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公开(公告)号：US5990179A
公开(公告)日：1999-11-23
申请号：US431187
申请日：1995-04-28
CPC分类号： A61N1/0448 , A61K9/0009 , Y10S514/946 , Y10S514/947
摘要： A composition suitable for transdermal electrotransport delivery of an agent through a body surface comprises a free acid/base form of an agent to be delivered by transdermal electrotransport, and a salt form of the agent, and optionally a permeation enhancer. Methods of enhancing transdermal electrotransport delivery and of forming a composition for the enhancement of transdermal electrotransport drug delivery, and a transdermal electrotransport delivery device (10) utilizing the compositions of the invention are disclosed.
摘要翻译： 适用于通过身体表面的药物透皮电转移递送的组合物包含通过透皮电转运递送的药物的游离酸/碱形式，以及任选的渗透促进剂的盐形式。 公开了增强透皮电转移递送和形成用于增强透皮电转运药物递送的组合物的方法，以及利用本发明组合物的透皮电转运递装置（10）。
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公开(公告)号：US5985316A
公开(公告)日：1999-11-16
申请号：US431188
申请日：1995-04-28
CPC分类号： A61K9/0009 , A61N1/30 , Y10S514/947
摘要： An electrotransport device (10) for transdermal delivery of an agent through a body surface has a donor reservoir (16) which contains a compound formed of the agent and a transdermal permeation enhancer, the compound being able to dissociate into an agent ion and an enhancer counter ion. Methods of enhancing transdermal electrotransport drug delivery and methods of forming a composition exhibiting enhanced transdermal electrotransport drug delivery are also provided.
摘要翻译： 用于透皮通过身体表面递送药物的电输送装置（10）具有供体储存器（16），其包含由所述药剂和透皮渗透促进剂形成的化合物，所述化合物能够离解成药剂离子和增强剂 抗衡离子 还提供了增强透皮电转运药物递送的方法和形成表现出增强的透皮电转运药物递送的组合物的方法。
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公开(公告)号：US20120175998A1
公开(公告)日：2012-07-12
申请号：US13328504
申请日：2011-12-16
IPC分类号： H02N11/00
CPC分类号： H01M14/00 , F03G7/005 , H01M4/131 , H01M4/134 , H01M10/052 , H01M10/058
摘要： Devices and methods for providing electrochemical actuation are described herein. In one embodiment, an actuator device includes an electrochemical cell including a negative electrode and a positive electrode At least a portion of the negative electrode is formed with a material formulated to at least one of intercalate, de-intercalate, alloy with, oxidize, reduce, or plate with a first portion of the positive electrode to an extent different than with a second portion of the positive electrode such that a differential strain is imparted between the first portion and the second portion of the positive electrode and such that at least a portion of the electrochemical cell is displaced. The electrochemical cell includes a portion that is pre-bent along an axis of the electrochemical cell to define a fold axis and the displacement of the at least a portion of the electrochemical cell is maximized along the fold axis.
摘要翻译： 本文描述了用于提供电化学致动的装置和方法。 在一个实施例中，致动器装置包括包括负极和正极的电化学电池。负极的至少一部分由配制成插层，去插入，合金，氧化，还原的至少一种的材料形成 或者具有与正极的第二部分不同的程度的正极的第一部分的板，使得在正极的第一部分和第二部分之间施加微分应变，使得至少一部分 的电化学电池被移位。 电化学电池包括沿着电化学电池的轴线预弯曲以限定折叠轴线的部分，并且电化学电池的至少一部分的位移沿折叠轴线最大化。
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公开(公告)号：US20110275997A1
公开(公告)日：2011-11-10
申请号：US13101749
申请日：2011-05-05
IPC分类号： A61M37/00
CPC分类号： A61M5/145 , A61M5/14248 , A61M31/00 , A61M35/00 , A61M37/00 , A61M2005/14506 , A61M2005/14513
摘要： Devices, methods, and kits for delivering a therapeutic agent to a patient are disclosed herein. In one embodiment, an apparatus comprises a reservoir for containing a fluid, a first actuator, a transfer structure, and a second actuator. The first actuator has a first configuration and a second configuration and is configured to exert a first force on the reservoir when moved from its first configuration to its second configuration such that a first volume of fluid within the reservoir is communicated out of the fluid reservoir. The transfer structure is disposed between the first actuator and the reservoir and has a surface configured to engage the reservoir such that the first force exerted by the first actuator is distributed across a surface of the reservoir engaged by the transfer structure. The second actuator has a first configuration and a second configuration and is configured to exert a second force on the reservoir when the second actuator is moved from its first configuration to its second configuration such that a second volume of fluid within the reservoir is communication out of the fluid reservoir.
