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    Stirred Cell And Method of Using Same
    11.
    发明申请
    Stirred Cell And Method of Using Same 审中-公开
    搅拌细胞和使用方法

    公开(公告)号：US20160228870A1

    公开(公告)日：2016-08-11

    申请号：US14994402

    申请日：2016-01-13

    Applicant: EMD Millipore Corporation

    Inventor： Phillip Clark ,  Kurt Greenizen ,  John Doyle

    IPC: B01L3/00 ,  G01N1/40

    CPC classification number: G01N1/4005 ,  B01L3/502 ,  B01L2200/026 ,  B01L2200/0689 ,  B01L2200/085 ,  B01L2200/087 ,  B01L2300/042 ,  B01L2300/048 ,  B01L2300/049 ,  B01L2300/0681 ,  B01L2300/14 ,  B01L2400/0487 ,  B01L2400/0605 ,  B01L2400/0633 ,  B01L2400/065

    Abstract: Fluid containment pressure vessel that eliminates the outer support housing present in certain conventional vessels, and provides an improved cap-to-body interface. In certain embodiments, the cap is threaded and configured to threadingly engage with the body of the pressure vessel, and has sufficient structural integrity to withstand the pressures in the device without the need for a support housing. In certain embodiments, an interlock mechanism is provided that prevents the cap from being opened (e.g., removed from the body) while the device is under pressure. In certain embodiments, a pressure relief valve is provided with a pre-loaded biasing mechanism to achieve the required pressure release rate. The vessel can be used for sample preparation, including purification or concentration of samples, particularly protein samples.

    Abstract translation: 流体容纳压力容器，其消除了存在于某些常规容器中的外部支撑壳体，并提供了改进的盖对体界面。 在某些实施例中，盖被螺纹并构造成与压力容器的主体螺纹接合，并且具有足够的结构完整性以承受装置中的压力而不需要支撑壳体。 在某些实施例中，提供了一种互锁机构，其在设备处于压力下时防止盖被打开（例如，从主体移除）。 在某些实施例中，泄压阀设置有预加载偏置机构以实现所需的压力释放速率。 该容器可用于样品制备，包括样品的纯化或浓缩，特别是蛋白质样品。

    IHC, Tissue Slide Fluid Exchange Disposable And System
    12.
    发明申请
    IHC, Tissue Slide Fluid Exchange Disposable And System 审中-公开
    IHC，组织滑动液体交换一次性和系统

    公开(公告)号：US20150260621A1

    公开(公告)日：2015-09-17

    申请号：US14618007

    申请日：2015-02-10

    Applicant: EMD Millipore Corporation

    Inventor： Chris Scott ,  Paul Sydlowski ,  John Doyle ,  Ryan Amara ,  Libby Kellard ,  Sara Gutierrez ,  Marc Emerick

    IPC: G01N1/31

    Abstract: Apparatus and method for Immunohistochemistry, including a slide holder assembly fixture, a slide holder, a slide holder frame, and a slide holder frame assembly adapted to be placed in communication with a driving force to draw fluid through the slide holder. The slide holder may include an injection port that allows consistent fluid delivery and recovery, while minimizing the introduction of air bubbles. The slide holder may include a reservoir that allows for filling, soaking, rinsing, flushing, uniform antibody coverage of the tissue and reduces handling time, space, and errors, and one or more sample chambers. The slide orientation in the slide holder allows for visualization of label information and tissue to confirm adequate antibody coverage. A multi-port frame allows multiple assays to be carried out concurrently, and is removable from a vacuum manifold and allows for easy transport from the vacuum manifold to an incubator/refrigerator and back.

    Abstract translation: 用于免疫组织化学的装置和方法，包括滑动支架组件夹具，滑动支架，滑动支架框架和滑动支架框架组件，其适于与驱动力连通以将流体通过滑块保持器拉动。 滑动架可以包括一个注射口，其允许一致的流体输送和回收，同时最小化气泡的引入。 载玻片保持器可以包括允许填充，浸泡，漂洗，冲洗，组织的均匀抗体覆盖并减少处理时间，空间和错误以及一个或多个样品室的储存器。 幻灯片固定器中的滑动方向允许标记信息和组织的可视化，以确认足够的抗体覆盖。 多端口框架允许多个测定同时进行，并且可从真空歧管移除，并且允许从真空歧管到培养箱/冰箱和背部的容易运输。

