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公开(公告)号：US20080152661A1
公开(公告)日：2008-06-26
申请号：US11840468
申请日：2007-08-17
申请人： David B. Rozema , Darren H. Wakefield , Jason Klein , So Wong , Jon A. Wolff , David L. Lewis , James E. Hagstrom , Andrei Blokhin , Vladimir Trubetskoy , Hans Herweijer
发明人： David B. Rozema , Darren H. Wakefield , Jason Klein , So Wong , Jon A. Wolff , David L. Lewis , James E. Hagstrom , Andrei Blokhin , Vladimir Trubetskoy , Hans Herweijer
IPC分类号： A61K31/70 , A61K39/395 , C12N5/00 , A61K38/00
CPC分类号： C12N15/87 , A01K2217/058 , A01K2267/0362 , A61K47/58 , A61K48/0041
摘要： The present invention is directed to compounds, compositions, and methods useful for delivering polynucleotides or other cell-impermeable molecules to mammalian cells. Described are polyconjugates systems that incorporate targeting, anti-opsonization, anti-aggregation, and transfection activities into small biocompatible in vivo delivery vehicles. The use of multiple reversible linkages connecting component parts provides for physiologically responsive activity modulation.
摘要翻译： 本发明涉及可用于将多核苷酸或其它细胞不可渗透分子递送至哺乳动物细胞的化合物，组合物和方法。 描述了将靶向，抗调理作用，抗聚集和转染活性结合到小的生物相容性体内递送载体中的多偶联体系。 连接组成部分的多个可逆连接的使用提供了生理响应活性调节。
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公开(公告)号：US08137695B2
公开(公告)日：2012-03-20
申请号：US11840468
申请日：2007-08-17
申请人： David B. Rozema , James E. Hagstrom , Jason Klein , David L. Lewis , Sean D. Monahan , Darren H. Wakefield , Jon A. Wolff , So Wong
发明人： David B. Rozema , James E. Hagstrom , Jason Klein , David L. Lewis , Sean D. Monahan , Darren H. Wakefield , Jon A. Wolff , So Wong
CPC分类号： C12N15/87 , A01K2217/058 , A01K2267/0362 , A61K47/58 , A61K48/0041
摘要： The present invention is directed to compounds, compositions, and methods useful for delivering polynucleotides or other cell-impermeable molecules to mammalian cells. Described are polyconjugates systems that incorporate targeting, anti-opsonization, anti-aggregation, and transfection activities into small biocompatible in vivo delivery vehicles. The use of multiple reversible linkages connecting component parts provides for physiologically responsive activity modulation.
摘要翻译： 本发明涉及可用于将多核苷酸或其它细胞不可渗透分子递送至哺乳动物细胞的化合物，组合物和方法。 描述了将靶向，抗调理作用，抗聚集和转染活性结合到小的生物相容性体内递送载体中的多偶联体系。 连接组成部分的多个可逆连接的使用提供了生理响应活性调节。
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公开(公告)号：US08658211B2
公开(公告)日：2014-02-25
申请号：US13368796
申请日：2012-02-08
申请人： David B. Rozema , Darren H. Wakefield , David L. Lewis , Jason Klein , So Wong , Jon A. Wolff , James E. Hagstrom
发明人： David B. Rozema , Darren H. Wakefield , David L. Lewis , Jason Klein , So Wong , Jon A. Wolff , James E. Hagstrom
IPC分类号： A61K9/14 , C07D207/444 , C07H21/02 , C12N15/00 , C12N15/11
CPC分类号： C12N15/87 , A01K2217/058 , A01K2267/0362 , A61K47/58 , A61K48/0041 , C12N15/111 , C12N2310/14 , C12N2310/351 , C12N2320/32 , C12N2800/95 , C12N2810/10
摘要： The present invention is directed to compounds, compositions, and methods useful for delivering polynucleotides or other cell-impermeable molecules to mammalian cells. Described are polyconjugates systems that incorporate targeting, anti-opsonization, anti-aggregation, and transfection activities into small biocompatible in vivo delivery vehicles. The use of multiple reversible or labile linkages connecting component parts provides for physiologically responsive activity modulation.
