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    Compounds Having Crth2 Antagonist Activity
    13.
    发明申请
    Compounds Having Crth2 Antagonist Activity 审中-公开

    公开(公告)号：US20070232681A1

    公开(公告)日：2007-10-04

    申请号：US10573670

    申请日：2004-10-13

    申请人： David Middlemiss ,  Mark Ashton ,  Edward Boyd ,  Frederick Brookfield ,  Richard Armer ,  Eric Pettipher

    发明人： David Middlemiss ,  Mark Ashton ,  Edward Boyd ,  Frederick Brookfield ,  Richard Armer ,  Eric Pettipher

    IPC分类号： A61K31/40 ,  A61K31/405 ,  C07D209/04 ,  C07D209/34

    CPC分类号： C04B35/632 ,  C07D209/30 ,  C07D401/12 ,  C07D403/12 ,  C07D417/12

    摘要： Compounds of general formula (I): wherein R1, R2, R3 and R4 are independently hydrogen, halo, C1-C6 alkyl, —O(C1-C6 alkyl), —CON(R9)2, —SOR9, —SO2R9, —SO2N(R9)2, —N(R9)2, —NR9COR9, —CO2R9, —COR9, —SR9, —OH, —NO2 or —CN; each R9 is independently hydrogen or C1-C6 alkyl; R5 and R6 are each independently hydrogen, or C1-C6 alkyl or together with the carbon atom to which they are attached form a C3-C7 cycloalkyl group; R7 is hydrogen or C1-C6 alkyl n is 1 or 2; X is a bond or, when n is 2, X may also be a NR9 group; wherein R9 is as defined above; when X is a bond R8 is C1-C6 alkyl, C2-C6 alkenyl, C2-C6 alkynyl, biphenyl or a 9-14 membered bicyclic or tricyclic heteroaryl group; when X is a NR9 group R8 may additionally be phenyl, naphthyl or a 5-7 membered heteroaromatic ring; and the R8 group is optionally substituted with one or more substituents selected from halo, C1-C6 alkyl, —O(C1-C6)alkyl, aryl, —O-aryl, heteroaryl, —O-heteroaryl, —CON(R9)2, —SOR9, —SO2R9, SO2N(9)2, —N(9)2, —NR9COR9, —CO2R9, —COR9, —SR9, —OH, —NO2 or —CN; wherein R9 is as defined above; and their pharmaceutically acceptable salts, hydrates, solvates, complexes and prodrugs are useful in the treatment of allergic diseases such as asthma, allergic rhinitis and atopic dermatitis.

    Ethanolamine derivatives
    17.
    发明授权
    Ethanolamine derivatives 失效
    乙醇胺衍生物

    公开(公告)号：US4908386A

    公开(公告)日：1990-03-13

    申请号：US287441

    申请日：1988-12-20

    申请人： Harry Finch ,  Lawrence H. C. Lunts ,  Alan Naylor ,  Ian F. Skidmore ,  Ian B. Campbell ,  David Middlemiss ,  Charles Willbe

    发明人： Harry Finch ,  Lawrence H. C. Lunts ,  Alan Naylor ,  Ian F. Skidmore ,  Ian B. Campbell ,  David Middlemiss ,  Charles Willbe

    IPC分类号： C07D213/65 ,  C07D295/096 ,  C07C143/74 ,  A61K31/18

    CPC分类号： C07D295/096 ,  C07D213/65 ,  Y10S514/826

    摘要： The present invention provides compounds of general formula (I) ##STR1## wherein Ar represents an unsubstituted or substituted phenyl gorup;R.sup.1 and R.sup.2 each represents a hydrogen atom or a C.sub.1-3 alkyl group;X represents a bond or a C.sub.1-7 alkylene, C.sub.2-7 alkenylene or C.sub.2-7 alkynylene chain;Y represents a bond or a C.sub.1-6 alkylene, C.sub.2-6 alkenylene or C.sub.2-6 alkynylene chain;Q represents a substituted phenyl or pyridyl ring;and physiologically acceptable salts and solvates thereof useful as stimulants of .sub.2 -adrenoreceptors and particularly in the treatment of diseases associated with reversible airways obstruction such as asthma and chronic bronchitis.

    摘要翻译： 本发明提供通式（I）的化合物，其中Ar表示未取代或取代的苯基; R1和R2各自表示氢原子或C1-3烷基; X表示键或C 1-7亚烷基，C 2-7亚烯基或C 2-7亚炔基链; Y表示键或C 1-6亚烷基，C 2-6亚烯基或C 2-6亚炔基链; Q表示取代的苯基或吡啶环; 以及其可用作2-肾上腺素受体的兴奋剂的生理上可接受的盐和溶剂合物，特别是用于治疗与可逆气道阻塞如哮喘和慢性支气管炎相关的疾病。