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公开(公告)号：US08822430B2
公开(公告)日：2014-09-02
申请号：US13956195
申请日：2013-07-31
Applicant: Gilead Sciences, Inc.
Inventor： Elizabeth M. Bacon , Eda Canales , Aesop Cho , Jeromy J. Cottell , Manoj C. Desai , Michael Graupe , Hongyan Guo , Randall L. Halcomb , Darryl Kato , Choung U. Kim , Thorsten A. Kirschberg , Evan S. Krygowski , Scott E. Lazerwith , John O. Link , Hongtao Liu , Qi Liu , Richard L. Mackman , Michael L. Mitchell , Jay P. Parrish , Hyung-Jung Pyun , Joseph H. Saugier , Scott D. Schroeder , Jianyu Sun , James G. Taylor , James D. Trenkle , Winston C. Tse , Randall W. Vivian , William J. Watkins , Lianhong Xu
IPC: C07D401/14 , C07D403/04 , C07D403/14 , C07D405/14 , C07D409/14 , C07D413/04 , C07D417/04 , C07D417/14 , C07D495/04 , A61K31/4178 , A61K31/7068 , A61K31/7052 , A61K31/4184 , A61P1/16 , A61P31/14
CPC classification number: C07D403/14 , A61K31/4025 , A61K31/4178 , A61K31/4184 , A61K31/427 , A61K31/435 , A61K31/437 , A61K31/4439 , A61K31/454 , A61K31/496 , A61K31/519 , A61K31/5377 , A61K31/5415 , A61K31/55 , A61K45/06 , A61P31/12 , C07D207/16 , C07D401/14 , C07D403/04 , C07D405/14 , C07D409/14 , C07D413/14 , C07D417/14 , C07D471/04 , C07D471/08 , C07D471/10 , C07D487/04 , C07D491/113 , C07D495/04 , C07F5/025
Abstract: The invention is related to anti-viral compounds, compositions containing such compounds, and therapeutic methods that include the administration of such compounds, as well as to processes and intermediates useful for preparing such compounds.
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公开(公告)号：US20140017199A1
公开(公告)日：2014-01-16
申请号：US13935117
申请日：2013-07-03
Applicant: Gilead Sciences, Inc.
Inventor： Manoj C. Desai , Allen Yu Hong , Hon Chung Hui , Hongtao Liu , Randall W. Vivian , Lianhong Xu
IPC: C07D277/28 , A61K45/06 , C07D417/14 , A61K31/496 , A61K31/427 , A61K31/5377
CPC classification number: G01N33/94 , A61K9/0053 , A61K9/08 , A61K31/4178 , A61K31/426 , A61K31/427 , A61K31/496 , A61K31/5377 , A61K45/06 , C07B2200/05 , C07D277/28 , C07D277/30 , C07D417/14 , G01N33/58 , A61K2300/00
Abstract: The present application provides for a compound of Formula IV, or a pharmaceutically acceptable salt, solvate, and/or ester thereof, compositions containing such compounds, therapeutic methods that include the administration of such compounds, and therapeutic methods and include the administration of such compounds with at least one additional therapeutic agent.
Abstract translation: 本申请提供式IV化合物或其药学上可接受的盐，溶剂合物和/或酯，含有这些化合物的组合物，包括施用这些化合物的治疗方法和治疗方法，包括给予这些化合物 与至少一种另外的治疗剂。
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公开(公告)号：US20220227787A1
公开(公告)日：2022-07-21
申请号：US17558130
申请日：2021-12-21
Applicant: Gilead Sciences, Inc.
Inventor： Daniel H. Byun , Eda Y. Canales , Laurent P. Debien , Petr Jansa , Rick A. Lee , Jennifer A. Loyer-Drew , Stephane Perreault , Hyung-Jung Pyun , Roland D. Saito , Michael S. Sangi , Adam J. Schrier , Marina E. Shatskikh , James G. Taylor , Jennifer A. Treiberg , Joshua J. Van Veldhuizen , Lianhong Xu
IPC: C07D519/00
Abstract: The present disclosure relates to novel compounds for use in therapeutic treatement of a disease associated with peptidylarginine deiminases (PADs), such as peptidylarginine deiminase type 4 (PAD4). The present disclosure also relates to processes and intermediates for the preparation of such compounds, methods of using such compounds and pharmaceutical compositions comprising the compounds described herein.
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公开(公告)号：US11352329B2
公开(公告)日：2022-06-07
申请号：US16925096
申请日：2020-07-09
Applicant: Gilead Sciences, Inc.
