公开(公告)号：US07424789B2

公开(公告)日：2008-09-16

申请号：US11218890

申请日：2005-09-02

申请人： David Zhou

发明人： David Zhou

IPC分类号： F24B3/00 ,  F24B13/00

CPC分类号： F24B1/198 ,  E04F19/005

摘要： A master bracket system is provided to install a modular fireplace mantel at a fireplace opening. The bracket is generally C-shaped having a base plain and a number of planar extensions with predetermined angles to one another. Each of the plain surfaces of the bracket has an eyelet at the mounting point to receive a bolt that secures the corresponding marble member to the bracket. The base plain provides a retaining base for a main bolt to hold the entire mantel assembly to the wall. A number of brackets are used for each of the opposite sides of the mantel structure against the structure wall. The bracket has bolts each threaded through the eyelets into connection with a machined metal insert, which is embedded within the mantel members and held in place by adhesive.

摘要翻译： 提供主支架系统，在壁炉开口处安装模块化壁炉壁炉。 支架大致为C形，具有基部平面和多个彼此具有预定角度的平面延伸部。 支架的每个平坦表面在安装点处具有孔眼以接收将相应的大理石构件固定到支架的螺栓。 基座平面为主螺栓提供一个保持底座，用于将整个壁架组件固定在墙壁上。 对于壁架结构的相对于结构壁的相对侧中使用多个托架。 支架具有螺栓，每个螺栓穿过孔眼，与加工的金属插入件相连接，该金属插入件嵌入在壁架构件内并通过粘合剂保持在适当位置。

公开(公告)号：US20060051237A1

公开(公告)日：2006-03-09

申请号：US11258636

申请日：2005-10-26

申请人： Naishu Wang ,  David Zhou

发明人： Naishu Wang ,  David Zhou

IPC分类号： G01N33/567 ,  G01N31/22 ,  C12M1/34 ,  G01N33/53

CPC分类号： G01N33/5302 ,  B01L3/5023 ,  B01L3/502746 ,  B01L2200/0621 ,  B01L2300/0672 ,  B01L2300/0825 ,  B01L2300/0867 ,  B01L2400/0406 ,  B01L2400/084 ,  G01N33/558

摘要： A self-contained apparatus using a gravitationally encouraged, interrupted, downward, diffusive and programmed flow of fluid to provide for rapid confirmatory immunological testing (“RCIT”) in, for example, a clinical, point-of-care setting. A fluid specimen such as blood, saliva or urine is deposited into a first chamber carrying a source of conjugate having mobilizable binding members such as immunographic antigens or antibodies specific to the condition being tested conjugated to a detectable label such as colloidal gold. The specimen is premixed with a first measured, reactive mix buffer solution carried within an openable tank. The specimen and solution are temporarily held within an incubation reservoir formed behind a dam made from porous, diffusive material. The delay and flow through the diffusive dam causes mixing of the specimen and solution to form a premixture which exhibits a more uniformly high degree of first affinity binding before flowing out of the first chamber toward one or more chromatographic test strips in a second chamber. In one embodiment, after a waiting period, a bladder containing a stop-wash buffer solution is opened to flow onto the strips. Additional embodiments provide one or more diffusive structures that can be pretreated with mixture enhancing chemicals such as surfactants. It is a rapid confirmatory immunological test apparatus having an analytical panel which can provide profile diagnostic results.

摘要翻译： 使用重力鼓励，中断，向下，扩散和编程的流体流的独立装置，用于在例如临床，护理点设置中提供快速确认免疫测试（“RCIT”）。 流体样品如血液，唾液或尿液沉积在携带具有可移动结合成员的缀合物源的第一室中，例如免疫印迹抗原或被检测条件特异的抗体与可检测标记如胶体金缀合。 样品与携带在可开罐内的第一测量的反应性混合缓冲溶液预混合。 试样和溶液临时保存在形成在由多孔扩散材料制成的坝后面的孵化池中。 通过扩散坝的延迟和流动导致样品和溶液的混合以形成预混合物，其在从第一室流出到第二室中的一个或多个色谱测试条之前，呈现出更均匀的高度的第一亲和力结合。 在一个实施例中，在等待时间之后，打开包含停止洗涤缓冲溶液的气囊以流动到条上。 另外的实施方案提供一种或多种可以用混合物增强化学物质例如表面活性剂预处理的扩散结构。 它是具有能够提供轮廓诊断结果的分析面板的快速确认性免疫测试装置。

