公开(公告)号：US20180086876A1

公开(公告)日：2018-03-29

申请号：US15540692

申请日：2015-01-26

Applicant: HITACHI, LTD.

Inventor： Yasuhiko TADA ,  Takahito MURAKI ,  Yuri KAJIHARA

IPC: C08G59/68 ,  G03F7/20 ,  G03F7/039 ,  G03F7/40 ,  H01L21/027

CPC classification number: C08G59/68 ,  C08G59/1438 ,  C08G59/226 ,  C08G59/4215 ,  C08G59/685 ,  C08L63/00 ,  G03F7/039 ,  G03F7/2024 ,  G03F7/40 ,  H01L21/027

Abstract: It is an object of the present invention to provide a thermosetting resin composition which allows stress relaxation in an ester exchange reaction and the long-term use of the thermosetting resin composition having such a structure. A thermosetting resin composition of the present invention contains: an ester bond; and a functional group protected by a protecting group. The functional group is deprotected by external stimulus. The functional group and the ester bond can be subjected to an ester exchange reaction.

公开(公告)号：US20160017059A1

公开(公告)日：2016-01-21

申请号：US14798608

申请日：2015-07-14

Applicant: HITACHI, LTD.

Inventor： Masashi MARUYAMA ,  Yasuhiko TADA ,  Keisuke SHIBUYA

IPC: C07K17/06 ,  C07K1/22

CPC classification number: C07K17/06 ,  B01D15/3809 ,  B01J20/289 ,  B01J20/3204 ,  B01J20/321 ,  B01J20/3212 ,  B01J20/3219 ,  B01J20/3225 ,  B01J20/3274 ,  B01J20/3278 ,  B01J20/3285 ,  B01J2220/58 ,  C07K1/22

Abstract: An adsorbent of the present invention includes a support; and a protein having an adsorption site for adsorbing a target substance, in which the protein includes a reversible binding site and a covalent binding site, the support includes an orientation-controlling site forming a reversible bond with the reversible binding site, and an immobilization site forming a covalent bond with the covalent binding site, the covalent binding site includes a nucleophilic functional group, and the immobilization site includes a functional group capable of reacting with the nucleophilic functional group by a nucleophilic substitution or a nucleophilic addition. Thus, it is possible to provide an adsorbent in which the utilization efficiency of the adsorption site of the protein is improved. As a result, the protein amount can be reduced, and the step for storing a culture solution can be simplified due to the faster purification step.

Abstract translation: 本发明的吸附剂包括载体; 以及具有吸附目标物质的吸附部位的蛋白质，其中所述蛋白质包含可逆结合位点和共价结合位点，所述载体包括与可逆结合位点形成可逆键的取向控制位点和固定位点 与共价结合位点形成共价键，共价结合位点包括亲核官能团，并且固定位点包括能够通过亲核取代或亲核加成与亲核官能团反应的官能团。 因此，可以提供蛋白质的吸附部位的利用效率提高的吸附剂。 结果，可以降低蛋白质量，并且由于更快的纯化步骤，可以简化用于储存培养溶液的步骤。