摘要翻译： 本文公开了用于将治疗剂递送至患者的装置，方法和试剂盒。 在一个实施例中，装置包括用于容纳流体的储存器，第一致动器，转印结构和第二致动器。 第一致动器具有第一构造和第二构造，并且构造成当从其第一构型移动到其第二构造时在储存器上施加第一力，使得储存器内的第一体积的流体被连通出流体储存器。 转移结构设置在第一致动器和储存器之间，并且具有构造成与储存器接合的表面，使得由第一致动器施加的第一力分布在由传送结构接合的储存器的表面上。 第二致动器具有第一构造和第二构造，并且构造成当第二致动器从其第一构型移动到其第二构造时在储存器上施加第二力，使得储存器内的第二体积的流体从 流体储存器。
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公开(公告)号：US07449307B2
公开(公告)日：2008-11-11
申请号：US10694639
申请日：2003-10-27
申请人： Michael Cima , Wendy Pryce Lewis , Javier Gonzalez-Zugasti , J. Richard Gyory , Anthony V. Lemmo , Julie Monagle
发明人： Michael Cima , Wendy Pryce Lewis , Javier Gonzalez-Zugasti , J. Richard Gyory , Anthony V. Lemmo , Julie Monagle
CPC分类号： B01L3/5085 , B01L3/5025 , B01L3/5088 , B01L2300/0609 , B01L2300/0819 , B01L2300/0829
摘要： The assay plate includes a substrate having an substrate surface and at least one raised pad extending from the substrate surface. The raised pad includes a substantially planar sample receiving surface configured for holding a sample thereon for in situ experimentation. The sample receiving surface preferably has at least one sharp edge at the junction between a sidewall coupling the sample receiving surface to the substrate surface. The sample receiving surface is preferably a circle, oval, square, rectangle, triangle, pentagon, hexagon, or octagon shape that is sized to hold a predetermined volume of the sample. A method of using the above described assay plate is also provided. Once a raised pad extending from a substrate is formed, a sample is deposited on the raised pad. Experiments are subsequently performed using the sample on the raised pad.