公开(公告)号：US20050186111A1

公开(公告)日：2005-08-25

申请号：US11090463

申请日：2005-03-25

申请人： Naishu Wang ,  David Zhou

发明人： Naishu Wang ,  David Zhou

IPC分类号： G01N21/00

CPC分类号： B01L3/5023 ,  B01L3/502746 ,  B01L2200/0621 ,  B01L2300/0672 ,  B01L2300/0825 ,  B01L2300/0867 ,  B01L2400/0406 ,  B01L2400/084

摘要： A self-contained device using a gravitationally encouraged, interrupted downward and programmed flow of fluid to provide for rapid confirmatory immunological testing (“RCIT”) in a point-of-care setting. A fluid specimen such as blood, saliva or urine is deposited into a first chamber carrying a colloidal conjugate of antigens or antibodies pathogenically specific to the condition being tested and premixed with a first measured, reactive mix buffer solution carried within an openable tank. Alternately, the buffer solution is preformulated to carry the colloidal conjugate in suspension. The premixture flows out of the first chamber toward chromatographic test strips having a single layer of uniformly dispersed porous matrix material such as polyethylene and inclined in a downward flow orientation. The flow is interrupted by a holding reservoir which is drained by siphoning, gravity and capillary forces. The delayed and regulated flow provides an incubation time for a better affinity binding of the specimen. In one embodiment, after a waiting period a bladder containing a stop-wash buffer solution is opened to flow into the reservoir and onto the strips. An absorbant pad collects excess fluid at the bottom end of the strips. It is a rapid confirmatory immunological test device having an analytical panel which can provide profile diagnostic results.

摘要翻译： 一个独立的设备，使用重力鼓励，中断向下和编程的流体流动，以便在一个护理环境中提供快速确认的免疫测试（“RCIT”）。 流体样品如血液，唾液或尿液沉积在携带抗原或抗体的胶体缀合物的第一室中，所述抗体或抗体对所测试的病症具有特异性特异性，并与携带在可开启罐内的第一测量的反应性混合缓冲溶液预混合。 或者，预先配制缓冲溶液以携带悬浮液中的胶体缀合物。 预混合物从第一室流出到具有单层均匀分散的多孔基体材料如聚乙烯并且以向下流动方向倾斜的色谱测试条。 流动被一个通过虹吸，重力和毛细管力排出的保持储存器中断。 延迟和调节的流动提供了孵育时间以更好地亲和地结合样品。 在一个实施方案中，在等待期之后，打开包含停止洗涤缓冲溶液的气囊以流入储存器和条上。 吸收垫在条的底端收集多余的流体。 它是一种具有可提供轮廓诊断结果的分析面板的快速确证免疫测试装置。

公开(公告)号：US20050163658A1

公开(公告)日：2005-07-28

申请号：US10767897

申请日：2004-01-28

申请人： Naishu Wang ,  David Zhou

发明人： Naishu Wang ,  David Zhou

IPC分类号： G01N33/53 ,  G01N33/558 ,  G01N31/22

CPC分类号： G01N33/558 ,  G01N2333/16

摘要： In a vertical flow immunoassay testing device, the fluid specimen is deposited in a sampling well whose inclined walls and filtration material separate mucus and other adhesive matters from the more fluid components. The mixing of the specimen with a buffer solution is triggered by the closure of the device's cap. The flow of the buffered specimen from a first chamber where it is exposed to a collodial gold conjugate to a second chamber holding a chromatographic test strip is temporarily interrupted by a holding reservoir. The specimen does not freely flow into the strip until the reservoir begins to overflow. The delay provides an incubation time for a better affinity binding of the specimen and regulates its flow through the strip.

摘要翻译： 在垂直流动免疫测定装置中，流体样本沉积在采样井中，其倾斜壁和过滤材料将粘液和其它粘合剂与更多的流体组分分开。 试样与缓冲溶液的混合是通过封闭装置的盖子来触发的。 被缓冲的样品从暴露于胶体金共轭体的第一室的流动保持着色谱测试条的第二室暂时被保持储存器中断。 试样不会自由地流入钢带，直到油层开始溢出。 延迟提供孵育时间以更好地亲和地结合样品并调节其通过条带的流动。