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公开(公告)号：US20210115124A1
公开(公告)日：2021-04-22
申请号：US17129251
申请日：2020-12-21
Applicant: Genentech, Inc.
Inventor： Patrick KOENIG , Chingwei Vivian LEE , Karthikan RAJAGOPAL , Amin FAMILI , Germaine FUH
IPC: C07K16/22 , A61K47/60 , A61K47/61 , A61K39/395 , A61K47/34 , C07K14/475 , C07K16/44 , C07K16/46 , C12N15/10 , C12N15/115
Abstract: The present invention provides anti-VEGF antibodies and compositions that include anti-VEGF antibodies (e.g., antibody conjugates, fusion proteins, and polymeric formulations), and uses thereof, for example for treatment of disorders associated with pathological angiogenesis. The present invention also provides methods of identifying antibody variants with improved properties, for example, enhanced binding affinity, stability, pharmacokinetics, and/or expression.
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公开(公告)号：US20180117152A1
公开(公告)日：2018-05-03
申请号：US15836107
申请日：2017-12-08
Applicant: Genentech, Inc.
Inventor： Chingwei Vivian LEE , Mark S. DENNIS , Germaine FUH
IPC: A61K39/395 , C07K16/28 , C07K14/725 , A61P35/00
CPC classification number: A61K39/39558 , A61P35/00 , C07K14/7051 , C07K16/2809 , C07K16/30 , C07K2317/24 , C07K2317/31 , C07K2317/92
Abstract: The invention provides anti-cluster of differentiation 3 (CD3) antibodies and methods of using the same.
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公开(公告)号：US20170096479A1
公开(公告)日：2017-04-06
申请号：US15274612
申请日：2016-09-23
Applicant: Genentech, Inc.
Inventor： Patrick KOENIG , Chingwei Vivian LEE , Karthikan RAJAGOPAL , Amin FAMILI , Germaine FUH
IPC: C07K16/22 , C07K16/46 , C12N15/10 , C12N15/115 , A61K47/34 , C07K16/44 , A61K39/395 , C07K14/475
CPC classification number: C07K16/22 , A61K39/3955 , A61K47/34 , A61K47/60 , A61K47/61 , A61K2039/505 , A61K2039/54 , C07K14/475 , C07K16/44 , C07K16/468 , C07K2317/14 , C07K2317/21 , C07K2317/24 , C07K2317/31 , C07K2317/55 , C07K2317/56 , C07K2317/565 , C07K2317/567 , C07K2317/76 , C07K2317/90 , C07K2317/92 , C07K2317/94 , C07K2318/20 , C07K2319/30 , C07K2319/31 , C12N15/1037 , C12N15/115 , C12N2310/16
Abstract: The present invention provides anti-VEGF antibodies and compositions that include anti-VEGF antibodies (e.g., antibody conjugates, fusion proteins, and polymeric formulations), and uses thereof, for example for treatment of disorders associated with pathological angiogenesis. The present invention also provides methods of identifying antibody variants with improved properties, for example, enhanced binding affinity, stability, pharmacokinetics, and/or expression.
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公开(公告)号：US20170073405A1
公开(公告)日：2017-03-16
申请号：US15137577
申请日：2016-04-25
Applicant: Genentech, Inc.
Inventor： Germaine FUH , Hans-Peter GERBER , Wei-Ching LIANG , Frederic FELLOUSE , Sachdev S. SIDHU , Christian WIESMANN
CPC classification number: C07K16/22 , A61K2039/505 , C07K16/005 , C07K16/32 , C07K2317/24 , C07K2317/31 , C07K2317/55 , C07K2317/56 , C07K2317/565 , C07K2317/73 , C07K2317/76 , C07K2317/92 , G01N33/6845
Abstract: Anti-VEGF antibodies and variants thereof, including those having high affinity for binding to VEGF, are disclosed. Also provided are methods of using phage display technology with naïve libraries to generate and select the anti-VEGF antibodies with desired binding and other biological activities. Further contemplated are uses of the antibodies in research, diagnostic and therapeutic applications.
Abstract translation: 公开了抗VEGF抗体及其变体，包括对VEGF结合具有高亲和力的抗体。 还提供了使用噬菌体展示技术与初始文库产生和选择具有所需结合和其他生物活性的抗VEGF抗体的方法。 进一步考虑的是抗体在研究，诊断和治疗应用中的用途。
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公开(公告)号：US20150232549A1
公开(公告)日：2015-08-20
申请号：US14636782
申请日：2015-03-03
Applicant: Genentech, Inc.
Inventor： Germaine FUH , Hans-Peter GERBER , Wei-Ching LIANG , Frederic FELLOUSE , Sachdev S. SIDHU , Christian WIESMANN
IPC: C07K16/22
CPC classification number: C07K16/22 , A61K2039/505 , C07K16/005 , C07K16/32 , C07K2317/24 , C07K2317/31 , C07K2317/55 , C07K2317/56 , C07K2317/565 , C07K2317/73 , C07K2317/76 , C07K2317/92 , G01N33/6845
Abstract: Anti-VEGF antibodies and variants thereof, including those having high affinity for binding to VEGF, are disclosed. Also provided are methods of using phage display technology with naïve libraries to generate and select the anti-VEGF antibodies with desired binding and other biological activities. Further contemplated are uses of the antibodies in research, diagnostic and therapeutic applications.
