公开(公告)号：US10131644B2

公开(公告)日：2018-11-20

申请号：US15199447

申请日：2016-06-30

Applicant: Genentech, Inc.

Inventor： Monique Bodil van Niel ,  Benjamin Fauber ,  Emanuela Gancia ,  Simon Gaines ,  Alberto Gobbi ,  Christopher Hurley ,  Tammy Ladduwahetty ,  Olivier Rene ,  David Vesey ,  Stuart Ward ,  Paul Winship

IPC: C07D279/02 ,  C07D417/10 ,  C07D417/12

Abstract: Compounds of the formula I: or pharmaceutically acceptable salts thereof, wherein m, n, p, q, r, X1, X2, X3, X4, Y, Z, A, R1, R2, R3, R4, R5 R6, R7, R8, R9, R10, R11, R12 and R13 are as defined herein. Also disclosed are methods of making the compounds and using the compounds for treatment of inflammatory diseases such as arthritis, muscular sclerosis and psoriasis.

公开(公告)号：US09550771B2

公开(公告)日：2017-01-24

申请号：US14481991

申请日：2014-09-10

Applicant: Genentech, Inc.

Inventor： Benjamin Fauber ,  Alberto Gobbi

IPC: C07D471/04 ,  C07D487/04

CPC classification number: C07D471/04 ,  C07D487/04

Abstract: Compounds of the formula I or II: or pharmaceutically acceptable salts thereof, wherein R1 is a group of formula (a), (b), (c); (d) or (e): and m, n, X, Y, R1, R2, R3, R4, Rb and Rc are as defined herein. Also disclosed are methods of making the compounds and using the compounds for treatment of inflammatory diseases such as arthritis.

Abstract translation: 并且m，n，X，Y，R 1，R 2，R 3，R 4，R b和R c如本文所定义。 还公开了制备化合物和使用该化合物治疗炎性疾病如关节炎的方法。

公开(公告)号：US20160168141A1

公开(公告)日：2016-06-16

申请号：US15047523

申请日：2016-02-18

Applicant: Genentech, Inc.

Inventor： Benjamin Fauber ,  Alberto Gobbi ,  Olivier Rene ,  Monique Bodil van Niel ,  Emanuela Gancia ,  Simon Gaines ,  Tammy Ladduwahetty ,  David Vesey ,  Stuart Ward ,  Paul Winship

IPC: C07D417/10

CPC classification number: C07D417/10 ,  C07D279/02 ,  C07D417/12 ,  C07D417/14 ,  C07D487/08 ,  C07D491/107 ,  C07D491/113

Abstract: Compounds of the formula I: or pharmaceutically acceptable salts thereof, wherein m, n, p, q, r, A, W, X1, X2, X3, X4, Y, Z, R1, R2, R3, R4, R5, R6, R7, R8, R9, R10, R11 and R12 are as defined herein. Also disclosed are methods of making the compounds and using the compounds for treatment of inflammatory diseases such as arthritis.

公开(公告)号：US20220332718A1

公开(公告)日：2022-10-20

申请号：US17172766

申请日：2021-02-10

Applicant: Genentech, Inc.

Inventor： Marian C. Bryan ,  Alberto Gobbi ,  James Richard Kiefer, Jr. ,  Aleksandr Kolesnikov ,  Alan G. Olivero ,  Joy Drobnick ,  Jun Liang ,  Naomi Rajapaksa ,  Chudi Ndubaku ,  Jianwen Feng

IPC: C07D487/04 ,  A61P37/02 ,  A61P35/00 ,  C07D519/00 ,  A61P29/00

Abstract: A method for treating an inflammatory or autoimmune disease with compounds of Formula 0, Formula I, and Formula II and methods of use as Interleukin-1 Receptor Associated Kinase (IRAK4) inhibitors are described herein.

公开(公告)号：US11034698B2

公开(公告)日：2021-06-15

申请号：US16715933

申请日：2019-12-16

Applicant: Genentech, Inc.

