公开(公告)号：US07424789B2

公开(公告)日：2008-09-16

申请号：US11218890

申请日：2005-09-02

申请人： David Zhou

发明人： David Zhou

IPC分类号： F24B3/00 ,  F24B13/00

CPC分类号： F24B1/198 ,  E04F19/005

摘要： A master bracket system is provided to install a modular fireplace mantel at a fireplace opening. The bracket is generally C-shaped having a base plain and a number of planar extensions with predetermined angles to one another. Each of the plain surfaces of the bracket has an eyelet at the mounting point to receive a bolt that secures the corresponding marble member to the bracket. The base plain provides a retaining base for a main bolt to hold the entire mantel assembly to the wall. A number of brackets are used for each of the opposite sides of the mantel structure against the structure wall. The bracket has bolts each threaded through the eyelets into connection with a machined metal insert, which is embedded within the mantel members and held in place by adhesive.

摘要翻译： 提供主支架系统，在壁炉开口处安装模块化壁炉壁炉。 支架大致为C形，具有基部平面和多个彼此具有预定角度的平面延伸部。 支架的每个平坦表面在安装点处具有孔眼以接收将相应的大理石构件固定到支架的螺栓。 基座平面为主螺栓提供一个保持底座，用于将整个壁架组件固定在墙壁上。 对于壁架结构的相对于结构壁的相对侧中使用多个托架。 支架具有螺栓，每个螺栓穿过孔眼，与加工的金属插入件相连接，该金属插入件嵌入在壁架构件内并通过粘合剂保持在适当位置。

公开(公告)号：US20060051237A1

公开(公告)日：2006-03-09

申请号：US11258636

申请日：2005-10-26

申请人： Naishu Wang ,  David Zhou

发明人： Naishu Wang ,  David Zhou

IPC分类号： G01N33/567 ,  G01N31/22 ,  C12M1/34 ,  G01N33/53

CPC分类号： G01N33/5302 ,  B01L3/5023 ,  B01L3/502746 ,  B01L2200/0621 ,  B01L2300/0672 ,  B01L2300/0825 ,  B01L2300/0867 ,  B01L2400/0406 ,  B01L2400/084 ,  G01N33/558

摘要： A self-contained apparatus using a gravitationally encouraged, interrupted, downward, diffusive and programmed flow of fluid to provide for rapid confirmatory immunological testing (“RCIT”) in, for example, a clinical, point-of-care setting. A fluid specimen such as blood, saliva or urine is deposited into a first chamber carrying a source of conjugate having mobilizable binding members such as immunographic antigens or antibodies specific to the condition being tested conjugated to a detectable label such as colloidal gold. The specimen is premixed with a first measured, reactive mix buffer solution carried within an openable tank. The specimen and solution are temporarily held within an incubation reservoir formed behind a dam made from porous, diffusive material. The delay and flow through the diffusive dam causes mixing of the specimen and solution to form a premixture which exhibits a more uniformly high degree of first affinity binding before flowing out of the first chamber toward one or more chromatographic test strips in a second chamber. In one embodiment, after a waiting period, a bladder containing a stop-wash buffer solution is opened to flow onto the strips. Additional embodiments provide one or more diffusive structures that can be pretreated with mixture enhancing chemicals such as surfactants. It is a rapid confirmatory immunological test apparatus having an analytical panel which can provide profile diagnostic results.