Inventor： Zhenhong R. Cai , Aesop Cho , Ana Zurisadai Gonzalez Buenrostro , Xiaochun Han , Salman Y. Jabri , Ryan McFadden , Yingmei Qi , Johannes Voigt , Jie Xu , Lianhong Xu , Hong Yang
IPC: C07D247/00 , A61P31/18 , C07D401/10 , C07D403/14 , C07D233/88 , C07D487/04 , C07D417/10 , C07D471/04 , C07D417/14 , C07D491/107 , C07D401/14 , C07D405/14 , C07D413/14 , C07D403/10 , C07D413/10 , A61K45/06
Abstract: The invention provides a compound of Formula I: or a pharmaceutically acceptable salt thereof as described herein. The invention also provides pharmaceutical compositions comprising a compound of Formula I, processes for preparing compounds of Formula I, therapeutic methods for treating the proliferation of the HIV virus, treating AIDS or delaying the onset of AIDS symptoms in a mammal using compounds of Formula I.
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公开(公告)号：US09139541B2
公开(公告)日：2015-09-22
申请号：US14601132
申请日：2015-01-20
Applicant: Gilead Sciences, Inc.
Inventor： Manoj C. Desai , Allen Yu Hong , Hongtao Liu , Randall W. Vivian , Lianhong Xu
IPC: A61K31/426 , A61K45/06 , C07D277/24 , C07D277/28 , A61K31/427 , A61K31/496 , C07D417/14 , A61K31/5377
CPC classification number: A61K31/427 , A61K31/426 , A61K31/4402 , A61K31/4535 , A61K31/47 , A61K31/496 , A61K31/5377 , A61K38/005 , A61K38/05 , A61K45/00 , A61K45/06 , C07C209/78 , C07C227/16 , C07C227/18 , C07C315/04 , C07D277/24 , C07D277/28 , C07D277/30 , C07D417/14 , C07K5/06 , C07K5/06026 , C07K5/06034 , C07K5/06052 , A61K2300/00
Abstract: The present application provides for a compound of Formula I, or a pharmaceutically acceptable salt, solvate, and/or ester thereof, compositions containing such compounds, therapeutic methods that include the administration of such compounds, and therapeutic methods and include the administration of such compounds with at least one additional therapeutic agent.
Abstract translation: 本申请提供式I化合物或其药学上可接受的盐，溶剂合物和/或酯，含有这些化合物的组合物，包括施用这些化合物的治疗方法和治疗方法，包括给予这些化合物 与至少一种另外的治疗剂。
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Patent Agency Ranking
公开(公告)号：US12240862B2
公开(公告)日：2025-03-04
申请号：US17558130
申请日：2021-12-21
Applicant: Gilead Sciences, Inc.
Inventor： Daniel H. Byun , Eda Y. Canales , Laurent P. Debien , Petr Jansa , Rick A. Lee , Jennifer A. Loyer-Drew , Stephane Perreault , Hyung-Jung Pyun , Roland D. Saito , Michael S. Sangi , Adam J. Schrier , Marina E. Shatskikh , James G. Taylor , Jennifer A. Treiberg , Joshua J. Van Veldhuizen , Lianhong Xu
IPC: A61P35/02 , C07D519/00
Abstract: The present disclosure relates to novel compounds for use in therapeutic treatment of a disease associated with peptidylarginine deiminases (PADs), such as peptidylarginine deiminase type 4 (PAD4). The present disclosure also relates to processes and intermediates for the preparation of such compounds, methods of using such compounds and pharmaceutical compositions comprising the compounds described herein.
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公开(公告)号：US10800772B2
公开(公告)日：2020-10-13
申请号：US15716431
申请日：2017-09-26
Applicant: Gilead Sciences, Inc.
Inventor： Zhenhong R. Cai , Hongyan Guo , Mingzhe Ji , Haolun Jin , Amy Lee , Ryan McFadden , Michael L. Mitchell , Manuel Munoz , Hyung-Jung Pyun , Lianhong Xu , Hong Yang
IPC: C07D417/04 , C07D471/04 , C07D487/04 , C07D417/14 , A61P31/18 , A61K31/428 , A61K31/439 , A61K31/454 , A61K31/4545 , A61K31/496 , A61K31/4985 , A61K31/519 , A61K31/5377 , A61K31/5383 , A61K31/55 , A61K31/551 , A61K45/06 , C07D471/08 , C07D487/08 , C07D487/10 , C07D491/107 , C07D498/04
Abstract: Compounds disclosed herein including compounds of Formula I: and salts thereof are provided. Pharmaceutical compositions comprising compounds disclosed herein, processes for preparing compounds disclosed herein, intermediates useful for preparing compounds disclosed herein and therapeutic methods for treating an HIV infection using compounds disclosed herein are also provided.
