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    Adjustable and Fillable Weight Plate
    11.
    发明公开
    Adjustable and Fillable Weight Plate 审中-公开

    公开(公告)号：US20240139574A1

    公开(公告)日：2024-05-02

    申请号：US17976780

    申请日：2022-10-29

    Applicant: David Diguardi ,  Mark Fleming

    Inventor： David Diguardi ,  Mark Fleming

    IPC: A63B21/06 ,  A63B21/072

    CPC classification number: A63B21/0603 ,  A63B21/072

    Abstract: An adjustable weight plate to be used with a standard or Olympic barbell handle, comprising a wide opening that is easy to fill with sand or other loose filler material, multiple inner compartments to separate out the sand and equalize the weight, and reinforcing dividers to strengthen the weight plate. The adjustable weight plate also comprises a metal collar to strengthen the inner radius of the weight plate, and an easy-fill funnel to fill the weight plate with sand.

    Crystal structure of Rho-kinase I kinase domain complexes and binding pockets thereof
    12.
    发明申请
    Crystal structure of Rho-kinase I kinase domain complexes and binding pockets thereof 有权
    Rho激酶I激酶结构域复合物的晶体结构及其结合位点

    公开(公告)号：US20090036654A1

    公开(公告)日：2009-02-05

    申请号：US11478194

    申请日：2006-06-28

    Applicant: Marc Jacobs ,  Koto Hayakawa ,  Mark Fleming ,  John Doran ,  Craig Marhefka

    Inventor： Marc Jacobs ,  Koto Hayakawa ,  Mark Fleming ,  John Doran ,  Craig Marhefka

    IPC: C07K14/00 ,  G06F17/50

    CPC classification number: C12N9/1205 ,  C07K2299/00

    Abstract: The present invention relates to human Rho-kinase I (ROCK I), ROCK I binding pockets, ROCK I-like binding pockets. More particularly, the present invention provides a computer comprising a data storage medium encoded with the structure coordinates of such binding pockets. This invention also relates to methods of using the structure coordinates to solve the structure of homologous proteins or protein complexes. In addition, this invention relates to methods of using the structure coordinates to screen for and design compounds, including inhibitory compounds, that bind to ROCK I protein or ROCK I protein homologues, or complexes thereof. The invention also relates to crystallizable compositions and crystals comprising ROCK I kinase domain and ROCK I kinase domain complexed with an inhibitor of that domain. The invention also relates to methods of identifying inhibitors of the ROCK I kinase domain.

    Abstract translation: 本发明涉及人Rho-kinase I（ROCK I），ROCK I结合口袋，ROCK I样结合口袋。 更具体地说，本发明提供了一种计算机，其包括用这种结合口袋的结构坐标编码的数据存储介质。 本发明还涉及使用结构坐标来解决同源蛋白质或蛋白质复合物的结构的方法。 此外，本发明涉及使用结构坐标筛选和设计结合ROCK I蛋白或ROCK I蛋白同源物的化合物（包括抑制性化合物）或其复合物的方法。 本发明还涉及包含与该结构域的抑制剂复合的ROCK I激酶结构域和ROCK I激酶结构域的可结晶组合物和晶体。 本发明还涉及鉴定ROCK I激酶结构域的抑制剂的方法。

    Method and apparatus for predicting and reporting a real estate value based on a weighted average of predicted values
    14.
    发明授权
    Method and apparatus for predicting and reporting a real estate value based on a weighted average of predicted values 有权
    基于预测值的加权平均值来预测和报告房地产价值的方法和装置

    公开(公告)号：US06876955B1

    公开(公告)日：2005-04-05

    申请号：US10324075

    申请日：2002-12-20

    Applicant: Mark Fleming ,  Chionglong Kuo

    Inventor： Mark Fleming ,  Chionglong Kuo

    IPC: G06Q30/00 ,  G06F17/60

    CPC classification number: G06Q30/06 ,  G06Q40/00

    Abstract: A system and method of accurately predicting and reporting a value of a property based on a weighted average of values predicted by at least two prediction models. The system and method include the steps of accessing predicted values, determined by the prediction models, for the property; determining property-specific proportional prediction error distribution information for each predicted value determined by each prediction model; assigning a weight to the predicted value determined by each prediction model by using the property-specific proportional prediction error distribution information; and generating a property-specific weighted average value based on combination of the weight and the predicted value determined by each prediction model and reporting the property-specific weighted average value to minimize prediction error during prediction of the property value.

