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11.发明申请FAD2 PERFORMANCE LOCI AND CORRESPONDING TARGET SITE SPECIFIC BINDING PROTEINS CAPABLE OF INDUCING TARGETED BREAKS 有权FAD2性能位置和相应目标位点特异性结合蛋白质可诱导目标突变公开(公告)号：US20140090116A1
公开(公告)日：2014-03-27
申请号：US14019293
申请日：2013-09-05
Applicant: Sangamo BioSciences, Inc. , Dow AgroSciences LLC
Inventor： William Michael Ainley , Steven R. Webb , Pon Samuel , Dmitry Y. Guschin , Jeffrey C. Miller , Lei Zhang
IPC: C12N15/66
CPC classification number: C12N15/8216 , C07K14/4702 , C07K2319/81 , C12N9/22 , C12N15/102 , C12N15/66 , C12N15/822 , C12N15/8247 , C12N15/902 , C12Y301/00
Abstract: Methods and compositions for gene disruption, gene editing or gene stacking within a FAD2 loci by cleaving, in a site directed manner, a location in a FAD2 gene in a soybean cell, to generate a break in the FAD2 gene and then optionally integrating into the break a nucleic acid molecule of interest is disclosed.
Abstract translation: FAD2基因座中的基因破坏，基因编辑或基因堆叠的方法和组合，通过以位点方式切割大豆细胞中FAD2基因的位置，在FAD2基因中产生断裂，然后任选地整合入 揭示目的核酸分子。
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12.发明申请METHODS AND COMPOSITIONS FOR NUCLEASE-MEDIATED TARGETED INTEGRATION OF TRANSGENES 审中-公开用于核转移介导的靶向转移整合的方法和组合物公开(公告)号：US20130326645A1
公开(公告)日：2013-12-05
申请号：US13889162
申请日：2013-05-07
Applicant: Dow AgroSciences LLC , Sangamo BioSciences, Inc.
Inventor： Gregory J. Cost , Fyodor Urnov , William M. Ainley , Joseph F. Petolino , Jayakumar Pon Samuel , Steven R. Webb , Lakshmi Sastry-Dent
CPC classification number: C12N15/8201 , C12N15/102 , C12N15/8209 , C12N15/8213 , C12N15/8216 , C12N15/8241 , C12N15/8247 , C12N15/8274 , C12N15/8278 , C12N15/8286 , C12N15/85 , C12N15/87 , C12N2800/80 , Y02A40/162
Abstract: Disclosed herein are methods and compositions for homology-independent targeted insertion of donor molecules into the genome of a cell.
Abstract translation: 本文公开了用于与供体分子同源性独立的靶向插入细胞基因组的方法和组合物。
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13.发明授权公开(公告)号：US11198883B2
公开(公告)日：2021-12-14
申请号：US16674831
申请日：2019-11-05
Applicant: Dow AgroSciences LLC , Sangamo Therapeutics, Inc.
Inventor： W. Michael Ainley , Dmitry Y. Guschin , Matthew Hayden , Daniel Isenegger , John Mason , Jeffrey C. Miller , Joseph F. Petolino , Yidong Ran , Tim Sawbridge , German Spangenberg , Steven R. Webb
Abstract: Disclosed herein are methods and compositions for parallel or sequential transgene stacking in plants to produce plants with selected phenotypes.
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公开(公告)号：US10287595B2
公开(公告)日：2019-05-14
申请号：US15292774
申请日：2016-10-13
Applicant: Dow AgroSciences LLC , Sangamo Therapeutics, Inc.
Inventor： W. Michael Ainley , Steven R. Webb , Jayakumar P. Samuel , Dmitry Y. Guschin , Jeffrey C. Miller , Lei Zhang
Abstract: Methods and compositions for gene disruption, gene editing or gene stacking within a FAD2 loci by cleaving, in a site directed manner, a location in a FAD2 gene in a soybean cell, to generate a break in the FAD2 gene and then optionally integrating into the break a nucleic acid molecule of interest is disclosed.
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公开(公告)号：US20190024100A1
公开(公告)日：2019-01-24
申请号：US16112200
申请日：2018-08-24
Applicant: Dow AgroSciences LLC
Inventor： Lakshmi Sastry-Dent , Zehui Cao , Shreedharan Sriram , Steven R. Webb , Debra L. Camper
Abstract: As disclosed herein, optimal native genomic loci from maize plants have been identified that represent best sites for targeted insertion of exogenous sequences.
