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公开(公告)号：US5155045A
公开(公告)日：1992-10-13
申请号：US857935
申请日：1986-04-30
IPC分类号： A61K31/565
CPC分类号： A61K31/565 , Y10S436/817 , Y10S436/906 , Y10T436/200833 , Y10T436/203332
摘要： A novel method for treating a human female is disclosed comprising the step of exposing the nasal region of said female to at least a portion of the axillary secretions of a human male. This exposure is preferably continued in amounts and for a duration which are effective to significantly alter an endocrine related characteristic, such as the menstrual cycle length, of that female. In particular, the portions of male axillary secretions to be exposed to the female preferably comprise one or more compounds such as androstenol, dehydroepiandrosterone, and/or a compound or compounds exhibiting a burnt heavy axiallary-like odor which elutes at about 50 minutes as shown on the FID response curve of FIG. 3B. Studies show that pooled male donor secretions are effective to alter aberrant menstrual cycles, particularly those exhibiting luteal phase defects such that they become presumptively fertile menstrual cycles having durations of about 29.5.+-.3 days. Symptoms of perimenopause, such as hot flashes, night sweats and irregular menstrual cycles, are also treatable using the methods of this invention, which tend to promote female endocrine regularity and longevity.
摘要翻译： 公开了一种治疗人类雌性的新方法，其包括将所述雌性的鼻腔暴露于人雄性的至少一部分腋窝分泌物的步骤。 这种暴露优选以有效显着改变该女性的内分泌相关特征（例如月经周期长度）的量和持续时间持续。 特别地，暴露于雌性的男性腋窝分泌物的部分优选包含一种或多种化合物，例如雄蕊醇，脱氢表雄酮和/或显示烧焦的重轴向样气味的化合物或化合物，其如图所示在约50分钟洗脱 在图1的FID响应曲线上。 3B。 研究表明，合并的雄性供体分泌物可有效改变异常月经周期，特别是那些呈现黄体期缺陷的那些，使得它们被假定为具有约29.5 +/- 3天持续时间的肥沃的月经周期。 围绝经期的症状，如潮热，盗汗和不规律的月经周期，也可使用本发明的方法治疗，这倾向于促进女性的内分泌规律性和长寿。
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公开(公告)号：US3986494A
公开(公告)日：1976-10-19
申请号：US519220
申请日：1974-10-30
CPC分类号： A61B10/0012 , A61D17/002 , G01N33/52 , A61B2010/0006 , Y10S436/906 , Y10T436/201666
摘要： A method of monitoring the concentration of a given volatile organic compound commonly found in vaginal secretions is described as providing a reliable diagnostic indication of ovulation, and more particularly is described as providing a simple home-test method of predicting the onset of the fertile period, thereby increasing the reliability of the "rhythm metod" of birth control.
摘要翻译： 描述了通常在阴道分泌物中发现的给定挥发性有机化合物的浓度的监测方法，提供了排卵的可靠诊断指示，更具体地说，提供了一种预测可育期发病的简单家庭测试方法， 从而提高了避孕节奏的可靠性。
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13.发明授权Method of detecting the presence of bronchogenic carcinoma by analysis of expired lung air 失效通过分析过期肺空气检测支气管癌的存在的方法
公开(公告)号：US4772559A
公开(公告)日：1988-09-20
申请号：US32951
申请日：1987-03-31
申请人： George Preti , John N. Labows , Ronald Daniele , James G. Kostelc
发明人： George Preti , John N. Labows , Ronald Daniele , James G. Kostelc
IPC分类号： G01N33/497 , G01N33/00 , G01N33/48
CPC分类号： G01N33/497 , Y10S436/813 , Y10S436/90 , Y10T436/145555 , Y10T436/173845 , Y10T436/212
摘要： A novel method of detecting and diagnosing lung cancers by monitoring and analyzing expired lung air for the presence of selected aromatic amines, particularly aniline and ortho-toluidine, is provided.
