公开(公告)号：US20150238743A1

公开(公告)日：2015-08-27

申请号：US14709640

申请日：2015-05-12

Applicant: FUJIFILM Corporation

Inventor： Yanlong CHE ,  Takayoshi OYAMADA ,  Junya YOSHIDA ,  Shotaro OGAWA

IPC: A61M37/00 ,  B32B37/10

CPC classification number: A61M37/0015 ,  A61K9/0021 ,  A61M2037/0046 ,  A61M2037/0053 ,  A61M2207/10 ,  B29C33/3857 ,  B29C33/40 ,  B29C33/424 ,  B29C2033/385 ,  B29L2031/7544 ,  B29L2031/756 ,  B32B3/30 ,  B32B25/20 ,  B32B27/26 ,  B32B27/283 ,  B32B37/025 ,  B32B37/1018 ,  B32B2255/26 ,  B32B2305/00 ,  B32B2307/724 ,  B32B2307/7265

Abstract: A molding compact for forming a transdermal absorption sheet on which a needle-shaped protruding part is arranged is a molding compact that is a laminate of: a first member having a needle-shaped recessed part formed on a front surface thereof, the needle-shaped recessed part being an inverse of the needle-shaped protruding part; a second member provided on a back surface of the first member, the second member being composed of a waterproof and moisture-permeable material; and a third member provided on a back surface of the second member, the third member being composed of a rigid body. Provided are a molding compact that makes it possible to prevent leakage of a drug-containing solution filled into the needle-shaped recessed part, and a manufacturing method for a transdermal absorption sheet using the molding compact.

Abstract translation: 用于形成其上布置有针状突起部的经皮吸收片的成形体是成型体，该成形体是以下层叠体：第一构件，其具有形成在其前表面上的针状凹部，针状 凹部是针状突出部的倒数; 设置在所述第一构件的后表面上的第二构件，所述第二构件由防水透湿材料构成; 以及设置在所述第二构件的后表面上的第三构件，所述第三构件由刚体构成。 提供一种成型体，其能够防止填充在针状凹部中的药物溶液的泄漏，以及使用该成型体的透皮吸收片的制造方法。

公开(公告)号：US20150238434A1

公开(公告)日：2015-08-27

申请号：US14709555

申请日：2015-05-12

Applicant: FUJIFILM Corporation

Inventor： Junya YOSHIDA ,  Seiji KASAHARA ,  Takayoshi OYAMADA ,  Yanlong CHE

IPC: A61K9/70

CPC classification number: A61K9/703 ,  A61K8/0204 ,  A61K8/732 ,  A61K8/735 ,  A61K9/0021 ,  A61K38/27 ,  A61K38/385 ,  A61K2800/91 ,  A61M37/0015 ,  A61M2037/0023 ,  A61M2037/0046 ,  A61M2037/0053 ,  A61Q19/08 ,  B29C41/22 ,  B29C59/005 ,  B29C59/022 ,  B29C2059/023 ,  B29K2995/0056 ,  B29K2995/0065 ,  B29L2031/7544

Abstract: A transdermal absorption sheet and a manufacturing method for the transdermal absorption sheet includes a laminating step of forming a multilayer film with a viscosity difference by forming, on a support, a lower layer containing a first transdermal absorption material and an upper layer containing a drug and a second transdermal absorption material and having a lower viscosity than the lower layer, a filling step of filling needle-like recessed portions corresponding to inverted needle-like protruding portions with a solution of the transdermal absorption material by pressing a mold in which the needle-like recessed portions are arranged in a two-dimensional array, against a surface of the multilayer film supported by the support to allow the multilayer film to flow, a solidifying step of solidifying the multilayer film with the mold pressed against the surface of the multilayer film, and a peeling-off step of peeling the solidified multilayer film from the mold.

Abstract translation: 透皮吸收片和透皮吸收片的制造方法包括层叠步骤，通过在载体上形成含有第一透皮吸收材料的下层和含有药物的上层，形成具有粘度差的多层膜，以及 第二透皮吸收材料，并且具有比下层更低的粘度;填充步骤，用经皮吸收材料的溶液填充与倒置的针状突起部分相对应的针状凹部， 相对于由支撑体支撑的多层膜的表面，将二维阵列的凹部排列成多层膜，以使多层膜流动，固化步骤使多层膜的模压力压在多层膜的表面上 以及从模具剥离固化的多层膜的剥离步骤。