公开(公告)号：US20140286963A1

公开(公告)日：2014-09-25

申请号：US14292461

申请日：2014-05-30

Applicant: Genentech, Inc.

Inventor： Jasvinder Atwal ,  Yongmei Chen ,  Cecilia Pui Chi Chiu ,  Robert A. Lazarus ,  Weiru Wang ,  Ryan J. Watts ,  Yan Wu ,  Yingnan Zhang

IPC: C07K16/40 ,  G01N33/573 ,  A61K47/48

CPC classification number: C07K16/40 ,  A61K39/3955 ,  A61K47/6871 ,  A61K2039/505 ,  C07K2317/51 ,  C07K2317/515 ,  C07K2317/56 ,  C07K2317/565 ,  C07K2317/76 ,  C07K2317/92 ,  C12P21/005 ,  G01N33/573

Abstract: The invention provides antibodies to specific neural proteins and methods of using the same.

Abstract translation: 本发明提供了针对特定神经蛋白的抗体及其使用方法。

公开(公告)号：US20230416825A1

公开(公告)日：2023-12-28

申请号：US18192505

申请日：2023-03-29

Applicant: Genentech, Inc.

Inventor： Amy Dressen ,  David B. Iaea ,  Moulay Hicham Alaoui Ismaili ,  Janet K. Jackman ,  Robert A. Lazarus ,  Kelly Michele Loyet ,  Henry R. Maun ,  Brian Louis Yaspan ,  Tangsheng Yi ,  Joseph R. Arron ,  Hilda Y Hernandez-Barry

IPC: C12Q1/6883 ,  C07K16/40 ,  C07K14/81 ,  G01N33/68 ,  C12N9/64

CPC classification number: C12Q1/6883 ,  C07K16/40 ,  C07K14/8135 ,  G01N33/6893 ,  C12N9/6445 ,  C12Q2600/106 ,  C12Q2600/156 ,  A61K38/00

Abstract: Provided herein are methods of treating a subject, methods of predicting the response of a subject and selecting a subject suffering from a disease associated with KLK5, such as asthma or Netherton Syndrome. In particular, provided herein are uses of KLK5 antagonists for the treatment or diagnosis of asthma or Netherton Sydrome, such as an antibody or an Fc fusion polypeptide as well as pharmaceutical formulations comprising the same.

公开(公告)号：US20170058049A1

公开(公告)日：2017-03-02

申请号：US15234649

申请日：2016-08-11

Applicant: Genentech, Inc.

Inventor： Jasvinder Atwal ,  Yongmei Chen ,  Cecilia Pui Chi Chiu ,  Robert A. Lazarus ,  Weiru Wang ,  Ryan J. Watts ,  Yan Wu ,  Yingnan Zhang

IPC: C07K16/40 ,  C12P21/00

CPC classification number: C07K16/40 ,  A61K39/3955 ,  A61K47/6871 ,  A61K2039/505 ,  C07K2317/51 ,  C07K2317/515 ,  C07K2317/56 ,  C07K2317/565 ,  C07K2317/76 ,  C07K2317/92 ,  C12P21/005 ,  G01N33/573

Abstract: The invention provides antibodies to specific neural proteins and methods of using the same.

Abstract translation: 本发明提供了针对特定神经蛋白的抗体及其使用方法。

公开(公告)号：US20140228277A1

公开(公告)日：2014-08-14

申请号：US14351525

申请日：2012-10-12

Applicant: GENENTECH, INC. ,  F. Hoffman-La Roche AG

Inventor： Robert A. Lazarus ,  Yingnan Zhang ,  Weiru Wang

IPC: C07K7/08 ,  C07K16/38

CPC classification number: C07K7/08 ,  A61K38/00 ,  C07K16/38 ,  G01N33/6896 ,  Y02A50/465

Abstract: The invention provides peptide inhibitors of BACE1 that bind to the active site in a noncanonical fashion, and methods of use thereof.

Abstract translation: 本发明提供了以非规范方式结合活性位点的BACE1肽抑制剂及其使用方法。

公开(公告)号：US08623821B2

公开(公告)日：2014-01-07

申请号：US13650958

申请日：2012-10-12

Applicant: Genentech, Inc.

Inventor： Kyle E. Landgraf ,  Robert A. Lazarus

IPC: A61K38/26 ,  A61P3/10 ,  A61P7/12 ,  C07K14/605

CPC classification number: C07K14/4753 ,  C07K7/06

Abstract: Provided herein are zymogen activating molecules such as zymogen activating peptides, and methods of identifying and using these zymogen activating molecules such as zymogen activating peptides.

Abstract translation: 本文提供了酶原激活分子，例如酶原活化肽，以及鉴定和使用这些酶原活化分子如酶原活化肽的方法。

公开(公告)号：US20130096072A1

公开(公告)日：2013-04-18

申请号：US13650958

申请日：2012-10-12

Applicant: Genentech, Inc.

Inventor： Kyle E. Landgraf ,  Robert A. Lazarus

IPC: C07K14/00 ,  C07K2/00 ,  C07K17/08 ,  C07K17/10 ,  C07K17/12 ,  C40B30/04 ,  A61K38/16 ,  A61P1/16 ,  C07K4/00 ,  A61K38/03 ,  G01N33/566 ,  C07K5/103 ,  C07K19/00

CPC classification number: C07K14/4753 ,  C07K7/06

Abstract: Provided herein are zymogen activating molecules such as zymogen activating peptides, and methods of identifying and using these zymogen activating molecules such as zymogen activating peptides.

Abstract translation: 本文提供了酶原激活分子，例如酶原活化肽，以及鉴定和使用这些酶原活化分子如酶原活化肽的方法。