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公开(公告)号：US20150359925A1
公开(公告)日：2015-12-17
申请号：US14836014
申请日：2015-08-26
Applicant: Ethicon, Inc.
Inventor： Yi-Lan Wang , Guanghui Zhang
IPC: A61L26/00
CPC classification number: A61L26/0052 , A61K38/39 , A61L24/0015 , A61L24/108 , A61L26/009 , A61L2300/25 , A61L2300/252 , A61L2300/418 , A61L2400/04
Abstract: The present invention is directed to a hemostatic or tissue sealing material having (a) a peptide having a sequence SEQ ID NO: 1 or an amino acid analog sequence thereof, and (b) a scaffold for said peptide or amino acid analogue sequence. The scaffold is preferably hemostatic, such as a natural or genetically engineered absorbable polymer, a synthetic absorbable polymer, or combinations thereof. The natural or genetically engineered absorbable polymers can be selected from the group consisting of a protein, a polysaccharide, or combinations thereof.
Abstract translation: 本发明涉及一种止血或组织密封材料，其具有（a）具有序列SEQ ID NO：1或其氨基酸类似物序列的肽，和（b）所述肽或氨基酸类似物序列的支架。 支架优选为止血剂，例如天然或遗传工程可吸收聚合物，合成可吸收聚合物或其组合。 天然或遗传工程可吸收聚合物可以选自蛋白质，多糖或其组合。
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公开(公告)号：US20220331475A1
公开(公告)日：2022-10-20
申请号：US17667787
申请日：2022-02-09
Applicant: Ethicon, Inc.
Inventor： Nir Nativ , Thomas Weindl , Benjamin D. Fitz , Gerard Llanos , Guanghui Zhang , Yi-Lan Wang , Meng Deng
Abstract: The present invention is directed to a hemostatic patch comprising a porous substrate and at least a pair of co-reactive polymer reagents comprising at least one nucleophilic polyalkylene oxide based component and at least one electrophilic polyalkylene oxide-based on the porous substrate in a molar ratio of about 0.2 to about 0.9:1 of primary nucleophilic groups in excess to available electrophilic groups. The present invention is also directed to processes for the manufacture and use of such hemostatic patches.
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公开(公告)号：US10456526B2
公开(公告)日：2019-10-29
申请号：US15649160
申请日：2017-07-13
Applicant: Ethicon, Inc.
Inventor： Yi-Lan Wang , Leo B. Kriksunov
Abstract: The present invention is directed to a multi-compartment medical device for segregated storage and on demand mixing of at least two components and expression of a resulting mixture from the device having a tubular barrel with an opening and a gasket sealing the rear end through which a plunger is axially slidable within the tubular barrel. At least one bypass is provided in the barrel in order to enable fluid movement of the components between front and rear compartments and rear compartments. The present invention is also directed to methods for the use of such devices.
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Patent Agency Ranking
14.发明申请公开(公告)号：US20190134258A1
公开(公告)日：2019-05-09
申请号：US15807068
申请日：2017-11-08
Applicant: Ethicon, Inc.
Inventor： Yi-Lan Wang , Leo B. Kriksunov
Abstract: The present invention is directed to a hemostatic semi-solid paste material comprising a bioabsorbable carrier hemostatic material; and a supplemental hemostatic agent; wherein the paste material has an elongated form extending along a lengthwise axis with an aspect ratio of at least 3; wherein the paste is self-supporting and syringe extrudable; and wherein the supplemental hemostatic agent has a non-homogenous distribution profile across a cross-section taken across the lengthwise axis. In another aspect, the present invention relates to devices for forming and expressing the hemostatic material.
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公开(公告)号：US10022411B2
公开(公告)日：2018-07-17
申请号：US14032556
申请日：2013-09-20
Applicant: Ethicon, Inc.
Inventor： Yi-Lan Wang , Xintian Ming
Abstract: The present invention relates generally to agents and devices for promoting hemostasis and, more particularly, to an extract of a plant-based “Traditional Chinese Medicinal” product and devices incorporating such agents for the delivery thereof to bleeding wounds.
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16.发明授权公开(公告)号：US09539358B2
公开(公告)日：2017-01-10
申请号：US14333697
申请日：2014-07-17
Applicant: Ethicon, Inc.
Inventor： Yi-Lan Wang , Guanghui Zhang
IPC: A61L26/00
CPC classification number: A61L26/0023 , A61L26/0061 , A61L26/0066 , A61L26/009 , A61L2300/404 , A61L2300/418 , A61L2400/04 , Y10T428/2982 , C08L1/04
Abstract: The present invention is directed to hemostatic material containing compacted ORC powder comprising particles having an average aspect ratio from about 1 to about 18, wherein said compacted ORC powder have preferably been processed in a compaction device, such as a ball milled ORC powder. The present invention further relates to methods of making the hemostatic material and a method of treating a wound by applying the hemostatic powder onto and/or into the wound of a patient.
Abstract translation: 本发明涉及包含压实的ORC粉末的止血材料，其包含平均纵横比为约1至约18的颗粒，其中所述压实的ORC粉末优选在压实装置如球磨的ORC粉末中加工。 本发明还涉及制止止血材料的方法以及通过将止血粉末施用于患者的伤口和/或进入伤口来治疗伤口的方法。
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公开(公告)号：US20140329769A1
公开(公告)日：2014-11-06
申请号：US14333697
申请日：2014-07-17
Applicant: Ethicon, Inc.
Inventor： Yi-Lan Wang , Guanghui Zhang
IPC: A61L26/00
CPC classification number: A61L26/0023 , A61L26/0061 , A61L26/0066 , A61L26/009 , A61L2300/404 , A61L2300/418 , A61L2400/04 , Y10T428/2982 , C08L1/04
Abstract: The present invention is directed to hemostatic material containing compacted ORC powder comprising particles having an average aspect ratio from about 1 to about 18, wherein said compacted ORC powder have preferably been processed in a compaction device, such as a ball milled ORC powder. The present invention further relates to methods of making the hemostatic material and a method of treating a wound by applying the hemostatic powder onto and/or into the wound of a patient.
Abstract translation: 本发明涉及包含压实的ORC粉末的止血材料，其包含平均纵横比为约1至约18的颗粒，其中所述压实的ORC粉末优选在压实装置如球磨的ORC粉末中加工。 本发明还涉及制止止血材料的方法以及通过将止血粉末施用于患者的伤口和/或进入伤口来治疗伤口的方法。
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公开(公告)号：US20140017348A1
公开(公告)日：2014-01-16
申请号：US14032556
申请日：2013-09-20
Applicant: Ethicon, Inc.
Inventor： Yi-Lan Wang , Xintian Ming
CPC classification number: A61K36/12 , A61K9/0014 , A61K36/287 , A61K38/39 , A61L26/0038 , A61L26/0057 , A61L2400/04 , A61K2300/00
Abstract: The present invention relates generally to agents and devices for promoting hemostasis and, more particularly, to an extract of a plant-based “Traditional Chinese Medicinal” product and devices incorporating such agents for the delivery thereof to bleeding wounds.
Abstract translation: 本发明一般涉及用于促进止血的药剂和装置，更具体地，涉及植物性“中药”产品的提取物和包含用于将其输送给出血伤口的药剂的提取物。
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