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Patent Agency Ranking
公开(公告)号：US10174331B2
公开(公告)日：2019-01-08
申请号：US13889162
申请日：2013-05-07
Applicant: Sangamo BioSciences, Inc. , Dow AgroSciences LLC
Inventor： Gregory J. Cost , Fyodor Urnov , W. Michael Ainley , Joseph F. Petolino , Jayakumar Pon Samuel , Steven R. Webb , Lakshmi Sastry-Dent
Abstract: Disclosed herein are methods and compositions for homology-independent targeted insertion of donor molecules into the genome of a cell.
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公开(公告)号：US09909131B2
公开(公告)日：2018-03-06
申请号：US14531748
申请日：2014-11-03
Applicant: Dow AgroSciences LLC
Inventor： Lakshmi Sastry-Dent , Zehui Cao , Shreedharan Sriram , Steven R. Webb , Debra L. Camper , W. Michael Ainley
CPC classification number: C12N15/8213 , A01H5/10 , C12N15/8243 , C12N15/8273 , C12N15/8274 , C12N15/8286
Abstract: As disclosed herein, optimal native genomic loci of soybean plants have been identified that represent best sites for targeted insertion of exogenous sequences.
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18.发明授权FAD2 performance loci and corresponding target site specific binding proteins capable of inducing targeted breaks 有权FAD2表达位点和相应的靶位点特异性结合蛋白能够诱导靶向性突变公开(公告)号：US09493779B2
公开(公告)日：2016-11-15
申请号：US14019293
申请日：2013-09-05
Applicant: Dow AgroSciences LLC , Sangamo BioSciences, Inc.
Inventor： William Michael Ainley , Steven R. Webb , Pon Samuel , Dmitry Y. Guschin , Jeffrey C. Miller , Lei Zhang
CPC classification number: C12N15/8216 , C07K14/4702 , C07K2319/81 , C12N9/22 , C12N15/102 , C12N15/66 , C12N15/822 , C12N15/8247 , C12N15/902 , C12Y301/00
Abstract: Methods and compositions for gene disruption, gene editing or gene stacking within a FAD2 loci by cleaving, in a site directed manner, a location in a FAD2 gene in a soybean cell, to generate a break in the FAD2 gene and then optionally integrating into the break a nucleic acid molecule of interest is disclosed.
Abstract translation: FAD2基因座中的基因破坏，基因编辑或基因堆叠的方法和组合，通过以位点方式切割大豆细胞中FAD2基因的位置，在FAD2基因中产生断裂，然后任选地整合入 揭示目的核酸分子。
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19.发明申请FAD3 PERFORMANCE LOCI AND CORRESPONDING TARGET SITE SPECIFIC BINDING PROTEINS CAPABLE OF INDUCING TARGETED BREAKS 有权FAD3性能位置和相应目标位点特异性结合蛋白质可诱导目标突变公开(公告)号：US20150067921A1
公开(公告)日：2015-03-05
申请号：US14019211
申请日：2013-09-05
Applicant: Sangamo BioSciences, Inc. , Dow AgroSciences LLC
Inventor： Noel Cogan , John Forster , Matthew Hayden , Tim Sawbridge , German Spangenberg , Steven R. Webb , Manju Gupta , William Michael Ainley , Matthew J. Henry , Jeffrey C. Miller , Dmitry Y. Guschin
CPC classification number: C12N15/79 , C12N9/22 , C12N15/63 , C12N15/8241 , C12N15/8247
Abstract: A method of gene editing or gene stacking within a FAD3 loci by cleaving, in a site directed manner, a location in a FAD3 gene in a cell, to generate a break in the FAD3 gene and then ligating into the break a nucleic acid molecule associated with one or more traits of interest is disclosed.
Abstract translation: 通过以位点方式切割细胞中FAD3基因的位置，在FAD3基因座中进行基因编辑或基因堆积的方法，以在FAD3基因中产生断裂，然后连接到断裂中，与核酸分子缔合 公开了一种或多种感兴趣的特征。
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公开(公告)号：US11198882B2
公开(公告)日：2021-12-14
申请号：US16112200
申请日：2018-08-24
Applicant: Dow AgroSciences LLC
Inventor： Lakshmi Sastry-Dent , Zehui Cao , Shreedharan Sriram , Steven R. Webb , Debra L. Camper
Abstract: As disclosed herein, optimal native genomic loci from maize plants have been identified that represent best sites for targeted insertion of exogenous sequences.
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