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公开(公告)号：US09518118B2
公开(公告)日：2016-12-13
申请号：US14851001
申请日：2015-09-11
Applicant: Genentech, Inc.
Inventor： Xiaocheng Chen , Mark Dennis , Jagath Reddy Junutula , Gail Lewis Phillips , Thomas Harden Pillow , Mark X. Sliwkowski
IPC: C07K16/28 , A61K47/48 , C07K16/32 , A61K39/395 , G01N33/574
CPC classification number: C07K16/32 , A61K31/5517 , A61K31/675 , A61K31/704 , A61K39/3955 , A61K47/68 , A61K47/6809 , A61K47/6849 , A61K47/6855 , A61K47/6863 , A61K49/00 , C07K16/2863 , C07K16/3015 , C07K2317/24 , C07K2317/34 , C07K2317/51 , C07K2317/515 , C07K2317/56 , C07K2317/565 , C07K2317/73 , C07K2317/92 , G01N33/57415 , G01N33/57446 , G01N33/57492 , G01N2333/82
Abstract: The invention provides anti-HER2 antibodies and immunoconjugates and methods of using the same.
Abstract translation: 本发明提供抗HER2抗体和免疫缀合物及其使用方法。
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公开(公告)号：US20140335107A1
公开(公告)日：2014-11-13
申请号：US14219473
申请日：2014-03-19
Applicant: GENENTECH, INC.
Inventor： Yvonne Chen , Mark Dennis , David Dornan , Kristi Elkins , Jagath Reddy Junutula , Andrew Polson
IPC: C07K16/28 , G01N33/574
Abstract: The present invention is directed to compositions of matter useful for the treatment of hematopoietic tumor in mammals and to methods of using those compositions of matter for the same.
Abstract translation: 本发明涉及可用于治疗哺乳动物造血肿瘤的物质组合物，以及使用这些物质组合物的方法。
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公开(公告)号：US20140099260A1
公开(公告)日：2014-04-10
申请号：US13973669
申请日：2013-08-22
Applicant: Genentech, Inc.
Inventor： Yvonne Chen , Mark Dennis , David Dornan , Kristi Elkins , Jagath Reddy Junutula , Andrew Polson , Bing Zheng
IPC: C07K16/28 , A61K45/06 , A61K39/395
CPC classification number: C07K16/2803 , A61K31/537 , A61K38/05 , A61K39/3955 , A61K39/39558 , A61K45/06 , A61K47/6803 , A61K47/6811 , A61K47/6849 , A61K47/6867 , A61K51/1027 , A61K2039/505 , C07K16/2896 , C07K16/3061 , C07K2317/24 , C07K2317/34 , C07K2317/40 , C07K2317/55 , C07K2317/56 , C07K2317/565 , C07K2317/567 , C07K2317/73 , C07K2317/92 , G01N33/57492 , Y02A50/412 , Y02A50/423
Abstract: The present invention is directed to compositions of matter useful for the treatment of hematopoietic tumor in mammals and to methods of using those compositions of matter for the same.
Abstract translation: 本发明涉及可用于治疗哺乳动物造血肿瘤的物质组合物，以及使用这些物质组合物的方法。
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公开(公告)号：US11866496B2
公开(公告)日：2024-01-09
申请号：US17234695
申请日：2021-04-19
Applicant: Genentech, Inc.
Inventor： Yvonne Chen , Mark Dennis , Kristi Elkins , Jagath Reddy Junutula , Andrew Polson , Bing Zheng
CPC classification number: C07K16/2803 , A61K39/39541 , A61K39/39558 , A61K47/6849 , A61K51/1027 , C07K16/2896 , C07K16/3061 , A61K2039/505 , C07K2317/24 , C07K2317/34 , C07K2317/55 , C07K2317/56 , C07K2317/565 , C07K2317/567 , C07K2317/92 , Y02A50/30
Abstract: The present invention is directed to compositions of matter useful for the treatment of hematopoietic tumor in mammals and to methods of using those compositions of matter for the same.
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公开(公告)号：US20200255539A1
公开(公告)日：2020-08-13
申请号：US16721525
申请日：2019-12-19
Applicant: Genentech, Inc.
Inventor： Xiaocheng Chen , Mark Dennis , Jagath Reddy Junutula , Gail Lewis Phillips , Thomas Harden Pillow , Mark X. Sliwkowski
IPC: C07K16/32 , G01N33/574 , C07K16/30 , A61K49/00 , A61K31/704 , A61K31/675 , A61K31/5517 , C07K16/28 , A61K39/395 , A61K47/68
Abstract: The invention provides anti-HER2 antibodies and immunoconjugates and methods of using the same.
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Patent Agency Ranking
公开(公告)号：US20200085840A1
公开(公告)日：2020-03-19
申请号：US16391738
申请日：2019-04-23
Applicant: Genentech, Inc.
Inventor： Xiaocheng Chen , Mark Dennis , Jagath Reddy Junutula , Gail Lewis Phillips , Thomas Harden Pillow , Mark X. Sliwkowski
IPC: A61K31/5517 , A61K47/68 , A61K39/395 , C07K16/00 , C07K16/32
Abstract: The invention provides immunoconjugates comprising anti-HER2 antibodies and methods of using the same.
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公开(公告)号：US10314846B2
公开(公告)日：2019-06-11
申请号：US15438418
申请日：2017-02-21
Applicant: GENENTECH, INC.
