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公开(公告)号：US20160039770A1
公开(公告)日：2016-02-11
申请号：US14821931
申请日：2015-08-10
Applicant: Genentech, Inc.
Inventor： Nicholas D. Smith , Mark R. Herbert
IPC: C07D231/56
CPC classification number: C07D231/56
Abstract: Described herein are amorphous and crystalline forms of pharmaceutically acceptable salts of the estrogen receptor modulator (E)-3-(4-((E)-2-(2-chloro-4-fluorophenyl)-1-(1H-indazol-5-yl)but-1-en-1-yl)phenyl)acrylic acid. Also described are pharmaceutical compositions suitable for administration to a mammal that include the estrogen receptor modulator, and methods of using the estrogen receptor modulator, alone and in combination with other compounds, for treating diseases or conditions that are associated with estrogen receptor activity.
Abstract translation: 本文描述的是雌激素受体调节剂（E）-3-（4 - （（E）-2-（2-氯-4-氟苯基）-1-（1H-吲唑-5-基） - 基）丁-1-烯-1-基）苯基）丙烯酸。 还描述了适用于给予包括雌激素受体调节剂的哺乳动物的药物组合物，以及使用雌激素受体调节剂单独使用并与其它化合物组合用于治疗与雌激素受体活性相关的疾病或病症的方法。
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公开(公告)号：US09868704B2
公开(公告)日：2018-01-16
申请号：US15186246
申请日：2016-06-17
Applicant: GENENTECH, INC.
Inventor： Nicholas D. Smith , Mehmet Kahraman , Steven P. Govek , Johnny Y. Nagasawa , Andiliy G. Lai , Jackaline D. Julien , Mark R. Herbert , Karensa L. Douglas
IPC: C07D231/56 , A61K31/416 , C07D209/08 , C07D249/18 , A61K31/7056 , A61K31/7068 , A61K31/7072 , A61K31/7076 , A61K31/708 , A61K31/7105 , C07D215/227 , C07D217/24 , C07D265/18 , C07D277/68 , C07D279/16 , C07D401/10 , C07D409/10 , C07D471/04 , C07D495/04 , C07D401/12 , C07D403/10 , C07D413/10 , C07D417/10 , C07C215/10
CPC classification number: C07D231/56 , A61K31/416 , A61K31/7056 , A61K31/7068 , A61K31/7072 , A61K31/7076 , A61K31/708 , A61K31/7105 , C07C215/10 , C07D209/08 , C07D215/227 , C07D217/24 , C07D249/18 , C07D265/18 , C07D277/68 , C07D279/16 , C07D401/10 , C07D401/12 , C07D403/10 , C07D409/10 , C07D413/10 , C07D417/10 , C07D471/04 , C07D495/04
Abstract: Described herein are compounds that are estrogen receptor modulators. Also described are pharmaceutical compositions and medicaments that include the compounds described herein, as well as methods of using such estrogen receptor modulators, alone and in combination with other compounds, for treating diseases or conditions that are mediated or dependent upon estrogen receptors.
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公开(公告)号：US20170275273A1
公开(公告)日：2017-09-28
申请号：US15620304
申请日：2017-06-12
Applicant: Genentech, Inc.
Inventor： Mehmet Kahraman , Steven P. Govek , Nicholas D. Smith , Jeffrey H. Hager , Edna Chow Maneval
IPC: C07D405/12 , A61K9/00 , A61K47/10 , A61K45/06 , A61K47/14 , A61K31/397 , A61K9/48 , A61K47/38 , A61K9/20
CPC classification number: C07D405/12 , A61K9/0014 , A61K9/0019 , A61K9/0095 , A61K9/2054 , A61K9/4866 , A61K31/397 , A61K45/06 , A61K47/10 , A61K47/14 , A61K47/38 , A61K2300/00
Abstract: Described herein are compounds that are estrogen receptor modulators. Also described are pharmaceutical compositions and medicaments that include the compounds described herein, as well as methods of using such estrogen receptor modulators, alone and in combination with other compounds, for treating diseases or conditions that are mediated or dependent upon estrogen receptors.
