COMPOUNDS CAPABLE OF AFFECTING DIFFERENTIATION, PROLIFERATION, REGENERATION, PLASTICITY AND SURVIVAL CELLS
    11.
    发明申请
    COMPOUNDS CAPABLE OF AFFECTING DIFFERENTIATION, PROLIFERATION, REGENERATION, PLASTICITY AND SURVIVAL CELLS 有权
    影响分化,增殖,再生,塑性和存活细胞的化合物

    公开(公告)号:US20090305951A1

    公开(公告)日:2009-12-10

    申请号:US12435043

    申请日:2009-05-04

    摘要: The present invention relates to a compound comprising the third Immunoglobulin (Ig3) module, and/or the fourth Immunoglobulin (Ig4) module, and/or the fifth immunoglobulin (Ig5) module, and/or the first Fibronectin III (Fn3,1) module, and/or the second Fibronectin III (Fn3,2) module of neural cell adhesion molecule (NCAM), or a fragment, or a variant thereof, capable of interacting with an Fibroblast Growth Factor (FGF) receptor and/or Adenosine-Tri-Phosphate (ATP) and/or L1, and thereby the compounds are capable of inducing differentiation, modulating proliferation, stimulate regeneration, neuronal plasticity and/or survival of cells. Further, the present invention relates to a pharmaceutical composition comprising said compound, a process of producing a pharmaceutical composition and the use of said compound.

    摘要翻译: 本发明涉及包含第三免疫球蛋白(Ig3)模块和/或第四免疫球蛋白(Ig4)模块和/或第五免疫球蛋白(Ig5)模块和/或第一纤连蛋白III(Fn3,1) 模块和/或能够与成纤维细胞生长因子(FGF)受体和/或腺苷 - 丝氨酸蛋白酶相互作用的神经细胞粘附分子(NCAM)的第二纤连蛋白III(Fn3,2)模块或其片段或其变体, 三磷酸盐(ATP)和/或L1,因此化合物能够诱导分化,调节增殖,刺激再生,神经元可塑性和/或细胞存活。 此外,本发明涉及包含所述化合物的药物组合物,制备药物组合物的方法和所述化合物的用途。

    Erbb Receptor-Derived Peptide Fragments
    12.
    发明申请
    Erbb Receptor-Derived Peptide Fragments 有权
    Erbb受体衍生的肽片段

    公开(公告)号:US20090092617A1

    公开(公告)日:2009-04-09

    申请号:US12226091

    申请日:2007-04-03

    CPC分类号: C07K14/71

    摘要: The invention relates to new peptide compounds capable of modulating cell proliferation, differentiation, survival and/or motility. The peptide compounds of the invention comprise short peptide fragments of the ErbB receptor and are capable of binding to ErbB and modulating activity of the receptor. The invention also relates to antibodies capable of binding to an epitope comprising a peptide sequence of the invention, pharmaceutical compositions comprising the peptide sequences and/or antibodies and uses thereof for treatment of conditions wherein modulating activity of ErbB is needed.

    摘要翻译: 本发明涉及能够调节细胞增殖,分化,存活和/或运动的新的肽化合物。 本发明的肽化合物包含ErbB受体的短肽片段,并且能够结合ErbB并调节受体的活性。 本发明还涉及能够结合包含本发明的肽序列的表位的抗体,包含肽序列和/或抗体的药物组合物及其用于治疗需要调节ErbB活性的病症的用途。

    IL-4-derived peptides for modulation of the chronic inflammatory response and treatment of autoimmune diseases
    13.
    发明授权
    IL-4-derived peptides for modulation of the chronic inflammatory response and treatment of autoimmune diseases 有权
    用于调节慢性炎症反应和治疗自身免疫疾病的IL-4衍生肽

    公开(公告)号:US08546321B2

    公开(公告)日:2013-10-01

    申请号:US13127574

    申请日:2009-11-17

    IPC分类号: A61K38/00 A61K38/03

    摘要: The present invention relates to small peptides derived from a cytokine, interleukin-4 (IL-4), capable of binding to the IL-4 receptors and inhibiting macrophage activation, and thereby preventing the onset of inflammatory response. The invention further relates to use of said peptides for the production of a medicament for the treatment of different pathological conditions, wherein IL-4 plays a prominent role.

