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公开(公告)号：US08586345B2
公开(公告)日：2013-11-19
申请号：US13052778
申请日：2011-03-21
申请人： David G. Simpson , Gary L. Bowlin , Gary E. Wnek , Peter J. Stevens , Marcus E. Carr , Jamil A. Matthews , Saravanamoorthy Rajendran
发明人： David G. Simpson , Gary L. Bowlin , Gary E. Wnek , Peter J. Stevens , Marcus E. Carr , Jamil A. Matthews , Saravanamoorthy Rajendran
CPC分类号： B29C67/0007 , A61F2/08 , A61K38/00 , A61K2035/126 , A61L15/32 , A61L27/18 , A61L27/24 , A61L27/26 , A61L27/34 , A61L27/3804 , A61L27/3839 , A61L27/3895 , A61L27/507 , A61L31/041 , A61L2430/30 , B29C41/006 , C07K14/78 , C12N5/0012 , C12N5/0068 , C12N2533/40 , C12N2533/54 , D01D5/0038 , D01F1/10 , D01F4/00 , Y10T428/298 , Y10T442/2525 , Y10T442/60 , Y10T442/614 , C08L67/04 , C08L89/00 , C08L89/06
摘要： The invention is directed to formation and use of electroprocessed collagen, including use as an extracellular matrix and, together with cells, its use in forming engineered tissue. The engineered tissue can include the synthetic manufacture of specific organs or tissues which may be implanted into a recipient. The electroprocessed collagen may also be combined with other molecules in order to deliver substances to the site of application or implantation of the electroprocessed collagen. The collagen or collagen/cell suspension is electrodeposited onto a substrate to form tissues and organs.
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公开(公告)号：US20100291058A1
公开(公告)日：2010-11-18
申请号：US12758360
申请日：2010-04-12
申请人： Gary L. Bowlin , David G. Simpson , Gary E. Wnek , Marcus E. Carr, JR. , Peter J. Stevens , Gary Cadd , I. Kelman Cohen
发明人： Gary L. Bowlin , David G. Simpson , Gary E. Wnek , Marcus E. Carr, JR. , Peter J. Stevens , Gary Cadd , I. Kelman Cohen
CPC分类号： A61L24/102 , A61F2/105 , A61F2013/00314 , A61F2013/00472 , A61K38/363 , A61K38/39 , A61L24/106 , C07K14/78 , Y10T428/298 , A61K2300/00
摘要： The present invention relates to sealants for skin and other tissues. The sealants include an electroprocessed material. The sealants may contain more than one electroprocessed materials and may contain additional substances. The invention further relates to methods of making and using such sealants.
摘要翻译： 本发明涉及用于皮肤和其它组织的密封剂。 密封剂包括电加工材料。 密封剂可能含有多于一种的电处理材料，并且可能含有其他物质。 本发明还涉及制造和使用这种密封剂的方法。
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公开(公告)号：US07615373B2
公开(公告)日：2009-11-10
申请号：US10447670
申请日：2003-05-28
申请人： David G. Simpson , Gary L. Bowlin , Gary E. Wnek , Peter J. Stevens , Marcus E. Carr , Jamil A. Matthews , Saravanamoorthy Rajendran
发明人： David G. Simpson , Gary L. Bowlin , Gary E. Wnek , Peter J. Stevens , Marcus E. Carr , Jamil A. Matthews , Saravanamoorthy Rajendran
CPC分类号： B29C67/0007 , A61F2/08 , A61K38/00 , A61K2035/126 , A61L15/32 , A61L27/18 , A61L27/24 , A61L27/26 , A61L27/34 , A61L27/3804 , A61L27/3839 , A61L27/3895 , A61L27/507 , A61L31/041 , A61L2430/30 , B29C41/006 , C07K14/78 , C12N5/0012 , C12N5/0068 , C12N2533/40 , C12N2533/54 , D01D5/0038 , D01F1/10 , D01F4/00 , Y10T428/298 , Y10T442/2525 , Y10T442/60 , Y10T442/614 , C08L67/04 , C08L89/00 , C08L89/06
摘要： The invention is directed to formation and use of electroprocessed collagen, including use as an extracellular matrix and, together with cells, its use in forming engineered tissue. The engineered tissue can include the synthetic manufacture of specific organs or tissues which may be implanted into a recipient. The electroprocessed collagen may also be combined with other molecules in order to deliver substances to the site of application or implantation of the electroprocessed collagen. The collagen or collagen/cell suspension is electrodeposited onto a substrate to form tissues and organs.
