公开(公告)号：US20210214663A1

公开(公告)日：2021-07-15

申请号：US17047349

申请日：2018-08-20

Applicant: Hewlett-Packard Development Company, L.P.

Inventor： Steven Barcelo ,  Anita Rogacs ,  Fausto D'Apuzzo ,  Caitlin DeJong ,  Milo Overbay

IPC: C12M1/32 ,  C12M1/26 ,  G01N21/3577 ,  C12Q1/18 ,  C12M3/06

Abstract: An example of an apparatus includes a plurality of wells, wherein each well is to receive a cell culture and a cell culture liquid. The apparatus also includes a collector to contact the cell culture liquid in a well selected from the plurality of wells. The collector is to draw a microfluidic sample of the cell culture liquid from the well. In addition, the apparatus includes a sensor substrate to receive the microfluidic sample, wherein the sensor substrate is to be used to measure a characteristic of the cell culture liquid. Also, the apparatus includes a microfluidic channel to transport the microfluidic sample from the collector to the sensor substrate.

公开(公告)号：US20240294014A1

公开(公告)日：2024-09-05

申请号：US18275789

申请日：2021-02-04

Applicant: Hewlett-Packard Development Company, L.P.

Inventor： Fausto D'Apuzzo ,  Yang Lei

IPC: B41J2/175 ,  G06V10/10 ,  G06V10/75 ,  H04N1/00

CPC classification number: B41J2/17546 ,  G06V10/19 ,  G06V10/751 ,  H04N1/00251

Abstract: In example implementations, an apparatus is provided. The apparatus includes a moveable stage, a print cartridge, a camera, and a processor. The moveable stage is to hold a well plate. The print cartridge holder is to hold a print cartridge that includes a print die over the moveable stage. The camera is located above the movable stage and the print cartridge holder. The camera is positioned such that the movable stage and the print die are within a field of view of the camera. The processor is to calculate a first offset a first offset of the well plate and a second offset of the print die. The movement of the movable stage is controlled by the processor in accordance with the first offset and the second offset.

公开(公告)号：US20230234052A1

公开(公告)日：2023-07-27

申请号：US18012219

申请日：2020-07-07

Applicant: Hewlett-Packard Development Company, L.P.

Inventor： Fausto D'Apuzzo ,  Viktor Shkolnikov ,  Alexander N. Govyadinov

IPC: B01L3/00

CPC classification number: B01L3/502715 ,  B01L2300/0654 ,  B01L2300/0877 ,  B01L2300/168 ,  B01L2300/0636

Abstract: A microfluidic sensing assembly may include a first structure supporting a sensor array, a second structure joined to the first structure and forming a microfluidic passage and a flat lens to focus light, following reflection of the light back and forth across the microfluidic passage, from the microfluidic passage onto the sensor array.

公开(公告)号：US20230008110A1

公开(公告)日：2023-01-12

申请号：US17778957

申请日：2020-04-04

Applicant: HEWLETT-PACKARD DEVELOPMENT COMPANY, L.P.

Inventor： Fausto D'Apuzzo ,  Viktor Shkolnikov ,  Alexander N. Govyadinov

IPC: G01N21/25 ,  G01N35/10 ,  B01L3/00

Abstract: An integrated fluid ejection and spectroscopic sensing system may include a fluid ejector to eject a droplet of fluid through an ejection orifice towards a deposition site, a sensor array, a dispersive element to project light onto the sensor array. The dispersive element, the sensor and the fluid ejector are joined as part of an integrated unit.

公开(公告)号：US20220088595A1

公开(公告)日：2022-03-24

申请号：US17415066

申请日：2019-06-04

Applicant: Hewlett-Packard Development Company, L.P.

Inventor： Fausto D'Apuzzo ,  Steven Barcelo ,  Anita Rogacs

IPC: B01L3/00 ,  G01N21/65 ,  G01J3/44 ,  G01J3/28

Abstract: Integrated microfluidic ejector chips and methods of use are provided. An example of an integrated microfluidic ejector chip includes a first set of microfluidic ejectors fed with a reference solution, and a second set of microfluidic ejectors fed with a sample solution. The first set of microfluidic ejectors and the second set of microfluidic ejectors are disposed on the integrated microfluidic ejector chip to print a pattern of proximately located spots on a sensor.

