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    Ultrapure hyaluronic acid and the use thereof
    13.
    发明授权
    Ultrapure hyaluronic acid and the use thereof 失效
    超纯透明质酸及其用途

    公开(公告)号：US4141973A

    公开(公告)日：1979-02-27

    申请号：US844833

    申请日：1977-10-25

    申请人： Endre A. Balazs

    发明人： Endre A. Balazs

    IPC分类号： C08B37/08 ,  A61K31/70 ,  C07G3/00

    CPC分类号： A61K31/715 ,  C08B37/0072

    摘要： An ultra-pure, high molecular weight hyaluronic acid fraction which is characterized by the absence of significant cellular infiltration of the vitreous and anterior chamber, absence of significant flare in the aqueous humor, absence of significant haze or flare in the vitreous and absence of pathological changes to the cornea, lens, iris, retina, and choroid of the owl monkey eye when one milliliter of a 1% solution of the sodium salt thereof dissolved in physiological buffer is implanted in the vitreous replacing about one-half the existing liquid vitreous. This material is obtained from animal tissue containing hyaluronic acid by a process which comprises removing the blood from animal tissue containing hyaluronic acid, extracting hyaluronic acid therefrom, deproteinizing the hyaluronic acid extract, and removing any unidentified inflammation causing agents persent therein by treating the deproteinized hyaluronic acid extract at a pH of 6.0 - 7.0 with a volume of chloroform at least about equal to that of the deproteinized extract, to form a two-phase mixture which is then stirred, sufficiently to ensure intimate contact between said two phases, at about 15.degree. - 40.degree. C., followed by separating out and discarding the chloroform phase.

    摘要翻译： 一种超纯高分子量透明质酸组分，其特征在于玻璃体和前房没有明显的细胞浸润，房水中没有明显的耀斑，玻璃体中没有明显的浑浊或耀斑，病理学不存在 当将1毫升1％的钠盐溶液溶解在生理缓冲液中时，眼眶猴角膜的角膜，晶状体，虹膜，视网膜和脉络膜的变化被植入玻璃体中，取代了大约一半的现有液体玻璃体。 该材料通过包含从包含透明质酸的动物组织中除去血液，从其中提取透明质酸的血液，使透明质酸提取物脱蛋白，以及通过处理脱蛋白的透明质酸来除去任何未鉴定的炎症引起的药物的方法从含有透明质酸的动物组织获得。 酸性提取物，其pH为6.0-7.0，体积氯仿至少等于脱蛋白提取物的氯仿，形成两相混合物，然后将其充分搅拌以确保所述两相之间的紧密接触，约为15 DEG-40℃，分离出氯仿相。

    Hyaluronate based compositions and cosmetic formulations containing same
    16.
    发明授权
    Hyaluronate based compositions and cosmetic formulations containing same 失效
    含有透明质酸盐的组合物和含有它们的化妆品制剂

    公开(公告)号：US4303676A

    公开(公告)日：1981-12-01

    申请号：US133481

    申请日：1980-03-21

    申请人： Endre A. Balazs

    发明人： Endre A. Balazs

    IPC分类号： A61K8/64 ,  A61K8/73 ,  A61Q19/00 ,  A61Q19/08 ,  C08L5/08 ,  A61K47/00 ,  A01N25/00

    CPC分类号： A61Q19/08 ,  A61K8/64 ,  A61K8/735 ,  A61Q19/00 ,  C08L5/08 ,  Y10S514/873

    摘要： A water based, viscoelastic composition for use in cosmetic formulations comprising, (a) a mixture of sodium hyalfractions having different molecular weights, (b) protein which is derived from the natural material from which the hyaluronate is obtained, and (c) water. Also disclosed are cosmetic formulations comprising about 0.05-5.0% of the above composition together with an emollient, a sugar alcohol, a neutral or anionic polysaccharide, a preservative, bacteriostatic and fungistatic substance which does not react with or degrade hyaluronic acid, and water.

    摘要翻译： 一种用于化妆品制剂的水基粘弹性组合物，其包含（a）具有不同分子量的高分子钠的混合物，（b）衍生自获得透明质酸酯的天然材料的蛋白质和（c）水。 还公开了包含约0.05-5.0％上述组合物以及不与皮肤透明质酸反应或降解的润肤剂，糖醇，中性或阴离子多糖，防腐剂，抑菌剂和抑真菌物质以及水的化妆品制剂。