    Abstract translation: 一种基于由至少两个预测模型预测的值的加权平均值来精确地预测和报告属性值的系统和方法。 该系统和方法包括访问由预测模型确定的用于属性的预测值的步骤; 确定由每个预测模型确定的每个预测值的特性比例预测误差分布信息; 通过使用所述特定的比例预测误差分布信息，将权重分配给由每个预测模型确定的预测值; 并且基于由每个预测模型确定的权重和预测值的组合来生成特性加权平均值，并且报告特性加权平均值，以在预测该属性值期间最小化预测误差。

    Crystal structure of Rho-kinase I kinase domain complexes and binding pockets thereof
    15.
    发明授权
    Crystal structure of Rho-kinase I kinase domain complexes and binding pockets thereof 有权
    Rho激酶I激酶结构域复合物的晶体结构及其结合位点

    公开(公告)号：US07655446B2

    公开(公告)日：2010-02-02

    申请号：US11478194

    申请日：2006-06-28

    Applicant: Marc Jacobs ,  Koto Hayakawa ,  Mark Fleming ,  John Doran ,  Craig Marhefka

    Inventor： Marc Jacobs ,  Koto Hayakawa ,  Mark Fleming ,  John Doran ,  Craig Marhefka

    IPC: C12N9/00 ,  G01N31/00

    CPC classification number: C12N9/1205 ,  C07K2299/00

    Abstract: The present invention relates to human Rho-kinase I (ROCK I), ROCK I binding pockets, ROCK I-like binding pockets. More particularly, the present invention provides a computer comprising a data storage medium encoded with the structure coordinates of such binding pockets. This invention also relates to methods of using the structure coordinates to solve the structure of homologous proteins or protein complexes. In addition, this invention relates to methods of using the structure coordinates to screen for and design compounds, including inhibitory compounds, that bind to ROCK I protein or ROCK I protein homologues, or complexes thereof. The invention also relates to crystallizable compositions and crystals comprising ROCK I kinase domain and ROCK I kinase domain complexed with an inhibitor of that domain. The invention also relates to methods of identifying inhibitors of the ROCK I kinase domain.

    Abstract translation: 本发明涉及人Rho-kinase I（ROCK I），ROCK I结合口袋，ROCK I样结合口袋。 更具体地说，本发明提供了一种计算机，其包括用这种结合口袋的结构坐标编码的数据存储介质。 本发明还涉及使用结构坐标来解决同源蛋白质或蛋白质复合物的结构的方法。 此外，本发明涉及使用结构坐标筛选和设计结合ROCK I蛋白或ROCK I蛋白同源物的化合物（包括抑制性化合物）或其复合物的方法。 本发明还涉及包含与该结构域的抑制剂复合的ROCK I激酶结构域和ROCK I激酶结构域的可结晶组合物和晶体。 本发明还涉及鉴定ROCK I激酶结构域的抑制剂的方法。

    Molecules comprising an IMPDH-like binding pocket and encoded data storage medium capable of graphically displaying them
    16.
    发明申请
    Molecules comprising an IMPDH-like binding pocket and encoded data storage medium capable of graphically displaying them 失效
    包含IMPDH样结合袋的分子和能够图形显示它们的编码数据存储介质

    公开(公告)号：US20070124083A1

    公开(公告)日：2007-05-31

    申请号：US11645289

    申请日：2006-12-21

    Applicant: Keith Wilson ,  Michael Sintchak ,  Mark Fleming ,  David Armistead

    Inventor： Keith Wilson ,  Michael Sintchak ,  Mark Fleming ,  David Armistead

    IPC: G06F19/00

    CPC classification number: C12Q1/32 ,  C07K2299/00 ,  C12N9/0006 ,  C12Y101/01205 ,  G06F19/706