摘要翻译： 本发明涉及可用于将多核苷酸或其它细胞不可渗透分子递送至哺乳动物细胞的化合物，组合物和方法。 描述了将靶向，抗调理作用，抗聚集和转染活性结合到小的生物相容性体内递送载体中的多偶联体系。 使用连接组成部分的多个可逆或不稳定的连接提供了生理响应活性调节。
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公开(公告)号：US08017109B2
公开(公告)日：2011-09-13
申请号：US12140703
申请日：2008-06-17
申请人： Darren H. Wakefield , David B. Rozema , Sean D. Monahan , Lori Higgs , Jon A. Wolff , James E. Hagstrom
发明人： Darren H. Wakefield , David B. Rozema , Sean D. Monahan , Lori Higgs , Jon A. Wolff , James E. Hagstrom
IPC分类号： A61K31/74
CPC分类号： C12N15/87 , A01K2217/058 , A01K2267/0362 , A61K47/58
摘要： The present invention is directed to membrane active polymers useful for cellular delivery of compounds. Described are polyconjugates systems that incorporate targeting, anti-opsonization, anti-aggregation, and transfection activities into small biocompatible in vivo delivery conjugates. The use of reversible modification provides for physiologically responsive activity modulation.
摘要翻译： 本发明涉及可用于细胞递送化合物的膜活性聚合物。 描述了将靶向，抗调理作用，抗聚集和转染活性结合到小的生物相容性体内递送缀合物中的多偶联体系。 使用可逆修饰提供了生理反应活性调节。
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公开(公告)号：US20130317079A1
公开(公告)日：2013-11-28
申请号：US13592403
申请日：2012-08-23
申请人： Darren H. Wakefield , David B. Rozema , Nicholas Rossi , Lauren Almeida , Anthony L. Perillo-Nicholas
发明人： Darren H. Wakefield , David B. Rozema , Nicholas Rossi , Lauren Almeida , Anthony L. Perillo-Nicholas
IPC分类号： A61K47/32
CPC分类号： B25F5/02 , A61K47/32 , A61K47/58 , B23D45/16 , B23Q13/00 , B27B5/29 , B27B9/00 , C08F220/00 , C08F220/34 , C08F220/36 , C08F220/18
摘要： The present invention is directed membrane active poly(acrylate) polymers and compositions for targeted delivery of RNA interference (RNAi) polynucleotides cells in vivo. RNAi polynucleotides are conjugated to the poly(acrylate) polymers and the polymers are reversibly modified to enable in vivo targeted delivery. Membrane activity of the poly(acrylate) provides for movement of the RNAi polynucleotides from outside the cell to inside the cell. Reversible modification provides physiological responsiveness.
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公开(公告)号：US08933047B2
公开(公告)日：2015-01-13
申请号：US13592403
申请日：2012-08-23
申请人： Darren H. Wakefield , David B. Rozema , Nicholas Rossi , Lauren Almeida , Anthony L. Perillo-Nicholas
发明人： Darren H. Wakefield , David B. Rozema , Nicholas Rossi , Lauren Almeida , Anthony L. Perillo-Nicholas
IPC分类号： C12N15/11 , C08F20/10 , C08F120/10 , C08F220/10 , A61K47/32 , C08F220/00 , C08F220/36
CPC分类号： B25F5/02 , A61K47/32 , A61K47/58 , B23D45/16 , B23Q13/00 , B27B5/29 , B27B9/00 , C08F220/00 , C08F220/34 , C08F220/36 , C08F220/18
摘要： The present invention is directed membrane active poly(acrylate) polymers and compositions for targeted delivery of RNA interference (RNAi) polynucleotides cells in vivo. RNAi polynucleotides are conjugated to the poly(acrylate) polymers and the polymers are reversibly modified to enable in vivo targeted delivery. Membrane activity of the poly(acrylate) provides for movement of the RNAi polynucleotides from outside the cell to inside the cell. Reversible modification provides physiological responsiveness.