摘要翻译： 使用重力鼓励，中断，向下，扩散和编程的流体流的独立装置，用于在例如临床，护理点设置中提供快速确认免疫测试（“RCIT”）。 流体样品如血液，唾液或尿液沉积在携带具有可移动结合成员的缀合物源的第一室中，例如免疫印迹抗原或被检测条件特异的抗体与可检测标记如胶体金缀合。 样品与携带在可开罐内的第一测量的反应性混合缓冲溶液预混合。 试样和溶液临时保存在形成在由多孔扩散材料制成的坝后面的孵化池中。 通过扩散坝的延迟和流动导致样品和溶液的混合以形成预混合物，其在从第一室流出到第二室中的一个或多个色谱测试条之前，呈现出更均匀的高度的第一亲和力结合。 在一个实施例中，在等待时间之后，打开包含停止洗涤缓冲溶液的气囊以流动到条上。 另外的实施方案提供一种或多种可以用混合物增强化学物质例如表面活性剂预处理的扩散结构。 它是具有能够提供轮廓诊断结果的分析面板的快速确认性免疫测试装置。

公开(公告)号：US20050186111A1

公开(公告)日：2005-08-25

申请号：US11090463

申请日：2005-03-25

申请人： Naishu Wang ,  David Zhou

发明人： Naishu Wang ,  David Zhou

IPC分类号： G01N21/00

CPC分类号： B01L3/5023 ,  B01L3/502746 ,  B01L2200/0621 ,  B01L2300/0672 ,  B01L2300/0825 ,  B01L2300/0867 ,  B01L2400/0406 ,  B01L2400/084

摘要： A self-contained device using a gravitationally encouraged, interrupted downward and programmed flow of fluid to provide for rapid confirmatory immunological testing (“RCIT”) in a point-of-care setting. A fluid specimen such as blood, saliva or urine is deposited into a first chamber carrying a colloidal conjugate of antigens or antibodies pathogenically specific to the condition being tested and premixed with a first measured, reactive mix buffer solution carried within an openable tank. Alternately, the buffer solution is preformulated to carry the colloidal conjugate in suspension. The premixture flows out of the first chamber toward chromatographic test strips having a single layer of uniformly dispersed porous matrix material such as polyethylene and inclined in a downward flow orientation. The flow is interrupted by a holding reservoir which is drained by siphoning, gravity and capillary forces. The delayed and regulated flow provides an incubation time for a better affinity binding of the specimen. In one embodiment, after a waiting period a bladder containing a stop-wash buffer solution is opened to flow into the reservoir and onto the strips. An absorbant pad collects excess fluid at the bottom end of the strips. It is a rapid confirmatory immunological test device having an analytical panel which can provide profile diagnostic results.

摘要翻译： 一个独立的设备，使用重力鼓励，中断向下和编程的流体流动，以便在一个护理环境中提供快速确认的免疫测试（“RCIT”）。 流体样品如血液，唾液或尿液沉积在携带抗原或抗体的胶体缀合物的第一室中，所述抗体或抗体对所测试的病症具有特异性特异性，并与携带在可开启罐内的第一测量的反应性混合缓冲溶液预混合。 或者，预先配制缓冲溶液以携带悬浮液中的胶体缀合物。 预混合物从第一室流出到具有单层均匀分散的多孔基体材料如聚乙烯并且以向下流动方向倾斜的色谱测试条。 流动被一个通过虹吸，重力和毛细管力排出的保持储存器中断。 延迟和调节的流动提供了孵育时间以更好地亲和地结合样品。 在一个实施方案中，在等待期之后，打开包含停止洗涤缓冲溶液的气囊以流入储存器和条上。 吸收垫在条的底端收集多余的流体。 它是一种具有可提供轮廓诊断结果的分析面板的快速确证免疫测试装置。

公开(公告)号：US20050163658A1

公开(公告)日：2005-07-28

申请号：US10767897

申请日：2004-01-28

申请人： Naishu Wang ,  David Zhou

发明人： Naishu Wang ,  David Zhou

IPC分类号： G01N33/53 ,  G01N33/558 ,  G01N31/22

CPC分类号： G01N33/558 ,  G01N2333/16

摘要： In a vertical flow immunoassay testing device, the fluid specimen is deposited in a sampling well whose inclined walls and filtration material separate mucus and other adhesive matters from the more fluid components. The mixing of the specimen with a buffer solution is triggered by the closure of the device's cap. The flow of the buffered specimen from a first chamber where it is exposed to a collodial gold conjugate to a second chamber holding a chromatographic test strip is temporarily interrupted by a holding reservoir. The specimen does not freely flow into the strip until the reservoir begins to overflow. The delay provides an incubation time for a better affinity binding of the specimen and regulates its flow through the strip.