    摘要翻译: 本发明涉及能够结合IL-4受体并抑制巨噬细胞活化的细胞因子,白细胞介素-4(IL-4)的小肽,从而防止炎性反应的发生。 本发明还涉及所述肽用于生产用于治疗不同病理状况的药物的用途,其中IL-4起突出作用。

    GDNF derived peptides
    14.
    发明授权
    GDNF derived peptides 有权
    GDNF衍生肽

    公开(公告)号:US08138148B2

    公开(公告)日:2012-03-20

    申请号:US12064190

    申请日:2006-08-15

    摘要: The present invention relates to peptide fragments derived from the proteins belonging to the TGFbeta superfamily, pharmaceutical compositions comprising these peptide fragments and uses thereof for treatment of a disease or condition wherein the effects of stimulating neuronal cell differentiation, neuronal cell survival, stimulating neural plasticity associated with learning and memory and/or inhibiting inflammatory response are beneficial for treatment.

    摘要翻译: 本发明涉及衍生自属于TGFbeta超家族的蛋白质的肽片段,包含这些肽片段的药物组合物及其用于治疗疾病或病症的用途,其中刺激神经细胞分化,神经元细胞存活,刺激神经可塑性相关的作用 学习和记忆和/或抑制炎症反应有利于治疗。

    Compounds capable of interacting with a cell-surface fibroblast growth factor receptor
    16.
    发明授权
    Compounds capable of interacting with a cell-surface fibroblast growth factor receptor 有权
    能够与细胞表面成纤维细胞生长因子受体相互作用的化合物

    公开(公告)号:US07951906B2

    公开(公告)日:2011-05-31

    申请号:US12370003

    申请日:2009-02-12

    IPC分类号: C07K4/00 G01N33/53

    摘要: The present invention relates to a method for modulating the interaction between at least two proteins, wherein at least one of the two proteins is a functional cell-surface receptor and the other protein is the receptor ligand. The invention features a binding site of said functional cell-surface receptor on the receptor ligand and discloses a series of amino acid sequences, which are part of the structure of said binding site and/or involved in the interaction between the receptor and the ligand. Moreover, the present invention features methods for molecular design and screening of a candidate compound capable of modulating the interaction between the functional cell-surface receptor and receptor ligand through the described binding site, and provides a screening assay for identification of such a compound. The invention further describes an antibody capable of binding to the above binding site and/or to an epitope comprising an amino acid sequence essential for executing the receptor ligand interaction through said binding site. The invention also concerns a variety of uses of the disclosed methods, peptide sequences and antibodies. The invention in preferred embodiments concerns the binding site of the fibroblast growth factor receptor (FGFR) on FGFR ligands, compounds capable of modulating the receptor ligand interaction through said binding site, and antibody capable of recognition of said binding site.

    摘要翻译: 本发明涉及调节至少两种蛋白质之间的相互作用的方法,其中两种蛋白质中的至少一种是功能性细胞表面受体,而另一种蛋白质是受体配体。 本发明的特征在于所述功能性细胞表面受体在受体配体上的结合位点,并公开了一系列氨基酸序列,其是所述结合位点结构的一部分和/或参与受体和配体之间的相互作用。 此外,本发明具有分子设计和筛选能够通过所述结合位点调节功能性细胞表面受体和受体配体之间的相互作用的候选化合物的方法,并提供了鉴定这种化合物的筛选试验。 本发明还描述了能够结合上述结合位点和/或包含通过所述结合位点执行受体配体相互作用所必需的氨基酸序列的表位的抗体。 本发明还涉及所公开的方法,肽序列和抗体的各种用途。 本发明在优选实施方案中涉及成纤维细胞生长因子受体(FGFR)对FGFR配体的结合位点,能够通过所述结合位点调节受体配体相互作用的化合物和能够识别所述结合位点的抗体。

    Survical promoting ncam binding and ncam ligand binding compounds
    18.
    发明申请
    Survical promoting ncam binding and ncam ligand binding compounds 审中-公开
    生存促进ncam结合和ncam配体结合化合物

