公开(公告)号：US20170188922A1

公开(公告)日：2017-07-06

申请号：US15394706

申请日：2016-12-29

Applicant: DexCom, Inc.

Inventor： Ted Tang Lee ,  Andrew Trinin Dennis ,  Shanger Wang ,  Jiong Zou

IPC: A61B5/1486 ,  A61K36/185 ,  A61K31/46 ,  A61K38/28 ,  A61K31/045 ,  A61B5/00 ,  A61K31/465 ,  A61K31/56 ,  A61K31/137 ,  A61K31/515 ,  A61B5/145 ,  A61K33/00 ,  A61K31/485

CPC classification number: G01N27/3273 ,  A61B5/0004 ,  A61B5/002 ,  A61B5/14532 ,  A61B5/14546 ,  A61B5/1473 ,  A61B5/1486 ,  A61B5/14865 ,  A61B2562/12 ,  A61K31/045 ,  A61K31/137 ,  A61K31/46 ,  A61K31/465 ,  A61K31/485 ,  A61K31/515 ,  A61K31/56 ,  A61K33/00 ,  A61K36/185 ,  A61K38/28 ,  C08G18/0828 ,  C08G18/12 ,  C08G18/3857 ,  C08G18/4018 ,  C08G18/44 ,  C08G18/4833 ,  C08G18/755 ,  C08L39/06 ,  C08L69/00 ,  C08L75/04 ,  C12N11/08 ,  C12Q1/002 ,  C12Q1/006 ,  G01N27/3275 ,  G01N33/66 ,  C08G18/3234

Abstract: Disclosed are devices for determining an analyte concentration (e.g., glucose). The devices comprise a sensor configured to generate a signal associated with a concentration of an analyte and a sensing membrane located over the sensor. The sensing membrane comprises a biointerface layer which interfaces with a biological fluid containing the analyte to be measured. The biointerface layer comprises a biointerface polymer, wherein the biointerface polymer comprises polyurethane and/or polyurea segments and one or more zwitterionic repeating units. The biointerface layer increases sensor longevity and decrease sensor inaccuracy by inhibiting accumulation of cells, proteins, and other biological species on the outermost layers of the sensor.

公开(公告)号：US20250025076A1

公开(公告)日：2025-01-23

申请号：US18399162

申请日：2023-12-28

Applicant: DexCom, Inc.

Inventor： Shuyu Lin ,  Daiting Rong ,  Stacy Hunt DuVall ,  Wenjie Lan ,  Jason M. Halac ,  Jiong Zou ,  Devon M. Headen ,  Shanger Wang ,  Shane Richard Parnell ,  Berta Esteban Fernandez de Avila ,  Shannon Reuben Woodruff

IPC: A61B5/1473

Abstract: An analyte monitoring sensor configured for in vivo measurement of at least one analyte is provided, the sensor comprising a substrate having a substrate surface, an aptamer protective layer encapsulating at least a portion of the substrate surface, the aptamer protective layer permeable to the at least one analyte, one or more aptamer conjugates associated with at least a portion of the substrate surface and positioned between the aptamer protective layer and the substrate for obtaining measurements related to the at least one analyte in vivo. Methods of extending in vivo performance of the analyte monitoring sensor are also described.

公开(公告)号：US20220409138A1

公开(公告)日：2022-12-29

申请号：US17895755

申请日：2022-08-25

Applicant: DexCom, Inc.

Inventor： Sebastian Bohm ,  Pradnya Prakash Samant ,  Jiong Zou

IPC: A61B5/00 ,  A61B5/1486 ,  A61B5/145

Abstract: Sensor devices including dissolvable tissue-piercing tips are provided. Methods of using and fabricating sensor devices are also provided.

公开(公告)号：US11262326B2

公开(公告)日：2022-03-01

申请号：US15395892

申请日：2016-12-30

Applicant: DexCom, Inc.

