公开(公告)号：US5256656A

公开(公告)日：1993-10-26

申请号：US853521

申请日：1992-05-12

申请人： Haruhiko Kikuchi ,  Hiroaki Satoh ,  Nobuhiro Yahata ,  Kiochiro Hagihara ,  Toru Hayakawa ,  Setsuko Mino ,  Makoto Yanai

发明人： Haruhiko Kikuchi ,  Hiroaki Satoh ,  Nobuhiro Yahata ,  Kiochiro Hagihara ,  Toru Hayakawa ,  Setsuko Mino ,  Makoto Yanai

IPC分类号： C07D471/08 ,  C07D498/08 ,  C07D513/08 ,  A61K31/54 ,  A61K31/535 ,  C07D265/36 ,  C07D498/02

CPC分类号： C07D471/08 ,  C07D513/08

摘要： Azabicyclo derivatives of formula (I) and pharmaceutically acceptable salts thereof: ##STR1## wherein A is a group of formula (a), (b) or (c): ##STR2## wherein R.sub.1 is hydrogen, C.sub.1 -C.sub.10 alkyl, aralkyl or di(C.sub.1 -C.sub.4) alkylamino(C.sub.1 -C.sub.6)alkyl;R.sub.2, R.sub.3 and R.sub.4 may be the same or different and each is hydrogen, amino, halogen, C.sub.1 -C.sub.4 alkoxy or phthalimide;X is O or NH;R is C.sub.1 -C.sub.4 alkyl; andY is NR, O or S;having 5-HT.sub.3 receptor antagonist activity.

摘要翻译： （I）的叠氮杂双环衍生物及其药学上可接受的盐：其中A是式（a），（b）或（c）的基团：（a） （c）其中R1是氢，C1-C10烷基，芳烷基或二（C1-C4）烷基氨基（C1-C6）烷基; R2，R3和R4可以相同或不同，各自为氢，氨基，卤素，C1-C4烷氧基或邻苯二甲酰亚胺; X是O或NH; R是C 1 -C 4烷基; Y为NR，O或S; 具有5-HT 3受体拮抗剂活性。

公开(公告)号：US5124324A

公开(公告)日：1992-06-23

申请号：US614219

申请日：1990-11-16

申请人： Haruhiko Kikuchi ,  Hiroaki Satoh ,  Makoto Yanai ,  Toshio Suguro ,  Koichiro Hagihara

发明人： Haruhiko Kikuchi ,  Hiroaki Satoh ,  Makoto Yanai ,  Toshio Suguro ,  Koichiro Hagihara

IPC分类号： C07D209/42 ,  C07D401/12 ,  C07D403/12 ,  C07D403/14

CPC分类号： C07D401/12 ,  C07D209/42 ,  C07D403/12 ,  C07D403/14

摘要： Disclosed are compounds of formula I ##STR1## wherein R.sub.1 is a hydrogen atom, a C.sub.1 -C.sub.6 alkyl group, benzyl or an indolyl carbonyl group, R.sub.2 is a saturated or unsaturated 5- or 8-membered heterocyclic group containing as a hetero atom one or more nitrogen atoms, the heterocyclic group is optionally substituted at an N or C atom by a C.sub.1 -C.sub.6 alkyl or aralkyl group, n is an integer of 1 to 5 and one or more hydrogen atoms, in an alkylene chain --(CH.sub.2).sub.n -- are optionally substituted by a C.sub.1 -C.sub.6 alkyl, phenyl and/or hydroxyl group, physiologically acceptable salts and quaternary ammonium salts thereof. The compounds are selective antagonists of 5-HT.sub.3 receptors and are useful in the treatment of psychotic disorders, neurotic diseases, gastric stasis symptoms, gastrointestinal disorders, nausea and vomiting.

