METHOD FOR PRODUCING PEPTIDE COMPOUND, PROTECTIVE GROUP-FORMING REAGENT, AND SUBSTITUTED BENZYL COMPOUND

    公开(公告)号:US20240317796A1

    公开(公告)日:2024-09-26

    申请号:US18735130

    申请日:2024-06-05

    Abstract: An object of the present invention is to provide a method for producing a peptide compound with an excellent yield, a protective group-forming reagent having an excellent yield, and a novel substituted benzyl compound. According to the present invention, there is provided a method for producing a peptide compound, including a step of using a substituted benzyl compound represented by Formula (1).




    In Formula (1), Y represents —OH, —NHR, —SH, or —X, R represents a hydrogen atom, an alkyl group, an arylalkyl group, a heteroarylalkyl group, or a 9-fluorenylmethoxycarbonyl group, X represents Cl, Br, or I, m represents 1 or 2, n represents an integer of 1 to 5, RB's each independently represent an aliphatic hydrocarbon group, RA, s each independently represent an aliphatic hydrocarbon group or an organic group having an aliphatic hydrocarbon group, where the number of carbon atoms in at least one aliphatic hydrocarbon group is 12 or more, and a benzene ring in Formula (1) may further have a substituent in addition to RA.

    METHOD FOR PRODUCING PEPTIDE, PROTECTIVE GROUP-FORMING REAGENT, AND CONDENSED POLYCYCLIC COMPOUND

    公开(公告)号:US20230357311A1

    公开(公告)日:2023-11-09

    申请号:US18338700

    申请日:2023-06-21

    Inventor: Hiroaki TSUYAMA

    CPC classification number: C07K1/064 C07K1/066 C07D311/88

    Abstract: An object of the present invention is to provide a method for producing a peptide with high purity and high efficiency, a protective group-forming reagent having excellent deprotective properties, and a novel condensed polycyclic compound. According to the present invention, there are provided a method for producing a peptide including a step of using a polycyclic compound represented by Formula (1), a protective group-forming reagent containing the polycyclic compound, and the polycyclic compound. At least one of R1 to R8 and R110 has RA, RA represents an aliphatic hydrocarbon group or an organic group having an aliphatic hydrocarbon group, and at least one aliphatic hydrocarbon group has 3 or more carbon atoms.

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