Inventor： Shanger Wang ,  Robert J. Boock ,  Andrew Trinin Dennis ,  Ted Tang Lee ,  Jeff T. Suri ,  David Sze ,  Mark A Tapsak ,  Huashi Zhang ,  Jiong Zou

IPC: A61B5/145 ,  G01N27/327 ,  C08G18/08 ,  C08G18/48 ,  C08G18/40 ,  C08G18/38 ,  C08G18/12 ,  C08G18/44 ,  C08G18/75 ,  C12N11/089 ,  C12N11/093 ,  C08L39/06 ,  C08L69/00 ,  C08L75/04 ,  C12Q1/00 ,  A61B5/00 ,  A61B5/1486 ,  G01N33/66 ,  A61K31/045 ,  A61K31/137 ,  A61K31/46 ,  A61K31/465 ,  A61K31/485 ,  A61K31/515 ,  A61K31/56 ,  A61K33/00 ,  A61K36/185 ,  A61K38/28 ,  A61B5/1473

Abstract: Disclosed are devices for determining an analyte concentration (e.g., glucose). The devices comprise a sensor configured to generate a signal associated with a concentration of an analyte and a sensing membrane located over the sensor. The sensing membrane comprises a biointerface layer which interfaces with a biological fluid containing the analyte to be measured. The biointerface layer can comprises a biointerface polymer, wherein the biointerface polymer comprises polyurethane and/or polyurea segments and one or more zwitterionic repeating units. The sensing membrane can also comprise an enzyme layer, wherein the enzyme layer comprises an enzyme and a polymer comprising polyurethane and/or polyurea segments and one or more zwitterionic repeating units. The sensing membrane can also comprise a diffusion-resistance layer, which can comprise a base polymer having a lowest Tg of greater than −50 C.

公开(公告)号：US11058329B2

公开(公告)日：2021-07-13

申请号：US15798249

申请日：2017-10-30

Applicant: DexCom, Inc.

Inventor： Peter C. Simpson ,  Minglian Shi ,  Sebastian Bohm ,  Maria Noel Brown Wells ,  John Patrick Majewski ,  Leah Morta Edra ,  Disha B. Sheth ,  John Michael Gray ,  Shanger Wang ,  Ted Tang Lee ,  Michael L. Moore ,  Jason Mitchell ,  Jennifer Blackwell ,  Neel Narayan Shah ,  Todd Andrew Newhouse ,  Jason Halac ,  Ryan Everett Schoonmaker ,  Paul V. Neale ,  Jiong Zou ,  Sean T. Saint

IPC: A61B5/145 ,  A61B5/00 ,  A61B5/1473 ,  A61B5/1486

Abstract: Sensor systems can be used to measure an analyte concentration. Sensor systems can include a base having a distal side configured to face towards a person's skin. An adhesive can couple the base to the skin. A transcutaneous analyte measurement sensor can be coupled to the base and can be located at least partially in the host. A transmitter can be coupled to the base and can transmit analyte measurement data to a remote device.

公开(公告)号：US20180199886A1

公开(公告)日：2018-07-19

申请号：US15872280

申请日：2018-01-16

Applicant: DexCom, Inc.

Inventor： Sebastian Bohm ,  Pradnya Prakash Samant ,  Jiong Zou

IPC: A61B5/00 ,  A61B5/145 ,  A61B5/1486

CPC classification number: A61B5/6848 ,  A61B5/14532 ,  A61B5/14865

Abstract: Sensor devices including dissolvable tissue-piercing tips are provided. Methods of using and fabricating sensor devices are also provided.

公开(公告)号：US20170188921A1

公开(公告)日：2017-07-06

申请号：US15394520

申请日：2016-12-29

Applicant: DexCom, Inc.

Inventor： Shanger Wang ,  Ted Tang Lee ,  Jiong Zou

IPC: A61B5/1486 ,  C12N11/08 ,  A61B5/145 ,  C12Q1/00

CPC classification number: G01N27/3273 ,  A61B5/0004 ,  A61B5/002 ,  A61B5/14532 ,  A61B5/14546 ,  A61B5/1473 ,  A61B5/1486 ,  A61B5/14865 ,  A61B2562/12 ,  A61K31/045 ,  A61K31/137 ,  A61K31/46 ,  A61K31/465 ,  A61K31/485 ,  A61K31/515 ,  A61K31/56 ,  A61K33/00 ,  A61K36/185 ,  A61K38/28 ,  C08G18/0828 ,  C08G18/12 ,  C08G18/3857 ,  C08G18/4018 ,  C08G18/44 ,  C08G18/4833 ,  C08G18/755 ,  C08L39/06 ,  C08L69/00 ,  C08L75/04 ,  C12N11/08 ,  C12Q1/002 ,  C12Q1/006 ,  G01N27/3275 ,  G01N33/66 ,  C08G18/3234

Abstract: Disclosed are devices for determining an analyte concentration (e.g., glucose). The devices comprise a sensor configured to generate a signal associated with a concentration of an analyte and a sensing membrane located over the sensor. The sensing membrane comprises an enzyme layer, wherein the enzyme layer comprises an enzyme and a polymer comprising polyurethane and/or polyurea segments and one or more zwitterionic repeating units. The enzyme layer protects the enzyme and prevents it from leaching from the sensing membrane into a host or deactivating.

