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公开(公告)号：US20180186875A1
公开(公告)日：2018-07-05
申请号：US15895741
申请日：2018-02-13
Applicant: Genentech, Inc.
Inventor： Jane L. GROGAN , Robert J. JOHNSTON , Yan WU , Wei-Ching LIANG , Patrick LUPARDUS , Mahesh YADAV , Dhaya SESHASAYEE , Meredith HAZEN
CPC classification number: C07K16/28 , A61K38/177 , A61K39/39558 , A61K45/06 , A61K2039/505 , A61K2039/507 , C07K16/2818 , C07K16/2827 , C07K16/2878 , C07K16/3061 , C07K2317/24 , C07K2317/33 , C07K2317/34 , C07K2317/55 , C07K2317/56 , C07K2317/567 , C07K2317/70 , C07K2317/75 , C07K2317/76 , C07K2317/90 , C07K2317/92 , C07K2317/94 , Y02A50/466
Abstract: The invention provides anti-TIGIT (T-cell immunoreceptor with Ig and ITIM domains) antibodies and methods of using the same.
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公开(公告)号：US20170073405A1
公开(公告)日：2017-03-16
申请号：US15137577
申请日：2016-04-25
Applicant: Genentech, Inc.
Inventor： Germaine FUH , Hans-Peter GERBER , Wei-Ching LIANG , Frederic FELLOUSE , Sachdev S. SIDHU , Christian WIESMANN
CPC classification number: C07K16/22 , A61K2039/505 , C07K16/005 , C07K16/32 , C07K2317/24 , C07K2317/31 , C07K2317/55 , C07K2317/56 , C07K2317/565 , C07K2317/73 , C07K2317/76 , C07K2317/92 , G01N33/6845
Abstract: Anti-VEGF antibodies and variants thereof, including those having high affinity for binding to VEGF, are disclosed. Also provided are methods of using phage display technology with naïve libraries to generate and select the anti-VEGF antibodies with desired binding and other biological activities. Further contemplated are uses of the antibodies in research, diagnostic and therapeutic applications.
Abstract translation: 公开了抗VEGF抗体及其变体，包括对VEGF结合具有高亲和力的抗体。 还提供了使用噬菌体展示技术与初始文库产生和选择具有所需结合和其他生物活性的抗VEGF抗体的方法。 进一步考虑的是抗体在研究，诊断和治疗应用中的用途。
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公开(公告)号：US20150232549A1
公开(公告)日：2015-08-20
申请号：US14636782
申请日：2015-03-03
Applicant: Genentech, Inc.
Inventor： Germaine FUH , Hans-Peter GERBER , Wei-Ching LIANG , Frederic FELLOUSE , Sachdev S. SIDHU , Christian WIESMANN
IPC: C07K16/22
CPC classification number: C07K16/22 , A61K2039/505 , C07K16/005 , C07K16/32 , C07K2317/24 , C07K2317/31 , C07K2317/55 , C07K2317/56 , C07K2317/565 , C07K2317/73 , C07K2317/76 , C07K2317/92 , G01N33/6845
Abstract: Anti-VEGF antibodies and variants thereof, including those having high affinity for binding to VEGF, are disclosed. Also provided are methods of using phage display technology with naïve libraries to generate and select the anti-VEGF antibodies with desired binding and other biological activities. Further contemplated are uses of the antibodies in research, diagnostic and therapeutic applications.
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公开(公告)号：US20240067752A1
公开(公告)日：2024-02-29
申请号：US18474445
申请日：2023-09-26
Applicant: Genentech, Inc.
Inventor： Robert F. KELLEY , Daniel K. KIRCHHOFER , Joyce LAI , Chingwei V. LEE , Wei-Ching LIANG , Michael T. LIPARI , Kelly M. LOYET , Tao SAI , Menno VAN LOOKEREN CAMPAGNE , Yan WU , Germaine FUH
IPC: C07K16/40 , A61K39/395
CPC classification number: C07K16/40 , A61K39/3955 , A61K2039/507 , C07K2317/24 , C07K2317/34 , C07K2317/53 , C07K2317/55 , C07K2317/92 , C07K2317/94
Abstract: The present invention provides anti-HtrA1 antibodies (including bispecific anti-HtrA1 anti-Factor D antibodies) and methods of making and using the same, for example, in methods of treating HtrA1-associated disorders, ocular disorders, and/or complement-associated disorders.
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公开(公告)号：US20210253693A1
公开(公告)日：2021-08-19
申请号：US17244682
申请日：2021-04-29
Applicant: Genentech, Inc.