    公开(公告)号:US20050069537A1

    公开(公告)日:2005-03-31

    申请号:US10450150

    申请日:2001-12-12

    摘要: The present invention relates to compounds capable of stimulating survival of cells presenting the neural cell adhesion molecule (NCAM) or an NCAM-ligand (counter-receptor), such as neurons. Further, the present invention relates to the use of pharmaceutical compositions and medicaments in the treatment or protection of cells presenting NCAM or NCAM ligands. More particularly the invention describes the use of a compound comprising a peptide comprising at least 5 contiguous amino acid residues from an amino acid sequence of NCAM, a fragment thereof, or a variant thereof or a mimic thereof, for the preparation of a medicament for preventing cell death of cells presenting said NCAM or an NCAM ligand.

    摘要翻译: 本发明涉及能够刺激呈现神经细胞粘附分子(NCAM)的细胞或NCAM-配体(反受体)如神经元的存活的化合物。 此外,本发明涉及药物组合物和药物在治疗或保护呈现NCAM或NCAM配体的细胞中的用途。 更具体地,本发明描述了使用包含由NCAM的氨基酸序列至少5个连续氨基酸残基的肽组成的化合物,其片段或其变体或其模拟物,用于制备用于预防 呈现所述NCAM或NCAM配体的细胞的细胞死亡。

    Antagonists of the Interleukin-1 Receptor
    19.
    发明申请
    Antagonists of the Interleukin-1 Receptor 有权
    白细胞介素-1受体的拮抗剂

    公开(公告)号:US20140073556A1

    公开(公告)日:2014-03-13

    申请号:US14003824

    申请日:2012-03-14

    IPC分类号: C07K7/08 C07K7/06

    摘要: The present invention discloses novel peptides derived from the IL-1 receptor antagonist protein (IL1 RA), capable of binding to the cell surface IL-1 receptor 1 (IL1 R1) and interfere with the binding of IL-1 to IL1 R1. This binding thus effectively antagonises the inflammatory effects of IL-1, such as by reducing TNF-alpha secretion from macrophages. This is of potential use as an anti-inflammatory factor throughout the human body, including the central nervous system. The use of said peptides as anti-inflammatory agents for treatment of pathological conditions wherein IL-1 plays a prominent role, such as inflammatory conditions of the body and the central nervous system, is thus an aspect of the present invention.

    摘要翻译: 本发明公开了能够结合细胞表面IL-1受体1(IL1R1)并干扰IL-1与IL1R1结合的来源于IL-1受体拮抗蛋白(IL1 RA)的新型肽。 因此,这种结合因此有效地拮抗IL-1的炎症作用,例如通过减少巨噬细胞的TNF-α分泌。 这可以作为整个人体的抗炎因子,包括中枢神经系统。 因此,所述肽作为抗炎剂用于治疗其中IL-1起突出作用的病理状况(例如身体和中枢神经系统的炎性病症)的用途是本发明的一个方面。

    Fibroblast growth factor receptor-derived peptides binding to NCAM
    20.
    发明授权
    Fibroblast growth factor receptor-derived peptides binding to NCAM 失效
    成纤维细胞生长因子受体衍生的肽结合NCAM

    公开(公告)号:US08637465B2

    公开(公告)日:2014-01-28

    申请号:US13322307

    申请日:2009-05-27

    IPC分类号: A61K38/17

    摘要: The present invention relates to the use of peptides that are capable of binding to, and modulating the activity of NCAM. The peptides are peptide fragments of FGFRs. They are derived from two distinct binding sites for binding of the immunoglobulin-like module 2 of FGFR to NCAM F3 modules 1-2. The invention further relates to use of said peptides for the production of a medicament for the treatment of different pathological conditions, wherein NCAM and/or FGFRs play a prominent role.

    摘要翻译: 本发明涉及能够结合并调节NCAM活性的肽的用途。 肽是FGFR的肽片段。 它们衍生自用于结合FGFR的免疫球蛋白样模块2与NCAM F3模块1-2的两个不同的结合位点。 本发明还涉及所述肽在生产用于治疗不同病理状况的药物中的用途,其中NCAM和/或FGFRs起着重要作用。