摘要翻译： 在垂直流动免疫测定装置中，流体样本沉积在采样井中，其倾斜壁和过滤材料将粘液和其它粘合剂与更多的流体组分分开。 试样与缓冲溶液的混合是通过封闭装置的盖子来触发的。 被缓冲的样品从暴露于胶体金共轭体的第一室的流动保持着色谱测试条的第二室暂时被保持储存器中断。 试样不会自由地流入钢带，直到油层开始溢出。 延迟提供孵育时间以更好地亲和地结合样品并调节其通过条带的流动。

公开(公告)号：US06650757B1

公开(公告)日：2003-11-18

申请号：US09405020

申请日：1999-09-27

申请人： David Zhou ,  Francois Charette ,  Keng D. Hsueh ,  Vy Tran ,  Hsiao-An Hsieh

发明人： David Zhou ,  Francois Charette ,  Keng D. Hsueh ,  Vy Tran ,  Hsiao-An Hsieh

IPC分类号： A61F1106

CPC分类号： G01H3/08 ,  G01H1/00 ,  G01M13/028 ,  G01M17/04

摘要： An apparatus for detecting unwanted noise includes a reference sensor that generates a reference signal in response to stimulation by a source. A combined noise detector picks up a combined noise signal, which includes both background noise and the unwanted noise generated by the source. A noise separation synthesis device filters both signals to generate a coherent unwanted noise signal from the combined noise signal as a function of the reference signal generated by the reference sensor. A comparator determines the presence of unwanted noise by calculating the Kurtosis value of the coherent unwanted noise signal.

摘要翻译： 用于检测不需要的噪声的装置包括参考传感器，其响应于源的刺激而产生参考信号。 组合噪声检测器拾取组合噪声信号，其包括背景噪声和源产生的不需要的噪声。 噪声分离合成装置对两个信号进行滤波，以根据由参考传感器产生的参考信号的组合噪声信号产生相干不需要的噪声信号。 比较器通过计算相干不需要的噪声信号的峰度值来确定存在不想要的噪声。

公开(公告)号：US20070184492A1

公开(公告)日：2007-08-09

申请号：US11738356

申请日：2007-04-20

申请人： Naishu Wang ,  David Zhou

发明人： Naishu Wang ,  David Zhou

IPC分类号： G01N33/53 ,  C12M3/00

CPC分类号： G01N33/5302 ,  B01L3/5023 ,  B01L3/502746 ,  B01L2200/0621 ,  B01L2300/0672 ,  B01L2300/0825 ,  B01L2300/0867 ,  B01L2400/0406 ,  B01L2400/084 ,  G01N33/558

摘要： A self-contained apparatus using a gravitationally encouraged, interrupted, downward, diffusive and programmed flow of fluid to provide for rapid confirmatory immunological testing (“RCIT”) in, for example, a clinical, point-of-care setting. A fluid specimen such as blood, saliva or urine is deposited into a first chamber carrying a source of conjugate having mobilizable binding members such as immunographic antigens or antibodies specific to the condition being tested conjugated to a detectable label such as colloidal gold. The specimen is premixed with a first measured, reactive mix buffer solution carried within an openable tank. The specimen and solution are temporarily held within an incubation reservoir formed behind a dam made from porous, diffusive material. The delay and flow through the diffusive dam causes mixing of the specimen and solution to form a premixture which exhibits a more uniformly high degree of first affinity binding before flowing out of the first chamber toward one or more chromatographic test strips in a second chamber. In one embodiment, after a waiting period, a bladder containing a stop-wash buffer solution is opened to flow onto the strips. Additional embodiments provide one or more diffusive structures that can be pretreated with mixture enhancing chemicals such as surfactants. It is a rapid confirmatory immunological test apparatus having an analytical panel which can provide profile diagnostic results.

