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11.发明授权Benzimidazolylcarbamic acid esters substituted on the benzenoid nucleus by an oxy or thio substituent 失效苯并咪唑基氨基甲酸酯通过氧基或硫取代基取代在苯环上
公开(公告)号：US4287199A
公开(公告)日：1981-09-01
申请号：US83883
申请日：1979-10-11
IPC分类号： A61K31/415 , A61K31/4184 , A61P33/10 , C07D235/32 , C07D401/12 , C07D403/12 , A61K31/445
CPC分类号： C07D235/32
摘要： The invention relates to 2-benzimidazolylcarbamic acid esters, substituted on the benzenoid nucleus by an aminoalkoxy, aminoalkylthio, an aminoalkylsulphinyl or an aminoalkylsulphonyl grouping. The invention also includes methods for making the compounds of the invention, compositions containing said compounds and the use of said compounds and compositions as anthelminitic agents.
摘要翻译： 本发明涉及2-苯并咪唑基氨基甲酸酯，其通过氨基烷氧基，氨基烷硫基，氨基烷基亚磺酰基或氨基烷基磺酰基在苯类核上取代。 本发明还包括制备本发明化合物的方法，含有所述化合物的组合物以及所述化合物和组合物作为anthelminitic剂的用途。
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公开(公告)号：US4247546A
公开(公告)日：1981-01-27
申请号：US967035
申请日：1978-12-06
IPC分类号： A61K9/00 , A61K31/66 , A61K31/665 , A61K31/67 , A61K31/675 , A61P33/10 , C07F9/24 , C07F9/572 , C07F9/6539 , C07F9/6571 , C07F9/6574 , C07F9/6578 , A01N57/32 , A01N57/22
CPC分类号： C07F9/6539 , A61K31/66 , C07F9/2487 , C07F9/5727 , C07F9/657154
摘要： The invention includes phosphonylureidobenzene compounds of the general formula ##STR1## or pharmaceutically acceptable salts in whichR.sup.1 and R.sup.2 are identical or different and represent an alkyl group, orR.sup.1 and R.sup.2 together represent a dimethylene group, a trimethylene group or a tetramethylene group,X and Y are identical or different and represent an oxygen atom or a sulphur atom andR.sup.3 and R.sup.4 are identical or different and represent an alkyl group, orR.sup.3 and R.sup.4 together represent a trimethylene group or a tetramethylene group, orR.sup.3 and R.sup.4, together with the carbon atom and nitrogen atom between them, form a thiazolidine ring system, which are used medicinally as parasiticides.The compounds are particularly effective in combatting helminths in carnivores.Also included in the invention are pharmaceutical compositions containing said phosphonylureidobenzene compounds and methods for the treatment of warm-blooded animals by administering said compounds or compositions.
摘要翻译： 本发明包括通式为（I）的膦酰基脲基化合物或其中R 1和R 2相同或不同并且表示烷基的药学上可接受的盐，或者R 1和R 2一起表示二亚甲基，三亚甲基或四亚甲基 基，X和Y相同或不同，表示氧原子或硫原子，R3和R4相同或不同，表示烷基，或R3和R4一起表示三亚甲基或四亚甲基，或R 3和R 4 与它们之间的碳原子和氮原子一起形成噻唑烷环体系，它们在医药上用作杀寄生虫剂。 这些化合物特别有效地对抗食肉动物的蠕虫。 本发明还包括含有所述膦酰基脲基化合物的药物组合物和通过施用所述化合物或组合物治疗温血动物的方法。
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公开(公告)号：US4015012A
公开(公告)日：1977-03-29
申请号：US579446
申请日：1975-05-21
IPC分类号： A61K31/155 , A61K31/165
CPC分类号： A61K31/155
摘要： New 4-acylaminophenylacetamidines of the formula: ##STR1## in which R is a straight or branched chain alkoxyalkyl having 3 to 8 carbon atoms or straight or branched chain alkenyloxyalkyl having 3 to 8 carbon atoms wherein the alkoxy moiety or alkenyloxy moiety may substituted by alkoxy or phenyl, and including the non-toxic pharmacologically acceptable salts thereof. The products have utility as parasiticides.The products are obtained by either of two methods: (1) via the reaction of an N'-(4-aminophenyl)-N,N-dimethylacetamidine with an acylating agent or (2) via the reaction of a 4-acylaminoaniline with an N,N-dimethylacetamide or N,N-dimethylthioacetamide.
