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    METHODS AND COMPOSITIONS FOR INHIBITION OF AXONAL DEGENERATION BY MODULATION OF THE DLK/JNK PATHWAY
    16.
    发明申请
    METHODS AND COMPOSITIONS FOR INHIBITION OF AXONAL DEGENERATION BY MODULATION OF THE DLK/JNK PATHWAY 审中-公开
    通过DLK / JNK PATHWAY调制来抑制AXONAL变性的方法和组合

    公开(公告)号：US20100056609A1

    公开(公告)日：2010-03-04

    申请号：US12548411

    申请日：2009-08-26

    申请人： Aaron DiAntonio ,  Bradley R. Miller ,  Jeffrey D. Milbrandt ,  Craig A. Press

    发明人： Aaron DiAntonio ,  Bradley R. Miller ,  Jeffrey D. Milbrandt ,  Craig A. Press

    IPC分类号： A61K31/7088 ,  A61K31/415 ,  C12Q1/48

    CPC分类号： A61K31/713 ,  A61K31/415 ,  A61K31/7088 ,  C12Q1/48 ,  G01N2333/91205 ,  G01N2500/10

    摘要： Methods of reducing Wallerian degeneration are disclosed. These methods comprise inhibiting expression or activity of a mixed lineage kinas such as a dual leucine-zipper-bearing kinase (DLK), inhibiting expression or activity of a molecule acting downstream from DLK, such as a c-Jun N-terminal kinase (JNK), or a combination thereof. Further disclosed are methods of screening candidate compounds for DLK inhibition activity. These methods comprise providing a neuronal culture comprising a plurality of axons; contacting the culture with a candidate compound and with an axon degeneration-triggering agent; and comparing axonal degeneration in the culture to a control culture comprising the axon degeneration-triggering agent but not the candidate compound.

    摘要翻译： 公开了降低瓦勒氏变性的方法。 这些方法包括抑制混合谱系的表达或活性，例如双重含亮氨酸 - 拉链的激酶（DLK），抑制DLK下游分子的表达或活性，例如c-Jun N-末端激酶（JNK ）或其组合。 进一步公开的是筛选候选化合物用于DLK抑制活性的方法。 这些方法包括提供包含多个轴突的神经元培养物; 使培养物与候选化合物和轴突变性引发剂接触; 并将培养物中的轴突变性与包含轴突变性引发剂但不是候选化合物的对照培养物进行比较。

    Artemin, a novel neurotrophic factor
    17.
    发明授权
    Artemin, a novel neurotrophic factor 失效
    Artemin，一种新型神经营养因子

    公开(公告)号：US06284540B1

    公开(公告)日：2001-09-04

    申请号：US09220528

    申请日：1998-12-24

    申请人： Jeffrey D. Milbrandt ,  Robert H. Baloh

    发明人： Jeffrey D. Milbrandt ,  Robert H. Baloh

    IPC分类号： C12N500

    CPC分类号： C07K14/475 ,  A61K38/00 ,  A61K48/00

    摘要： A novel growth factor, artemin, which belongs to the GDNF/neurturin/persephin family of growth factors, is disclosed. The human and mouse amino sequences have been identified. Human and mouse artemin genomic DNA sequences have been cloned and sequenced and the respective cDNA sequences identified. In addition, methods for treating degenerative conditions using artemin, methods for detecting artemin gene alterations and methods for detecting and monitoring patient levels of artemin are provided.

    摘要翻译： 公开了属于GDNF / neurturin / persephin生长因子家族的新生长因子artemin。 人和小鼠氨基酸序列已被鉴定。 已经克隆并测序了人和小鼠artemin基因组DNA序列，并鉴定了各自的cDNA序列。 另外，提供了使用artemin进行退行性病症的方法，用于检测artemin基因改变的方法以及用于检测和监测artemin患者水平的方法。