公开(公告)号：US20230310407A1

公开(公告)日：2023-10-05

申请号：US18207447

申请日：2023-06-08

Applicant: Georgetown University ,  The Board of Regents of the University of Oklahoma

Inventor： Milton L. Brown ,  Yali Kong ,  Courtney Houchen ,  Sripathi M. Sureban ,  Parthasarathy Chandrakesan

IPC: A61K31/454 ,  A61P39/00 ,  A61K31/4184

CPC classification number: A61K31/454 ,  A61P39/00 ,  A61K31/4184

Abstract: Provided are methods useful for preventing and mitigating radiation injury, including acute radiation syndrome, comprising administering to a subject a therapeutically effective amount of a compound represented by formula I




or a pharmaceutically acceptable salt thereof, wherein Z is —O— or —N(H)—.

公开(公告)号：US20230033749A1

公开(公告)日：2023-02-02

申请号：US17728485

申请日：2022-04-25

Applicant: Georgetown University ,  The Board of Regents of the University of Oklahoma

Inventor： Milton L. Brown ,  Yali Kong ,  Courtney Houchen ,  Sripathi M. Sureban ,  Parthasarathy Chandrakesan

IPC: A61K31/454 ,  A61P39/00 ,  A61K31/4184

Abstract: Provided are methods useful for preventing and mitigating radiation injury, including acute radiation syndrome, comprising administering to a subject a therapeutically effective amount of a compound represented by formula I or a pharmaceutically acceptable salt thereof, wherein Z is —O— or —N(H)—.

公开(公告)号：US10023551B2

公开(公告)日：2018-07-17

申请号：US15573183

申请日：2016-05-12

Applicant: GEORGETOWN UNIVERSITY

Inventor： Milton L. Brown ,  Yali Kong ,  Jacqueline Smith ,  Kan Wang ,  Shujie Hou

IPC: C07D311/58 ,  C07D311/02 ,  A61P35/00 ,  G01N21/64 ,  A61K47/69 ,  C07C321/14 ,  C07C69/017 ,  C07C69/003 ,  C07C271/28

Abstract: A glutathione-cleavable prodrug is provided herein, as well as methods for its use in treating cancer, including triple negative breast cancer. The prodrug can be cleaved by glutathione under physiological conditions to generate a biologically active agent. The compound described herein is advantageous as the compound is fluorescent and can therefore be monitored within a subject.

公开(公告)号：US09758481B2

公开(公告)日：2017-09-12

申请号：US14696005

申请日：2015-04-24

Applicant: Georgetown University

Inventor： Jeffrey A. Toretsky ,  Aykut Uren ,  Milton Lang Brown ,  Yali Kong

IPC: C07D209/38 ,  A61K31/404 ,  C07D401/06 ,  A61K38/00 ,  C07K7/08 ,  C07K7/06 ,  A61K45/06

CPC classification number: C07D209/38 ,  A61K31/404 ,  A61K38/00 ,  A61K45/06 ,  C07D401/06 ,  C07K7/06 ,  C07K7/08

Abstract: Peptides and compounds are provided that function as EWS-FLI1 protein inhibitors. The peptides and compounds have utility in the treatment of Ewing's sarcoma family of tumors. Also provided are methods of preparing the compounds and assays for identifying inhibitors of EWS-FLI1 protein.