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公开(公告)号：US07097976B2
公开(公告)日：2006-08-29
申请号：US10321741
申请日：2002-12-16
申请人： Giulia Kennedy
发明人： Giulia Kennedy
CPC分类号： C12N15/1072 , C12Q1/6827 , C12Q1/6883 , C12Q1/6886 , C12Q2600/158 , C12Q2565/501
摘要： Methods are provided for identification of genes that are imprinted. In another embodiment methods are provided for identification and analysis of genes whose expression shows allelic imbalance. The expression products transcribed from genes that are present in the genome as two or more alleles may be distinguished by hybridization to an array designed to interrogate individual alleles. Genes whose transcription products are present in amounts that vary from expected are candidates for allelic imbalance, imprinting and imprinting errors.
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公开(公告)号：US08030455B2
公开(公告)日：2011-10-04
申请号：US12645412
申请日：2009-12-22
申请人： Giulia Kennedy
发明人： Giulia Kennedy
IPC分类号： C07K16/00
CPC分类号： C07K14/47
摘要： The present invention provides the art with the DNA coding sequences of polynucleotides that are up-or-down-regulated in cancer and dysplasia. These polynucleotides and encoded proteins or polypeptides can be used in the diagnosis or identification of cancer and dysplasia. Inhibitors of the up-regulated polynucleotides and proteins can decrease the abnormality of cancer and dysplasia. Enhancing the expression of down-regulated polynucleotides or introducing down-regulated proteins to cells can decrease the growth and/or abnormal characteristics of cancer and dysplasia.
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公开(公告)号：US08029997B2
公开(公告)日：2011-10-04
申请号：US11511198
申请日：2006-08-28
申请人： Giulia Kennedy
发明人： Giulia Kennedy
CPC分类号： C12N15/1072 , C12Q1/6827 , C12Q1/6883 , C12Q1/6886 , C12Q2600/158 , C12Q2565/501
摘要： Methods are provided for identification of genes that are imprinted. In another embodiment methods are provided for identification and analysis of genes whose expression shows allelic imbalance. The expression products transcribed from genes that are present in the genome as two or more alleles may be distinguished by hybridization to an array designed to interrogate individual alleles. Genes whose transcription products are present in amounts that vary from expected are candidates for allelic imbalance, imprinting and imprinting errors.
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公开(公告)号：US07666992B2
公开(公告)日：2010-02-23
申请号：US11929813
申请日：2007-10-30
申请人： Giulia Kennedy
发明人： Giulia Kennedy
CPC分类号： C07K14/47
摘要： The present invention provides the art with the DNA coding sequences of polynucleotides that are up-or-down-regulated in cancer and dysplasia. These polynucleotides and encoded proteins or polypeptides can be used in the diagnosis or identification of cancer and dysplasia. Inhibitors of the up-regulated polynucleotides and proteins can decrease the abnormality of cancer and dysplasia. Enhancing the expression of down-regulated polynucleotides or introducing down-regulated proteins to cells can decrease the growth and/or abnormal characteristics of cancer and dysplasia.
摘要翻译： 本发明提供了在癌症和发育不良中上下调的多核苷酸的DNA编码序列的技术。 这些多核苷酸和编码的蛋白质或多肽可用于诊断或鉴定癌症和发育不良。 上调多核苷酸和蛋白质的抑制剂可以减少癌症和发育异常的异常。 增强下调多核苷酸的表达或将下调蛋白引入细胞可以降低癌症和发育不良的生长和/或异常特征。
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公开(公告)号：US20070250809A1
公开(公告)日：2007-10-25
申请号：US11674726
申请日：2007-02-14
申请人： Giulia Kennedy , Yaron Turpaz , Chun Zhang
发明人： Giulia Kennedy , Yaron Turpaz , Chun Zhang
IPC分类号： G06F9/44
摘要： A computer system for visualizing recombination events in a group of individuals is provided. According to one aspect of the invention, high-density SNP genotype data is obtained from related individuals in a family. A pedigree is created, haplotypes are reconstructed and likely recombination breakpoints are identified with the use of publicly available computer programs. A software tool is then used facilitate the visualization of the recombination events in the family.
摘要翻译： 提供了用于在一组个体中可视化重组事件的计算机系统。 根据本发明的一个方面，从家族中的相关个体获得高密度SNP基因型数据。 创建谱系，单倍型被重建，并且可能使用公共可用的计算机程序识别重组断点。 然后使用软件工具来促进家族中重组事件的可视化。
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16.发明申请Gene products differentially expressed in cancerous cells and their methods of use V 有权在癌细胞中差异表达的基因产物及其使用方法V公开(公告)号：US20050130926A1
公开(公告)日：2005-06-16
申请号：US10977087
申请日：2004-10-28
申请人： Christoph Reinhard , Anne Jefferson , Vivien Chan , Joerg Kaufmann , Hong Xin , Giulia Kennedy , Greg Harrowe , Hamiduddin Khoja , Venkatakrishna Shyamala
发明人： Christoph Reinhard , Anne Jefferson , Vivien Chan , Joerg Kaufmann , Hong Xin , Giulia Kennedy , Greg Harrowe , Hamiduddin Khoja , Venkatakrishna Shyamala
IPC分类号： A61K38/00 , C07K14/47 , C07K14/72 , C12N9/12 , C12Q1/68 , G01N33/574 , G01N33/68 , A61K39/395 , A61K48/00 , C07H21/04 , C12N9/64
CPC分类号： G01N33/5005 , A01K2217/05 , A01K2217/075 , A61K38/00 , A61K2039/505 , C07K14/47 , C07K14/723 , C12N9/1205 , C12Q1/6886 , C12Q2600/112 , C12Q2600/136 , C12Q2600/158 , C12Y207/01037 , G01N33/5008 , G01N33/5011 , G01N33/57415 , G01N33/57419 , G01N33/57496 , G01N33/68 , G01N33/6842 , G01N2500/00
摘要： The present invention provides polynucleotides, as well as polypeptides encoded thereby, that are differentially expressed in cancer cells. These polynucleotides are useful in a variety of diagnostic and therapeutic methods. The present invention further provides methods of reducing growth of cancer cells. These methods are useful for treating cancer.