摘要翻译： 本发明涉及电加工胶原的形成和使用，包括用作细胞外基质，并与细胞一起用于形成工程化组织。 工程组织可以包括可以植入受体的特定器官或组织的合成制造。 电处理胶原蛋白也可以与其他分子组合，以将物质递送到电加工胶原的施用部位或植入。 将胶原或胶原/细胞悬浮液电沉积在基质上以形成组织和器官。
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公开(公告)号：US20110280841A1
公开(公告)日：2011-11-17
申请号：US13008329
申请日：2011-01-18
申请人： Gary L. Bowlin , Gary E. Wnek , David G. Simpson
发明人： Gary L. Bowlin , Gary E. Wnek , David G. Simpson
IPC分类号： A61K35/36 , A61K31/65 , A61K35/39 , B05D1/04 , A61P19/08 , A61P3/10 , A61P31/00 , A61P17/00 , A61K38/18 , A61K35/32
CPC分类号： C12N5/0622 , A61F2/08 , A61K35/12 , A61K2035/126 , A61L15/32 , A61L27/18 , A61L27/225 , A61L27/24 , A61L27/26 , A61L27/34 , A61L27/38 , A61L27/3847 , A61L27/507 , A61L31/041 , A61L2400/04 , A61L2430/30 , B29C41/006 , B29C67/0007 , C07K14/75 , C07K14/78 , C12N5/0012 , C12N5/0062 , C12N5/0068 , C12N2503/00 , C12N2510/00 , C12N2533/40 , C12N2533/54 , C12N2533/56 , Y10S514/801 , C08L89/00 , C08L67/04 , C08L89/06
摘要： The invention is directed to novel compositions comprising an electroprocessed material and a substance, their formation and use. The electroprocessed material can, for example, be one or more natural materials, one or more synthetic materials, or a combination thereof. The substance can be one or more therapeutic or cosmetic substances or other compounds, molecules, cells, vesicles. The compositions can be used in substance delivery, including drug delivery within an organism by, for example, releasing substances or containing cells that release substances. The compositions can be used for other purposes, such as prostheses or similar implants.
摘要翻译： 本发明涉及包含电处理材料和物质的新型组合物，其形成和用途。 电加工材料可以例如是一种或多种天然材料，一种或多种合成材料或其组合。 该物质可以是一种或多种治疗或化妆物质或其它化合物，分子，细胞，囊泡。 组合物可用于物质递送，包括通过例如释放物质或含有释放物质的细胞在生物体内的药物递送。 组合物可以用于其它目的，例如假体或类似的植入物。
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公开(公告)号：US09399082B2
公开(公告)日：2016-07-26
申请号：US12937322
申请日：2009-04-10
IPC分类号： A61K9/00 , A61L15/44 , A61F13/00 , A61L15/28 , A61L15/32 , D01D5/00 , D01F1/10 , D01F6/92 , D01F9/00
CPC分类号： A61L15/44 , A61F13/00034 , A61F13/00063 , A61F2013/00472 , A61F2013/0054 , A61F2013/00927 , A61L15/28 , A61L15/32 , A61L2300/418 , A61L2400/04 , D01D5/0015 , D01F1/10 , D01F6/92 , D01F9/00 , C08L5/02
摘要： The invention generally relates to dextran fibers which are preferably electrospun and devices formed from such fibers. In particular, such devices may include substances of interest (such as therapeutic substances) associated with the electrospun fibers. Upon exposure to a liquid the electrospun fibers dissolve immediately and the substances of interest are released into the liquid. Exemplary devices include bandages formed from electrospun dextran fibers and associated agents that promote hemostasis, such as thrombin and fibrinogen.