Inventor： Marian C. Bryan ,  Steven Do ,  Joy Drobnick ,  Alberto Gobbi ,  Tamiko Katsumoto ,  James Richard Kiefer, Jr. ,  Jun Liang ,  Naomi S. Rajapaksa ,  Yongsheng Chen ,  Liqiang Fu ,  Kwong Wah Lai ,  Zhiguo Liu ,  John Wai ,  Fei Wang

IPC: C07D487/04 ,  C07D519/00

Abstract: Compounds of Formula I, Formula II, Formula III, Formula IV, Formula V, Formula VI, Formula VII, Formula VIII, and methods of use as Interleukin-1 Receptor Associated Kinase (IRAK4) inhibitors are described herein.

公开(公告)号：US20190263794A1

公开(公告)日：2019-08-29

申请号：US16398795

申请日：2019-04-30

Applicant: Genentech, Inc.

Inventor： Sarah M. Bronner ,  James J. Crawford ,  Andrew Cridland ,  Patrick Cyr ,  Benjamin Fauber ,  Emanuela Gancia ,  Alberto Gobbi ,  Christopher Hurley ,  Jonathan Killen ,  Wendy Lee ,  Olivier Rene ,  Monique Bodil Van Niel ,  Stuart Ward ,  Paul Winship ,  Jason Zbieg

IPC: C07D413/14 ,  C07D403/14 ,  C07D405/14

Abstract: Compounds of formula I: or pharmaceutical salts thereof, wherein m, n, p, q A, B, R1, R2, R3, R4, R5, R6 and R7 are as defined herein. Also disclosed are methods of making the compounds and using the compounds for treatment of inflammatory diseases such as arthritis.

公开(公告)号：US09981916B2

公开(公告)日：2018-05-29

申请号：US14533358

申请日：2014-11-05

Applicant: Genentech, Inc.

Inventor： Monique Bodil van Niel ,  Andrew Cridland ,  Benjamin Fauber ,  Alberto Gobbi ,  Christopher Hurley ,  David Hurst ,  Jonathan Killen ,  Robert Maxey ,  Stuart Ward

IPC: C07D237/28 ,  C07D403/06 ,  C07D413/06 ,  C07D401/04 ,  C07D417/04 ,  C07D405/12 ,  C07D491/048 ,  C07D403/14 ,  C07D491/107 ,  C07D401/12

CPC classification number: C07D237/28 ,  C07D401/04 ,  C07D401/12 ,  C07D403/06 ,  C07D403/14 ,  C07D405/12 ,  C07D413/06 ,  C07D417/04 ,  C07D491/048 ,  C07D491/107

Abstract: Compounds of the formula I: or a pharmaceutical salt thereof, wherein X, Ar1, R1, R2, R3, R4, R5, R6 and R7 are as defined herein. Also disclosed are methods of making the compounds and using the compounds for treatment of inflammatory diseases such as arthritis.

公开(公告)号：US20140031330A1

公开(公告)日：2014-01-30

申请号：US13939962

申请日：2013-07-11

Applicant: Genentech, Inc.

Inventor： Monique Bodil van Niel ,  Benjamin Fauber ,  Simon Gaines ,  Alberto Gobbi ,  Olivier Rene ,  David Vesey ,  Stuart Ward

IPC: C07D487/04 ,  C07D417/12 ,  C07D471/04 ,  C07D295/185

CPC classification number: C07D295/185 ,  C07D275/02 ,  C07D279/02 ,  C07D281/02 ,  C07D291/02 ,  C07D417/10 ,  C07D417/12 ,  C07D417/14 ,  C07D451/14 ,  C07D471/04 ,  C07D471/08 ,  C07D471/10 ,  C07D487/04 ,  C07D487/08 ,  C07D491/10 ,  C07D498/10 ,  C07D513/10 ,  C07D515/12

Abstract: Compounds of the formula I: or pharmaceutically acceptable salts thereof, wherein m, n, p, q, r, A, W, X1, X2, X3, X4, Y, Z, R1, R2, R3, R4, R5, R6, R7, R8, R9, R10, R11, and R12 are as defined herein. Also disclosed are methods of making the compounds and using the compounds for treatment of inflammatory diseases such as arthritis.

Abstract translation: 式I化合物或其药学上可接受的盐，其中m，n，p，q，r，A，W，X1，X2，X3，X4，Y，Z，R1，R2，R3，R4，R5，R6 ，R7，R8，R9，R10，R11和R12如本文所定义。 还公开了制备化合物和使用该化合物治疗炎性疾病如关节炎的方法。