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11.发明申请ASSOCIATION OF EDG5 POLYMORPHISM V286A WITH TYPE II DIABETES MELLITUS AND VENOUS THROMBOSIS/PULMONARY EMBOLISM AND THE USE THEREOF 失效EDG5多态性V286A与II型糖尿病和静脉血栓形成/肺动脉栓塞的联合及其使用公开(公告)号：US20110104704A1
公开(公告)日：2011-05-05
申请号：US13006619
申请日：2011-01-14
申请人： Detlef Kozian , Evi Kostenis , Karl-Ernst Siegler , Martina Jacobs , Jean-Francois Deleuze , Sylvain Ricard , Sandrine Mace
发明人： Detlef Kozian , Evi Kostenis , Karl-Ernst Siegler , Martina Jacobs , Jean-Francois Deleuze , Sylvain Ricard , Sandrine Mace
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6883 , C12Q2600/156
摘要： The present invention relates to a method of identifying an increase in risk for type II Diabetes mellitus, venous thrombosis, or pulmonary embolism in a subject, wherein the presence of an amino acid exchange at position 286 from valine (Val) to alanine (Ala) in the EDG5 protein in a biological sample taken from the subject.
摘要翻译： 本发明涉及鉴定受试者中II型糖尿病，静脉血栓形成或肺栓塞风险增加的方法，其中286位从缬氨酸（Val）到丙氨酸（Ala）的氨基酸交换的存在 在取自受试者的生物样品中的EDG5蛋白中。
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12.发明授权Association of EDG5 polymorphism V286A with type II diabetes mellitus and venous thrombosis/pulmonary embolism and the use thereof 失效EDG5多态性V286A与II型糖尿病和静脉血栓形成/肺栓塞的关系及其用途公开(公告)号：US07262273B2
公开(公告)日：2007-08-28
申请号：US10393870
申请日：2003-03-21
申请人： Detlef Kozian , Evi Kostenis , Karl-Ernst Siegler , Martina Jacobs , Jean-Francois Deleuze , Sylvain Ricard , Sandrine Mace
发明人： Detlef Kozian , Evi Kostenis , Karl-Ernst Siegler , Martina Jacobs , Jean-Francois Deleuze , Sylvain Ricard , Sandrine Mace
CPC分类号： C12Q1/6883 , C12Q2600/156
摘要： The present invention relates to a method of identifying an increase in risk for type II Diabetes mellitus, venous thrombosis, or pulmonary embolism in a subject, wherein the presence of an amino acid exchange at position 286 from valine (Val) to alanine (Ala) in the EDG5 protein in a biological sample taken from the subject.
摘要翻译： 本发明涉及鉴定受试者中II型糖尿病，静脉血栓形成或肺栓塞风险增加的方法，其中286位从缬氨酸（Val）到丙氨酸（Ala）的氨基酸交换的存在 在取自受试者的生物样品中的EDG5蛋白中。
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13.发明授权Analysis and use of PAR1 polymorphisms for evaluating the risk of cardiovascular disorders 失效分析和使用PAR1多态性评估心血管疾病风险公开(公告)号：US07892744B2
公开(公告)日：2011-02-22
申请号：US12567942
申请日：2009-09-28
申请人： Detlef Kozian , Joerg Czech , Karl-Ernst Siegler , Jean-Francois Deleuze , Sylvain Ricard , Sandrine Mace
发明人： Detlef Kozian , Joerg Czech , Karl-Ernst Siegler , Jean-Francois Deleuze , Sylvain Ricard , Sandrine Mace
CPC分类号： C12Q1/6883 , C07H17/08 , C07K14/723 , C12Q2600/156
摘要： The invention relates to polynucleotide sequences comprising genetic variations of the PAR1 gene at positions 3090 and/or 3329. The occurrence of these variants in humans correlates with increased occurrence of particular cardiovascular disorders. The invention furthermore relates to methods for detecting said genetic variations for the purpose of patient diagnosis.