摘要翻译： 提供了通过监测和分析过期肺空气来检测和诊断肺癌的新方法，用于选择的芳族胺，特别是苯胺和邻甲苯胺的存在。
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14.发明授权Method for detecting bovine estrus by determining methyl heptanol concentrations in vaginal secretions 失效通过测定阴道分泌物中的甲基庚醇浓度来检测牛发情的方法
公开(公告)号：US4467814A
公开(公告)日：1984-08-28
申请号：US359954
申请日：1982-03-19
申请人： George Preti
发明人： George Preti
CPC分类号： A61B10/0012 , A61D17/002
摘要： A novel method for determining when cows are in estrus is disclosed comprising the step of monitoring the vaginal secretions of a cow to determine an increase in the amount of an indicator compound in said secretions. A significant increase in the amount of the indicator compound, concentrations above about 0.1 micrograms per gram of collected secretion, is indicative of estrus. The preferred indicator alcohols have ethyl ester indices of 8.1 to 8.9. In particular these alcohols are methyl-1-heptanols, such as 6-methyl-1-heptanol, or are methyl hydroxy heptenes, such as 2-methyl-7 hyroxy-.DELTA.-3-4 heptene. Alternatively, a cow may be determined to be in estrus simply to ascertaining that the concentration of methyl-1-heptanol is at least 0.1 microgram per gram of collected vaginal secretion.
摘要翻译： 公开了一种用于确定奶牛何时发情的新方法，其包括监测牛的阴道分泌物以确定所述分泌物中指示剂化合物的量增加的步骤。 指示剂化合物的量显着增加，浓度高于每克收集分泌物约0.1微克，表示发情。 优选的指示剂醇具有8.1至8.9的乙酯指数。 特别地，这些醇是甲基-1-庚醇，例如6-甲基-1-庚醇，或是甲基羟基庚烯，例如2-甲基-7-羟基-D -TATA-4-庚烯。 或者，可以简单地确定一只母牛处于发情状态，以确定甲基-1-庚醇的浓度为每克收集的阴道分泌至少0.1微克。
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15.发明授权Method of predicting and determining ovulation by monitoring the concentration of volatile sulfur-containing compounds present in mouth air 失效通过监测口腔空气中挥发性含硫化合物的浓度来预测和确定排卵的方法
公开(公告)号：US4119089A
公开(公告)日：1978-10-10
申请号：US764750
申请日：1977-02-02
IPC分类号： A61B10/00
CPC分类号： A61B10/0012 , A61B2010/0006 , Y10S436/90 , Y10S436/906 , Y10T436/18 , Y10T436/182
摘要： A novel method is provided for precisely predicting and then ascertaining the time of ovulation by monitoring the mouth air of a female, a first peak after menses in the concentration of said volatile sulfur-containing compounds in said mouth air predicting ovulation by about 5 to 7 days, and a second increase thereafter being indicative of ovulation. Alternatively, a method is provided wherein TPTZ is utilized to sense secondary characteristics associated with the production of volatile sulfur compounds for the purpose of providing a simple colorimetric home test for determining the precise time of ovulation.
摘要翻译： 提供了一种新颖的方法，用于通过监测女性的口腔空气来精确预测并确定排卵时间，月经后的第一个峰值是所述口腔空气中所述挥发性含硫化合物的浓度预测排卵约5至7 天，其后再次表示排卵。 或者，提供了一种方法，其中TPTZ用于感测与挥发性硫化合物的生产相关的次级特性，目的是提供用于确定排卵的精确时间的简单的比色家庭测试。
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公开(公告)号：US4010738A
公开(公告)日：1977-03-08
申请号：US564348
申请日：1975-04-02
CPC分类号： A61B10/0012 , A61D17/002 , A61B2010/0006 , Y10S436/906 , Y10T436/171538
摘要： A method of monitoring the concentration of a given volatile organic compound, or of urea, or both, which compound(s) is commonly found in vaginal secretions is described as providing a reliable diagnostic indication of ovulation, and more particularly is described as providing a simple home-test method of predicting the onset of the fertile period, thereby increasing the reliability of the "rhythm method" of birth control.