Inventor： Xiaocheng Chen , Mark Dennis , Jagath Reddy Junutula , Gail Lewis Phillips , Thomas Harden Pillow , Mark X. Sliwkowski
IPC: A61K39/395 , A61K31/5517 , A61K47/68 , C07K16/00 , C07K16/32
Abstract: The invention provides immunoconjugates comprising anti-HER2 antibodies and methods of using the same.
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公开(公告)号：US09896506B2
公开(公告)日：2018-02-20
申请号：US14734957
申请日：2015-06-09
Applicant: Genentech, Inc.
Inventor： Yvonne Chen , Mark Dennis , David Dornan , Kristi Elkins , Jagath Reddy Junutula , Andrew Polson , Bing Zheng
IPC: C07K16/28 , C07K16/30 , A61K39/395 , A61K47/68 , A61K38/05 , A61K45/06 , A61K51/10 , G01N33/574 , A61K31/537 , A61K39/00
CPC classification number: C07K16/2803 , A61K31/537 , A61K38/05 , A61K39/39558 , A61K45/06 , A61K47/6803 , A61K47/6811 , A61K47/6849 , A61K47/6867 , A61K51/1027 , A61K2039/505 , C07K16/3061 , C07K2317/24 , C07K2317/34 , C07K2317/40 , C07K2317/55 , C07K2317/56 , C07K2317/565 , C07K2317/567 , C07K2317/73 , C07K2317/92 , G01N33/57492 , Y02A50/412 , Y02A50/423
Abstract: The present invention is directed to compositions of matter useful for the treatment of hematopoietic tumor in mammals, including immunoconjugates comprising anti-CD79b cysteine-engineered antibody huMA79b.v28, and to methods of using those compositions of matter for the same.
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公开(公告)号：US20170166635A1
公开(公告)日：2017-06-15
申请号：US15346532
申请日：2016-11-08
Applicant: GENENTECH, INC.
Inventor： Weiguang Mao , Jagath Reddy Junutula , Paul Polakis
IPC: C07K16/28 , C07K16/30 , G01N33/574 , A61K38/05 , A61K39/395
CPC classification number: C07K16/28 , A61K38/05 , A61K39/39558 , A61K45/06 , A61K47/6849 , A61K47/6851 , A61K47/6869 , A61K47/6889 , A61K2039/505 , C07K16/30 , C07K16/3069 , C07K2317/14 , C07K2317/24 , C07K2317/40 , C07K2317/51 , C07K2317/515 , C07K2317/56 , C07K2317/73 , C07K2317/77 , G01N33/574 , G01N33/57492
Abstract: Cysteine engineered anti-TENB2 antibodies are engineered by replacing one or more amino acids of a parent anti-TENB2 antibody with non cross-linked, reactive cysteine amino acids. Methods of design, preparation, screening, and selection of the cysteine engineered anti-TENB2 antibodies are provided. Cysteine engineered anti-TENB2 antibodies (Ab) are conjugated with one or more drug moieties (D) through a linker (L) to form cysteine engineered anti-TENB2 antibody-drug conjugates having Formula I: Ab-(L-D)p (I) where p is 1 to 4. Diagnostic and therapeutic uses for cysteine engineered antibody drug compounds and compositions are disclosed.
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公开(公告)号：US20150017188A1
公开(公告)日：2015-01-15
申请号：US14152287
申请日：2014-01-10
Applicant: Genentech, Inc.
Inventor： Charles W. Eigenbrot, JR. , Jagath Reddy Junutula , Henry Lowman , Helga E. Raab , Richard Vandlen
CPC classification number: A61K47/6803 , A01K2267/0331 , A61K45/06 , A61K47/6817 , A61K47/6851 , A61K47/6889 , C07K16/00 , C07K16/32 , C07K2317/21 , C07K2317/51 , C07K2317/52 , C07K2317/55 , C07K2317/624
Abstract: Antibodies are engineered by replacing one or more amino acids of a parent antibody with non cross-linked, highly reactive cysteine amino acids. Antibody fragments may also be engineered with one or more cysteine amino acids to form cysteine engineered antibody fragments (ThioFab). Methods of design, preparation, screening, and selection of the cysteine engineered antibodies are provided. Cysteine engineered antibodies (Ab), optionally with an albumin-binding peptide (ABP) sequence, are conjugated with one or more drug moieties (D) through a linker (L) to form cysteine engineered antibody-drug conjugates having Formula I: Ab-(L-D)p I where p is 1 to 4. Diagnostic and therapeutic uses for cysteine engineered antibody drug compounds and compositions are disclosed.
Abstract translation: 通过用非交联的高反应性半胱氨酸氨基酸替代亲本抗体的一个或多个氨基酸来设计抗体。 抗体片段也可以用一个或多个半胱氨酸氨基酸进行工程化以形成半胱氨酸改造的抗体片段（ThioFab）。 提供了设计，制备，筛选和选择半胱氨酸改造的抗体的方法。 任选与白蛋白结合肽（ABP）序列的半胱氨酸改造的抗体（Ab）通过接头（L）与一个或多个药物部分（D）缀合，形成具有式I：Ab- （LD）p I，其中p为1至4.披露了半胱氨酸改造的抗体药物化合物和组合物的诊断和治疗用途。
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