes of symbols of alphabet of finite state automata. A data type when compared to another data type must compare both names and the contents.

公开(公告)号：US20050255588A1

公开(公告)日：2005-11-17

申请号：US11029763

申请日：2005-01-05

申请人： Henry Young ,  Paul Lucas

发明人： Henry Young ,  Paul Lucas

IPC分类号： A61K35/12 ,  A61K48/00 ,  C12N5/074 ,  C12N5/0775 ,  C12N5/08

CPC分类号： C12N5/0607 ,  A61K35/12 ,  A61K48/00 ,  C12N5/0652 ,  C12N2502/03 ,  C12N2510/00

摘要： The present invention relates to pluripotent stem cells, particularly to pluripotent embryonic-like stem cells. The invention further relates to methods of purifying pluripotent embryonic-like stem cells and to compositions, cultures and clones thereof. The present invention also relates to a method of transplanting the pluripotent stem cells of the present invention in a mammalian host, such as human, comprising introducing the stem cells, into the host. The invention further relates to methods of in vivo administration of a protein or gene of interest comprising transfecting a pluripotent stem cell with a construct comprising DNA which encodes a protein of interest and then introducing the stem cell into the host where the protein or gene of interest is expressed. The present also relates to methods of producing mesodermal, endodermal or ectodermal lineage-committed cells by culturing or transplantation of the pluripotent stem cells of the present invention.

摘要翻译： 本发明涉及多能干细胞，特别涉及多能胚胎样干细胞。 本发明还涉及纯化多能胚胎样干细胞及其组合物，培养物和克隆的方法。 本发明还涉及将本发明的多能干细胞移植到哺乳动物宿主例如人中的方法，包括将干细胞导入宿主。 本发明还涉及体内施用目的蛋白质或基因的方法，包括用包含编码目的蛋白质的DNA的构建体转染多能干细胞，然后将干细胞导入宿主，其中感兴趣的蛋白质或基因 被表达。 本发明还涉及通过培养或移植本发明的多能干细胞来产生中胚层，内胚层或外胚层谱系确定的细胞的方法。

公开(公告)号：US07369920B2

公开(公告)日：2008-05-06

申请号：US11387042

申请日：2006-03-21

申请人： Vladislav Davidkovich ,  Gordon Hill ,  Dave Chamberlain ,  Paul Lucas

发明人： Vladislav Davidkovich ,  Gordon Hill ,  Dave Chamberlain ,  Paul Lucas

IPC分类号： G06F19/00 ,  F04B40/06 ,  H01L21/306 ,  C16C16/52

CPC分类号： G05D16/2013 ,  Y10T137/2863

摘要： A pressure control system for controlling pressure of a fluid in a chamber includes a pressure sensor configured to measure the pressure of the fluid in the chamber, and a valve configured to control the pressure of the fluid in the chamber by regulating flow of the fluid from the chamber. The pressure control system further includes a controller. The controller is configured to estimate the volume of the chamber, and to generate a pump speed curve of the valve. The controller is further configured to monitor and modify the pump speed curve so as to maintain a slope of the pump speed curve to at least a minimum value, and to use the modified pump speed curve to adjust the position of the valve in response to pressure measurements by the pressure sensor, so as to maintain the pressure in the chamber at a desired pressure setpoint.

摘要翻译： 用于控制腔室中的流体压力的压力控制系统包括被配置成测量腔室中的流体压力的压力传感器，以及构造成通过调节流体的流动来控制腔室中的流体压力的阀 房间。 压力控制系统还包括控制器。 控制器被配置为估计室的体积并产生阀的泵速曲线。 该控制器还被配置为监测和修改泵速曲线，以将泵速曲线的斜率保持在至少最小值，并且使用改进的泵速曲线来响应于压力来调节阀的位置 通过压力传感器进行测量，以便将腔室中的压力保持在期望的压力设定点。

公开(公告)号：US20070191930A1

公开(公告)日：2007-08-16

申请号：US11354039

申请日：2006-02-15

申请人： Paul Lucas ,  Elliott Badder

发明人： Paul Lucas ,  Elliott Badder

IPC分类号： A61F2/06

CPC分类号： A61F2/07 ,  A61F2/848 ,  A61F2/852 ,  A61F2/856 ,  A61F2002/061 ,  A61F2002/065 ,  A61F2002/075 ,  A61F2002/3008 ,  A61F2002/30329 ,  A61F2002/30538 ,  A61F2002/30599 ,  A61F2220/0025 ,  A61F2230/0067 ,  A61F2250/0006 ,  A61F2250/006 ,  A61F2250/0063 ,  A61F2250/0098

摘要： An endovascular graft adapter for use in abdominal aortic aneurysms comprising a graft adapter body defining an upper graft adapter section member and a lower graft adapter section member. The upper and lower graft adapter section members respectively have a pair of cut-out sections formed through sidewalls thereof and both pairs of cut-out sections are respectively aligned with the right and left renal arteries. The upper graft adapter section member has an upper axially directed through passage extending from a proximal end to a distal end thereof and the lower graft adapter section member has a lower axially directed through passage extending from a proximal end to a distal end thereof. The upper and lower axially directed through passages are in alignment each with respect to the other.

摘要翻译： 一种用于腹主动脉瘤的血管内移植物适配器，其包括限定上移植物适配器部件和下移植物适配器部件的移植适配器主体。 上下移植物适配器部件分别具有通过其侧壁形成的一对切口部分，并且两对切口部分分别与右肾动脉和左肾动脉对准。 上移植物适配器部件具有从其近端延伸到其远端的上轴向通过通道，并且下移植物适配器部件具有从其近端延伸到其远端的下轴向通过通道。 上下轴向通过的通道相对于另一个对齐。

公开(公告)号：US20060192170A1

公开(公告)日：2006-08-31

申请号：US11410411

申请日：2006-04-25

申请人： Paul Lucas ,  Anthony Carbone

发明人： Paul Lucas ,  Anthony Carbone

IPC分类号： F16K1/42

CPC分类号： F16K3/06

摘要： Valve assemblies are disclosed including a housing having a flow channel and an annular surface surrounding the flow channel, a slide plate movable to a closed position, and a seal ring positioned between the annular surface and the slide plate. The seal ring can include first and second sides, a first surface extending between the sides and facing towards the annular surface of the housing, and a second surface axially spaced from the first surface and extending between the first and the second sides and facing towards the slide plate. The second surface can include a continuous annular sealing portion for contacting the slide plate when the seal ring is biased against the slide plate so that a fluid-tight seal can be formed between the continuous annular sealing portion and the slide plate, and at least one passageway positioned between the annular sealing portion and the second side.

摘要翻译： 公开了一种阀组件，其包括具有流动通道和围绕流动通道的环形表面的壳体，可移动到关闭位置的滑动板和位于环形表面和滑动板之间的密封环。 密封环可以包括第一和第二侧面，在侧面之间延伸并面向壳体的环形表面的第一表面和与第一表面轴向间隔开并且在第一和第二侧面之间并且面向第二表面的第二表面 滑板 第二表面可以包括连续的环形密封部分，用于当密封环偏置在滑动板上时接触滑板，使得可以在连续的环形密封部分和滑动板之间形成流体密封，并且至少一个 通道定位在环形密封部分和第二侧面之间。