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    Adjustable and fillable weight plate
    1.
    发明授权
    Adjustable and fillable weight plate 有权

    公开(公告)号：US12070645B2

    公开(公告)日：2024-08-27

    申请号：US17976780

    申请日：2022-10-29

    Applicant: David Diguardi ,  Mark Fleming

    Inventor： David Diguardi ,  Mark Fleming

    IPC: A63B21/06 ,  A63B21/072

    CPC classification number: A63B21/0603 ,  A63B21/072

    Abstract: An adjustable weight plate to be used with a standard or Olympic barbell handle, comprising a wide opening that is easy to fill with sand or other loose filler material, multiple inner compartments to separate out the sand and equalize the weight, and reinforcing dividers to strengthen the weight plate. The adjustable weight plate also comprises a metal collar to strengthen the inner radius of the weight plate, and an easy-fill funnel to fill the weight plate with sand.

    Adjustable and Fillable Weight Plate
    2.
    发明公开
    Adjustable and Fillable Weight Plate 审中-公开

    公开(公告)号：US20240139574A1

    公开(公告)日：2024-05-02

    申请号：US17976780

    申请日：2022-10-29

    Applicant: David Diguardi ,  Mark Fleming

    Inventor： David Diguardi ,  Mark Fleming

    IPC: A63B21/06 ,  A63B21/072

    CPC classification number: A63B21/0603 ,  A63B21/072

    Abstract: An adjustable weight plate to be used with a standard or Olympic barbell handle, comprising a wide opening that is easy to fill with sand or other loose filler material, multiple inner compartments to separate out the sand and equalize the weight, and reinforcing dividers to strengthen the weight plate. The adjustable weight plate also comprises a metal collar to strengthen the inner radius of the weight plate, and an easy-fill funnel to fill the weight plate with sand.

    Automated grill cleaning system
    5.
    发明授权
    Automated grill cleaning system 有权

    公开(公告)号：US10244895B2

    公开(公告)日：2019-04-02

    申请号：US15252780

    申请日：2016-08-31

    Applicant: Mark Fleming

    Inventor： Mark Fleming

    IPC: A47J37/07 ,  B08B1/00 ,  A47L13/34

    Abstract: An automated grill cleaning system for automatically cleaning a grill in a cooker includes a cooking unit that may be used to cook. The cooking unit has a housing and a grill is positioned in the housing. The housing has an outer wall. A cleaning unit is coupled to the cooking unit and the cleaning unit is positioned on the outer wall. The cleaning unit selectively engages the grill. The cleaning unit urges itself to travel along the grill to abrade debris from the grill.

    Automated Grill Cleaning System
    6.
    发明申请
    Automated Grill Cleaning System 审中-公开

    公开(公告)号：US20180056338A1

    公开(公告)日：2018-03-01

    申请号：US15252780

    申请日：2016-08-31

    Applicant: Mark Fleming

    Inventor： Mark Fleming

    IPC: B08B1/00 ,  A47J37/07

    CPC classification number: A47J37/0786 ,  A47J37/0704 ,  A47L13/34 ,  B08B1/002 ,  B08B1/005 ,  B08B1/008

    Abstract: An automated grill cleaning system for automatically cleaning a grill in a cooker includes a cooking unit that may be used to cook. The cooking unit has a housing and a grill is positioned in the housing. The housing has an outer wall. A cleaning unit is coupled to the cooking unit and the cleaning unit is positioned on the outer wall. The cleaning unit selectively engages the grill. The cleaning unit urges itself to travel along the grill to abrade debris from the grill.

    Method and apparatus for predicting and reporting a real estate value based on a weighted average of predicted values
    8.
    发明授权
    Method and apparatus for predicting and reporting a real estate value based on a weighted average of predicted values 有权
    基于预测值的加权平均值来预测和报告房地产价值的方法和装置

    公开(公告)号：US07305328B1

    公开(公告)日：2007-12-04

    申请号：US10975337

    申请日：2004-10-29

    Applicant: Mark Fleming ,  Chionglong Kuo

    Inventor： Mark Fleming ,  Chionglong Kuo

    IPC: G06F17/60

    CPC classification number: G06Q30/06 ,  G06Q40/00

    Abstract: A system and method of accurately predicting and reporting a value of a property based on a weighted average of values predicted by at least two prediction models. The system and method include the steps of accessing predicted values, determined by the prediction models, for the property; determining property-specific proportional prediction error distribution information for each predicted value determined by each prediction model; assigning a weight to the predicted value determined by each prediction model by using the property-specific proportional prediction error distribution information; and generating a property-specific weighted average value based on combination of the weight and the predicted value determined by each prediction model and reporting the property-specific weighted average value to minimize prediction error during prediction of the property value.

    Abstract translation: 一种基于由至少两个预测模型预测的值的加权平均值来精确地预测和报告属性值的系统和方法。 该系统和方法包括访问由预测模型确定的用于属性的预测值的步骤; 确定由每个预测模型确定的每个预测值的特性比例预测误差分布信息; 通过使用所述特定的比例预测误差分布信息，将权重分配给由每个预测模型确定的预测值; 并且基于由每个预测模型确定的权重和预测值的组合来生成特性加权平均值，并且报告特性加权平均值，以在预测该属性值期间最小化预测误差。

    Crystal structure of Rho-kinase I kinase domain complexes and binding pockets thereof
    9.
    发明申请
    Crystal structure of Rho-kinase I kinase domain complexes and binding pockets thereof 有权
    Rho激酶I激酶结构域复合物的晶体结构及其结合位点

    公开(公告)号：US20090036654A1

    公开(公告)日：2009-02-05

    申请号：US11478194

    申请日：2006-06-28

    Applicant: Marc Jacobs ,  Koto Hayakawa ,  Mark Fleming ,  John Doran ,  Craig Marhefka

    Inventor： Marc Jacobs ,  Koto Hayakawa ,  Mark Fleming ,  John Doran ,  Craig Marhefka

    IPC: C07K14/00 ,  G06F17/50

    CPC classification number: C12N9/1205 ,  C07K2299/00

    Abstract: The present invention relates to human Rho-kinase I (ROCK I), ROCK I binding pockets, ROCK I-like binding pockets. More particularly, the present invention provides a computer comprising a data storage medium encoded with the structure coordinates of such binding pockets. This invention also relates to methods of using the structure coordinates to solve the structure of homologous proteins or protein complexes. In addition, this invention relates to methods of using the structure coordinates to screen for and design compounds, including inhibitory compounds, that bind to ROCK I protein or ROCK I protein homologues, or complexes thereof. The invention also relates to crystallizable compositions and crystals comprising ROCK I kinase domain and ROCK I kinase domain complexed with an inhibitor of that domain. The invention also relates to methods of identifying inhibitors of the ROCK I kinase domain.

    Abstract translation: 本发明涉及人Rho-kinase I（ROCK I），ROCK I结合口袋，ROCK I样结合口袋。 更具体地说，本发明提供了一种计算机，其包括用这种结合口袋的结构坐标编码的数据存储介质。 本发明还涉及使用结构坐标来解决同源蛋白质或蛋白质复合物的结构的方法。 此外，本发明涉及使用结构坐标筛选和设计结合ROCK I蛋白或ROCK I蛋白同源物的化合物（包括抑制性化合物）或其复合物的方法。 本发明还涉及包含与该结构域的抑制剂复合的ROCK I激酶结构域和ROCK I激酶结构域的可结晶组合物和晶体。 本发明还涉及鉴定ROCK I激酶结构域的抑制剂的方法。

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