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公开(公告)号：US20240199579A1
公开(公告)日：2024-06-20
申请号：US18386675
申请日：2023-11-03
发明人： Kevin M. Allan , Lina Chan , Andrei Chtchemelinine , Jeffrey T. Deignan , Kassibla E. Dempah , Kelly J. Eberle , Danielle M. Elfgren , Timothy G. Elford , Kevin D. Haggerty , Jesse W. Li , Tianmin Niu , Andrew C. Stevens , Ana F. Voica , Kevin S. Williamson , Boran Xu , Guojun Yu
IPC分类号： C07D401/14 , C07D217/02 , C07D217/24 , C07D249/04 , C07D401/06
CPC分类号： C07D401/14 , C07D217/02 , C07D217/24 , C07D249/04 , C07D401/06
摘要： Disclosed are syntheses of a Cot (cancer Osaka thyroid) inhibitor, which has the following formula:
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公开(公告)号：US10030033B2
公开(公告)日：2018-07-24
申请号：US15227527
申请日：2016-08-03
发明人： Amy Cagulada , Johann Chan , Lina Chan , Denise A. Colby , Kapil Kumar Karki , Darryl Kato , Katie Ann Keaton , Sudha Kondappally , Chris Levins , Adam Littke , Ruben Martinez , Dominika Pcion , Troy Reynolds , Bruce Ross , Michael Sangi , Adam J. Schrier , Pamela Seng , Dustin Siegel , Nathan Shapiro , Donald Tang , James G. Taylor , Jonathan Tripp , Andrew W. Waltman , Lawrence Yu
IPC分类号： C07D498/16 , C07D403/12 , C07D498/18 , C07C271/34 , C07D241/44 , C07C205/57 , C07C233/09 , C07C251/12 , C07C255/61
摘要： The present disclosure provides processes for the preparation of a compound of formula I: which is useful as an antiviral agent. The disclosure also provides compounds and processes for the preparation of the compounds that are synthetic intermediates to the compound of formula I.
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公开(公告)号：US20240174702A1
公开(公告)日：2024-05-30
申请号：US18314989
申请日：2023-05-10
发明人： Ernest A. Carra , Lina Chan , Roland D. Saito
IPC分类号： C07F9/6558 , A61K45/06
CPC分类号： C07F9/65583 , A61K45/06 , C07B2200/13
摘要： Disclosed herein are solid forms of a compound useful for modulating Cot. The disclosure also relates to pharmaceutical compositions containing one or more of the solid forms disclosed herein, as well as methods of using the solid forms in the treatment of conditions mediated by Cot. The disclosure also relates to methods for obtaining such solid forms.
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公开(公告)号：US20170210756A1
公开(公告)日：2017-07-27
申请号：US15227527
申请日：2016-08-03
发明人： Amy Cagulada , Johann Chan , Lina Chan , Denise A. Colby , Kapil Kumar Karki , Darryl Kato , Katie Ann Keaton , Sudha Kondapally , Christopher Levins , Adam Littke , Ruben Martinez , Dominika Pcion , Troy Reynolds , Bruce Ross , Michael Sangi , Adam J. Schrier , Pamela Seng , Dustin Siegel , Nathan Shapiro , Donald Tang , James G. Taylor , Jonathan Tripp , Andrew W. Waltman , Lawrence Yu
IPC分类号： C07D498/18 , C07C271/34 , C07C255/61 , C07C205/57 , C07C233/09 , C07C251/12 , C07D403/12 , C07D241/44
CPC分类号： C07D498/18 , C07C51/09 , C07C205/57 , C07C209/00 , C07C227/02 , C07C233/09 , C07C251/12 , C07C255/61 , C07C271/34 , C07C2601/02 , C07D241/44 , C07D403/12 , C07D453/02 , C07D498/16 , C07K5/0808
摘要： The present disclosure provides processes for the preparation of a compound of formula I: which is useful as an antiviral agent. The disclosure also provides compounds and processes for the preparation of the compounds that are synthetic intermediates to the compound of formula I.
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公开(公告)号：US11845737B2
公开(公告)日：2023-12-19
申请号：US17218765
申请日：2021-03-31
发明人： Kevin M. Allan , Lina Chan , Andrei Chtchemelinine , Jeffrey T. Deignan , Kassibla E. Dempah , Kelly J. Eberle , Danielle M. Elfgren , Timothy G. Elford , Kevin D. Haggerty , Jesse W. Li , Tianmin Niu , Andrew C. Stevens , Ana F. Voica , Kevin S. Williamson , Boran Xu , Guojun Yu
IPC分类号： C07D401/14 , C07D217/02 , C07D217/24 , C07D249/04 , C07D401/06
CPC分类号： C07D401/14 , C07D217/02 , C07D217/24 , C07D249/04 , C07D401/06
摘要： Disclosed are syntheses of a Cot (cancer Osaka thyroid) inhibitor, which has the following formula:
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公开(公告)号：US20220380340A1
公开(公告)日：2022-12-01
申请号：US17218765
申请日：2021-03-31
发明人： Kevin M. Allan , Lina Chan , Andrei Chtchemelinine , Jeffrey T. Deignan , Kassibla E. Dempah , Kelly J. Eberle , Danielle M. Elfgren , Timothy G. Elford , Kevin D. Haggerty , Jesse W. Li , Tianmin Niu , Andrew C. Stevens , Ana F. Voica , Kevin S. Williamson , Boran Xu , Guojun Yu
IPC分类号： C07D401/14 , C07D249/04 , C07D217/24 , C07D401/06 , C07D217/02
摘要： Disclosed are syntheses of a Cot (cancer Osaka thyroid) inhibitor, which has the following formula:
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公开(公告)号：US09440991B2
公开(公告)日：2016-09-13
申请号：US14576143
申请日：2014-12-18
发明人： Amy Cagulada , Johann Chan , Lina Chan , Denise A. Colby , Kapil Kumar Karki , Darryl Kato , Katie Ann Keaton , Sudha Kondapally , Chris Levins , Adam Littke , Ruben Martinez , Dominika Pcion , Troy Reynolds , Bruce Ross , Michael Sangi , Adam J. Schrier , Pamela Seng , Dustin Siegel , Nathan Shapiro , Donald Tang , James G. Taylor , Jonathan Tripp , Andrew W. Waltman , Lawrence Yu
IPC分类号： C07D403/12 , C07D413/14 , C07D498/16 , C07C227/02 , C07D453/02 , C07C209/00 , C07C51/09 , C07K5/083
CPC分类号： C07D498/18 , C07C51/09 , C07C205/57 , C07C209/00 , C07C227/02 , C07C233/09 , C07C251/12 , C07C255/61 , C07C271/34 , C07C2601/02 , C07D241/44 , C07D403/12 , C07D453/02 , C07D498/16 , C07K5/0808
摘要： The present disclosure provides processes for the preparation of a compound of formula I: which is useful as an antiviral agent. The disclosure also provides compounds and processes for the preparation of the compounds that are synthetic intermediates to the compound of formula I.
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