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    IL-4-derived peptides for modulation of the chronic inflammatory response and treatment of autoimmune diseases
    5.
    发明授权
    IL-4-derived peptides for modulation of the chronic inflammatory response and treatment of autoimmune diseases 有权
    用于调节慢性炎症反应和治疗自身免疫疾病的IL-4衍生肽

    公开(公告)号：US08546321B2

    公开(公告)日：2013-10-01

    申请号：US13127574

    申请日：2009-11-17

    申请人： Elisabeth Bock ,  Vladimir Berezin

    发明人： Elisabeth Bock ,  Vladimir Berezin

    IPC分类号： A61K38/00 ,  A61K38/03

    CPC分类号： C07K14/5406 ,  A61K38/00 ,  Y02A50/414

    摘要： The present invention relates to small peptides derived from a cytokine, interleukin-4 (IL-4), capable of binding to the IL-4 receptors and inhibiting macrophage activation, and thereby preventing the onset of inflammatory response. The invention further relates to use of said peptides for the production of a medicament for the treatment of different pathological conditions, wherein IL-4 plays a prominent role.

    摘要翻译： 本发明涉及能够结合IL-4受体并抑制巨噬细胞活化的细胞因子，白细胞介素-4（IL-4）的小肽，从而防止炎性反应的发生。 本发明还涉及所述肽用于生产用于治疗不同病理状况的药物的用途，其中IL-4起突出作用。

    GDNF derived peptides
    6.
    发明授权
    GDNF derived peptides 有权
    GDNF衍生肽

    公开(公告)号：US08138148B2

    公开(公告)日：2012-03-20

    申请号：US12064190

    申请日：2006-08-15

    申请人： Elisabeth Bock ,  Vladimir Berezin

    发明人： Elisabeth Bock ,  Vladimir Berezin

    IPC分类号： A61K38/18 ,  A61K38/16 ,  A61K38/03 ,  A61K38/04

    CPC分类号： C07K14/47 ,  A61K38/00 ,  C07K14/475 ,  C07K14/495

    摘要： The present invention relates to peptide fragments derived from the proteins belonging to the TGFbeta superfamily, pharmaceutical compositions comprising these peptide fragments and uses thereof for treatment of a disease or condition wherein the effects of stimulating neuronal cell differentiation, neuronal cell survival, stimulating neural plasticity associated with learning and memory and/or inhibiting inflammatory response are beneficial for treatment.

    摘要翻译： 本发明涉及衍生自属于TGFbeta超家族的蛋白质的肽片段，包含这些肽片段的药物组合物及其用于治疗疾病或病症的用途，其中刺激神经细胞分化，神经元细胞存活，刺激神经可塑性相关的作用 学习和记忆和/或抑制炎症反应有利于治疗。

    Compounds capable of interacting with a cell-surface fibroblast growth factor receptor
    8.
    发明授权
    Compounds capable of interacting with a cell-surface fibroblast growth factor receptor 有权
    能够与细胞表面成纤维细胞生长因子受体相互作用的化合物

    公开(公告)号：US07951906B2

    公开(公告)日：2011-05-31

    申请号：US12370003

    申请日：2009-02-12

    申请人： Elisabeth Bock ,  Vladimir Berezin ,  Morten Albrechtsen

    发明人： Elisabeth Bock ,  Vladimir Berezin ,  Morten Albrechtsen

    IPC分类号： C07K4/00 ,  G01N33/53

    CPC分类号： C07K7/06 ,  A61K38/00 ,  C07K7/08 ,  C07K16/22 ,  G01N33/566 ,  G01N33/74 ,  G01N2333/50

    摘要： The present invention relates to a method for modulating the interaction between at least two proteins, wherein at least one of the two proteins is a functional cell-surface receptor and the other protein is the receptor ligand. The invention features a binding site of said functional cell-surface receptor on the receptor ligand and discloses a series of amino acid sequences, which are part of the structure of said binding site and/or involved in the interaction between the receptor and the ligand. Moreover, the present invention features methods for molecular design and screening of a candidate compound capable of modulating the interaction between the functional cell-surface receptor and receptor ligand through the described binding site, and provides a screening assay for identification of such a compound. The invention further describes an antibody capable of binding to the above binding site and/or to an epitope comprising an amino acid sequence essential for executing the receptor ligand interaction through said binding site. The invention also concerns a variety of uses of the disclosed methods, peptide sequences and antibodies. The invention in preferred embodiments concerns the binding site of the fibroblast growth factor receptor (FGFR) on FGFR ligands, compounds capable of modulating the receptor ligand interaction through said binding site, and antibody capable of recognition of said binding site.

