公开(公告)号：US11279967B2

公开(公告)日：2022-03-22

申请号：US17036730

申请日：2020-09-29

Applicant: Gen-Probe Incorporated

Inventor： David A. Buse ,  David Howard Combs ,  Byron J. Knight ,  Norbert D. Hagen ,  David Opalsky ,  Jason F. Rhubottom ,  Keith Moravick ,  Tyler Moore ,  Anita Prasad ,  Bruce Richardson

IPC: C12Q1/6806 ,  G01N35/04 ,  B01L3/00 ,  B01L7/00 ,  C12Q1/686

Abstract: A system for performing a nucleic acid amplification assay that includes a receptacle holder formed from a thermally conductive material and having a receptacle well for receiving a lower portion of a vial; a thermal element for cycling the temperature of the receptacle holder; a signal detection module in optical communication with the receptacle well; and a robotic pipettor. The receptacle holder supports a capped vial having a plastic, opaque cap in a snap-fit with a single plastic vial containing a nucleic acid amplification reagent. An upper portion of the cap includes a probe recess that is configured to be removably engaged by an end of a probe of the robotic pipettor. A lower portion of the vial is contained within the receptacle well, and the cap is situated above a top surface of the receptacle holder.

公开(公告)号：US10961572B2

公开(公告)日：2021-03-30

申请号：US16434910

申请日：2019-06-07

Applicant: Gen-Probe Incorporated

Inventor： David Buse ,  David Howard Combs ,  Norbert D. Hagen ,  David Opalsky ,  Bruce Richardson ,  Anita Prasad ,  Keith Moravick ,  Tyler Moore

IPC: C12Q1/686 ,  B01L7/00 ,  G01N21/64 ,  B01L9/06

Abstract: A thermally conductive receptacle holder includes a plurality of wells that each receive a receptacle. A cross-brace is mounted to a support to exert a force onto an outer surface of a compressive housing such that the compressive housing exerts a force onto the receptacle holder. An optical fiber associated with each well provides optical communication between the receptacle well and an excitation signal source and/or an emission signal detector.

公开(公告)号：US20210017579A1

公开(公告)日：2021-01-21

申请号：US17036730

申请日：2020-09-29

Applicant: Gen-Probe Incorporated

Inventor： David A. Buse ,  David Howard Combs ,  Byron J. Knight ,  Norbert D. Hagen ,  David Opalsky ,  Jason F. Rhubottom ,  Keith Moravick ,  Tyler Moore ,  Anita Prasad ,  Bruce Richardson

IPC: C12Q1/6806 ,  G01N35/04 ,  B01L3/00 ,  B01L7/00 ,  C12Q1/686

Abstract: A system for performing a nucleic acid amplification assay comprises a thermally-conductive receptacle holder with one or more receptacle wells, each conforming to an outer surface of a lower portion of a vial. A through-hole extends from an inner surface of each well to an outer surface of the holder. A thermal element is positioned proximal to the holder for altering a temperature of the holder. A signal detection module is configured to generate an excitation signal directed through the through-hole of the well and detect an optical emission from a fluid contained in the vial supported by the well. At least one well supports a capped vial containing a reagent for a nucleic acid amplification assay and including an opaque cap sealing an open end of the vial. The lower portion of the vial is contained within a well, and the cap is situated above a top surface of the holder.

公开(公告)号：USD982177S1

公开(公告)日：2023-03-28

申请号：US29751801

申请日：2020-09-23

Applicant: GEN-PROBE INCORPORATED

Designer： Byron J. Knight ,  David A. Buse ,  David Opalsky ,  Norbert D. Hagen ,  Tyler Moore ,  Anita Prasad ,  Bruce Richardson

公开(公告)号：US20210079452A1

公开(公告)日：2021-03-18

申请号：US17033395

申请日：2020-09-25

Applicant: Gen-Probe Incorporated

Inventor： David Buse ,  Norbert D. Hagen ,  David Opalsky ,  Bruce Richardson ,  Anita Prasad ,  Tyler Moore ,  Byron J. Knight

IPC: C12Q1/6806 ,  G01N35/04 ,  B01L3/00 ,  B01L7/00 ,  C12Q1/686

Abstract: A receptacle cap includes a probe recess configured to receive a probe inserted therein to thereby frictionally secure the receptacle cap to the probe, and a closed lower end of the receptacle is insertable into an open end of a reaction receptacle to close the reaction receptacle. The receptacle cap and the reaction receptacle include interlocking features for securing the receptacle cap to the reaction receptacle.