摘要翻译： 本发明一般涉及优选静电纺丝的葡聚糖纤维和由这种纤维形成的装置。 特别地，这样的装置可以包括与静电纺丝纤维相关联的感兴趣的物质（例如治疗物质）。 当暴露于液体时，电纺纤维立即溶解，感兴趣的物质被释放到液体中。 示例性装置包括由电纺丝葡聚糖纤维形成的绷带和促进止血的相关药物，例如凝血酶和纤维蛋白原。
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公开(公告)号：US20130178949A1
公开(公告)日：2013-07-11
申请号：US13811286
申请日：2011-06-28
申请人： Gary L. Bowlin , Michael J. McClure , David G. Simpson , Hu Yang
发明人： Gary L. Bowlin , Michael J. McClure , David G. Simpson , Hu Yang
IPC分类号： A61F2/02
CPC分类号： A61F2/02 , D01D5/0061 , D01D5/0076 , D01F6/62 , D01F6/625 , D04H1/728
摘要： Electrospun materials are fabricated using air-flow impedance technology, which results in the production of scaffolds in which some regions are dense with low porosity and others regions are less dense and more porous. The dense regions provide structural support for the scaffold while the porous regions permit entry of cells and other materials into the scaffold, e.g. when used for tissue engineering.
摘要翻译： 使用气流阻抗技术制造电纺丝材料，这导致支架的生产，其中一些区域是致密的，具有低孔隙率，而其它区域较不致密且更多孔。 致密区域为支架提供结构支撑，而多孔区域允许细胞和其他材料进入支架，例如， 用于组织工程。
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公开(公告)号：US20110150973A1
公开(公告)日：2011-06-23
申请号：US12937322
申请日：2009-04-10
CPC分类号： A61L15/44 , A61F13/00034 , A61F13/00063 , A61F2013/00472 , A61F2013/0054 , A61F2013/00927 , A61L15/28 , A61L15/32 , A61L2300/418 , A61L2400/04 , D01D5/0015 , D01F1/10 , D01F6/92 , D01F9/00 , C08L5/02
摘要： The invention generally relates to dextran fibers which are preferably electrospun and devices formed from such fibers. In particular, such devices may include substances of interest (such as therapeutic substances) associated with the electrospun fibers. Upon exposure to a liquid the electrospun fibers dissolve immediately and the substances of interest are released into the liquid. Exemplary devices include bandages formed from electrospun dextran fibers and associated agents that promote hemostasis, such as thrombin and fibrinogen.
摘要翻译： 本发明一般涉及优选静电纺丝的葡聚糖纤维和由这种纤维形成的装置。 特别地，这样的装置可以包括与静电纺丝纤维相关联的感兴趣的物质（例如治疗物质）。 当暴露于液体时，电纺纤维立即溶解，感兴趣的物质被释放到液体中。 示例性装置包括由电纺丝葡聚糖纤维形成的绷带和促进止血的相关药物，例如凝血酶和纤维蛋白原。
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公开(公告)号：US20110288026A1
公开(公告)日：2011-11-24
申请号：US13052778
申请日：2011-03-21
申请人： David G. Simpson , Gary L. Bowlin , Gary E. Wnek , Peter J. Stevens , Marcus E. Carr , Jamil A. Matthews , Saravanamoorthy Rajendran
发明人： David G. Simpson , Gary L. Bowlin , Gary E. Wnek , Peter J. Stevens , Marcus E. Carr , Jamil A. Matthews , Saravanamoorthy Rajendran
CPC分类号： B29C67/0007 , A61F2/08 , A61K38/00 , A61K2035/126 , A61L15/32 , A61L27/18 , A61L27/24 , A61L27/26 , A61L27/34 , A61L27/3804 , A61L27/3839 , A61L27/3895 , A61L27/507 , A61L31/041 , A61L2430/30 , B29C41/006 , C07K14/78 , C12N5/0012 , C12N5/0068 , C12N2533/40 , C12N2533/54 , D01D5/0038 , D01F1/10 , D01F4/00 , Y10T428/298 , Y10T442/2525 , Y10T442/60 , Y10T442/614 , C08L67/04 , C08L89/00 , C08L89/06
摘要： The invention is directed to formation and use of electroprocessed collagen, including use as an extracellular matrix and, together with cells, its use in forming engineered tissue. The engineered tissue can include the synthetic manufacture of specific organs or tissues which may be implanted into a recipient. The electroprocessed collagen may also be combined with other molecules in order to deliver substances to the site of application or implantation of the electroprocessed collagen. The collagen or collagen/cell suspension is electrodeposited onto a substrate to form tissues and organs.