摘要翻译： 新的具有3-8个碳原子的直链或支链烷氧基烷基或具有3-8个碳原子的直链或支链链烯氧基烷基的4-氨基苯基乙酰胺，其中R是具有3-8个碳原子的直链或支链烷氧基烷基，其中烷氧基部分或烯氧基部分可被烷氧基取代 或苯基，并且包括其无毒的药理学上可接受的盐。 该产品具有作为杀寄生虫剂的作用。
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公开(公告)号：US3970699A
公开(公告)日：1976-07-20
申请号：US505738
申请日：1974-09-13
IPC分类号： A61K31/165 , A61K31/155 , A61P33/10 , C07C67/00 , C07C231/00 , C07C231/02 , C07C231/12 , C07C239/00 , C07C257/14 , C07C257/20 , C07C103/34
CPC分类号： A61K31/155
摘要： New 4-acylaminophenylacetamidines of the formula: ##SPC1##In which R is a straight or branched chain alkoxyalkyl having 3 to 8 carbon atoms or straight or branched chain alkenyloxyalkyl having 3 to 8 carbon atoms wherein the alkoxy moiety or alkenyloxy moiety may substituted by alkoxy or phenyl, and including the non-toxic pharmacologically acceptable salts thereof. The products have utility as parasiticides.The products are obtained by either of two methods: (1) via the reaction of an N'-(4-aminophenyl)-N,N-dimethylacetamidine with an acylating agent or (2) via the reaction of a 4-acylaminoaniline with an N,N-dimethylacetamide or N,N-dimethylthioacetamide.
摘要翻译： 新的4-酰基氨基苯基乙酰胺的下式：
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15.发明授权
公开(公告)号：US5955482A
公开(公告)日：1999-09-21
申请号：US828464
申请日：1997-03-28
申请人： Klaus Urbahns , Otto Behner , Siegfried Goldmann , Hans-Georg Heine , Bodo Junge , Rudolf Schohe-Loop , Egbert Wehinger , Hartmund Wollweber , Henning Sommermeyer , Thomas Glaser , Reilinde Wittka , Jean-Marie-Viktor de Vry
发明人： Klaus Urbahns , Otto Behner , Siegfried Goldmann , Hans-Georg Heine , Bodo Junge , Rudolf Schohe-Loop , Egbert Wehinger , Hartmund Wollweber , Henning Sommermeyer , Thomas Glaser , Reilinde Wittka , Jean-Marie-Viktor de Vry
IPC分类号： A61K31/435 , A61K31/44 , A61K31/4427 , A61P9/10 , A61P25/00 , A61P43/00 , C07D211/90 , C07D401/04 , C07D211/86
CPC分类号： C07D211/90
摘要： The present invention relates to the use of 1,4-dihydropyridine-3,5-dicarboxylic acid esters, some of which are known, of the general formula (I) ##STR1## in which A and R.sup.1 -R.sup.3 have the meaning given in the description, as medicaments, in particular for treatment of the central nervous system, and new selected active compounds.
摘要翻译： 本发明涉及其中一些已知的通式（I）的1,4-二氢吡啶-3,5-二羧酸酯的用途，其中A和R1-R3具有说明书中给出的含义， 作为药物，特别是用于治疗中枢神经系统，以及新选择的活性化合物。
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16.发明授权1,4-dihydropyridine-3,5-dicarboxylic acid esters in treatment of neuronal diseases 失效1,4-二氢吡啶-3,5-二羧酸酯治疗神经元疾病
公开(公告)号：US5665741A
公开(公告)日：1997-09-09
申请号：US516668
申请日：1995-08-18
申请人： Klaus Urbahns , Otto Behner , Siegfried Goldmann , Hans-Georg Heine , Bodo Junge , Rudolf Schohe-Loop , Egbert Wehinger , Hartmund Wollweber , Henning Sommermeyer , Thomas Glaser , Reilinde Wittka , Jean-Marie-Viktor de Vry
发明人： Klaus Urbahns , Otto Behner , Siegfried Goldmann , Hans-Georg Heine , Bodo Junge , Rudolf Schohe-Loop , Egbert Wehinger , Hartmund Wollweber , Henning Sommermeyer , Thomas Glaser , Reilinde Wittka , Jean-Marie-Viktor de Vry
IPC分类号： A61K31/435 , A61K31/44 , A61K31/4427 , A61P9/10 , A61P25/00 , A61P43/00 , C07D211/90 , C07D401/04
CPC分类号： C07D211/90
摘要： The present invention relates to the use of 1,4-dihydropyridine-3,5-dicarboxylic acid esters, some of which are known, of the general formula (I) ##STR1## in which A and R.sup.1 -R.sup.3 have the meaning given in the description, as medicaments, in particular for treatment of the central nervous system, and new selected active compounds.
摘要翻译： 本发明涉及1,4-二氢吡啶-3,5-二羧酸酯的用途，其中一些是通式（I）的化合物，其中A和R 1 -R 3具有 在描述中给出的，作为药物，特别是用于治疗中枢神经系统的药物，以及新的选择的活性化合物。
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17.发明授权Benzimidazolylcarbamic acid ester compounds, their production, and their medicinal use 失效苯并咪唑基氨基甲酸酯化合物，其生产及其药用
公开(公告)号：US4353913A
公开(公告)日：1982-10-12
申请号：US224584
申请日：1981-01-12
IPC分类号： A61K31/415 , A61K31/4184 , A61P33/10 , C07D235/32 , C07D401/12 , C07D403/12 , A61K31/44 , A61K31/445 , C07D401/02
CPC分类号： C07D235/32
摘要： The invention relates to 2-benzimidazolylcarbamic acid esters, substituted on the benzenoid nucleus by an aminoalkoxy, aminoalkylthio, an aminoalkylsulphinyl or an aminoalkylsulphonyl grouping. The invention also includes methods for making the compounds of the invention, compositions containing said compounds and the use of said compounds and compositions as anthelmintic agents.