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Patent Agency Ranking
公开(公告)号：US20240067752A1
公开(公告)日：2024-02-29
申请号：US18474445
申请日：2023-09-26
Applicant: Genentech, Inc.
Inventor： Robert F. KELLEY , Daniel K. KIRCHHOFER , Joyce LAI , Chingwei V. LEE , Wei-Ching LIANG , Michael T. LIPARI , Kelly M. LOYET , Tao SAI , Menno VAN LOOKEREN CAMPAGNE , Yan WU , Germaine FUH
IPC: C07K16/40 , A61K39/395
CPC classification number: C07K16/40 , A61K39/3955 , A61K2039/507 , C07K2317/24 , C07K2317/34 , C07K2317/53 , C07K2317/55 , C07K2317/92 , C07K2317/94
Abstract: The present invention provides anti-HtrA1 antibodies (including bispecific anti-HtrA1 anti-Factor D antibodies) and methods of making and using the same, for example, in methods of treating HtrA1-associated disorders, ocular disorders, and/or complement-associated disorders.
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公开(公告)号：US20200222547A1
公开(公告)日：2020-07-16
申请号：US16575749
申请日：2019-09-19
Applicant: Genentech, Inc. , Ascendis Pharma A/S
Inventor： Sebastian STARK , Thomas KNAPPE , Harald RAU , Nicola BISEK , Burkhardt LAUFER , Samuel WEISBROD , Tobias VOIGT , Germaine FUH , Patrick KOENIG , Chingwei Vivian LEE , Daniela BUMBACA YADAV
IPC: A61K47/61 , A61K47/69 , A61K39/395 , A61K9/00
Abstract: The present invention relates to hydrogel prodrug compositions comprising cross-linked hyaluronic acid (HA), or a derivative or a salt thereof, wherein the cross-linker system comprises a biodegradable spacer, wherein the cross-linked HA comprises a conjugated drug-linker, and wherein the linker is capable of releasing the drug under physiological conditions. The present invention further relates to methods for preparing the hydrogel prodrug compositions. The present invention further relates to methods for treating an ocular condition using the hydrogel compositions.
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公开(公告)号：US20190100581A1
公开(公告)日：2019-04-04
申请号：US16033499
申请日：2018-07-12
Applicant: Genentech, Inc.
Inventor： Patrick KOENIG , Chingwei Vivian LEE , Karthikan RAJAGOPAL , Amin FAMILI , Germaine FUH
IPC: C07K16/22 , C07K16/46 , A61K47/61 , C12N15/10 , C12N15/115 , C07K16/44 , A61K47/34 , A61K47/60 , C07K14/475 , A61K39/395 , A61K39/00
Abstract: The present invention provides anti-VEGF antibodies and compositions that include anti-VEGF antibodies (e.g., antibody conjugates, fusion proteins, and polymeric formulations), and uses thereof, for example for treatment of disorders associated with pathological angiogenesis. The present invention also provides methods of identifying antibody variants with improved properties, for example, enhanced binding affinity, stability, pharmacokinetics, and/or expression.
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公开(公告)号：US20190031750A1
公开(公告)日：2019-01-31
申请号：US16033353
申请日：2018-07-12
Applicant: Genentech, Inc.
Inventor： Patrick KOENIG , Chingwei Vivian LEE , Karthikan RAJAGOPAL , Amin FAMILI , Germaine FUH
IPC: C07K16/22 , A61K47/60 , C07K16/46 , A61K47/61 , C12N15/10 , A61K39/395 , C12N15/115
Abstract: The present invention provides anti-VEGF antibodies and compositions that include anti-VEGF antibodies (e.g., antibody conjugates, fusion proteins, and polymeric formulations), and uses thereof, for example for treatment of disorders associated with pathological angiogenesis. The present invention also provides methods of identifying antibody variants with improved properties, for example, enhanced binding affinity, stability, pharmacokinetics, and/or expression.
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公开(公告)号：US20170145113A1
公开(公告)日：2017-05-25
申请号：US15336171
申请日：2016-10-27
Applicant: Genentech, Inc.
Inventor： Robert F. KELLEY , Daniel K. KIRCHHOFER , Joyce LAI , Chingwei V. LEE , Wei-Ching LIANG , Michael T. LIPARI , Kelly M. LOYET , Tao SAI , Menno VAN LOOKEREN CAMPAGNE , Yan WU , Germaine FUH
IPC: C07K16/40
Abstract: The present invention provides anti-HtrA1 antibodies (including bispecific anti-HtrA1 anti-Factor D antibodies) and methods of making and using the same, for example, in methods of treating HtrA1-associated disorders, ocular disorders, and/or complement-associated disorders.
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