公开(公告)号：US20070269906A1

公开(公告)日：2007-11-22

申请号：US11881455

申请日：2007-07-27

申请人： Naishu Wang ,  David Zhou

发明人： Naishu Wang ,  David Zhou

IPC分类号： G01N33/536 ,  G01N33/00

CPC分类号： G01N33/54386 ,  G01N33/536 ,  G01N33/558 ,  Y10T436/117497 ,  Y10T436/118339 ,  Y10T436/119163 ,  Y10T436/2575

摘要： A device and method for enhancing rapid confirmatory immunological testing (“RCIT”) in chromatography strip-type rapid IVD devices useful in, for example, clinical, point-of-care, laboratory or over-the-counter settings. The device drives a flow fluid, primarily under the force of gravity alone, through a first chamber having a porous dam structure to enhance and substantially complete the first affinity binding reaction between a source of mobilizable labeled binding members and an analyte in the fluid. Flow through the dam causes a delay, mixing and trapping of the typically chemically disuniform initial fluid front so that fluid exiting the dam exhibits a more uniformly high degree of first affinity binding and decreased non-affinity binding. Afterward, and without further human interaction, the fluid then flows under the combined, turbulence creating forces of gravity, siphoning, and capillarity, through a second chamber containing a chromatographic strip which captures the labeled analytes in a second affinity binding reaction. By separating the two affinity binding reactions, competition for analytes during each reaction is reduced, and thus accuracy improved.

摘要翻译： 用于例如在临床，护理点，实验室或非处方设置中有用的色谱条带型快速IVD装置中的快速确认免疫测试（“RCIT”）的装置和方法。 该装置主要在重力作用下驱动流体流体通过具有多孔坝结构的第一室，以增强并基本上完成可移动标记的结合构件的源和流体中的分析物之间的第一亲和结合反应。 通过大坝的流动导致典型的化学不均匀初始流体前沿的延迟，混合和捕获，使得离开坝的流体表现出更均匀的高度的第一亲和力结合和减少的非亲和力结合。 之后，并且在没有进一步的人类相互作用的情况下，流体在组合的湍流之下通过包含在第二亲和力结合反应中捕获标记分析物的色谱条的第二室产生重力，虹吸和毛细作用力。 通过分离两种亲和力结合反应，减少了每次反应期间对分析物的竞争，从而提高了精确度。

公开(公告)号：US20060292700A1

公开(公告)日：2006-12-28

申请号：US11158547

申请日：2005-06-22

申请人： Naishu Wang ,  David Zhou

发明人： Naishu Wang ,  David Zhou

IPC分类号： G01N33/558

CPC分类号： G01N33/558 ,  G01N33/54386

摘要： A lateral flow chromatographic immunoassay rapid test device having an additional interrupting, porous, diffusive pad pretreated with a surfactant interposed between the conjugate pad and the reaction membrane. The diffusive pad causes improved mixing of the fluid to provide a more mixture of molecules in the fluid and a more uniformly dispersed fluid flow having a more uniformly high degree of first affinity binding and a more even fluid front to cross into the reaction membrane, thereby increasing the sensitivity and specificity of the second affinity binding at both test and control lines, and thereby providing an important advancement of the existing lateral flow rapid test technology.