摘要翻译： 本发明提供在癌细胞中差异表达的多核苷酸以及由此编码的多肽。 这些多核苷酸可用于各种诊断和治疗方法。 本发明还提供减少癌细胞生长的方法。 这些方法可用于治疗癌症。
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公开(公告)号：US20110060768A1
公开(公告)日：2011-03-10
申请号：US12879419
申请日：2010-09-10
申请人： Giulia Kennedy , Yaron Turpaz , Chun Zhang
发明人： Giulia Kennedy , Yaron Turpaz , Chun Zhang
IPC分类号： G06F17/30
摘要： A computer system for visualizing recombination events in a group of individuals is provided. According to one aspect of the invention, high-density SNP genotype data is obtained from related individuals in a family. A pedigree is created, haplotypes are reconstructed and likely recombination breakpoints are identified with the use of publicly available computer programs. A software tool is then used facilitate the visualization of the recombination events in the family.
摘要翻译： 提供了用于在一组个体中可视化重组事件的计算机系统。 根据本发明的一个方面，从家族中的相关个体获得高密度SNP基因型数据。 创建谱系，单倍型被重建，并且可能使用公共可用的计算机程序识别重组断点。 然后使用软件工具来促进家族中重组事件的可视化。
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18.发明授权Computer software for visualizing recombination events in a group of individuals from recombination breakpoints and assignments in high density SNP genotyping data by generating a color-coded view for each individual chromosome and a whole genome view for the group 有权计算机软件，用于通过为每个单独的染色体生成一个颜色编码的视图和该组的整个基因组视图来显现来自重组断裂点和高密度SNP基因分型数据中的分配的一组个体中的重组事件公开(公告)号：US07818281B2
公开(公告)日：2010-10-19
申请号：US11674726
申请日：2007-02-14
申请人： Giulia Kennedy , Yaron Turpaz , Chun Zhang
发明人： Giulia Kennedy , Yaron Turpaz , Chun Zhang
摘要： A computer system for visualizing recombination events in a group of individuals is provided. According to one aspect of the invention, high-density SNP genotype data is obtained from related individuals in a family. A pedigree is created, haplotypes are reconstructed and likely recombination breakpoints are identified with the use of publicly available computer programs. A software tool is then used facilitate the visualization of the recombination events in the family.
摘要翻译： 提供了用于在一组个体中可视化重组事件的计算机系统。 根据本发明的一个方面，从家族中的相关个体获得高密度SNP基因型数据。 创建谱系，单倍型被重建，并且可能使用公共可用的计算机程序识别重组断点。 然后使用软件工具来促进家族中重组事件的可视化。
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公开(公告)号：US06429302B1
公开(公告)日：2002-08-06
申请号：US09490818
申请日：2000-01-25
申请人： Giulia Kennedy
发明人： Giulia Kennedy
IPC分类号： C07H2102
CPC分类号： C07K14/82 , C07K14/47 , C12Q1/6883 , C12Q1/6886 , C12Q2600/136 , Y02A90/24
摘要： The present invention is based on the discovery of polynucleotides that represent novel genes that are differentially expressed in pancreatic disease, e.g., pancreatic cancer, dysplasia, pancreatitis, or diabetes. The invention features methods of identifying cells affected by such pancreatic diseases by detection of a gene product encoded by such differentially expressed genes, as well as methods of modulating expression of such gene products to effect therapy (e.g., to decrease growth and/or affect abnormal characteristics of cancerous or dysplastic pancreatic cells.)
摘要翻译： 本发明基于代表在胰腺疾病例如胰腺癌，发育不良，胰腺炎或糖尿病中差异表达的新基因的多核苷酸的发现。 本发明的特征在于通过检测由这种差异表达的基因编码的基因产物来鉴定受这种胰腺疾病影响的细胞的方法，以及调节这些基因产物的表达以进行治疗的方法（例如，降低生长和/或影响异常 癌性或发育不良型胰腺细胞的特征）
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公开(公告)号：US20090275069A1
公开(公告)日：2009-11-05
申请号：US11929951
申请日：2007-10-30
申请人： Giulia Kennedy
发明人： Giulia Kennedy
CPC分类号： C07K14/47
摘要： The present invention provides the art with the DNA coding sequences of polynucleotides that are up-or-down-regulated in cancer and dysplasia. These polynucleotides and encoded proteins or polypeptides can be used in the diagnosis or identification of cancer and dysplasia. Inhibitors of the up-regulated polynucleotides and proteins can decrease the abnormality of cancer and dysplasia. Enhancing the expression of down-regulated polynucleotides or introducing down-regulated proteins to cells can decrease the growth and/or abnormal characteristics of cancer and dysplasia.
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