摘要翻译： 本发明涉及膜活性聚（丙烯酸酯）聚合物和用于在体内靶向递送RNA干扰（RNAi）多核苷酸细胞的组合物。 RNAi多核苷酸与聚（丙烯酸酯）聚合物缀合，并且可逆地修饰聚合物以实现体内靶向递送。 聚（丙烯酸酯）的膜活性提供了从细胞外部到细胞内的RNAi多核苷酸的移动。 可逆修饰提供生理反应。
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公开(公告)号：US20090048410A1
公开(公告)日：2009-02-19
申请号：US12123104
申请日：2008-05-19
CPC分类号： C12N15/87 , A01K2217/058 , A01K2267/0362 , A61K47/58 , A61K48/0008 , A61K48/0025 , A61K48/0041
摘要： The present invention is directed to a class of membrane active polymers useful for cellular delivery of compounds. Conjugation of the described membrane active polymers to targeting, anti-opsonization, and anti-aggregation agents provides polymers suitable for in vivo delivery. The use of multiple reversible linkages connecting component parts provides for physiologically responsive activity modulation.
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公开(公告)号：US20080287630A1
公开(公告)日：2008-11-20
申请号：US12140703
申请日：2008-06-17
申请人： Darren H. Wakefield , David B. Rozema , Sean D. Monahan , Lori Higgs , Jon A. Wolff , James E. Hagstrom
发明人： Darren H. Wakefield , David B. Rozema , Sean D. Monahan , Lori Higgs , Jon A. Wolff , James E. Hagstrom
IPC分类号： C08F220/52
CPC分类号： C12N15/87 , A01K2217/058 , A01K2267/0362 , A61K47/58
摘要： The present invention is directed to membrane active polymers useful for cellular delivery of compounds. Described are polyconjugates systems that incorporate targeting, anti-opsonization, anti-aggregation, and transfection activities into small biocompatible in vivo delivery conjugates. The use of reversible modification provides for physiologically responsive activity modulation.
摘要翻译： 本发明涉及可用于细胞递送化合物的膜活性聚合物。 描述了将靶向，抗调理作用，抗聚集和转染活性结合到小的生物相容性体内递送缀合物中的多偶联体系。 使用可逆修饰提供了生理反应活性调节。
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公开(公告)号：US20080281041A1
公开(公告)日：2008-11-13
申请号：US12123091
申请日：2008-05-19
IPC分类号： C08G83/00
CPC分类号： A61K48/0041 , A01K2217/058 , A01K2267/0362 , A61K47/58 , A61K47/60 , C12N15/87
摘要： The present invention is directed to reversibly inactivation of membrane active polymers useful for cellular delivery of compounds. Described are polyconjugates systems that incorporate targeting, anti-opsonization, anti-aggregation, and transfection activities into small biocompatible in vivo delivery conjugates. The use of multiple reversible linkages connecting component parts provides for physiologically responsive activity modulation.
摘要翻译： 本发明涉及用于细胞递送化合物的膜活性聚合物的可逆失活。 描述了将靶向，抗调理作用，抗聚集和转染活性结合到小的生物相容性体内递送缀合物中的多偶联体系。 连接组成部分的多个可逆连接的使用提供了生理响应活性调节。
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公开(公告)号：US08138383B2
公开(公告)日：2012-03-20
申请号：US12123104
申请日：2008-05-19
IPC分类号： C07C9/22
CPC分类号： C12N15/87 , A01K2217/058 , A01K2267/0362 , A61K47/58 , A61K48/0008 , A61K48/0025 , A61K48/0041
摘要： The present invention is directed to a class of membrane active polymers useful for cellular delivery of compounds. Conjugation of the described membrane active polymers to targeting, anti-opsonization, and anti-aggregation agents provides polymers suitable for in vivo delivery. The use of multiple reversible linkages connecting component parts provides for physiologically responsive activity modulation.
摘要翻译： 本发明涉及一类可用于细胞递送化合物的膜活性聚合物。 所述膜活性聚合物与靶向，抗调理作用和抗聚集剂的结合提供了适合于体内递送的聚合物。 连接组成部分的多个可逆连接的使用提供了生理响应活性调节。
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