摘要翻译： 测定板包括具有基底表面的基底和从基底表面延伸的至少一个凸起垫。 凸起垫包括基本平坦的样品接收表面，其构造成用于将样品保持在其上用于原位实验。 样品接收表面优选在将样品接收表面耦合到衬底表面的侧壁之间的接合处具有至少一个尖锐边缘。 样品接收表面优选为圆形，椭圆形，正方形，矩形，三角形，五边形，六边形或八边形，其尺寸适于保持样品的预定体积。 还提供了使用上述测定板的方法。 一旦形成了从衬底延伸的凸起垫，则将样品沉积在凸起垫上。 随后使用凸起垫上的样品进行实验。
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公开(公告)号：US07087035B2
公开(公告)日：2006-08-08
申请号：US09733506
申请日：2000-12-08
申请人： Joseph C. Trautman , Michel J. N. Cormier , Kellee Eng , Wei-Qi Lin , Hyunok L. Kim , Sara L. Sendelbeck , Armand P. Neukermans , Bruce P. Edwards , Wai-Loong Lim , Andrew I. Poutiatine , J. Richard Gyory
发明人： Joseph C. Trautman , Michel J. N. Cormier , Kellee Eng , Wei-Qi Lin , Hyunok L. Kim , Sara L. Sendelbeck , Armand P. Neukermans , Bruce P. Edwards , Wai-Loong Lim , Andrew I. Poutiatine , J. Richard Gyory
CPC分类号： A61M37/0015 , A61B17/205 , A61M5/425 , A61M2037/0023 , A61M2037/0046
摘要： A device and method for enhancing skin piercing by microprotrusions involves pre-stretching the skin to enhance pathway formation when the microprotrusions are pressed into the skin. An expandable device includes skin engaging opposite ends that contact the skin surface so that when the device is expanded the skin is stretched. The skin is placed under a tension of about 0.01 to about 10 megapascals, preferably about 0.05 to 2 megapascals. The device has a plurality of microprotrusions which penetrate the skin while the skin is being stretched by the expanded device. Another stretching device employs suction for skin stretching.
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公开(公告)号：US06317629B1
公开(公告)日：2001-11-13
申请号：US08351381
申请日：1994-12-02
申请人： Ronald P. Haak , J. Richard Gyory , Robert M. Myers , Felix A. Landrau , Harold F. Sanders , Lothar W. Kleiner , Linda M. Hearney
发明人： Ronald P. Haak , J. Richard Gyory , Robert M. Myers , Felix A. Landrau , Harold F. Sanders , Lothar W. Kleiner , Linda M. Hearney
IPC分类号： A61N130
CPC分类号： A61N1/0436 , A61N1/0444 , A61N1/0448 , A61N1/303
摘要： An iontophoretic delivery device (10) is provided. Device (10) has an electronic circuit (32) having electronic components such as batteries (30) mounted thereon. Device (10) also includes a pair of electrode assemblies (18, 19). The electronic circuit (32) is electrically connected to the electrode assemblies (18, 19) using an electrically conductive adhesive (34). The adhesive can also be used to electrically connect two or more electronic components within circuit (32) or to connect an electronic component to the electronic circuit (32). In one practice of the invention, the electrically conductive adhesive (44) functions as an electrode and electrically connects the circuit (32) to an agent-containing reservoir (24, 25). In a further practice of the invention, the electrically conductive adhesive (93) functions as an agent reservoir and contains the agent to be iontophoretically delivered.
摘要翻译： 提供了一种离子电渗疗法输送装置（10）。 设备（10）具有电子电路（32），其具有安装在其上的电池（30）等电子部件。 装置（10）还包括一对电极组件（18,19）。 使用导电粘合剂（34）将电子电路（32）电连接到电极组件（18,19）。 粘合剂也可以用于电连接电路（32）内的两个或更多个电子部件或将电子部件连接到电子电路（32）。 在本发明的一个实践中，导电粘合剂（44）用作电极并将电路（32）电连接到含药剂的储存器（24,25）。 在本发明的进一步实践中，导电粘合剂（93）用作试剂储存器并且包含待离子电渗传递的试剂。
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公开(公告)号：US5993435A
公开(公告)日：1999-11-30
申请号：US139036
申请日：1998-08-24
申请人： Ronald P. Haak , J. Richard Gyory , Felix Theeuwes
发明人： Ronald P. Haak , J. Richard Gyory , Felix Theeuwes
IPC分类号： A61N1/30
CPC分类号： A61N1/0444 , A61N1/0448 , A61N1/0436
摘要： A selectively permeable membrane (14) is positioned between the agent reservoir (15) and the electrode (11) of a donor electrode assembly (8) in an iontophoretic delivery device (10). Optionally, an electrolyte reservoir (13) is positioned intermediate the electrode (11) and the agent reservoir (15). In certain embodiments, the membrane (14) is permeable to species of less than a predetermined molecular weight and substantially less permeable to species of greater than the predetermined molecular weight. The agent is capable of dissociating into agent ions and counter ions. The size selectivity of the membrane (14), the molecular weight of the agent ions, the molecular weight of the counter ions, and optionally the molecular weight of the electrolyte ions are selected to (A) inhibit agent ions from interacting with the electrode (11), and from permeating into the electrolyte reservoir (13), where they might otherwise be degraded and (B) inhibit electrolyte ions, having a charge similar to that of the agent ions, from permeating into the agent reservoir (15) and competing with the agent ions for iontophoretic delivery into the patient.