公开(公告)号：US10563251B2

公开(公告)日：2020-02-18

申请号：US15951818

申请日：2018-04-12

Applicant: Gen-Probe Incorporated

Inventor： David Buse ,  David Howard Combs ,  Norbert D. Hagen ,  David Opalsky ,  Bruce Richardson ,  Anita Prasad ,  Keith Moravick ,  Tyler Moore

IPC: C12Q1/686 ,  B01L7/00 ,  G01N21/64 ,  B01L9/06

Abstract: First and second sets of receptacles containing reagents for first and second amplification reactions, respectively, are placed in first and second receptacle holders, each associated with a thermal element. The receptacles are subjected to different first and second incubation processes resulting in the first and second amplification reactions in each of the first and second sets of receptacles that contain a first or a second target nucleic acid, respectively. The presence or absence of the first or second target nucleic acid, if any, is determined for each receptacle of the first and second sets of receptacles.

公开(公告)号：US20180230517A1

公开(公告)日：2018-08-16

申请号：US15951818

申请日：2018-04-12

Applicant: Gen-Probe Incorporated

Inventor： David Buse ,  David Howard Combs ,  Norbert D. Hagen ,  David Opalsky ,  Bruce Richardson ,  Anita Prasad ,  Keith Moravick ,  Tyler Moore

IPC: C12Q1/686 ,  B01L7/00

Abstract: First and second sets of receptacles containing reagents for first and second amplification reactions, respectively, are placed in first and second receptacle holders, each associated with a thermal element. The receptacles are subjected to different first and second incubation processes resulting in the first and second amplification reactions in each of the first and second sets of receptacles that contain a first or a second target nucleic acid, respectively. The presence or absence of the first or second target nucleic acid, if any, is determined for each receptacle of the first and second sets of receptacles.

公开(公告)号：US11788115B2

公开(公告)日：2023-10-17

申请号：US17033395

申请日：2020-09-25

Applicant: Gen-Probe Incorporated

Inventor： David Buse ,  Norbert D. Hagen ,  David Opalsky ,  Bruce Richardson ,  Anita Prasad ,  Tyler Moore ,  Byron J. Knight

IPC: C12Q1/6806 ,  G01N35/04 ,  B01L3/00 ,  B01L7/00 ,  C12Q1/686

CPC classification number: C12Q1/6806 ,  B01L3/50825 ,  B01L3/565 ,  B01L7/5255 ,  C12Q1/686 ,  G01N35/04 ,  B01L3/527 ,  B01L2200/026 ,  B01L2200/0689 ,  B01L2300/046 ,  G01N2035/0418 ,  G01N2035/0436

Abstract: A receptacle cap includes a probe recess configured to receive a probe inserted therein to thereby frictionally secure the receptacle cap to the probe, and a closed lower end of the receptacle is insertable into an open end of a reaction receptacle to close the reaction receptacle. The receptacle cap and the reaction receptacle include interlocking features for securing the receptacle cap to the reaction receptacle.

公开(公告)号：US20220162677A1

公开(公告)日：2022-05-26

申请号：US17668775

申请日：2022-02-10

Applicant: Gen-Probe Incorporated

Inventor： David A. Buse ,  David Howard Combs ,  Byron J. Knight ,  Norbert D. Hagen ,  David Opalsky ,  Jason F. Rhubottom ,  Keith Moravick ,  Tyler Moore ,  Anita Prasad ,  Bruce Richardson

IPC: C12Q1/6806 ,  G01N35/04 ,  B01L3/00 ,  B01L7/00 ,  C12Q1/686

Abstract: A method for performing a nucleic acid amplification assay employs a thermally-conductive receptacle holder with one or more receptacle wells, each conforming to an outer surface of a lower portion of a vial. A through-hole extends from an inner surface of each well to an outer surface of the holder. A thermal element is positioned proximal to the holder for altering a temperature of the holder. A signal detection module is configured to generate an excitation signal directed through the through-hole of the well and detect an optical emission from a fluid contained in the vial supported by the well. At least one well supports a capped vial containing a reagent for a nucleic acid amplification assay and including an opaque cap sealing an open end of the vial. The lower portion of the vial is contained within a well, and the cap is situated above a top surface of the holder.

公开(公告)号：US20210017578A1

公开(公告)日：2021-01-21

申请号：US17036307

申请日：2020-09-29

Applicant: Gen-Probe Incorporated

Inventor： Byron J. Knight ,  David A. Buse ,  Norbert D. Hagen ,  David Opalsky ,  Tyler Moore ,  Anita Prasad ,  Bruce Richardson

IPC: C12Q1/6806 ,  G01N35/04 ,  B01L3/00 ,  B01L7/00 ,  C12Q1/686

Abstract: A cap that is securable to a vial includes a plug configured for insertion into an open end of the vial. An upper portion of the cap defines a probe recess with an open top end and configured to receive a distal end of a probe of a pipettor inserted into the open top end, to frictionally secure the cap to an end of the probe. The cap includes a radially-oriented annular surface with one or more locking members depending from a periphery of the annular surface. The locking members are spaced from the plug and each locking member includes a radial locking groove and a radial locking ridge beneath the radial locking groove. A lip of the vial snaps into the radial locking groove above the radial locking ridge to secure the cap to the vial when the plug is inserted into the open end of the vial.