公开(公告)号：US20220080372A1

公开(公告)日：2022-03-17

申请号：US17415217

申请日：2019-06-04

Applicant: Hewlett-Packard Development Company, L.P.

Inventor： Steven Barcelo ,  Fausto D'Apuzzo ,  Anita Rogacs

IPC: B01F33/301 ,  G01N21/25 ,  G05D11/13 ,  B01F35/83 ,  B01F31/85

Abstract: A system and a method for on-chip dilution of a calibration solution are provided. An exemplary system includes a microfluidic ejector chip. The microfluidic ejector chip includes a calibration reservoir to contain a calibration standard and a dilution reservoir to contain a dilution solvent. A first fluid control device couples the calibration reservoir to a mixing chamber, and a second fluid control device couples a dilution reservoir to the mixing chamber. The mixing chamber is fluidically coupled to a microfluidic ejector.

公开(公告)号：US20220026361A1

公开(公告)日：2022-01-27

申请号：US17297427

申请日：2018-12-18

Applicant: Hewlett-Packard Development Company, L.P.

Inventor： Fausto D'Apuzzo ,  Steven Barcelo ,  Raghuvir N. Sengupta

IPC: G01N21/64 ,  G01N21/65

Abstract: In an example method, an ordered array of microdots including an analyte printed on a surface of a surface-enhanced substrate of an analysis chip is probed with an excitation beam of electromagnetic radiation. Emitted radiation is detected from a number of microdots of the ordered array of microdots. Calibration data is generated for the analysis chip with respect to the analyte based on a detected shift in the emitted radiation as compared to the excitation beam.

公开(公告)号：US11125693B2

公开(公告)日：2021-09-21

申请号：US16076077

申请日：2017-01-31

Applicant: HEWLETT-PACKARD DEVELOPMENT COMPANY, L.P.

Inventor： Fausto D'Apuzzo ,  Aleksandr Polyakov ,  Anita Rogacs

IPC: G01N21/65 ,  G01N21/552

Abstract: A surface enhanced infrared absorption stage may include a substrate, a static island extending from the substrate and a movable nano finger extending from the substrate. The static island may have a plasmonically active island cap and a dimension parallel to the substrate of at least one micrometer. The movable nano finger may be aligned with the dimension. The movable nano finger may have a plasmonically active finger cap closable to less than or equal to 5 nm of the island cap.

公开(公告)号：US20230251180A1

公开(公告)日：2023-08-10

申请号：US18012632

申请日：2020-07-08

Applicant: Hewlett-Packard Development Company, L.P.

Inventor： Fausto D'Apuzzo ,  Viktor Shkolnikov ,  Alexander N. Govyadinov

IPC: G01N15/14 ,  B01L3/00

CPC classification number: G01N15/1404 ,  G01N15/1434 ,  B01L3/502761 ,  G01N2015/1495 ,  B01L2300/0654 ,  B01L2200/0663 ,  B01L2400/086 ,  B01L2400/0487

Abstract: An example method for measuring deformability of a cell via a pressure field, consistent with the present disclosure, includes flowing a biologic sample containing a plurality of cells along a first fluidic channel and into an intersection between the first fluidic channel and a second fluidic channel of a microfluidic device. The method includes introducing a pressure field at the intersection and into the first fluidic channel via the second fluidic channel and a plurality of apertures in a channel wall disposed in the intersection. The method further includes measuring deformability of a cell among the plurality of cells responsive to the introduction of the pressure field.

公开(公告)号：US20230014003A1

公开(公告)日：2023-01-19

申请号：US17778766

申请日：2019-12-20

Applicant: HEWLETT-PACKARD DEVELOPMENT COMPANY, L.P.

Inventor： Fausto D'Apuzzo ,  Viktor Shkolnikov ,  Alexander N. Govyadinov

IPC: B41J2/14 ,  B41J2/165 ,  B41J2/21

Abstract: An integrated fluid ejection and imaging system may include a fluid ejector to eject a droplet of fluid onto a deposition site on a target, an imager to image the deposition site and a packaging supporting the fluid ejector and imager such that the fluid ejector and the imager are concurrently aimed at the deposition site on the target.