摘要翻译： 一种侧流色谱免疫测定快速测试装置，其具有预先用表面活性剂预处理的另外的中断，多孔扩散垫，所述表面活性剂插入在所述共轭垫和所述反应膜之间。 扩散垫引起改善的流体混合以在流体中提供更多的分子混合物，以及更均匀地分散的流体流，其具有更均匀的高度的第一亲和力结合和更均匀的流体前沿以穿过反应膜，由此 增加了测试和对照线上第二亲和力结合的灵敏度和特异性，从而提供了现有侧流快速测试技术的重要进步。

公开(公告)号：US08696917B2

公开(公告)日：2014-04-15

申请号：US12699302

申请日：2010-02-03

申请人： James R. Petisce ,  David Zhou ,  Mena Valiket

发明人： James R. Petisce ,  David Zhou ,  Mena Valiket

IPC分类号： H01B13/00

CPC分类号： G01N27/3272 ,  A61B5/0006 ,  A61B5/415 ,  A61B2562/0209 ,  A61B2562/028 ,  A61B2562/043 ,  A61B2562/12 ,  A61B2562/125 ,  B32B37/025 ,  B32B2309/105 ,  B32B2311/02 ,  B32B2457/00 ,  B32B2535/00 ,  B81C1/00539

摘要： Methods for fabricating analyte sensor components using IC- or MEMs-based fabrication techniques and sensors prepared therefrom. Fabrication of the analyte sensor component comprises providing an inorganic substrate having deposited thereon a release layer, a first flexible dielectric layer and a second flexible dielectric layer insulating there between electrodes, contact pads and traces connecting the electrodes and the contact pads of a plurality of sensors. Openings are provided in one of the dielectric layers over one or more of the electrodes to receive an analyte sensing membrane for the detection of an analyte of interest and for electrical connection with external electronics. The plurality of fabricated sensor components are lifted off the inorganic substrate.

摘要翻译： 使用基于IC或MEM的制造技术和由其制备的传感器来制造分析物传感器部件的方法。 分析物传感器部件的制造包括提供其上沉积有释放层的无机基材，在电极之间绝缘的第一柔性介电层和绝缘的第二柔性介电层，连接多个传感器的电极和接触焊盘的接触焊盘和迹线 。 在一个或多个电极中的一个电介质层中提供开口，以接收用于检测感兴趣分析物并与外部电子器件电连接的分析物感测膜。 将多个制造的传感器部件从无机基板上提起。

公开(公告)号：US20100200538A1

公开(公告)日：2010-08-12

申请号：US12699302

申请日：2010-02-03

申请人： James R. Petisce ,  David Zhou ,  Mena Valiket

发明人： James R. Petisce ,  David Zhou ,  Mena Valiket

IPC分类号： B32B38/10

CPC分类号： G01N27/3272 ,  A61B5/0006 ,  A61B5/415 ,  A61B2562/0209 ,  A61B2562/028 ,  A61B2562/043 ,  A61B2562/12 ,  A61B2562/125 ,  B32B37/025 ,  B32B2309/105 ,  B32B2311/02 ,  B32B2457/00 ,  B32B2535/00 ,  B81C1/00539

摘要： Methods for fabricating analyte sensor components using IC- or MEMs-based fabrication techniques and sensors prepared therefrom. Fabrication of the analyte sensor component comprises providing an inorganic substrate having deposited thereon a release layer, a first flexible dielectric layer and a second flexible dielectric layer insulating there between electrodes, contact pads and traces connecting the electrodes and the contact pads of a plurality of sensors. Openings are provided in one of the dielectric layers over one or more of the electrodes to receive an analyte sensing membrane for the detection of an analyte of interest and for electrical connection with external electronics. The plurality of fabricated sensor components are lifted off the inorganic substrate.

摘要翻译： 使用基于IC或MEM的制造技术和由其制备的传感器来制造分析物传感器部件的方法。 分析物传感器部件的制造包括提供其上沉积有释放层的无机基材，在电极之间绝缘的第一柔性介电层和绝缘的第二柔性介电层，连接多个传感器的电极和接触焊盘的接触焊盘和迹线 。 在一个或多个电极中的一个电介质层中提供开口，以接收用于检测感兴趣分析物并与外部电子器件电连接的分析物感测膜。 将多个制造的传感器部件从无机基板上提起。