摘要翻译： 选择性渗透膜（14）位于药剂储存器（15）和离子电渗输送装置（10）中的施主电极组件（8）的电极（11）之间。 可选地，电解质储存器（13）位于电极（11）和药剂储存器（15）之间。 在某些实施方案中，膜（14）对于小于预定分子量的物质是可渗透的，并且对于大于预定分子量的物质基本上较不可渗透。 该试剂能够解离成试剂离子和抗衡离子。 选择膜（14）的尺寸选择性，试剂离子的分子量，抗衡离子的分子量和任选的电解质离子的分子量以使（A）抑制剂离子与电极相互作用（ 11），并且从渗透到电解质储存器（13）中，否则可能会降解，并且（B）抑制具有类似于试剂离子的电荷的电解质离子渗透到试剂储存器（15）中并且竞争 用离子电渗疗法输送到患者体内。
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9.发明授权
公开(公告)号：US5883135A
公开(公告)日：1999-03-16
申请号：US846225
申请日：1997-04-28
CPC分类号： A61N1/0412 , A61K9/0009 , A61N1/0428 , A61N1/30
摘要： An electrotransport composition comprises at least one C.sub.2 -C.sub.4 lower alcohol, unsaturated derivatives thereof, or mixtures thereof, and at least one C.sub.8 -C.sub.14 higher alcohol, unsaturated derivatives thereof, or mixtures thereof. An electrotransport device and a method of increasing transdermal electrotransport flux utilize the composition of the invention for delivering pharmaceutically-acceptable agents across a body surface such as skin.
摘要翻译： 电转运组合物包含至少一种C 2 -C 4低级醇，其不饱和衍生物或其混合物，和至少一种C 8 -C 14高级醇，其不饱和衍生物或其混合物。 电传输装置和增加透皮电传导通量的方法利用本发明的组合物用于在诸如皮肤的身体表面上递送药学上可接受的试剂。
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公开(公告)号：US5533972A
公开(公告)日：1996-07-09
申请号：US129519
申请日：1993-09-30
申请人： J. Richard Gyory , John R. Peery
发明人： J. Richard Gyory , John R. Peery
IPC分类号： A61N1/30
CPC分类号： A61N1/0448 , A61N1/0436
摘要： A dry-state iontophoretic drug delivery device (10, 30) is provided. The device has drug and electrolyte reservoirs (15, 16) which are initially in a non-hydrated condition. In one embodiment of the invention, a sealed liquid-containing pouch (21, 22) is provided in each electrode assembly (8, 9). Water or other liquid (20) is released from the pouch (21, 22) by pulling a tab (27, 28) attached to a portion (25, 26) of the pouch (21, 22) which is capable of being torn or ripped in order to hydrate the drug and electrolyte reservoirs (15, 16) and activate the device (10, 30). In another embodiment, the device (30) is held in a package (32). The device (30) has pouches (21, 22) which release their liquid contents automatically upon removal of the device (30) from the package (32). In yet another embodiment, the device (40) is held in a package (42) having a compression zone (46). The pouches (21, 22) must be moved through the compression zone (46) when removing the device (40) from the package (42). Compression causes the pouches (21, 22) to rupture and release the hydrating liquid (20).
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