公开(公告)号：US4944746A

公开(公告)日：1990-07-31

申请号：US322923

申请日：1989-03-14

申请人： Hiroo Iwata ,  Sen Yamagata ,  Waro Taki ,  Takehisa Matsuda ,  Haruhiko Kikuchi ,  Yasuhiro Yonekawa ,  Yasuhiro Goto

发明人： Hiroo Iwata ,  Sen Yamagata ,  Waro Taki ,  Takehisa Matsuda ,  Haruhiko Kikuchi ,  Yasuhiro Yonekawa ,  Yasuhiro Goto

IPC分类号： A61M25/00 ,  A61B17/12

CPC分类号： A61B17/12109 ,  A61B17/12136 ,  A61M2025/1054

摘要： An apparatus for separating a balloon from a catheter member of a balloon is capable of melting and breaking a heat-meltable connecting member through which the balloon is connected to the catheter body by causing an electric current to flow between at least a pair of electrodes arranged on or in the vicinity of the connecting member. The apparatus has impedance measuring means for measuring the impedance of an electrode circuit including a pair of electrodes and lead lines connected to the electrodes, and judging means for comparing the measured value of the impedance with a predetermined reference range and capable of producing an abnormal signal when the measured value of the impedance does not fall within the predetermined reference range. The apparatus enables the operator to judge whether the electrode circuit is in safe condition, before changing the balloon with a settable liquid and to charge a settable liquid into the balloon only when the safe condition of the electrode circuit is confirmed, so that the balloon after the setting of the liquid can be separated from the catheter body without fail, thus eliminating any risk for the catheter body to dangerously remain in the living body.

摘要翻译： 用于从球囊的导管构件分离球囊的装置能够熔化和破坏可热熔连接构件，气球通过该热连接构件连接到导管主体，通过使电流在布置的至少一对电极之间流动 在连接构件上或附近。 该装置具有用于测量电极电路的阻抗的阻抗测量装置，该电极电路包括一对连接到电极的电极和引线，以及判断装置，用于将阻抗的测量值与预定的参考范围进行比较，并且能够产生异常信号 当阻抗的测量值不在预定参考范围内时。 该设备使得操作者能够在电极回路处于安全状态之前，在用可固化液体改变球囊之前，仅在电极回路的安全状态被确认之后才将可固定液体充入球囊中， 液体的设置可以不导通地与导管体分离，从而消除导管体危险地残留在生物体中的任何风险。

公开(公告)号：US07373777B2

公开(公告)日：2008-05-20

申请号：US11260376

申请日：2005-10-28

申请人： Jun Koike ,  Takaki Miyauchi ,  Haruhiko Kikuchi

发明人： Jun Koike ,  Takaki Miyauchi ,  Haruhiko Kikuchi

IPC分类号： B29C45/67 ,  B22D17/26

CPC分类号： B29C45/67 ,  B29C45/68 ,  F15B11/036 ,  F15B15/088 ,  F15B2015/1495 ,  F15B2211/20538 ,  F15B2211/30525 ,  F15B2211/3058 ,  F15B2211/3111 ,  F15B2211/40515 ,  F15B2211/41536 ,  F15B2211/428 ,  F15B2211/7055 ,  F15B2211/775

摘要： A die drive unit has a cylinder mechanism which hydraulically drives a piston member and an additional drive mechanism which drives the piston member by means of a drive source other than a hydraulic one. A first oil chamber is formed on one side of the piston member. A second oil chamber and a third oil chamber are formed on the other side of the piston member. The first oil chamber and the second oil chamber are connected to each other by an oil passage. The piston pressure receiving area of the first oil chamber is equal to the sum of those of the second and third oil chambers.

摘要翻译： 模具驱动单元具有液压驱动活塞构件的气缸机构和通过除了液压驱动单元之外的驱动源驱动活塞构件的附加驱动机构。 第一油室形成在活塞件的一侧上。 第二油室和第三油室形成在活塞构件的另一侧上。 第一油室和第二油室通过油路相互连接。 第一油室的活塞压力接收面积等于第二和第三油室的活塞压力接收面积的总和。

公开(公告)号：US5945434A

公开(公告)日：1999-08-31

申请号：US952509

申请日：1997-11-28

申请人： Masashi Suzuki ,  Masahiro Ueno ,  Ryuta Fukutomi ,  Hiroaki Satoh ,  Haruhiko Kikuchi ,  Koichiro Hagihara ,  Takeo Arai ,  Sugure Taniguchi ,  Setsuko Mino ,  Yumiko Noguchi

