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16 条记录 (耗时 0.062 秒)

    Method of identifying inhibitors of Tie-2
    11.
    发明授权
    Method of identifying inhibitors of Tie-2 失效
    识别Tie-2抑制剂的方法

    公开(公告)号：US07369946B2

    公开(公告)日：2008-05-06

    申请号：US09815341

    申请日：2001-03-22

    申请人： Nancy J. Bump ,  Lee D. Arnold ,  Richard W. Dixon ,  Hans Wolfgang Hoeffken ,  Karen Allen ,  Cornelia Bellamacina

    发明人： Nancy J. Bump ,  Lee D. Arnold ,  Richard W. Dixon ,  Hans Wolfgang Hoeffken ,  Karen Allen ,  Cornelia Bellamacina

    IPC分类号： G06F19/00

    CPC分类号： C07K14/71 ,  A61K38/00 ,  C07K2299/00

    摘要： The present invention relates to polypeptides which comprise the ligand binding domain of Tie-2, crystalline forms of these polypeptides and the use of these crystalline forms to determine the three dimensional structure of the catalytic domain of Tie-2. The invention also relates to the use of the three dimensional structure of the Tie-2 catalytic domain both alone, or in complex with inhibitors, in methods of designing and/or identifying potential inhibitors of Tie-2 activity, for example, compounds which inhibit the binding of a native substrate to the Tie-2 catalytic domain.

    摘要翻译： 本发明涉及包含Tie-2的配体结合结构域，这些多肽的结晶形式以及这些结晶形式用于确定Tie-2催化结构域的三维结构的多肽。 本发明还涉及在设计和/或鉴定Tie-2活性的潜在抑制剂的方法中单独或与抑制剂复合的Tie-2催化结构域的三维结构的用途，例如抑制 天然底物与Tie-2催化结构域的结合。

    Use of formate-based porous metal organic frameworks for methane storage
    14.
    发明授权
    Use of formate-based porous metal organic frameworks for methane storage 失效
    使用甲酸基多孔金属有机骨架进行甲烷储存

    公开(公告)号：US08343261B2

    公开(公告)日：2013-01-01

    申请号：US12921505

    申请日：2009-03-17

    申请人： Emi Leung ,  Ulrich Mueller ,  Gerhard Cox ,  Hans Wolfgang Hoeffken

    发明人： Emi Leung ,  Ulrich Mueller ,  Gerhard Cox ,  Hans Wolfgang Hoeffken

    IPC分类号： B01D53/02

    CPC分类号： C07F3/003 ,  B01D53/02 ,  B01D2253/204 ,  B01D2256/24 ,  B01D2257/7022 ,  B01D2259/4525 ,  B01J20/226 ,  C07C7/13 ,  C07C53/06 ,  C10L3/06 ,  C10L3/108 ,  Y02E60/321 ,  C07C9/04

    摘要： The present invention relates to the use of a porous metal organic framework comprising at least a first organic compound and, if appropriate, a second organic compound, in which at least the first organic compound is at least partially coordinated in a bidentate fashion to at least one metal ion, where the at least one metal ion is Mg(II) and the first organic compound is derived from formic acid and the second organic compound is derived from acetic acid, for storing or isolating methane. Furthermore, the invention relates to a porous metal organic framework based on magnesium formate and acetate and also its preparation.

    摘要翻译： 本发明涉及多孔金属有机骨架的用途，所述多孔金属有机骨架包含至少第一有机化合物和（如果合适的话）第二有机化合物，其中至少第一有机化合物至少部分地以双齿形式协调至少至少 一种金属离子，其中至少一种金属离子是Mg（II），第一种有机化合物衍生自甲酸，第二种有机化合物衍生自乙酸，用于储存或分离甲烷。 此外，本发明涉及一种基于甲酸镁和乙酸盐的多孔金属有机骨架及其制备方法。