公开(公告)号：US20220364115A1

公开(公告)日：2022-11-17

申请号：US17731027

申请日：2022-04-27

Applicant: GLAXOSMITHKLINE BIOLOGICALS SA

Inventor： Stefano COLLOCA

IPC: C12N15/86 ,  A61P37/04 ,  A61K39/155

Abstract: A new promoter comprising: (i) an hCMV enhancer sequence; (ii) an hCMV promoter sequence; (iii) a splice donor region; (iv) a cell-derived enhancer sequence; and (v) a splice acceptor region.

公开(公告)号：US20180125968A1

公开(公告)日：2018-05-10

申请号：US15848100

申请日：2017-12-20

Applicant: GLAXOSMITHKLINE BIOLOGICALS, SA

Inventor： Stefano COLLOCA ,  Riccardo CORTESE ,  Antonella FOLGORI ,  Alfredo NICOSIA

IPC: A61K39/29 ,  C12N7/00 ,  C12N15/86

Abstract: The present application relates to novel administration regimens for poxviral vectors comprising nucleic acid constructs encoding antigenic proteins and invariant chains. In particular the use of said poxviral vectors for priming or for boosting an immune response is disclosed.

公开(公告)号：US20220275397A1

公开(公告)日：2022-09-01

申请号：US17742221

申请日：2022-05-11

Applicant: GLAXOSMITHKLINE BIOLOGICALS SA

Inventor： Virginia AMMENDOLA ,  Stefania CAPONE ,  Stefano COLLOCA ,  Antonella FOLGORI ,  Rossella MERONE

IPC: C12N15/86 ,  A61K39/21 ,  C07K14/005 ,  A61K39/12 ,  A61P31/18 ,  A61P31/14

Abstract: The present invention relates to isolated polynucleotide and polypeptide sequences derived from novel chimpanzee adenovirus ChAd157, as well as to recombinant polynucleotides, vectors, adenoviruses, cells and compositions comprising said polynucleotide and polypeptide sequences.

公开(公告)号：US20220204566A1

公开(公告)日：2022-06-30

申请号：US17565796

申请日：2021-12-30

Applicant: GLAXOSMITHKLINE BIOLOGICALS SA

Inventor： Stefano COLLOCA ,  Virginia AMMENDOLA ,  Fabiana GRAZIOLI ,  Alessandra Franz VITELLI ,  Alfredo NICOSIA ,  Riccardo CORTESE

IPC: C07K14/005 ,  C12N15/86 ,  C07K14/075 ,  C07K14/75 ,  A61K39/12 ,  C12N15/861 ,  A61K39/155 ,  A61K39/21 ,  C12N7/00

Abstract: There is provided inter alia an isolated polynucleotide, wherein the polynucleotide encodes a polypeptide selected from the group consisting of: (a) a polypeptide having the amino acid sequence according to SEQ ID NO: 1, (b) a functional derivative of a polypeptide having the amino acid sequence according to SEQ ID NO: 1, wherein the functional derivative has an amino acid sequence which is at least 80% identical over its entire length to the amino acid sequence of SEQ ID NO: 1, and (c) a polypeptide having the amino acid sequence according to SEQ ID NO: 3.

公开(公告)号：US20200164061A1

公开(公告)日：2020-05-28

申请号：US16782268

申请日：2020-02-05

Applicant: GLAXOSMITHKLINE BIOLOGICALS SA

Inventor： Stefano COLLOCA ,  Riccardo CORTESE ,  Antonella FOLGORI ,  Alfredo NICOSIA

IPC: A61K39/29 ,  C12N15/86 ,  C12N7/00 ,  C07K14/005 ,  C07K14/74 ,  A61K39/00

Abstract: The present application relates to novel administration regimens for poxviral vectors comprising nucleic acid constructs encoding antigenic proteins and invariant chains. In particular the use of said poxviral vectors for priming or for boosting an immune response is disclosed.

公开(公告)号：US20170333550A1

公开(公告)日：2017-11-23

申请号：US15461978

申请日：2017-03-17

Applicant: GLAXOSMITHKLINE BIOLOGICALS, SA

Inventor： Stefano COLLOCA ,  Riccardo CORTESE ,  Antonella FOLGORI ,  Alfredo NICOSIA

IPC: A61K39/29 ,  C12N7/00 ,  A61K39/00

CPC classification number: A61K39/29 ,  A61K39/12 ,  A61K2039/5254 ,  A61K2039/5256 ,  A61K2039/53 ,  A61K2039/545 ,  A61K2039/6031 ,  C12N7/00 ,  C12N15/86 ,  C12N2710/10334 ,  C12N2710/10343 ,  C12N2710/24034 ,  C12N2710/24043 ,  C12N2710/24143 ,  C12N2770/24222 ,  C12N2770/24234

Abstract: The present application relates to novel administration regimens for poxviral vectors comprising nucleic acid constructs encoding antigenic proteins and invariant chains. In particular the use of said poxviral vectors for priming or for boosting an immune response is disclosed.

公开(公告)号：US20230158134A1

公开(公告)日：2023-05-25

申请号：US18075064

申请日：2022-12-05

Applicant: GLAXOSMITHKLINE BIOLOGICALS SA

Inventor： Virginia AMMENDOLA ,  Stefano COLLOCA ,  Alessandra VITELLI ,  Benjamin WIZEL

IPC: A61K39/12 ,  A61K39/205 ,  C07K14/005 ,  C12N15/86 ,  A61K39/235 ,  C12N7/00

CPC classification number: A61K39/12 ,  A61K39/205 ,  C07K14/005 ,  C12N15/86 ,  A61K39/235 ,  C12N7/00 ,  A61P31/14

Abstract: The invention provides adenoviral vectors comprising transgenes encoding Lyssaviral antigens. The vectors can be used to produce vaccines for the prophylaxis, amelioration and treatment of diseases caused by Lyssaviral diseases, e.g., rabies.

公开(公告)号：US20210246468A1

公开(公告)日：2021-08-12

申请号：US16973630

申请日：2019-06-11

Applicant: GLAXOSMITHKLINE BIOLOGICALS SA

Inventor： Virginia AMMENDOLA ,  Stefania CAPONE ,  Stefano COLLOCA ,  Antonella FOLGORI ,  Rosella MERONE

IPC: C12N15/86 ,  A61K39/21 ,  A61P37/04

Abstract: The present invention relates to isolated polynucleotide and polypeptide sequences derived from novel chimpanzee adenovirus ChAd157, as well as to recombinant polynucleotides, vectors, adenoviruses, cells and compositions comprising said polynucleotide and polypeptide sequences.

公开(公告)号：US20210189422A1

公开(公告)日：2021-06-24

申请号：US16756380

申请日：2018-10-16

Applicant: GLAXOSMITHKLINE BIOLOGICALS SA

Inventor： Stefano COLLOCA

IPC: C12N15/86 ,  A61K39/235

Abstract: An adenoviral vector comprising two expression cassettes, wherein each expression cassette comprises a transgene and a promoter, and wherein each transgene encodes an RSV antigenic protein or a fragment thereof.

公开(公告)号：US20210189420A1

公开(公告)日：2021-06-24

申请号：US16756373

申请日：2018-10-16

Applicant: GLAXOSMITHKLINE BIOLOGICALS SA

Inventor： Stefano COLLOCA

IPC: C12N15/86 ,  A61K39/155 ,  A61P37/04

Abstract: A new promoter comprising: (i) an hCMV enhancer sequence; (ii) an hCMV promoter sequence; (iii) a splice donor region; (iv) a cell-derived enhancer sequence; and (v) a splice acceptor region.