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公开(公告)号：US08496935B2
公开(公告)日：2013-07-30
申请号：US13049727
申请日：2011-03-16
申请人： Erik E Karrer , Madan M. Paidhungat , Steven H Bass , Margaret Neighbors , Juha Punnonen , Steven J. Chapin
发明人： Erik E Karrer , Madan M. Paidhungat , Steven H Bass , Margaret Neighbors , Juha Punnonen , Steven J. Chapin
CPC分类号： C07K14/70521 , C07K2319/30
摘要： The invention provides immunosuppressive polypeptides and nucleic acids encoding such polypeptides. In one aspect, the invention provides mutant CTLA-4 polypeptides and nucleic acids encoding mutant CTLA-4 polypeptides. Compositions and methods for utilizing such polypeptides and nucleic acids are also provided.
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公开(公告)号：US08318176B2
公开(公告)日：2012-11-27
申请号：US13011497
申请日：2011-01-21
申请人： Erik E. Karrer , Madan M. Paidhungat , Steven H. Bass , Margaret Neighbors , Juha Punnonen , Steven J. Chapin
发明人： Erik E. Karrer , Madan M. Paidhungat , Steven H. Bass , Margaret Neighbors , Juha Punnonen , Steven J. Chapin
IPC分类号： C07K4/12 , C07K14/725 , A61K38/17
CPC分类号： C07K14/70521 , C07K2319/30
摘要： The invention provides immunosuppressive polypeptides and nucleic acids encoding such polypeptides. In one aspect, the invention provides mutant CTLA-4 polypeptides and nucleic acids encoding mutant CTLA-4 polypeptides. Compositions and methods for utilizing such polypeptides and nucleic acids are also provided.
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公开(公告)号：US20110177071A1
公开(公告)日：2011-07-21
申请号：US13045335
申请日：2011-03-10
申请人： Erik E. Karrer , Madan M. Paidhungat , Steven H. Bass , Margaret Neighbors , Juha Punnonen , Steven J. Chapin
发明人： Erik E. Karrer , Madan M. Paidhungat , Steven H. Bass , Margaret Neighbors , Juha Punnonen , Steven J. Chapin
IPC分类号： A61K39/395 , A61P37/06
CPC分类号： C07K14/70521 , C07K2319/30
摘要： The invention provides immunosuppressive polypeptides and nucleic acids encoding such polypeptides. In one aspect, the invention provides mutant CTLA-4 polypeptides and nucleic acids encoding mutant CTLA-4 polypeptides. Compositions and methods for utilizing such polypeptides and nucleic acids are also provided.
摘要翻译： 本发明提供免疫抑制多肽和编码这种多肽的核酸。 一方面，本发明提供突变CTLA-4多肽和编码突变CTLA-4多肽的核酸。 还提供了用于利用这些多肽和核酸的组合物和方法。
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公开(公告)号：US20110159542A1
公开(公告)日：2011-06-30
申请号：US13011351
申请日：2011-01-21
申请人： Erik E. Karrer , Madan M. Paidhungat , Steven H. Bass , Margaret Neighbors , Juha Punnonen , Steven J. Chapin
发明人： Erik E. Karrer , Madan M. Paidhungat , Steven H. Bass , Margaret Neighbors , Juha Punnonen , Steven J. Chapin
CPC分类号： C07K14/70521 , C07K2319/30
摘要： The invention provides immunosuppressive polypeptides and nucleic acids encoding such polypeptides. In one aspect, the invention provides mutant CTLA-4 polypeptides and nucleic acids encoding mutant CTLA-4 polypeptides. Compositions and methods for utilizing such polypeptides and nucleic acids are also provided.