    摘要翻译： 本发明涉及调节至少两种蛋白质之间的相互作用的方法，其中两种蛋白质中的至少一种是功能性细胞表面受体，而另一种蛋白质是受体配体。 本发明的特征在于所述功能性细胞表面受体在受体配体上的结合位点，并公开了一系列氨基酸序列，其是所述结合位点结构的一部分和/或参与受体和配体之间的相互作用。 此外，本发明具有分子设计和筛选能够通过所述结合位点调节功能性细胞表面受体和受体配体之间的相互作用的候选化合物的方法，并提供了鉴定这种化合物的筛选试验。 本发明还描述了能够结合上述结合位点和/或包含通过所述结合位点执行受体配体相互作用所必需的氨基酸序列的表位的抗体。 本发明还涉及所公开的方法，肽序列和抗体的各种用途。 本发明在优选实施方案中涉及成纤维细胞生长因子受体（FGFR）对FGFR配体的结合位点，能够通过所述结合位点调节受体配体相互作用的化合物和能够识别所述结合位点的抗体。

    Survical promoting ncam binding and ncam ligand binding compounds
    9.
    发明申请
    Survical promoting ncam binding and ncam ligand binding compounds 审中-公开
    生存促进ncam结合和ncam配体结合化合物

    公开(公告)号：US20050069537A1

    公开(公告)日：2005-03-31

    申请号：US10450150

    申请日：2001-12-12

    申请人： Vladimir Berezin ,  Elisabeth Bock ,  Lene Kohler

    发明人： Vladimir Berezin ,  Elisabeth Bock ,  Lene Kohler

    IPC分类号： A61K38/00 ,  A61K39/395 ,  A61P3/10 ,  A61P9/10 ,  A61P13/12 ,  A61P15/00 ,  A61P21/02 ,  A61P25/00 ,  A61P25/02 ,  A61P25/14 ,  A61P25/16 ,  A61P25/28 ,  C07K14/47 ,  C07K14/705 ,  A61K38/08

    CPC分类号： C07K14/70503 ,  A61K38/00 ,  A61K2039/505

    摘要： The present invention relates to compounds capable of stimulating survival of cells presenting the neural cell adhesion molecule (NCAM) or an NCAM-ligand (counter-receptor), such as neurons. Further, the present invention relates to the use of pharmaceutical compositions and medicaments in the treatment or protection of cells presenting NCAM or NCAM ligands. More particularly the invention describes the use of a compound comprising a peptide comprising at least 5 contiguous amino acid residues from an amino acid sequence of NCAM, a fragment thereof, or a variant thereof or a mimic thereof, for the preparation of a medicament for preventing cell death of cells presenting said NCAM or an NCAM ligand.

    摘要翻译： 本发明涉及能够刺激呈现神经细胞粘附分子（NCAM）的细胞或NCAM-配体（反受体）如神经元的存活的化合物。 此外，本发明涉及药物组合物和药物在治疗或保护呈现NCAM或NCAM配体的细胞中的用途。 更具体地，本发明描述了使用包含由NCAM的氨基酸序列至少5个连续氨基酸残基的肽组成的化合物，其片段或其变体或其模拟物，用于制备用于预防 呈现所述NCAM或NCAM配体的细胞的细胞死亡。

    Peptides derived from NCAM (FGLs)
    10.
    发明授权
    Peptides derived from NCAM (FGLs) 有权
    衍生自NCAM（FGL）的肽

    公开(公告)号：US08470964B2

    公开(公告)日：2013-06-25

    申请号：US12745129

    申请日：2008-11-28

    申请人： Vladimir Berezin ,  Elisabeth Bock ,  Soren Ebdrup ,  Boris Klementiev

    发明人： Vladimir Berezin ,  Elisabeth Bock ,  Soren Ebdrup ,  Boris Klementiev

    IPC分类号： C07K2/00 ,  A61K38/00

    CPC分类号： C07K14/70503 ,  A61K38/00

    摘要： The present invention relates to novel compounds comprising at most 13 contiguous amino acid residues derived from the fibronectin type 3,11 module of neural cell adhesion molecule (NCAM), or a variant or fragment thereof, capable of interacting with an FGFR and thereby the compounds are capable of inducing differentiation, modulating proliferation, stimulate regeneration, neuronal plasticity or survival of cells. Further, the present invention relates to the use of the compounds for production of a medicament for treatment of conditions and diseases, in which NCAM or FGFR play a prominent role.

    摘要翻译： 本发明涉及包含至少13个连续氨基酸残基的新化合物，其衍生自神经细胞粘附分子（NCAM）的3型纤连蛋白模块或其变体或片段，其能够与FGFR相互作用，从而使化合物 能够诱导分化，调节增殖，刺激再生，神经元可塑性或细胞存活。 此外，本发明涉及该化合物用于制备用于治疗NCAM或FGFR起重要作用的病症和疾病的药物的用途。