摘要翻译： 本发明涉及包含位点3090和/或3329上的PAR1基因的遗传变异的多核苷酸序列。人类中这些变体的发生与特定心血管疾病的增加的发生相关。 本发明还涉及用于检测用于患者诊断目的的所述遗传变异的方法。
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公开(公告)号：US20080312098A1
公开(公告)日：2008-12-18
申请号：US11913873
申请日：2006-05-03
申请人： Detlef Kozian , Matthias Herrmann , Karl-Ernst Siegler , Jean-Francois Deleuze , Sylvain Ricard , Sandrine Mace
发明人： Detlef Kozian , Matthias Herrmann , Karl-Ernst Siegler , Jean-Francois Deleuze , Sylvain Ricard , Sandrine Mace
IPC分类号： C40B30/04 , C12Q1/68 , C12Q1/02 , G01N33/566 , A61K31/15 , A61P9/00 , C07H21/04 , G01N33/567 , G01N33/53
CPC分类号： C12Q1/6883 , C12Q1/6897 , C12Q2600/156 , C12Q2600/158
摘要： The use of the single nucleotide polymorphism (SNP) at position −(97) of the GIP gene for the identification of a cardiovascular disease or of an increased risk for developing a cardiovascular disease in a biological sample taken from an individual to be examined.
摘要翻译： 在GIP基因的位置（97）处使用单核苷酸多态性（SNP）来鉴定从被检查个体获取的生物样品中的心血管疾病或发展心血管疾病的风险增加。
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15.发明申请Method of Diagnosis of a Predisposition to Develop Thrombotic Disease and Its Uses 失效诊断血栓形成疾病倾向的方法及其应用公开(公告)号：US20080038722A1
公开(公告)日：2008-02-14
申请号：US10592692
申请日：2005-03-16
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6883 , C12Q2600/156
摘要： The present invention refers to a method of diagnosis of a predisposition to develop thrombotic disease, to test systems and their use for the diagnosis of a predisposition to develop thrombotic disease, to a P2X1 promoter variant and its use for screening for an anti-thrombotic agent, and to methods for identifying an individual that can be prophylactically or therapeutically treated with an anti-thrombotic agent, or for adapting a therapeutic or prophylactic dose of an anti-thrombotic agent.
摘要翻译： 本发明涉及诊断发生血栓形成疾病的倾向，测试系统及其用于诊断倾向于发展血栓形成性疾病的用途的方法，以诊断P 启动子变体及其用于筛选抗血栓形成剂的用途，以及用于鉴定可以用抗血栓形成剂预防性或治疗性治疗的个体的方法，或用于调整治疗或预防剂量的抗血栓形成剂 血栓形成剂。
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16.发明授权Method of diagnosis of a predisposition to develop thrombotic disease and its uses 失效诊断倾向性发展为血栓性疾病及其用途的方法公开(公告)号：US07785781B2
公开(公告)日：2010-08-31
申请号：US10592692
申请日：2005-03-16
CPC分类号： C12Q1/6883 , C12Q2600/156
摘要： The present invention refers to a method of diagnosis of a predisposition to develop thrombotic disease, to test systems and their use for the diagnosis of a predisposition to develop thrombotic disease, to a P2X1 promoter variant and its use for screening for an anti-thrombotic agent, and to methods for identifying an individual that can be prophylactically or therapeutically treated with an anti-thrombotic agent, or for adapting a therapeutic or prophylactic dose of an anti-thrombotic agent.
摘要翻译： 本发明涉及诊断P2V1启动子变体及其用于筛选抗血栓形成剂的用于发展血栓形成疾病，测试系统及其用于诊断倾向于发展血栓形成疾病的用途的倾向性的方法 以及用于鉴定可以用抗血栓形成剂预防性或治疗性治疗的个体的方法，或用于调整治疗或预防剂量的抗血栓形成剂。
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17.发明授权EGLN2 variants and use thereof in preventing or treating thromboembolic disorders and coronary heart diseases 失效EGLN2变体及其在预防或治疗血栓栓塞性疾病和冠心病中的用途公开(公告)号：US08211427B2
公开(公告)日：2012-07-03
申请号：US13015994
申请日：2011-01-28
申请人： Detlef Kozian , Matthias Herrmann
发明人： Detlef Kozian , Matthias Herrmann
CPC分类号： C12N9/0071
摘要： The present invention refers to human EGLN2 variants having at position 58 of the amino acid sequence a serine or a leucine and their use in the prevention or treatment of thromboembolic or coronary heart diseases, in particular stroke, prolonged reversible ischemic neurological deficit (PRIND), transitoric ischemic attack (TIA), myocardial infarction and/or early myocardial infarction.