    Abstract: The present invention relates to a data storage medium encoded with the corresponding structure coordinates of molecules and molecular complexes which comprise the active site binding pockets of IMPDH. Such data storage material is capable of displaying such molecules and molecular complexes, or their structural homologues, as a graphical three-dimensional representation on a computer screen. This invention also relates to methods of using the structure coordinates to solve the structure of homologous proteins or protein complexes. In addition, this invention relates to methods of using the structure coordinates to screen and design compounds, including inhibitory compounds, that bind to IMPDH or homologues thereof. This invention also relates to molecules and molecular complexes which comprise the active site binding pockets of IMPDH or close structural homologues of the active site binding pockets. This invention also relates to compounds and pharmaceutical compositions which are inhibitors of IMPDH.

    Abstract translation: 本发明涉及用包含IMPDH的活性位点结合口袋的分子和分子复合物的相应结构坐标编码的数据存储介质。 这样的数据存储材料能够在计算机屏幕上显示这样的分子和分子复合物或其结构同系物作为图形三维表示。 本发明还涉及使用结构坐标来解决同源蛋白质或蛋白质复合物的结构的方法。 此外，本发明涉及使用结构坐标来筛选和设计结合IMPDH或其同系物的化合物（包括抑制性化合物）的方法。 本发明还涉及包含IMPDH的活性位点结合袋或活性位点结合口袋的紧密结构同系物的分子和分子复合物。 本发明还涉及作为IMPDH抑制剂的化合物和药物组合物。

    Molecules comprising a calcineurin-like binding pocket and encoded data storage medium capable of graphically displaying them
    17.
    发明申请
    Molecules comprising a calcineurin-like binding pocket and encoded data storage medium capable of graphically displaying them 审中-公开
    包含钙调神经磷酸酶结合口袋的分子和能够图形显示它们的编码数据存储介质

    公开(公告)号：US20070010952A1

    公开(公告)日：2007-01-11

    申请号：US11471290

    申请日：2006-06-19

    Applicant: David Armistead ,  Matthew Fitzgibbon ,  Mark Fleming ,  James Griffith ,  Eunice Kim ,  Joseph Kim ,  Michael Sintchak ,  John Thomson ,  Keith Wilson

    Inventor： David Armistead ,  Matthew Fitzgibbon ,  Mark Fleming ,  James Griffith ,  Eunice Kim ,  Joseph Kim ,  Michael Sintchak ,  John Thomson ,  Keith Wilson

    IPC: G06F19/00 ,  C07K14/705

    CPC classification number: C07K14/705 ,  C12N9/16

    Abstract: The present invention relates to crystallized molecules and molecular complexes which comprise the active site binding pocket or the FKBP12/FK506 binding pocket of calcineurin or close structural homologues to either binding pocket. This invention also relates to a data storage material encoded with the corresponding structure coordinates of those crystallized molecules or molecular complexes. Such data storage material is capable of displaying such molecules and molecular complexes as a graphical three-dimensional representation on a computer screen. In addition, this invention relates to methods of using the structure coordinates of those molecules or molecular complexes to solve the structure of homologous proteins. This invention also relates to methods of using the structure coordinates to screen and design compounds that bind to calcineurin or homologues thereof.

    Abstract translation: 本发明涉及结晶分子和分子复合物，其包含活性位点结合口袋或钙调神经磷酸酶的FKBP12 / FK506结合口袋或紧密结构同源物至结合口袋。 本发明还涉及用这些结晶分子或分子复合物的对应结构坐标编码的数据存储材料。 这样的数据存储材料能够在计算机屏幕上显示作为图形三维表示的分子和分子复合物。 此外，本发明涉及使用这些分子或分子复合物的结构坐标来解决同源蛋白质结构的方法。 本发明还涉及使用结构坐标来筛选和设计结合钙调神经磷酸酶或其同系物的化合物的方法。

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