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公开(公告)号：US5854036A
公开(公告)日：1998-12-29
申请号：US716259
申请日：1996-09-10
IPC分类号： C12Q1/42 , A61K31/34 , A61K35/74 , A61P25/24 , A61P25/26 , C07D307/94 , C07G99/00 , C12P17/04 , C12R1/645
CPC分类号： C07D307/94 , C12P17/04
摘要： The present invention concerns novel compounds obtained by fermenting a microorganism of the genus Memnonoiella or Stachybotrys, which compounds are inhibitors of the enzyme inositol monophosphatase (EC 3.1.3.25). The present invention also relates to the use of these novel compounds in treating manic depression and pharmaceutical formulations comprising said compounds as active ingredient; a further object is the use of these compounds in an analytical method for detecting inositol monophosphatase.
摘要翻译： PCT No.PCT / EP95 / 01045 Sec。 371日期：1996年9月10日 102（e）1996年9月10日PCT 1995年3月21日PCT PCT。 公开号WO95 / 26344 日期1995年10月5日本发明涉及通过发酵Memnonoiella或Stachybotrys的微生物获得的新型化合物，该化合物是肌醇单磷酸酶的抑制剂（EC 3.1.3.25）。 本发明还涉及这些新化合物在治疗躁狂抑郁症中的用途以及包含所述化合物作为活性成分的药物制剂; 另一个目的是在检测肌醇单磷酸酶的分析方法中使用这些化合物。
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12.发明授权
公开(公告)号：US5843890A
公开(公告)日：1998-12-01
申请号：US462997
申请日：1995-06-05
IPC分类号： A61K31/44 , A61K38/00 , A61P3/00 , A61P31/00 , C07D513/22 , C07K5/078 , C12P17/18 , C12P21/04 , C12R1/01 , A61K35/70
CPC分类号： C07K5/06139 , A61K38/00
摘要： The present invention is directed to new antibiotic substances denominated antibiotic GE 2270 factors B.sub.1, B.sub.2, C.sub.1, C.sub.2, D.sub.1, D.sub.2, E and T, the addition salts thereof, the pharmaceutical compositions thereof and their use as medicaments, particularly in the treatment of infectious diseases involving microorganisms susceptible to them and their use as animal growth promoters.
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公开(公告)号：US5610143A
公开(公告)日：1997-03-11
申请号：US493043
申请日：1995-06-21
申请人： Sergio Stella , Nicoletta Montanini , Francis J. LeMonnier , Luigi Colombo , Enrico Selva , Maurizio Denaro
发明人： Sergio Stella , Nicoletta Montanini , Francis J. LeMonnier , Luigi Colombo , Enrico Selva , Maurizio Denaro
CPC分类号： C07K5/0821 , A23K20/195 , C07K5/06139 , C12R1/465 , A61K38/00
摘要： The present invention is directed to new antibiotic substances denominated antibiotics GE 37468 A, B and C, their addition salts with bases, the pharmaceutical compositions thereof and their use as medicaments, particularly in the treatment of infectious diseases involving microorganisms susceptible to them.The compounds of the invention are also active as growth promotant agents in animals, such as poultry, swine, ruminants, etc.
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公开(公告)号：US5567676A
公开(公告)日：1996-10-22
申请号：US457365
申请日：1995-06-01
申请人： Enrico Selva , Grazia Beretta , Angelo Borghi , Maurizio Denaro
发明人： Enrico Selva , Grazia Beretta , Angelo Borghi , Maurizio Denaro
IPC分类号： C12P21/02 , A61K38/00 , A61P31/04 , C07G11/00 , C07K20060101 , C07K9/00 , C07K14/195 , C07K14/41 , C12R1/045 , A61K38/14 , A61K38/12
CPC分类号： C07K9/008
摘要： The present invention concerns new antiobiotic substances demoninated de-acyl antibiotics A40926, de-acyl antibiotic A 40926P and antibiotic A 40926 amino glucronyl aglycon, and the use of these substances in the treatment of infectious diseases involving microorganisms susceptible to it.
摘要翻译： 本发明涉及脱酰基抗生素A40926，去酰基抗生素A40926P和抗生素A40926氨基葡糖苷酸苷的新抗生素物质，以及这些物质用于治疗涉及对其敏感的微生物的感染性疾病的用途。
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公开(公告)号：US5618724A
公开(公告)日：1997-04-08
申请号：US648646
申请日：1996-05-16
申请人： Sergio Stella , Nicoletta Montanini , Francis J. LeMonnier , Luigi Colombo , Enrico Selva , Maurizio Denaro
发明人： Sergio Stella , Nicoletta Montanini , Francis J. LeMonnier , Luigi Colombo , Enrico Selva , Maurizio Denaro
IPC分类号： A23K20/195 , A61K38/00 , C07K5/078 , C07K5/097 , C12M1/02
CPC分类号： C07K5/0821 , A23K20/195 , C07K5/06139 , C12R1/465 , A61K38/00
摘要： The present invention is directed to new antibiotic substances denominated antibiotics GE 37468 A, B and C, their addition salts with bases, the pharmaceutical compositions thereof and their use as medicaments, particularly in the treatment of infectious diseases involving microorganisms susceptible to them.The compounds of the invention are also active as growth promotant agents in animals, such as poultry, swine, ruminants, etc.