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公开(公告)号：US09655880B2
公开(公告)日：2017-05-23
申请号：US15256879
申请日：2016-09-06
Applicant: Genentech, Inc.
Inventor： Steven P. Govek , Mehmet Kahraman , Nicholas D. Smith , Jeffrey H. Hager , Edna Chow Maneval
IPC: A61K31/397 , A61K9/00 , A61K9/08 , A61K9/20 , A61K9/48 , A61K45/06 , A61K9/06 , C07D405/12
CPC classification number: A61K31/397 , A61K9/0014 , A61K9/0053 , A61K9/06 , A61K9/08 , A61K9/20 , A61K9/48 , A61K45/06 , C07D405/12
Abstract: Described herein are compounds that are estrogen receptor modulators. Also described are pharmaceutical compositions and medicaments that include the compounds described herein, as well as methods of using such estrogen receptor modulators, alone and in combination with other compounds, for treating diseases or conditions that are mediated or dependent upon estrogen receptors.
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公开(公告)号：US20160367526A1
公开(公告)日：2016-12-22
申请号：US15256879
申请日：2016-09-06
Applicant: Genentech, Inc.
Inventor： Steven P. Govek , Mehmet Kahraman , Nicholas D. Smith , Jeffrey H. Hager , Edna Chow Maneval
CPC classification number: A61K31/397 , A61K9/0014 , A61K9/0053 , A61K9/06 , A61K9/08 , A61K9/20 , A61K9/48 , A61K45/06 , C07D405/12
Abstract: Described herein are compounds that are estrogen receptor modulators. Also described are pharmaceutical compositions and medicaments that include the compounds described herein, as well as methods of using such estrogen receptor modulators, alone and in combination with other compounds, for treating diseases or conditions that are mediated or dependent upon estrogen receptors.
Abstract translation: 本文描述的是雌激素受体调节剂的化合物。 还描述了包括本文所述化合物的药物组合物和药物，以及使用这种雌激素受体调节剂单独使用并与其它化合物联合用于治疗介导或依赖于雌激素受体的疾病或病症的方法。
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Patent Agency Ranking
公开(公告)号：US20160304450A1
公开(公告)日：2016-10-20
申请号：US14972333
申请日：2015-12-17
Applicant: Genentech, Inc.
Inventor： Jun Liang , Daniel Fred Ortwine , Xiaojing Wang , Steven P. Govek , Mehmet Kahraman , Johnny Y. Nagasawa , Nicholas D. Smith , Simon Charles Goodacre , Nicholas Charles Ray
IPC: C07D205/04 , A61K31/404 , A61K45/06 , A61K31/397 , C07D207/04 , A61K31/40 , C07D409/12 , A61K31/4025 , C07D413/12 , A61K31/422 , C07D417/12 , A61K31/427 , C07D401/14 , A61K31/4439 , C07D411/12 , C07D403/12
CPC classification number: C07D205/04 , A61K31/381 , A61K31/397 , A61K31/40 , A61K31/4025 , A61K31/404 , A61K31/416 , A61K31/422 , A61K31/426 , A61K31/427 , A61K31/4439 , A61K31/5415 , A61K45/06 , C07D207/04 , C07D207/08 , C07D401/14 , C07D403/02 , C07D403/12 , C07D403/14 , C07D409/02 , C07D409/12 , C07D411/02 , C07D411/12 , C07D413/02 , C07D413/12 , C07D417/02 , C07D417/12 , C07D417/14 , C07D493/04 , A61K2300/00
Abstract: Described herein are compounds that are estrogen receptor modulators of Formula (I): and stereoisomers, tautomers, or pharmaceutically acceptable salts thereof, wherein SERMF is a selective estrogen receptor modulator fragment and with the substituents and structural features described herein. Also described are pharmaceutical compositions and medicaments that include the compounds described herein, as well as methods of using such estrogen receptor modulators, alone and in combination with other compounds, for treating diseases or conditions that are mediated or dependent upon estrogen receptors.
