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公开(公告)号：US09399082B2
公开(公告)日：2016-07-26
申请号：US12937322
申请日：2009-04-10
IPC分类号： A61K9/00 , A61L15/44 , A61F13/00 , A61L15/28 , A61L15/32 , D01D5/00 , D01F1/10 , D01F6/92 , D01F9/00
CPC分类号： A61L15/44 , A61F13/00034 , A61F13/00063 , A61F2013/00472 , A61F2013/0054 , A61F2013/00927 , A61L15/28 , A61L15/32 , A61L2300/418 , A61L2400/04 , D01D5/0015 , D01F1/10 , D01F6/92 , D01F9/00 , C08L5/02
摘要： The invention generally relates to dextran fibers which are preferably electrospun and devices formed from such fibers. In particular, such devices may include substances of interest (such as therapeutic substances) associated with the electrospun fibers. Upon exposure to a liquid the electrospun fibers dissolve immediately and the substances of interest are released into the liquid. Exemplary devices include bandages formed from electrospun dextran fibers and associated agents that promote hemostasis, such as thrombin and fibrinogen.
摘要翻译： 本发明一般涉及优选静电纺丝的葡聚糖纤维和由这种纤维形成的装置。 特别地，这样的装置可以包括与静电纺丝纤维相关联的感兴趣的物质（例如治疗物质）。 当暴露于液体时，电纺纤维立即溶解，感兴趣的物质被释放到液体中。 示例性装置包括由电纺丝葡聚糖纤维形成的绷带和促进止血的相关药物，例如凝血酶和纤维蛋白原。
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公开(公告)号：US20130178949A1
公开(公告)日：2013-07-11
申请号：US13811286
申请日：2011-06-28
申请人： Gary L. Bowlin , Michael J. McClure , David G. Simpson , Hu Yang
发明人： Gary L. Bowlin , Michael J. McClure , David G. Simpson , Hu Yang
IPC分类号： A61F2/02
CPC分类号： A61F2/02 , D01D5/0061 , D01D5/0076 , D01F6/62 , D01F6/625 , D04H1/728
摘要： Electrospun materials are fabricated using air-flow impedance technology, which results in the production of scaffolds in which some regions are dense with low porosity and others regions are less dense and more porous. The dense regions provide structural support for the scaffold while the porous regions permit entry of cells and other materials into the scaffold, e.g. when used for tissue engineering.
摘要翻译： 使用气流阻抗技术制造电纺丝材料，这导致支架的生产，其中一些区域是致密的，具有低孔隙率，而其它区域较不致密且更多孔。 致密区域为支架提供结构支撑，而多孔区域允许细胞和其他材料进入支架，例如， 用于组织工程。
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公开(公告)号：US20110150973A1
公开(公告)日：2011-06-23
申请号：US12937322
申请日：2009-04-10
CPC分类号： A61L15/44 , A61F13/00034 , A61F13/00063 , A61F2013/00472 , A61F2013/0054 , A61F2013/00927 , A61L15/28 , A61L15/32 , A61L2300/418 , A61L2400/04 , D01D5/0015 , D01F1/10 , D01F6/92 , D01F9/00 , C08L5/02
摘要： The invention generally relates to dextran fibers which are preferably electrospun and devices formed from such fibers. In particular, such devices may include substances of interest (such as therapeutic substances) associated with the electrospun fibers. Upon exposure to a liquid the electrospun fibers dissolve immediately and the substances of interest are released into the liquid. Exemplary devices include bandages formed from electrospun dextran fibers and associated agents that promote hemostasis, such as thrombin and fibrinogen.
摘要翻译： 本发明一般涉及优选静电纺丝的葡聚糖纤维和由这种纤维形成的装置。 特别地，这样的装置可以包括与静电纺丝纤维相关联的感兴趣的物质（例如治疗物质）。 当暴露于液体时，电纺纤维立即溶解，感兴趣的物质被释放到液体中。 示例性装置包括由电纺丝葡聚糖纤维形成的绷带和促进止血的相关药物，例如凝血酶和纤维蛋白原。
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公开(公告)号：US20080159985A1
公开(公告)日：2008-07-03
申请号：US11963109
申请日：2007-12-21
申请人： Gary L. Bowlin , Gary E. Wnek , David G. Simpson
发明人： Gary L. Bowlin , Gary E. Wnek , David G. Simpson
IPC分类号： A61K35/00 , C12N5/06 , A61K38/02 , A61K31/7052 , A61K31/70 , A61K38/14 , A61K31/726
CPC分类号： C12N5/0622 , A61F2/08 , A61K35/12 , A61K2035/126 , A61L15/32 , A61L27/18 , A61L27/225 , A61L27/24 , A61L27/26 , A61L27/34 , A61L27/38 , A61L27/3847 , A61L27/507 , A61L31/041 , A61L2400/04 , A61L2430/30 , B29C41/006 , B29C67/0007 , C07K14/75 , C07K14/78 , C12N5/0012 , C12N5/0062 , C12N5/0068 , C12N2503/00 , C12N2510/00 , C12N2533/40 , C12N2533/54 , C12N2533/56 , Y10S514/801 , C08L89/00 , C08L67/04 , C08L89/06
摘要： The invention is directed to novel compositions comprising an electroprocessed material and a substance, their formation and use. The electroprocessed material can, for example, be one or more natural materials, one or more synthetic materials, or a combination thereof. The substance can be one or more therapeutic or cosmetic substances or other compounds, molecules, cells, vesicles. The compositions can be used in substance delivery, including drug delivery within an organism by, for example, releasing substances or containing cells that release substances. The compositions can be used for other purposes, such as prostheses or similar implants.
摘要翻译： 本发明涉及包含电处理材料和物质的新型组合物，其形成和用途。 电加工材料可以例如是一种或多种天然材料，一种或多种合成材料或其组合。 该物质可以是一种或多种治疗或化妆物质或其它化合物，分子，细胞，囊泡。 组合物可用于物质递送，包括通过例如释放物质或含有释放物质的细胞在生物体内的药物递送。 组合物可以用于其它目的，例如假体或类似的植入物。
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