公开(公告)号：US20210189421A1

公开(公告)日：2021-06-24

申请号：US16756376

申请日：2018-10-16

Applicant: GLAXOSMITHKLINE BIOLOGICALS SA

Inventor： Virginia AMMENDOLA ,  Stefano COLLOCA ,  Alessandra VITELLI

IPC: C12N15/86 ,  C12N7/00 ,  A61K9/00 ,  A61K39/12

Abstract: Replication competent simian adenoviral vectors are provided for the delivery of exogenous immunogens. Vectors of the invention demonstrate superior replication and expression of exogenous immunogens. They are useful as prophylactic and therapeutic vaccines as well as in gene therapy.

公开(公告)号：US20210154290A1

公开(公告)日：2021-05-27

申请号：US16772194

申请日：2018-12-14

Applicant: GLAXOSMITHKLINE BIOLOGICALS SA

Inventor： Virginia AMMENDOLA ,  Babak BAYAT ,  Clarisse LORIN ,  Ventzislav Bojidarov VASSILEV ,  Alessandra VITELLI

IPC: A61K39/29 ,  C12N7/00 ,  C07K14/005 ,  A61K39/39 ,  A61P31/20

Abstract: The present invention relates to immunogenic compositions and combinations thereof which may find use in immunisation regimens for the treatment of chronic hepatitis B. An immunogenic composition comprises a replication-defective chimpanzee adenoviral (ChAd) vector comprising polynucleotides encoding HBs, HBc human invariant chain (hIi) fused to the HBc. Another immunogenic composition comprises a Modified Vaccinia Virus Ankara (MVA) vector comprising polynucleotides encoding HBs and HBc. Another immunogenic composition comprises recombinant HBs, C-terminal truncated recombinant HBc and an adjuvant containing MPL and QS-21.

公开(公告)号：US20180216081A1

公开(公告)日：2018-08-02

申请号：US15747545

申请日：2016-07-25

Applicant: GLAXOSMITHKLINE BIOLOGICALS, SA

Inventor： Stefano COLLOCA ,  Virginia AMMENDOLA ,  Fabiana GRAZIOLI ,  Alessandra VITELLI ,  Alfredo NICOSIA ,  Riccardo CORTESE

IPC: C12N7/00 ,  C12N15/86 ,  C07K14/005 ,  A61K35/761 ,  C07K14/35 ,  A61K39/04 ,  A61P31/06

CPC classification number: A61K39/04 ,  A61K9/0019 ,  A61K35/761 ,  A61K39/12 ,  A61K39/39 ,  A61K45/05 ,  A61K2039/5256 ,  A61K2039/545 ,  A61P31/06 ,  C07K14/005 ,  C07K14/35 ,  C12N7/00 ,  C12N15/85 ,  C12N15/86 ,  C12N2710/10321 ,  C12N2710/10341 ,  C12N2710/10343 ,  C12N2740/16234 ,  C12N2760/18534

Abstract: There is provided adenoviral vectors encoding a mycobacterial antigen derived from a chimp adenovirus, and to related aspects.