摘要翻译： 本发明涉及具有丝氨酸或亮氨酸的氨基酸序列58位的人EGLN2变异体及其在预防或治疗血栓栓塞或冠心病，特别是中风，长期可逆性缺血性神经功能缺损（PRIND）， 经皮缺血发作（TIA），心肌梗死和/或早期心肌梗死。
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18.发明授权公开(公告)号：US06645741B2
公开(公告)日：2003-11-11
申请号：US10015593
申请日：2001-12-17
申请人： Detlef Kozian , Birgit Reuner
发明人： Detlef Kozian , Birgit Reuner
IPC分类号： C12P1934
CPC分类号： C12Q1/6853 , C12Q1/6809 , Y10T436/143333 , C12Q2565/102 , C12Q2525/173 , C12Q2521/107
摘要： The invention relates to a novel method for analyzing the composition of an mRNA sample and analyzing differential gene expression using two differently labeled primers, and to the use of the method. In the method for analyzing an RNA sample, a) a first primer, which is, where appropriate, labeled with a first dye, is used to prepare the first strand of a complementary DNA sample or cDNA sample from an RNA sample, b) a second primer, which is preferably labeled with a second dye, is used to prepare the second strand of this cDNA sample, c) the first primer, which is labeled with a first dye, and the second primer, which is labeled with a second dye, are used to amplify the cDNA sample, and d) the composition of the amplified, labeled cDNA sample is analyzed.
摘要翻译： 本发明涉及一种用于分析mRNA样品的组成并使用两个不同标记的引物分析差异基因表达的新方法以及该方法的使用。在分析RNA样品的方法中，a）第一引物，其中 在适当的情况下用第一染料标记，用于从RNA样品制备互补DNA样品或cDNA样品的第一条链，b）优选用第二染料标记的第二引物用于制备 该cDNA样品的第二条链，c）用第一染料标记的第一引物，用第二染料标记的第二引物用于扩增cDNA样品，并且d）扩增的 分析标记的cDNA样品。
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19.发明申请EGLN2 VARIANTS AND USE THEREOF IN PREVENTING OR TREATING THROMBOEMBOLIC DISORDERS AND CORONARY HEART DISEASE 失效EGLN2变异体及其在预防或治疗血栓性疾病和冠状动脉疾病中的应用公开(公告)号：US20090220479A1
公开(公告)日：2009-09-03
申请号：US12089627
申请日：2006-09-30
申请人： Detlef Kozian , Matthias Herrmann
发明人： Detlef Kozian , Matthias Herrmann
IPC分类号： A61K38/46 , C12N9/14 , C12N15/11 , C12N15/00 , C12N5/06 , A01K67/027 , C07K16/18 , C12P21/02 , C12Q1/68 , C12Q1/34 , C40B30/00
CPC分类号： C12N9/0071
摘要： The present invention refers to human EGLN2 variants having at position 58 of the amino acid sequence a serine or a leucine and their use in the prevention or treatment of thromboembolic or coronary heart diseases, in particular stroke, prolonged reversible ischemic neurological deficit (PRIND), transitoric ischemic attack (TIA), myocardial infarction and/or early myocardial infarction.
摘要翻译： 本发明涉及具有丝氨酸或亮氨酸的氨基酸序列58位的人EGLN2变异体及其在预防或治疗血栓栓塞或冠心病，特别是中风，长期可逆性缺血性神经功能缺损（PRIND）， 经皮缺血发作（TIA），心肌梗死和/或早期心肌梗死。
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20.发明授权EGLN2 variants and use thereof in preventing or treating thromboembolic disorders and coronary heart disease 失效EGLN2变体及其在预防或治疗血栓栓塞性疾病和冠心病中的用途公开(公告)号：US08114398B2
公开(公告)日：2012-02-14
申请号：US12089627
申请日：2006-09-30
申请人： Detlef Kozian , Matthias Herrmann
发明人： Detlef Kozian , Matthias Herrmann
CPC分类号： C12N9/0071
摘要： The present invention refers to human EGLN2 variants having at position 58 of the amino acid sequence a serine or a leucine and their use in the prevention or treatment of thromboembolic or coronary heart diseases, in particular stroke, prolonged reversible ischemic neurological deficit (PRIND), transitoric ischemic attack (TIA), myocardial infarction and/or early myocardial infarction.
摘要翻译： 本发明涉及具有丝氨酸或亮氨酸的氨基酸序列58位的人EGLN2变异体及其在预防或治疗血栓栓塞或冠心病，特别是中风，长期可逆性缺血性神经功能缺损（PRIND）， 经皮缺血发作（TIA），心肌梗死和/或早期心肌梗死。
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