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15.发明授权Methods of targeting agents to cells expressing the polymeric immunoglobulin receptor 失效将试剂靶向表达高分子免疫球蛋白受体的细胞的方法公开(公告)号：US07404954B2
公开(公告)日：2008-07-29
申请号：US11038956
申请日：2005-01-19
CPC分类号： C07K16/2803 , A61K48/00 , A61K2039/505 , C07K2317/21 , C07K2317/23 , C07K2317/34 , C07K2317/55 , C07K2317/622 , C07K2317/77 , C07K2319/00
摘要： The invention provides compositions and methods for specific binding to a region of the polymeric immunoglobulin receptor (pIgR) of a cell with the provisos that the ligand does not substantially bind to the most abundant form of the secretory component (SC) of pIgR present in an organ of interest of an animal of interest under physiological conditions, and does not bind to the pIgR stalk. In some embodiments, the ligand decreases cleavage of SC from the stalk by at least one-third. The ligands and methods of the invention can be used with both birds and mammals. In more preferred embodiments, the animal is a mammal. In the most preferred embodiment, the animal is a human. The ligand may be targeted into the cell or may undergo retrograde transcytosis and release at the basolateral side of the cell, and may comprise a biologically active composition.
摘要翻译： 本发明提供了用于特异性结合细胞的聚合免疫球蛋白受体（pIgR）的区域的组合物和方法，条件是配体基本上不与存在于pIgR中的pIgR的分泌成分（SC）的最丰富形式结合 在生理条件下感兴趣的动物感兴趣的器官，并且不与pIgR茎结合。 在一些实施方案中，配体减少SC从茎的裂解至少三分之一。 本发明的配体和方法可以与鸟类和哺乳动物一起使用。 在更优选的实施方案中，动物是哺乳动物。 在最优选的实施方案中，动物是人。 配体可以靶向细胞或者可能在细胞的基底外侧发生逆行转胞吞作用和释放，并且可以包含生物活性组合物。
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16.发明授权Ligands directed to the non-secretory component, non-stalk region of plgR and methods of use thereof 失效指向非分泌成分的配体，无茎区的plgR及其使用方法公开(公告)号：US06855810B2
公开(公告)日：2005-02-15
申请号：US09818247
申请日：2001-03-26
IPC分类号： C12N15/09 , A61K31/215 , A61K31/70 , A61K38/00 , A61K39/395 , A61K45/00 , A61K47/42 , A61K47/48 , A61K48/00 , A61K51/00 , A61P11/00 , C07K7/00 , C07K14/705 , C07K16/28 , C07K16/46 , C07K19/00 , C12N5/10 , C12P21/04 , C07K16/00
CPC分类号： C07K16/2803 , A61K48/00 , A61K2039/505 , C07K2317/21 , C07K2317/23 , C07K2317/34 , C07K2317/55 , C07K2317/622 , C07K2317/77 , C07K2319/00
摘要： The invention provides compositions and methods for specific binding to a region of the polymeric immunoglobulin receptor (pIgR) of a cell with the provisos that the ligand does not substantially bind to the most abundant form of the secretory component (SC) of pIgR present in an organ of interest of an animal of interest under physiological conditions, and does not bind to the pIgR stalk. In some embodiments, the ligand decreases cleavage of SC from the stalk by at least one-third. The ligands and methods of the invention can be used with both birds and mammals. In more preferred embodiments, the animal is a mammal. In the most preferred embodiment, the animal is a human. The ligand may be targeted into the cell or may undergo retrograde transcytosis and release at the basolateral side of the cell, and may comprise a biologically active composition.
摘要翻译： 本发明提供了用于特异性结合细胞的聚合免疫球蛋白受体（pIgR）的区域的组合物和方法，条件是配体基本上不与存在于pIgR中的pIgR的分泌成分（SC）的最丰富形式结合 在生理条件下感兴趣的动物感兴趣的器官，并且不与pIgR茎结合。 在一些实施方案中，配体减少SC从茎的裂解至少三分之一。 本发明的配体和方法可以与鸟类和哺乳动物一起使用。 在更优选的实施方案中，动物是哺乳动物。 在最优选的实施方案中，动物是人。 配体可以靶向细胞或者可能在细胞的基底外侧发生逆行转胞吞作用和释放，并且可以包含生物活性组合物。
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