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公开(公告)号：US5985316A
公开(公告)日：1999-11-16
申请号：US431188
申请日：1995-04-28
CPC分类号： A61K9/0009 , A61N1/30 , Y10S514/947
摘要： An electrotransport device (10) for transdermal delivery of an agent through a body surface has a donor reservoir (16) which contains a compound formed of the agent and a transdermal permeation enhancer, the compound being able to dissociate into an agent ion and an enhancer counter ion. Methods of enhancing transdermal electrotransport drug delivery and methods of forming a composition exhibiting enhanced transdermal electrotransport drug delivery are also provided.
摘要翻译： 用于透皮通过身体表面递送药物的电输送装置（10）具有供体储存器（16），其包含由所述药剂和透皮渗透促进剂形成的化合物，所述化合物能够离解成药剂离子和增强剂 抗衡离子 还提供了增强透皮电转运药物递送的方法和形成表现出增强的透皮电转运药物递送的组合物的方法。
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12.发明授权Percutaneous absorption enhancer dispenser for use in coadministering drug and percutaneous absorption enhancer 失效用于联合给药和经皮吸收增强剂的经皮吸收增强剂分配器
公开(公告)号：US4460372A
公开(公告)日：1984-07-17
申请号：US481209
申请日：1983-04-01
CPC分类号： A61K9/7084 , A61M37/00
摘要： A dosage form that coadministers a drug and a percutaneous absorption enhancer to a defined area of the skin. The dosage form comprises a body that contains supplies of drug and enhancer and has a basal surface that contacts the area of skin and transmits the drug and enhancer to the area for absorption thereby. The drug is provided to the basal surface at a rate at least as great as the rate at which the skin is able to absorb the drug whereas the enhancer is via a rate controlling means at a substantially constant rate that increases the permeability of the treated area of skin to the drug to a level at which the drug is absorbed a therapeutically effective rate.
摘要翻译： 将药物和经皮吸收增强剂共同施用于皮肤的限定区域的剂型。 剂型包括含有药物和增强剂供应的身体，并具有与皮肤区域接触的基底表面，并将药物和增强剂传递到吸收区域。 药物以至少与皮肤能够吸收药物的速率一样大的速率提供给基底表面，而增强剂通过速率控制装置以基本上恒定的速率提高，这增加了处理区域的渗透性 的皮肤对药物的吸收水平达到治疗有效率。
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公开(公告)号：US5865792A
公开(公告)日：1999-02-02
申请号：US895096
申请日：1997-07-16
CPC分类号： A61N1/0432 , A61N1/044 , A61N1/0448 , A61N1/30 , A61N1/325 , A61N1/0436 , A61N1/0444
摘要： The invention is directed to a composition and product for use in an electrotransport device. The composition includes an ionized drug, an anti-inflammatory agent and a solvent. Preferably, the anti-inflammatory agent is hydrocortisone or esters thereof, and the solvent is an alcohol, a glycol, a glycerol, a cyclodextrin, a nonionic surfactant or mixtures thereof. The composition preferably further includes a gel matrix that is a swellable, hydrophilic polymer, a water soluble hydrophilic polymer or a solid polymer. A hydrophobic polymer and/or additives may also be included.
摘要翻译： 本发明涉及一种用于电输送装置的组合物和产品。 组合物包括电离药物，抗炎剂和溶剂。 优选地，抗炎剂是氢化可的松或其酯，溶剂是醇，二醇，甘油，环糊精，非离子表面活性剂或其混合物。 组合物优选还包括可溶胀亲水性聚合物，水溶性亲水聚合物或固体聚合物的凝胶基质。 还可以包括疏水性聚合物和/或添加剂。
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公开(公告)号：US5512293A
公开(公告)日：1996-04-30
申请号：US164181
申请日：1993-12-09
CPC分类号： A61K9/0004 , A61K9/006 , A61K9/2027
摘要： This invention pertains to a sustained release delivery device for delivering a beneficial agent into the oral cavity of a patient. More particularly, the invention relates to a device comprising about 0.1% to about 20% by weight beneficial agent, about 40% to about 95% by weight ethylene vinyl acetate copolymer having a vinyl acetate content of about 4% to about 80% and about 1% to about 60% by weight polyvinyl pyrrolidone.
摘要翻译： 本发明涉及一种用于将有益药物输送到患者的口腔中的持续释放递送装置。 更具体地说，本发明涉及包含约0.1％至约20％重量的有益剂，约40％至约95％重量的乙酸乙烯酯含量为约4％至约80％的乙烯 - 乙酸乙烯酯共聚物和约 1％至约60％重量的聚乙烯吡咯烷酮。
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15.发明授权
公开(公告)号：US4704282A
公开(公告)日：1987-11-03
申请号：US626095
申请日：1984-06-29
CPC分类号： A61K9/7053 , A61K9/7069 , Y10S424/14 , Y10S514/953 , Y10S514/965
摘要： A transdermal therapeutic system using a subsaturated matrix is provided having improved approved release characteristics. Reinforcing means preferably in the form of a fabric are embedded in the upper surface of the subsaturated matrix. At least a portion of the reinforcing means is selected such that the active agent to be delivered to the skin has a solubility, C.sub.r therein which is lower than the initial solubility C.sub.o of the agent in the matrix. In addition, the relationship between the diffusion coefficients of the agent in the matrix D.sub.m and the portion of reinforcing means D.sub.r and the solubilities is given by the relationship: D.sub.r .multidot.C.sub.r
摘要翻译： 提供使用亚饱和基质的透皮治疗系统具有改进的批准的释放特征。 优选以织物形式的加强装置嵌入在亚饱和基质的上表面中。 加强装置的至少一部分被选择为使得递送到皮肤的活性剂具有低于基质中试剂的初始溶解度Co的溶解度Cr。 另外，矩阵Dm中的试剂的扩散系数与加强装置Dr的部分之间的关系与溶解度之间的关系由DrxCr
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公开(公告)号：US4379454A
公开(公告)日：1983-04-12
申请号：US235068
申请日：1981-02-17
CPC分类号： A61K9/7084
摘要： A dosage form that coadministers a drug and a percutaneous absorption enhancer to a defined area of the skin. The dosage form comprises a body that contains supplies of drug and enhancer and has a basal surface that contacts the area of skin and transmits the drug and enhancer to the area for absorption thereby. The drug is provided to the basal surface at a rate at least as great as the rate at which the skin is able to absorb the drug whereas the enhancer is via a rate controlling means at a substantially constant rate that increases the permeability of the treated area of skin to the drug to a level at which the drug is absorbed at a therapeutically effective rate.