Inventor： Jane L. GROGAN , Robert J. JOHNSTON , Yan WU , Wei-Ching LIANG , Patrick LUPARDUS , Mahesh YADAV , Dhaya SESHASAYEE , Meredith HAZEN
IPC: C07K16/28 , C07K16/30 , A61K39/395 , A61K45/06 , A61K38/17
Abstract: The invention provides anti-TIGIT (T-cell immunoreceptor with Ig and ITIM domains) antibodies and methods of using the same.
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Patent Agency Ranking
公开(公告)号：US20210032328A1
公开(公告)日：2021-02-04
申请号：US17064464
申请日：2020-10-06
Applicant: Genentech, Inc.
Inventor： Jane L. GROGAN , Robert J. JOHNSTON , Yan WU , Wei-Ching LIANG , Patrick LUPARDUS , Mahesh YADAV , Dhaya SESHASAYEE , Meredith HAZEN
IPC: C07K16/28 , C07K16/30 , A61K39/395 , A61K45/06 , A61K38/17
Abstract: The invention provides anti-TIGIT (T-cell immunoreceptor with Ig and ITIM domains) antibodies and methods of using the same.
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公开(公告)号：US20170342163A1
公开(公告)日：2017-11-30
申请号：US15653201
申请日：2017-07-18
Applicant: Genentech, Inc.
Inventor： Yan WU , Menno van LOOKEREN CAMPAGNE , Daniel KIRCHHOFER , Michael Terry LIPARI , Kenneth J. KATSCHKE, Jr. , Paul M. MORAN , Scott STAWICKI , Wei-Ching LIANG
IPC: C07K16/40
CPC classification number: C07K16/40 , C07K2317/34 , C07K2317/76 , C07K2317/92
Abstract: The invention provides anti-HtrA1 antibodies and methods of using the same.
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公开(公告)号：US20170239366A1
公开(公告)日：2017-08-24
申请号：US15386577
申请日：2016-12-21
Applicant: Genentech, Inc.
Inventor： Steven R. LEONG , Andrew POLSON , Paul POLAKIS , Yan WU , Wei-Ching LIANG , Ron FIRESTEIN
IPC: A61K47/48 , A61K31/5377 , C07K16/30 , A61K31/5517 , A61K39/395 , C07K19/00
CPC classification number: C07K16/3015 , A61K31/5377 , A61K31/5517 , A61K39/3955 , A61K45/06 , A61K47/6803 , A61K47/6849 , A61K51/1027 , A61K2039/505 , C07K16/2827 , C07K16/3069 , C07K2317/24 , C07K2317/33 , C07K2317/34 , C07K2317/41 , C07K2317/567 , C07K2317/77 , C07K2317/92 , G01N33/57492 , A61K2300/00
Abstract: The invention provides anti-B7-H4 antibodies and immunoconjugates and methods of using the same.
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公开(公告)号：US20170145113A1
公开(公告)日：2017-05-25
申请号：US15336171
申请日：2016-10-27
Applicant: Genentech, Inc.
Inventor： Robert F. KELLEY , Daniel K. KIRCHHOFER , Joyce LAI , Chingwei V. LEE , Wei-Ching LIANG , Michael T. LIPARI , Kelly M. LOYET , Tao SAI , Menno VAN LOOKEREN CAMPAGNE , Yan WU , Germaine FUH
IPC: C07K16/40
Abstract: The present invention provides anti-HtrA1 antibodies (including bispecific anti-HtrA1 anti-Factor D antibodies) and methods of making and using the same, for example, in methods of treating HtrA1-associated disorders, ocular disorders, and/or complement-associated disorders.
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公开(公告)号：US20150203581A1
公开(公告)日：2015-07-23
申请号：US14593950
申请日：2015-01-09
Applicant: GENENTECH, INC.
Inventor： Wei-Ching LIANG , Gregory D. PLOWMAN , Yan WU , Weilan YE
CPC classification number: C07K16/2842 , A61K47/6835 , A61K2039/505 , A61K2039/507 , C07K16/22 , C07K2317/24 , C07K2317/31 , C07K2317/56 , C07K2317/565 , C07K2317/92 , Y02A50/386 , Y02A50/41 , Y02A50/412
Abstract: The present invention provides new anti-α5β1 antibodies, compositions and kits comprising the antibodies, and methods of making and using the antibodies.
Abstract translation: 本发明提供新的抗α5和bgr1抗体，包含抗体的组合物和试剂盒，以及制备和使用抗体的方法。
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