摘要翻译： 本发明涉及电加工胶原的形成和使用，包括用作细胞外基质，并与细胞一起用于形成工程化组织。 工程组织可以包括可以植入受体的特定器官或组织的合成制造。 电处理胶原蛋白也可以与其他分子组合，以将物质递送到电加工胶原的施用部位或植入。 将胶原或胶原/细胞悬浮液电沉积在基质上以形成组织和器官。
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公开(公告)号：US20100310658A1
公开(公告)日：2010-12-09
申请号：US12796207
申请日：2010-06-08
IPC分类号： A61K9/00 , C07K14/435 , A61K38/36 , A61K35/00 , A61K38/18 , A61K35/12 , C12Q1/02 , A61P17/02 , A61P7/00 , C25D9/02
CPC分类号： C12N5/0622 , A61K35/12 , A61K2035/126 , A61L15/32 , A61L27/225 , A61L27/24 , A61L27/26 , A61L27/38 , A61L31/041 , A61L2400/04 , B29C41/006 , C07K14/75 , C07K14/78 , C12N5/0012 , C12N5/0062 , C12N5/0068 , C12N2503/00 , C12N2510/00 , C12N2533/40 , C12N2533/54 , C12N2533/56 , C08L89/00
摘要： The invention is directed to formation and use of electroprocessed fibrin as an extracellular matrix and, together with cells, its use in forming engineered tissue. The engineered tissue can include the synthetic manufacture of specific organs or tissues which may be implanted into a recipient. The electroprocessed fibrin may also be combined with other molecules in order to deliver the molecules to the site of application or implantation of the electroprocessed fibrin. The fibrin or fibrin/cell suspension is electrodeposited onto a substrite to form the tissues and organs.
摘要翻译： 本发明涉及形成和使用电加工的纤维蛋白作为细胞外基质，并与细胞一起用于形成工程化组织。 工程组织可以包括可以植入受体的特定器官或组织的合成制造。 电加工的纤维蛋白也可以与其它分子组合以将分子递送到电加工的纤维蛋白的施用位点或植入。 将纤维蛋白或纤维蛋白/细胞悬浮液电沉积到一个亚晶体上以形成组织和器官。
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公开(公告)号：US07759082B2
公开(公告)日：2010-07-20
申请号：US10764691
申请日：2004-01-26
IPC分类号： C12Q1/56
CPC分类号： C12N5/0622 , A61K35/12 , A61K2035/126 , A61L15/32 , A61L27/225 , A61L27/24 , A61L27/26 , A61L27/38 , A61L31/041 , A61L2400/04 , B29C41/006 , C07K14/75 , C07K14/78 , C12N5/0012 , C12N5/0062 , C12N5/0068 , C12N2503/00 , C12N2510/00 , C12N2533/40 , C12N2533/54 , C12N2533/56 , C08L89/00
摘要： The invention is directed to formation and use of electroprocessed fibrin as an extracellular matrix and, together with cells, its use in forming engineered tissue. The engineered tissue can include the synthetic manufacture of specific organs or tissues which may be implanted into a recipient. The electroprocessed fibrin may also be combined with other molecules in order to deliver the molecules to the site of application or implantation of the electroprocessed fibrin. The fibrin or fibrin/cell suspension is electrodeposited onto a substrate to form the tissues and organs.
摘要翻译： 本发明涉及形成和使用电加工的纤维蛋白作为细胞外基质，并与细胞一起用于形成工程化组织。 工程组织可以包括可以植入受体的特定器官或组织的合成制造。 电加工的纤维蛋白也可以与其它分子组合以将分子递送到电加工的纤维蛋白的施用位点或植入。 将纤维蛋白或纤维蛋白/细胞悬浮液电沉积在基质上以形成组织和器官。
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