摘要翻译： 本发明涉及2-苯并咪唑基氨基甲酸酯，其通过氨基烷氧基，氨基烷硫基，氨基烷基亚磺酰基或氨基烷基磺酰基在苯类核上取代。 本发明还包括制备本发明化合物的方法，含有所述化合物的组合物以及所述化合物和组合物作为驱肠剂的用途。
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18.发明授权Substituted omicron-phenylenediamine derivatives, process for their preparation and their use as medicaments 失效取代的微米 - 苯二胺衍生物，其制备方法及其作为药物的用途
公开(公告)号：US4246260A
公开(公告)日：1981-01-20
申请号：US21869
申请日：1979-03-19
IPC分类号： A61K31/265 , A61K31/40 , A61K31/435 , A61K31/55 , A61P33/00 , A61P33/10 , C07C67/00 , C07C231/00 , C07C233/25 , C07C233/43 , C07C239/00 , C07C279/24 , C07C313/00 , C07C317/40 , C07C317/42 , C07C323/41 , C07C323/43 , C07D295/15 , A61K31/325 , C07C125/06
CPC分类号： C07D295/15
摘要： The invention relates to new substituted o-phenylenediamine derivatives of the general formula ##STR1## in which R represents optionally substituted alkyl, optionally substituted alkenyl or optionally substituted alkinyl,X represents O, S, SO or SO.sub.2 andR.sup.1 and R.sup.2 are different from one another and individually represent ##STR2## in which R.sup.3 and R.sup.4 are identical or different and represent alkyl andR.sup.5 represents hydrogen, optionally substituted alkyl or optionally substituted alkoxy, and salts thereof.Also included in the invention are (1) methods for preparing the above-described compounds, (2) compositions containing the above-described compounds and (3) methods for the treatment of helminthiasis.
摘要翻译： 本发明涉及通式为（I）的新的取代的邻苯二胺衍生物，其中R代表任选取代的烷基，任选取代的烯基或任选取代的炔基，X代表O，S，SO或SO 2，R 1和R 2是 各自独立地表示其中R 3和R 4相同或不同并且表示烷基且R 5表示氢，任选取代的烷基或任选取代的烷氧基及其盐的
。 本发明还包括（1）制备上述化合物的方法，（2）含有上述化合物的组合物和（3）治疗蠕虫病的方法。 -
19.发明授权Substituted benzenesulphonic acid esters, processes for their preparation and their use as medicaments 失效取代的苯磺酸酯，其制备方法及其作为药物的用途
公开(公告)号：US4194004A
公开(公告)日：1980-03-18
申请号：US847890
申请日：1977-11-02
IPC分类号： A01N47/20 , C07C67/00 , C07C301/00 , C07C303/30 , C07C309/72 , C07C309/76 , C07C325/00 , C07C335/28 , C07D295/15 , A61K31/27 , A61K31/255 , C07C143/68
CPC分类号： C07D295/15 , C07C309/72 , C07C309/76
摘要： Novel substituted benzenesulphonic acid esters, particularly useful as anthelmintics are provided. The novel compounds are those of the general formula ##STR1## in which R represents hydrogen, optionally substituted alkyl, cyano, alkoxy, halogen, trifluoromethyl, amino, acylamino or nitro,X represents SO.sub.3 andR.sup.1 and R.sup.2 are different from one another and individually represent one of the radicals ##STR2## wherein Y represents S andR.sub.3 represents hydrogen, optionally substituted alkyl or alkoxy,and salts thereof. Also included in the invention are methods for preparing the novel compounds, compositions containing them and methods for the use of the compounds and compositions.
摘要翻译： 提供了特别用作驱肠剂的新型取代苯磺酸酯。 新化合物是通式为其中R表示氢，任选取代的烷基，氰基，烷氧基，卤素，三氟甲基，氨基，酰氨基或硝基的通式（I）的化合物，X表示SO 3，R 1和R 2不同于 另一个并且各自独立地表示基团之一，其中Y表示S且R 3表示氢，任选取代的烷基或烷氧基，及其盐。 本发明还包括制备新化合物的方法，含有它们的组合物和使用该化合物和组合物的方法。
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公开(公告)号：US4032655A
公开(公告)日：1977-06-28
申请号：US693414
申请日：1976-06-07
IPC分类号： A61K31/155 , A61K31/27
CPC分类号： A61K31/155
摘要： N-[2-(Substituted amido)phenyl]-N',N"-bis-carbonylguanidines bearing an optionally substituted phenoxy, phenylthio, phenylsulfinyl or phenylsulfonyl group in the 4- or 5-position of the 2-(substituted amido)phenyl group are anthelmintic agents. The compounds, of which N-(2-acetamido-4-phenylthiophenyl)-N',N"-bis-carbomethoxyguanidine is a typical example, are prepared through the reaction of isothiourea-S-alkyl ether and an appropriately substituted 2-aminoanilide.
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