发明人： Masashi Suzuki ,  Masahiro Ueno ,  Ryuta Fukutomi ,  Hiroaki Satoh ,  Haruhiko Kikuchi ,  Koichiro Hagihara ,  Takeo Arai ,  Sugure Taniguchi ,  Setsuko Mino ,  Yumiko Noguchi

IPC分类号： C07D231/56 ,  C07D401/12 ,  A61K31/445

CPC分类号： C07D231/56 ,  C07D401/12

摘要： An indazole compound having the formula (I): wherein:R.sub.1 is hydrogen, C.sub.1 -C.sub.6 alkyl, C.sub.3 -C.sub.6 alkenyl or C.sub.3 -C.sub.6 cycloalkyl;Q is carbonyl, thiocarbonyl or methylene; andR.sub.2 is a group of the formula (II) or (IV); ##STR1## wherein R.sub.1 is C.sub.1 -C.sub.6 alkyl, C.sub.3 -C.sub.6 alkenyl or benzyl, of which a phenyl group thereof is optionally mono- or di-substituted by the same or different halogen or methoxy; m is 0 to 2; n and o is 1 or 2. The compound exhibits 5-HT.sub.4 receptor agonist activity.

摘要翻译： PCT No.PCT / JP96 / 01475第 371日期1997年11月28日 102（e）1997年11月28日日期PCT提交1996年5月31日PCT公布。 WO96 / 38420 PCT出版物 日期：1996年12月5日具有式（I）的吲唑化合物：其中：R1为氢，C1-C6烷基，C3-C6烯基或C3-C6环烷基; Q是羰基，硫代羰基或亚甲基; 并且R 2是式（II）或（IV）的基团; 其中R 1是C 1 -C 6烷基，C 3 -C 6烯基或苄基，其中苯基任选被相同或不同的卤素或甲氧基单取代或二取代; m为0〜2; n和o是1或2.化合物显示5-HT 4受体激动剂活性。

公开(公告)号：US5753654A

公开(公告)日：1998-05-19

申请号：US737133

申请日：1996-11-07

申请人： Haruhiko Kikuchi ,  Hiroaki Satoh ,  Ruta Fukutomi ,  Kohei Inomata ,  Masashi Suzuki ,  Koichiro Hagihara ,  Takeo Arai ,  Setsuko Mino ,  Haruko Eguchi

发明人： Haruhiko Kikuchi ,  Hiroaki Satoh ,  Ruta Fukutomi ,  Kohei Inomata ,  Masashi Suzuki ,  Koichiro Hagihara ,  Takeo Arai ,  Setsuko Mino ,  Haruko Eguchi

IPC分类号： A61K31/535 ,  C07D265/30 ,  C07D265/36 ,  C07D413/00

CPC分类号： A61K31/535 ,  C07D265/30 ,  C07D265/36 ,  C07D413/00

摘要： Novel diaminomethylidene derivatives represented by formula (I) ##STR1## wherein R.sup.1 is a hydrogen atom, a C.sub.1 -C.sub.6 alkyl group, a C.sub.3 -C.sub.6 cycloalkyl group and others, R.sup.2 is a group of the following formula ##STR2## and others, R.sup.3 is a hydrogen atom, a C.sub.1 -C.sub.6 alkyl group and others, X is O, S, CHNO.sub.2, C(COOR.sup.4).sub.2, C(COOR.sup.4)CN or C(CN).sub.2) or pharmacologically acceptable salts thereof. The above-mentioned compounds are useful as a gastrointestinal prokinetic agent to be used for the treatment of digestive tract diseases.

公开(公告)号：US5246945A

公开(公告)日：1993-09-21

申请号：US830853

申请日：1992-02-04

申请人： Haruhiko Kikuchi ,  Hiroaki Satoh ,  Toshio Suguro ,  Koichiro Hagihara ,  Toru Hayakawa ,  Setsuko Mino

发明人： Haruhiko Kikuchi ,  Hiroaki Satoh ,  Toshio Suguro ,  Koichiro Hagihara ,  Toru Hayakawa ,  Setsuko Mino