公开(公告)号：US20170188905A1

公开(公告)日：2017-07-06

申请号：US15394764

申请日：2016-12-29

Applicant: DexCom, Inc.

Inventor： Ted Tang Lee ,  Andrew Trinin Dennis ,  Shanger Wang ,  Jiong Zou

IPC: A61B5/1486 ,  A61K36/185 ,  A61K31/46 ,  A61K38/28 ,  A61B5/145 ,  A61K31/485 ,  A61K31/465 ,  A61K31/56 ,  A61K31/137 ,  A61K31/515 ,  A61K33/00 ,  A61K31/045

CPC classification number: G01N27/3273 ,  A61B5/0004 ,  A61B5/002 ,  A61B5/14532 ,  A61B5/14546 ,  A61B5/1473 ,  A61B5/1486 ,  A61B5/14865 ,  A61B2562/12 ,  A61K31/045 ,  A61K31/137 ,  A61K31/46 ,  A61K31/465 ,  A61K31/485 ,  A61K31/515 ,  A61K31/56 ,  A61K33/00 ,  A61K36/185 ,  A61K38/28 ,  C08G18/0828 ,  C08G18/12 ,  C08G18/3857 ,  C08G18/4018 ,  C08G18/44 ,  C08G18/4833 ,  C08G18/755 ,  C08L39/06 ,  C08L69/00 ,  C08L75/04 ,  C12N11/08 ,  C12Q1/002 ,  C12Q1/006 ,  G01N27/3275 ,  G01N33/66 ,  C08G18/3234

Abstract: Disclosed are devices for determining an analyte concentration (e.g., glucose). The devices comprise a sensor configured to generate a signal associated with a concentration of an analyte and a sensing membrane located over the sensor. The sensing membrane comprises a biointerface layer which interfaces with a biological fluid containing the analyte to be measured. The biointerface layer comprises a biointerface polymer, wherein the biointerface polymer comprises polyurethane and/or polyurea segments and one or more zwitterionic repeating units. The biointerface layer increases sensor longevity and decrease sensor inaccuracy by inhibiting accumulation of cells, proteins, and other biological species on the outermost layers of the sensor.

公开(公告)号：US20240138720A1

公开(公告)日：2024-05-02

申请号：US18516661

申请日：2023-11-21

Applicant: Dexcom, Inc.

Inventor： Ted Tang Lee ,  Andrew Trinin Dennis ,  Shanger Wang ,  Jiong Zou

IPC: A61B5/145

CPC classification number: A61B5/14532

Abstract: Disclosed are devices for determining an analyte concentration. The devices comprise a sensor configured to generate a signal associated with a concentration of an analyte and an electronics unit operatively connected to the sensor. The electronics unit may be engaged with a housing that may secure the device to a host's skin. In this regard, in one embodiment, the housing may be attached to an adhesive patch that is fastened to the skin of the host.

公开(公告)号：US20240074682A1

公开(公告)日：2024-03-07

申请号：US18241658

申请日：2023-09-01

Applicant: DexCom, Inc.

Inventor： Berta Esteban Fernandez de Avila ,  Devon M. Headen ,  Stacy Hunt DuVall ,  Jiong Zou ,  Shane Richard Parnell ,  Nicholas Vincent Apollo ,  Joshua Ray Windmiller

IPC: A61B5/145 ,  A61B5/00 ,  A61B5/1486 ,  A61B5/318

CPC classification number: A61B5/14546 ,  A61B5/14865 ,  A61B5/318 ,  A61B5/6847

Abstract: Devices and methods for measuring a concentration of a target analyte in a biological fluid in vivo are provided herein. In some examples, a device includes an indwelling sensor and sensor electronics. The sensor may include a substrate; a first electrode disposed on the substrate; an ionophore disposed on the substrate to selectively transport the target ion to or within the first electrode; and a second electrode disposed on the substrate. The sensor electronics is configured to generate a signal corresponding to an electromotive force which is at least partially based on a potential difference that is generated between the first electrode and the second electrode responsive to the ionophore transporting the target ion to the first electrode.