摘要翻译： 将药物和经皮吸收增强剂共同施用于皮肤的限定区域的剂型。 剂型包括含有药物和增强剂供应的身体，并具有与皮肤区域接触的基底表面，并将药物和增强剂传递到吸收区域。 药物以至少与皮肤能够吸收药物的速率一样大的速率提供给基底表面，而增强剂通过速率控制装置以基本上恒定的速率提高，这增加了处理区域的渗透性 的皮肤接触到药物以治疗有效率被吸收的水平。
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公开(公告)号：US07011844B2
公开(公告)日：2006-03-14
申请号：US10302490
申请日：2002-11-22
申请人： Robert M. Gale , Melinda K. Nelson , Michel J. N. Cormier , Suneel K. Gupta , Patricia S. Campbell
发明人： Robert M. Gale , Melinda K. Nelson , Michel J. N. Cormier , Suneel K. Gupta , Patricia S. Campbell
IPC分类号： A61K9/70
CPC分类号： A61K9/7084 , A61K31/135 , A61K31/138 , A61K31/57 , A61K2300/00
摘要： Composition of matter for application to a body surface or membrane to administer fluoxetine by permeation through the body surface or membrane, the composition comprising fluoxetine to be administered, at a therapeutically effective rate, alone or in combination with a permeation enhancer or mixture. A preferred embodiment is directed to the transdermal administration of fluoxetine at reduced skin irritation levels wherein fluoxetine, preferably provided as fluoxetine acetate, is coadministered with a corticosteroid such as hydrocortisone. Also disclosed are drug delivery devices containing the fluoxetine or fluoxetine and enhancer composition and methods for the transdermal administration of the fluoxetine and fluoxetine/enhancer composition.
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公开(公告)号：US06324424B1
公开(公告)日：2001-11-27
申请号：US09105074
申请日：1998-06-26
IPC分类号： A61N130
CPC分类号： A61N1/0432 , A61N1/0436 , A61N1/044 , A61N1/0444 , A61N1/0448 , A61N1/30 , A61N1/325
摘要： The invention is directed to a composition and product for use in an electrotransport device. The composition includes an ionized drug, an anti-inflammatory agent and a solvent. Preferably, the anti-inflammatory agent is hydrocortisone or esters thereof, and the solvent is water and a material such as an alcohol, a glycol, a glycerol, a cyclodextrin, a nonionic surfactant and/or mixtures thereof.
摘要翻译： 本发明涉及一种用于电输送装置的组合物和产品。 组合物包括电离药物，抗炎剂和溶剂。 优选地，抗炎剂是氢化可的松或其酯，并且溶剂是水和诸如醇，二醇，甘油，环糊精，非离子表面活性剂和/或其混合物的材料。
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公开(公告)号：US5840327A
公开(公告)日：1998-11-24
申请号：US704426
申请日：1996-08-15
CPC分类号： A61K9/703 , A61K9/7053 , A61K9/7084
摘要： A device for the transdermal administration of a drug to a sensitive body area such as the scrotum. Devices according to the invention provide an improved quality of adhesion to the body area while also providing patient comfort during use and upon removal of the device. Also disclosed are methods of transdermal delivery such as the transcrotal delivery of testosterone to hypogonadic males.
摘要翻译： 用于将药物透皮给药到诸如阴囊的敏感体区的装置。 根据本发明的装置提供了对身体区域的改善的粘附质量，同时还在使用期间和在移除装置时提供患者舒适度。 还公开了透皮递送的方法，例如将睾酮向性腺功能低下的男性的转录递送。
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公开(公告)号：US06572879B1
公开(公告)日：2003-06-03
申请号：US08473631
申请日：1995-06-07
IPC分类号： A61M3700
CPC分类号： A61K9/7053 , A61K9/0014 , A61K9/7084 , A61K31/48 , A61K47/14 , A61K47/18 , Y10S514/947
摘要： Composition of matter for application to a body surface or membrane to administer pergolide by permeation through the body surface or membrane, the composition comprising pergolide to be administered, at a therapeutically effective rate, alone or in combination with a permeation enhancer or mixture. Also disclosed are drug delivery devices containing the pergolide or pergolide and enhancer composition and methods for the transdermal administration of the pergolide and pergolide/enhancer composition.
摘要翻译： 用于通过渗透身体表面或膜的身体表面或膜施用于pergolide的物质的组成，所述组合物包含以治疗有效速率单独或与渗透增强剂或混合物组合的待施用的pergolide。 还公开了含有pergolide或pergolide和增强剂组合物的药物递送装置和透皮给药pergolide和pergolide /增强剂组合物的方法。
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