公开(公告)号：US20150368264A1

公开(公告)日：2015-12-24

申请号：US14740954

申请日：2015-06-16

Applicant: Gilead Sciences, Inc.

Inventor： Anna Chiu ,  John Enquist, JR. ,  Nolan Griggs ,  Christopher Hale ,  Norihiro Ikemoto ,  Katie Ann Keaton ,  Matt Kraft ,  Scott E. Lazerwith ,  Michel Leeman ,  Zhihui Peng ,  Kate Schrier ,  Jonathan Trinidad ,  Jochem Van Herpt ,  Andrew W. Waltman

IPC: C07D498/14 ,  C07D309/40 ,  C07C237/20 ,  C07D213/82 ,  C07D319/06 ,  C07C235/78

Abstract: Methods of making compounds of Formula I are disclosed:

Abstract translation: 公开了制备式I化合物的方法：

公开(公告)号：US20220354873A1

公开(公告)日：2022-11-10

申请号：US17665724

申请日：2022-02-07

Applicant: Gilead Sciences, Inc.

Inventor： Steven Donald Axt ,  Pavel Robertovich Badalov ,  Katrien Brak ,  Silvio Campagna ,  Andrei Chtchemelinine ,  Edward Doerffler ,  Morin Mae Frick ,  Detian Gao ,  Lars V. Heumann ,  Brittanie Hoang ,  Willard Lew ,  Robert Ronald Milburn ,  Sean Timothy Neville ,  Bruce Ross ,  Erik Rueden ,  Robert William Scott ,  Dustin Siegel ,  Andrew C. Stevens ,  Clarissa Tadeus ,  Tiago Vieira ,  Andrew W. Waltman ,  Xianghong Wang ,  Mark Charles Whitcomb ,  Lydia Wolfe ,  Chia-Yun Yu

IPC: A61K31/685 ,  A61K31/706 ,  A61K31/7056 ,  A61K31/53 ,  C07H1/00 ,  C07H1/02 ,  C07H11/00 ,  C07H15/18 ,  A61K31/6615 ,  A61K31/665 ,  A61K31/683 ,  C07D487/04 ,  C07D519/00 ,  C07F9/24 ,  C07F9/6561 ,  A61K31/675 ,  A61K45/06 ,  A61K31/00

Abstract: Provided are methods of preparing compounds and pharmaceutical compositions for treating Filoviridae virus infections The compounds, compositions, and methods provided are particularly useful for the treatment of Marburg virus, Ebola virus and Cueva virus infections.

公开(公告)号：US11344565B2

公开(公告)日：2022-05-31

申请号：US14926063

申请日：2015-10-29

Applicant: Gilead Sciences, Inc.

Inventor： Steven Donald Axt ,  Pavel Robertovich Badalov ,  Katrien Brak ,  Silvio Campagna ,  Andrei Chtchemelinine ,  Edward Doerffler ,  Morin Mae Frick ,  Detian Gao ,  Lars V. Heumann ,  Brittanie Hoang ,  Willard Lew ,  Robert Ronald Milburn ,  Sean Timothy Neville ,  Bruce Ross ,  Erik Rueden ,  Robert William Scott ,  Dustin Siegel ,  Andrew C. Stevens ,  Clarissa Tadeus ,  Tiago Vieira ,  Andrew W. Waltman ,  Xianghong Wang ,  Mark Charles Whitcomb ,  Lydia Wolfe ,  Chia-Yun Yu

IPC: C07H5/06 ,  C07H7/06 ,  A61K31/685 ,  A61K31/706 ,  A61K31/7056 ,  A61K31/53 ,  C07H1/00 ,  C07H1/02 ,  C07H11/00 ,  C07H15/18 ,  A61K31/6615 ,  A61K31/665 ,  A61K31/683 ,  C07D487/04 ,  C07D519/00 ,  C07F9/24 ,  C07F9/6561 ,  A61K31/675 ,  A61K45/06 ,  A61K31/00

Abstract: Provided are methods of preparing compounds and pharmaceutical compositions comprising a compound Formula VIII for treating Filoviridae virus infections. In one aspect, the compound of Formula VIII is formed from a reaction mixture comprising the compound of Formula IX, the compound of Formula X, a coupling agent such as magnesium chloride and a non-nucleophilic base such as diisopropylethylamine. The compound of Formula IX can be formed from a compound of Formula V and a cyanating agent. The compound of Formula V can be synthesized from a reaction mixture comprising a deprotonating agent such as phenylmagnesium chloride; a silylating agent such as chlorotrimethylsilane; a coupling agent such as isopropylmagnesium chloride, an additive such as LaCl3-2LiCl, LaCl3, CeCl3, NdCl3, or YCl3; a compound of Formula VI; and 7-iodopyrrolo[2,1-f][1,2,4]triazin-4-amine. The compounds, compositions, and methods provided are particularly useful for the treatment of Marburg virus, Ebola virus and Cueva virus infections.

公开(公告)号：US10030033B2

公开(公告)日：2018-07-24

申请号：US15227527

申请日：2016-08-03

Applicant: Gilead Sciences, Inc.

Inventor： Amy Cagulada ,  Johann Chan ,  Lina Chan ,  Denise A. Colby ,  Kapil Kumar Karki ,  Darryl Kato ,  Katie Ann Keaton ,  Sudha Kondappally ,  Chris Levins ,  Adam Littke ,  Ruben Martinez ,  Dominika Pcion ,  Troy Reynolds ,  Bruce Ross ,  Michael Sangi ,  Adam J. Schrier ,  Pamela Seng ,  Dustin Siegel ,  Nathan Shapiro ,  Donald Tang ,  James G. Taylor ,  Jonathan Tripp ,  Andrew W. Waltman ,  Lawrence Yu

IPC: C07D498/16 ,  C07D403/12 ,  C07D498/18 ,  C07C271/34 ,  C07D241/44 ,  C07C205/57 ,  C07C233/09 ,  C07C251/12 ,  C07C255/61

Abstract: The present disclosure provides processes for the preparation of a compound of formula I: which is useful as an antiviral agent. The disclosure also provides compounds and processes for the preparation of the compounds that are synthetic intermediates to the compound of formula I.