摘要翻译： 描述了通常在阴道分泌物中发现给定的挥发性有机化合物或尿素或两者的浓度的方法，以提供排卵的可靠诊断指示，更具体地描述为提供一种 简单的家庭测试方法来预测可育期的发病，从而提高节育方法的可靠性。
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17.发明申请Methods of reducing the perception of body odors with olfactory adaptation and cross-adapting agents 审中-公开减少嗅觉适应和交叉适应剂对身体气味的感知的方法公开(公告)号：US20070020210A1
公开(公告)日：2007-01-25
申请号：US11514032
申请日：2006-08-30
申请人： George Preti , Charles Wysocki , Leslie Smith , Keith McDermott
发明人： George Preti , Charles Wysocki , Leslie Smith , Keith McDermott
IPC分类号： A61K8/28
摘要： Deodorant compositions are disclosed comprising a cross-adapting agent, alone or in combination with other such agents, in an amount effective to reduce perception of malodor. Deodorant compositions are also disclosed comprising a cross-adapting agent, alone or in combination with other such agents, in an amount effective to reduce perception of gender-specific malodor. The methods feature reducing perceived body odor comprising administering a deodorant composition wherein the composition comprises an amount of cross-adapting agent effective to reduce perception of such odor. Other methods feature blocking perceived body odor comprising administering a deodorant composition wherein the composition comprises an amount of cross-adapting agent effective to occupy an odorant receptor site, thereby blocking interaction of the site with other odorants. Methods of making deodorant compositions are also provided wherein a cross-adapting agent, alone or in combination with other such agents, are included in an amount effective to reduce perception of malodor.
摘要翻译： 公开的除臭剂组合物包含与有效减少恶臭感的量单独或与其它此类试剂组合的交叉适应剂。 还公开了除臭剂组合物，其包含与有效降低对性别特异性恶臭感觉的量单独或与其它此类试剂组合的交叉适应剂。 所述方法的特征在于减少感觉到的身体气味，包括施用除臭剂组合物，其中所述组合物包含一定量的有效减少对这种气味的感知的交叉适应剂。 其他方法特征是阻止感觉到的身体气味，包括施用除臭剂组合物，其中组合物包含有效占据加味剂受体位点的量的交叉适应剂，从而阻止位点与其它气味剂的相互作用。 还提供了制备除臭剂组合物的方法，其中单独或与其它此类试剂组合的交叉适应剂以有效减少恶臭感的量包括在内。
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公开(公告)号：US5877223A
公开(公告)日：1999-03-02
申请号：US490760
申请日：1990-03-08
IPC分类号： A61K31/12
CPC分类号： A61K31/12
摘要： Certain volatile compounds naturally present in herring gull eggs are effective for repelling animals and birds, particularly canids, from the locus to which such compounds are applied. More particularly, the volatile compounds which are effective animal repellents include compounds exhibiting mint-like odors such as the compounds pulegone and piperitone. The invention relates to methods of using these compounds to repel animals, and to repellent compositions comprising effective repellent amounts of such compounds.
摘要翻译： 天然存在于鲱鱼卵中的某些挥发性化合物可有效地从施用此类化合物的场所排斥动物和鸟，特别是犬。 更具体地，作为有效的动物驱避剂的挥发性化合物包括显示薄荷状气味的化合物，例如化合物脓液和胡椒醛。 本发明涉及使用这些化合物排斥动物的方法，以及包含有效排斥量的这种化合物的排斥组合物。
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19.发明授权Axillary androstenol and dehydroepiandrosterone as fertile period onset indicators 失效脯氨酸和脱水表雄酮作为生育期发病指标
公开(公告)号：US4670401A
公开(公告)日：1987-06-02
申请号：US695053
申请日：1985-01-25
CPC分类号： G01N33/743 , Y10S436/906 , Y10T436/200833 , Y10T436/203332
摘要： Method for determining the onset of the fertile period of a human female comprising the step of monitoring the axillary secretions of said female during the course of her menstrual cycle to determine variations in the concentration of androstenol or dehydroepiandrosterone sulfate. A first significant increase in the concentration of either of those compounds following the cessation of menses is indicative of the onset of the fertile period. In each case, a follicular phase peak occurs which exceeds by at least twice the concentration of those compounds present at any other time during the menstrual cycle. As a result, the monitoring of these compounds may act as reliable indicators predicting the occurrence of ovulation in five to seven days, and/or indicating the onset of the fertile period at a time when appropriate contraceptive measures can still be taken to avoid pregnancy or sexual intercourse can promote fertility.
摘要翻译： 用于确定人类雌性生育期发病的方法，包括在月经周期中监测所述雌性腋窝分泌物的步骤，以确定硫氨酸或脱氢表雄酮硫酸盐浓度的变化。 月经停止后，这些化合物中的任一种的浓度首次显着增加，表明可育期的开始。 在每种情况下，发生卵泡相峰，其超过在月经周期期间的任何其他时间存在的那些化合物的浓度的至少两倍。 因此，这些化合物的监测可以作为预测五至七天排卵发生的可靠指标，和/或表示在仍然可以采取适当的避孕措施避免怀孕或/或 性交可以促进生育。
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