摘要翻译： 本发明涉及新的抗生素物质GE 37468A，B和C，它们与碱的加成盐，其药物组合物及其作为药物的用途，特别是用于治疗涉及对它们敏感的微生物的感染性疾病。 本发明的化合物在动物如动物，如家禽，猪，反刍动物等中也是有活性的。
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公开(公告)号：US5606036A
公开(公告)日：1997-02-25
申请号：US447152
申请日：1995-05-22
申请人： Rolf H. Hermann , Romeo Ciabatti , Enrico Selva , Maurizio Denaro
发明人： Rolf H. Hermann , Romeo Ciabatti , Enrico Selva , Maurizio Denaro
CPC分类号： C07K9/008
摘要： The present invention relates to novel ester derivatives of antibiotic A 40926 complex and its N-acylaminoglucuronyl aglycone. The compounds of the invention are prepared according to an esterification process involving reaction of an A 40926 substrate with an excess of the selected alkanol in the presence of concentrated mineral acid and are reactive as antibiotics.
摘要翻译： 本发明涉及抗生素A40926复合物的新型酯衍生物及其N-酰氨基葡萄糖醛酸糖苷配基。 本发明的化合物根据酯化方法制备，该方法包括在浓无机酸存在下A404026底物与过量的选择的链烷醇的反应，并作为抗生素反应。
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公开(公告)号：US5514649A
公开(公告)日：1996-05-07
申请号：US428787
申请日：1995-04-21
申请人： Enrico Selva , Sergio Stella , Luigi Colombo , Maurizio Denaro
发明人： Enrico Selva , Sergio Stella , Luigi Colombo , Maurizio Denaro
IPC分类号： A61K31/435 , A61K38/00 , A61P31/00 , C07D513/22 , C07G11/00 , C07K5/078 , C12P1/06 , C12R1/01 , C07K5/00 , A61K35/00 , C07K7/00
CPC分类号： C07K5/06139 , A61K38/00
摘要： The present invention is directed to a new antibiotic substance denominated antibiotic GE 2270 factor C.sub.2a, the addition salts thereof, the pharmaceutical compositions thereof and its use as medicament, particularly in the treatment of infectious diseases involving microorganisms susceptible to it and its use as animal growth promoter.
摘要翻译： 本发明涉及一种新型抗生素物质GE 2270因子C2a，其加成盐，其药物组合物及其作为药物的用途，特别是用于治疗涉及对其敏感的微生物的感染性疾病及其作为动物生长的用途 启动子。
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18.发明授权Nocardia sp. ATCC 53492, or an antibiotic A 42867 producing mutant or variant thereof 失效诺卡氏菌 ATCC 53492或产生其突变体或变体的抗生素A 42867
公开(公告)号：US4956293A
公开(公告)日：1990-09-11
申请号：US270884
申请日：1988-11-14
IPC分类号： C07G11/00 , A23K20/195 , A61K20060101 , A61K35/66 , A61K35/74 , A61P31/04 , C07G20060101 , C12N20060101 , C12N1/20 , C12P20060101 , C12P1/04 , C12P1/06 , C12R1/365
CPC分类号： C12P1/06 , Y10S435/872
摘要： A novel antibiotic, A 42867, is prepared by cultivating the strain Nocardia sp. ATCC 53492, or an antibiotic A 42867-producing mutant or variant thereof, under submerged aerobic conditions in the presence of assimilable sources of carbon, nitrogen and inorganic salts. The antibiotic and its addition salts are useful in the treatment of infectious diseases and as growth promotant agents.
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公开(公告)号：US4804534A
公开(公告)日：1989-02-14
申请号：US78501
申请日：1987-07-28
IPC分类号： C07G11/00 , A23K20/195 , A61K20060101 , A61K35/66 , A61K35/74 , A61P31/04 , C07G20060101 , C12N20060101 , C12N1/20 , C12P20060101 , C12P1/04 , C12P1/06 , C12R1/365
CPC分类号： C12P1/06 , Y10S435/872
摘要： A novel antibiotic, A 42867, is prepared by cultivating the strain Nocardia sp. ATCC 53492, or an antibiotic A 42867-producing mutant or variant thereof, under submerged aerobic conditions in the presence of assimilable sources of carbon, nitrogen and inorganic salts. The antibiotic and its addition salts are useful in the treatment of infectious diseases and as growth promotant agents.
摘要翻译： 通过培养菌株诺卡氏菌（Nocardia sp。）制备新型抗生素A 42867。 ATCC 53492或产生抗生素A 42867的突变体或其变体，在潜在的有氧条件下，在可同化的碳源，氮和无机盐的存在下。 抗生素及其加成盐可用于治疗感染性疾病和作为生长促进剂。
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