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公开(公告)号：US20180221348A1
公开(公告)日：2018-08-09
申请号：US15831703
申请日：2017-12-05
Applicant: Gilead Sciences, Inc.
Inventor： Manoj C. Desai , Allen Yu Hong , Hongtao Liu , Randall W. Vivian , Lianhong Xu
IPC: A61K31/427 , A61K31/5377
CPC classification number: A61K31/427 , A61K31/426 , A61K31/4402 , A61K31/4535 , A61K31/47 , A61K31/496 , A61K31/5377 , A61K38/005 , A61K38/05 , A61K45/00 , A61K45/06 , C07C209/78 , C07C227/16 , C07C227/18 , C07C315/04 , C07D277/24 , C07D277/28 , C07D277/30 , C07D417/14 , C07K5/06 , C07K5/06026 , C07K5/06034 , C07K5/06052 , A61K2300/00
Abstract: The present application provides for a compound of Formula I, or a pharmaceutically acceptable salt, solvate, and/or ester thereof, compositions containing such compounds, therapeutic methods that include the administration of such compounds, and therapeutic methods and include the administration of such compounds with at least one additional therapeutic agent.
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公开(公告)号：US20180127388A1
公开(公告)日：2018-05-10
申请号：US15658818
申请日：2017-07-25
Applicant: Gilead Sciences, Inc.
Inventor： Kerim Babaoglu , Gediminas Brizgys , Jacob Y. Cha , Xiaowu Chen , Hongyan Guo , Randall L. Halcomb , Xiaochun Han , Richard Huang , Hongtao Liu , Ryan McFadden , Michael L. Mitchell , Yingmei Qi , Paul A. Roethle , Lianhong Xu , Hong Yang
IPC: C07D277/82 , C07D498/04 , A61K31/428 , C07D487/04 , C07D471/04 , C07D417/14 , C07D417/10 , C07D417/04 , C07D277/68 , C07D277/66 , A61K45/06 , A61K31/553 , A61K31/551 , A61K31/5383 , A61K31/538 , A61K31/5377 , A61K31/513 , A61K31/506 , A61K31/501 , A61K31/4985 , A61K31/497 , A61K31/496 , A61K31/4741 , A61K31/4709 , A61K31/454 , A61K31/444 , A61K31/4439 , A61K31/4375 , A61K31/437 , A61K31/436 , C07D491/06
CPC classification number: C07D277/82 , A61K31/428 , A61K31/436 , A61K31/437 , A61K31/4375 , A61K31/4439 , A61K31/444 , A61K31/454 , A61K31/4709 , A61K31/4741 , A61K31/496 , A61K31/497 , A61K31/4985 , A61K31/501 , A61K31/506 , A61K31/513 , A61K31/5377 , A61K31/538 , A61K31/5383 , A61K31/551 , A61K31/553 , A61K45/06 , C07D277/66 , C07D277/68 , C07D417/04 , C07D417/10 , C07D417/14 , C07D471/04 , C07D487/04 , C07D491/06 , C07D498/04 , A61K2300/00
Abstract: Compounds disclosed herein including compounds of formula I′: and salts thereof are provided. Pharmaceutical compositions comprising compounds disclosed herein, processes for preparing compounds disclosed herein, intermediates useful for preparing compounds disclosed herein and therapeutic methods for treating an HIV infection using compounds disclosed herein are also provided.
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公开(公告)号：US09879023B2
公开(公告)日：2018-01-30
申请号：US15257482
申请日：2016-09-06
Applicant: Gilead Sciences, Inc.
Inventor： Kerim Babaoglu , Michael L. Mitchell , Ryan McFadden , Paul A. Roethle , Lianhong Xu , Hong Yang
IPC: C07D491/06 , C07D277/64 , C07D417/10 , A61K9/12 , A61K9/20 , A61K9/48 , A61K31/428 , A61K31/4741 , A61K45/06 , A61K9/00
CPC classification number: C07D491/06 , A61K9/0019 , A61K9/12 , A61K9/20 , A61K9/48 , A61K31/428 , A61K31/4741 , A61K45/06 , C07D277/62 , C07D277/64 , C07D277/82 , C07D417/04 , C07D417/10 , C07D491/052
Abstract: The invention provides compounds of formula I: or a salt thereof as described herein. The invention also provides pharmaceutical compositions comprising a compound of formula I, processes for preparing compounds of formula I, intermediates useful for preparing compounds of formula I and therapeutic methods for treating the proliferation of the HIV virus, treating AIDS or delaying the onset of AIDS or ARC symptoms in a mammal using compounds of formula I.
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