IPC分类号： A61K31/40 ,  A61K31/415 ,  A61K31/425 ,  A61K31/44 ,  A61K31/4427 ,  A61K31/445 ,  A61K31/451 ,  A61K31/47 ,  A61P1/00 ,  A61P1/04 ,  A61P1/08 ,  A61P25/00 ,  A61P25/04 ,  A61P25/06 ,  A61P25/18 ,  A61P25/20 ,  A61P43/00 ,  C07D211/18 ,  C07D211/22 ,  C07D211/26 ,  C07D401/12 ,  C07D417/12 ,  C07D471/04

CPC分类号： C07D401/12 ,  C07D211/18 ,  C07D211/22 ,  C07D417/12 ,  C07D471/04

摘要： Disclosed are compounds of formula (I) ##STR1## in which A is ##STR2## The compounds are selective antagonists of 5HT at 5-HT.sub.3 receptors and useful in the treatment of psychotic disorders, neurotic diseases, gastric stasis symptoms, gastrointestinal disorders, nausea and vomiting.

公开(公告)号：US5238964A

公开(公告)日：1993-08-24

申请号：US835744

申请日：1992-02-13

申请人： Haruhiko Kikuchi ,  Hiroji Yanamoto

发明人： Haruhiko Kikuchi ,  Hiroji Yanamoto

IPC分类号： A61K31/24 ,  A61K31/40

CPC分类号： A61K31/40 ,  A61K31/24

摘要： A method for the treatment of cerebrovascular contraction in mammals involving administration of a pharmaceutical composition containing as an effective ingredient a p-guanidinobenzoic acid derivative represented by the formula ##STR1## wherein R denotes a group represented by the formula ##STR2## or a pharmaceutically acceptable salt thereof, and a pharmaceutically acceptable carrier.

摘要翻译： 一种治疗哺乳动物脑血管收缩的方法，涉及给药药物组合物，所述药物组合物含有下式表示的对胍胍苯甲酸衍生物作为有效成分，其中R表示由式“IMAGE”表示的基团或药学上可接受的 其盐和药学上可接受的载体。

公开(公告)号：US5187166A

公开(公告)日：1993-02-16

申请号：US730699

申请日：1991-07-16

申请人： Haruhiko Kikuchi ,  Hiroaki Satoh ,  Nobuhiro Yahata ,  Koichiro Hagihara ,  Toru Hayakawa ,  Setsuko Mino ,  Makoto Yanai

发明人： Haruhiko Kikuchi ,  Hiroaki Satoh ,  Nobuhiro Yahata ,  Koichiro Hagihara ,  Toru Hayakawa ,  Setsuko Mino ,  Makoto Yanai

IPC分类号： C07D471/08 ,  C07D498/08 ,  C07D513/08

CPC分类号： C07D471/08 ,  C07D513/08

摘要： Azabicyclo derivatives of formula (I) and pharmaceutically acceptable salts thereof: ##STR1## wherein A is a group of formula (a), (b) or (c): ##STR2## wherein R.sub.1 is hydrogen, C.sub.1 -C.sub.10 alkyl, aralkyl or di(C.sub.1 -C.sub.4) alkylamino(C.sub.1 -C.sub.6)alkyl;R.sub.2, R.sub.3 and R.sub.4 may be the same or different and each is hydrogen, amino, halogen, C.sub.1 -C.sub.4 alkoxy or phthalimide; X is O or NH;R is C.sub.1 -C.sub.4 alkyl; andY is NR, O or S;having 5-HT.sub.3 receptor antagonist activity.

公开(公告)号：US4610828A

公开(公告)日：1986-09-09

申请号：US783872

申请日：1985-10-03

申请人： Haruhiko Kikuchi

发明人： Haruhiko Kikuchi

IPC分类号： C07B57/00 ,  A61K31/205 ,  C07B31/00 ,  C07C67/00 ,  C07C227/00 ,  C07C227/34 ,  C07C229/22

CPC分类号： A61K31/205

摘要： L-carnitine and salts thereof are resolved from DL-carnitine by the use as a resolving agent of dibenzoyl-L(+)tartaric acid. L-carnitine is known as vitamin B.sub.T and is useful as a medicine.

摘要翻译： L-肉毒碱及其盐通过用作二苯甲酰-L（+）酒石酸的拆分剂从DL-肉碱中分离出来。 左旋肉碱被称为维生素BT，可用作药物。