    FILTRATION DEVICE
    13.
    发明申请
    FILTRATION DEVICE 有权
    过滤装置

    公开(公告)号：US20150108058A1

    公开(公告)日：2015-04-23

    申请号：US14572825

    申请日：2014-12-17

    Applicant: EMD Millipore Corporation

    Inventor： Phillip Clark ,  John Doyle

    IPC: B01D65/00 ,  B01D61/22 ,  B01D61/32 ,  B01D61/08 ,  B01D61/18

    CPC classification number: B01D65/003 ,  B01D29/01 ,  B01D35/301 ,  B01D61/08 ,  B01D61/18 ,  B01D61/22 ,  B01D61/32 ,  B01D63/087 ,  B01D2201/204 ,  B01D2201/34 ,  B01D2201/342 ,  B01D2313/04 ,  Y10T29/49863 ,  Y10T156/10

    Abstract: A vacuum filter device comprising a filter body having two holders on opposite sides of a filter. Each holder contains a closed container in a fluid-tight, sealed relationship. The filter is retained by a compression sealing element and the sealing element is maintained in place by a compression element formed of a ring. The compression element is bonded to a portion of the body to hold it, the sealing element and filter in place under a compression seal. Optionally a port in the compression element is formed to align with the vent of the device. Further, an alignment feature on the compression element ensures the port is in alignment with the vent of the device. The device also includes a vacuum port communicating with the downstream side of the filter, and hence the filtrate container.

    Abstract translation: 一种真空过滤器装置，包括在过滤器的相对侧上具有两个保持器的过滤器主体。 每个支架都包含一个封闭的容器，流体密封，密封的关系。 过滤器由压缩密封元件保持，并且密封元件通过由环形成的压缩元件保持在适当位置。 压缩元件结合到主体的一部分以将其保持，密封元件和过滤器在压缩密封下就位。 可选地，压缩元件中的端口形成为与装置的通气口对准。 此外，压缩元件上的对准特征确保端口与设备的通风口对准。 该装置还包括与过滤器的下游侧连通并且因此与滤液容器连通的真空口。

    Stirred cell and method of using same
    14.
    发明授权
    Stirred cell and method of using same 有权

    公开(公告)号：US10656060B2

    公开(公告)日：2020-05-19

    申请号：US16115762

    申请日：2018-08-29

    Applicant: EMD Millipore Corporation

    Inventor： Phillip Clark ,  Kurt Greenizen ,  John Doyle

    IPC: G01N1/40 ,  B01L3/00

    Abstract: Fluid containment pressure vessel that eliminates the outer support housing present in certain conventional vessels, and provides an improved cap-to-body interface. In certain embodiments, the cap is threaded and configured to threadingly engage with the body of the pressure vessel, and has sufficient structural integrity to withstand the pressures in the device without the need for a support housing. In certain embodiments, an interlock mechanism is provided that prevents the cap from being opened (e.g., removed from the body) while the device is under pressure. In certain embodiments, a pressure relief valve is provided with a pre-loaded biasing mechanism to achieve the required pressure release rate. The vessel can be used for sample preparation, including purification or concentration of samples, particularly protein samples.

    Centrifugal Filter
    17.
    发明申请
    Centrifugal Filter 有权

    公开(公告)号：US20130186830A1

    公开(公告)日：2013-07-25

    申请号：US13739008

    申请日：2013-01-11

    Applicant: EMD Millipore Corporation

    Inventor： Louis Bonhomme ,  John Doyle ,  Kurt Greenizen ,  George Gagne ,  Sean Devin ,  Gerard Lombard ,  Vincent Smith

    IPC: B01D63/16

    CPC classification number: B01D63/16 ,  B01D61/145 ,  B01D61/18 ,  B01D63/08 ,  B01D2313/08 ,  B01L3/502 ,  B01L3/5021 ,  B01L3/5635 ,  B01L2300/0681

    Abstract: Filtration device suited for concentration of liquid samples, particularly biomolecules, and a method of concentrating, desalting, purifying and/or fractionating liquid samples. In certain embodiments the device includes a housing having a sample reservoir, and two substantially vertically oriented and spaced apart membranes disposed in the housing. An underdrain is associated with each membrane such that fluid passing through each membrane flows through a respective underdrain into a filtrate collection chamber. The fluid that does not pass through the membrane is collected in the retentate collection chamber, and can be recovered such as by a reverse spinning step, achieving recoveries greater than about 90%. The substantially vertical orientation of the membranes increases the available membrane area by at least 2.7 times the area available in a conventional filter device. The two-panel configuration also maintains more available membrane area in use during the last stages of filtration than a one-panel configuration.

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