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公开(公告)号：US20160297767A1
公开(公告)日：2016-10-13
申请号：US15186246
申请日：2016-06-17
Applicant: GENENTECH, INC.
Inventor： Nicholas D. Smith , Mehmet Kahraman , Steven P. Govek , Johnny Y. Nagasawa , Andiliy G. Lai , Jackaline D. Julien , Mark R. Herbert , Celine Bonnefous , Karensa L. Douglas
IPC: C07D231/56 , C07C215/10
CPC classification number: C07D231/56 , A61K31/416 , A61K31/7056 , A61K31/7068 , A61K31/7072 , A61K31/7076 , A61K31/708 , A61K31/7105 , C07C215/10 , C07D209/08 , C07D215/227 , C07D217/24 , C07D249/18 , C07D265/18 , C07D277/68 , C07D279/16 , C07D401/10 , C07D401/12 , C07D403/10 , C07D409/10 , C07D413/10 , C07D417/10 , C07D471/04 , C07D495/04
Abstract: Described herein are compounds that are estrogen receptor modulators. Also described are pharmaceutical compositions and medicaments that include the compounds described herein, as well as methods of using such estrogen receptor modulators, alone and in combination with other compounds, for treating diseases or conditions that are mediated or dependent upon estrogen receptors.
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公开(公告)号：US20160090378A1
公开(公告)日：2016-03-31
申请号：US14963658
申请日：2015-12-09
Applicant: Genentech, Inc.
Inventor： Mehmet Kahraman , Steven P. Govek , Nicholas D. Smith , Jeffrey H. Hager , Edna Chow Maneval
IPC: C07D405/12 , A61K45/06 , A61K31/397
CPC classification number: C07D405/12 , A61K9/0014 , A61K9/0019 , A61K9/0095 , A61K9/2054 , A61K9/4866 , A61K31/397 , A61K45/06 , A61K47/10 , A61K47/14 , A61K47/38 , A61K2300/00
Abstract: Described herein are compounds that are estrogen receptor modulators. Also described are pharmaceutical compositions and medicaments that include the compounds described herein, as well as methods of using such estrogen receptor modulators, alone and in combination with other compounds, for treating diseases or conditions that are mediated or dependent upon estrogen receptors.
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公开(公告)号：US10227334B2
公开(公告)日：2019-03-12
申请号：US15620304
申请日：2017-06-12
Applicant: Genentech, Inc.
Inventor： Mehmet Kahraman , Steven P. Govek , Nicholas D. Smith , Jeffrey H. Hager , Edna Chow Maneval
IPC: C07D405/12 , A61K31/397 , A61K45/06 , A61K47/10 , A61K47/14 , A61K47/38 , A61K9/00 , A61K9/20 , A61K9/48
Abstract: Described herein are compounds that are estrogen receptor modulators. Also described are pharmaceutical compositions and medicaments that include the compounds described herein, as well as methods of using such estrogen receptor modulators, alone and in combination with other compounds, for treating diseases or conditions that are mediated or dependent upon estrogen receptors.
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公开(公告)号：US09783503B2
公开(公告)日：2017-10-10
申请号：US14821931
申请日：2015-08-10
Applicant: Genentech, Inc.
Inventor： Nicholas D. Smith , Mark R. Herbert
IPC: C07D231/56
CPC classification number: C07D231/56
Abstract: Described herein are amorphous and crystalline forms of pharmaceutically acceptable salts of the estrogen receptor modulator (E)-3-(4-((E)-2-(2-chloro-4-fluorophenyl)-1-(1H-indazol-5-yl)but-1-en-1-yl) phenyl)acrylic acid. Also described are pharmaceutical compositions suitable for administration to a mammal that include the estrogen receptor modulator, and methods of using the estrogen receptor modulator, alone and in combination with other compounds, for treating diseases or conditions that are associated with estrogen receptor activity.
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