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公开(公告)号：US12071657B2
公开(公告)日：2024-08-27
申请号：US16643054
申请日：2017-10-20
Applicant: Hewlett-Packard Development Company, L.P.
Inventor： Adam Higgins , Pavel Kornilovich , Alexander N. Govyadinov , Michael J. Day
IPC: B01L3/00 , B01L7/00 , B01L99/00 , C12Q1/6806 , C12Q1/686
CPC classification number: C12Q1/686 , B01L3/502746 , B01L7/525 , C12Q1/6806 , B01L2300/0816 , B01L2300/0867 , B01L2300/0883 , B01L2400/0688 , B01L2400/0694
Abstract: A nucleic acid amplifier may include a sample preparation zone, a fluid ejector, an amplification zone and a capillary break between the amplification zone and the fluid ejector.
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公开(公告)号：US11865540B2
公开(公告)日：2024-01-09
申请号：US16317429
申请日：2016-09-23
Applicant: Hewlett-Packard Development Company, L.P.
Inventor： Pavel Kornilovich , Alexander N. Govyadinov
IPC: G01N33/68 , G01N21/33 , G01N21/64 , G01N33/52 , C07C309/05 , C07C309/73 , A01N1/02 , G01N1/40 , B01L3/00
CPC classification number: B01L3/50273 , B01L3/502738 , B01L3/502746 , B01L2200/0605 , B01L2200/0621 , B01L2300/0861 , B01L2300/0867 , B01L2400/0433 , B01L2400/0442
Abstract: A microfluidic device may include at least four interconnected microfluidic channels and a set of fluid actuators. The set of fluid actuators may include a fluid actuator asymmetrically located within at least two of the at least four interconnected microfluidic channels. Each of the at least four interconnected microfluidic channels may be activated to a fluid inputting state, a fluid outputting state and a fluid blocking state in response to selective actuation of different combinations of fluid actuators of the set.
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公开(公告)号：US20230251180A1
公开(公告)日：2023-08-10
申请号：US18012632
申请日：2020-07-08
Applicant: Hewlett-Packard Development Company, L.P.
Inventor： Fausto D'Apuzzo , Viktor Shkolnikov , Alexander N. Govyadinov
CPC classification number: G01N15/1404 , G01N15/1434 , B01L3/502761 , G01N2015/1495 , B01L2300/0654 , B01L2200/0663 , B01L2400/086 , B01L2400/0487
Abstract: An example method for measuring deformability of a cell via a pressure field, consistent with the present disclosure, includes flowing a biologic sample containing a plurality of cells along a first fluidic channel and into an intersection between the first fluidic channel and a second fluidic channel of a microfluidic device. The method includes introducing a pressure field at the intersection and into the first fluidic channel via the second fluidic channel and a plurality of apertures in a channel wall disposed in the intersection. The method further includes measuring deformability of a cell among the plurality of cells responsive to the introduction of the pressure field.
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公开(公告)号：US20230014003A1
公开(公告)日：2023-01-19
申请号：US17778766
申请日：2019-12-20
Applicant: HEWLETT-PACKARD DEVELOPMENT COMPANY, L.P.
Inventor： Fausto D'Apuzzo , Viktor Shkolnikov , Alexander N. Govyadinov
Abstract: An integrated fluid ejection and imaging system may include a fluid ejector to eject a droplet of fluid onto a deposition site on a target, an imager to image the deposition site and a packaging supporting the fluid ejector and imager such that the fluid ejector and the imager are concurrently aimed at the deposition site on the target.
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公开(公告)号：US11911731B2
公开(公告)日：2024-02-27
申请号：US16316896
申请日：2016-10-21
Applicant: Hewlett-Packard Development Company, L.P.
Inventor： Erik D. Torniainen , Alexander N. Govyadinov , Pavel Kornilovich , David P. Markel , Richard W. Seaver
CPC classification number: B01F23/41 , B01F25/20 , B01F25/31 , B01F33/30 , B01F35/71755 , B01F35/717612
Abstract: An immiscible droplet generation system may include a chip, a microfluidic channel integrated into the chip, an input to the microfluidic channel through which the microfluidic channel is to be filled with a first fluid that is to be moved through the microfluidic channel and a droplet generator. The droplet generator is integrated into the chip to generate a droplet of a second fluid, immiscible within the first fluid, and to inject the droplet into the first fluid in the microfluidic channel.
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Patent Agency Ranking
公开(公告)号：US20230250378A1
公开(公告)日：2023-08-10
申请号：US18012613
申请日：2020-07-08
Applicant: Hewlett-Packard Development Company, L.P.
Inventor： Fausto D'Apuzzo , Viktor Shkolnikov , Alexander N. Govyadinov
CPC classification number: C12M23/16 , C12M35/04 , C12M41/40 , G01N15/1463 , G01N15/1459 , G01N2015/1495 , G01N2015/1006
Abstract: An example method for measuring deformability of a cell responsive to a pressure wave, consistent with the present disclosure, includes moving a cell of a sample into a cell probing chamber of a microfluidic device. While the cell is in the cell probing chamber, the method includes generating a pressure wave within the cell probing chamber by actuating a fluidic pump. The method further includes determining a deformability of the cell responsive to the pressure wave, using an imaging array synchronized with the actuation of the fluidic pump.
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公开(公告)号：US11141729B2
公开(公告)日：2021-10-12
申请号：US16605162
申请日：2018-01-24
Applicant: HEWLETT-PACKARD DEVELOPMENT COMPANY, L.P.
Inventor： Viktor Shkolnikov , Alexander N. Govyadinov , Pavel Kornilovich
Abstract: An object focuser may include a substrate, a sample fluid passage supported by the substrate, a first inertial pump supported by the substrate to pump a sample fluid entraining an object through the sample fluid passage, a first sheath fluid passage, a second inertial pump supported by the substrate to pump a first sheath fluid through the first sheath fluid passage, a second sheath fluid passage and a second inertial pump supported by the substrate to pump a second sheath fluid through the second sheath fluid passage. The first sheath fluid passage and the second sheath fluid passage are connected to the sample fluid passage at a convergence on opposite sides of the sample fluid passage.
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公开(公告)号：US20190118214A1
公开(公告)日：2019-04-25
申请号：US16221431
申请日：2018-12-14
Applicant: Hewlett-Packard Development Company, L.P.
Inventor： Alexander N. Govyadinov , Paul A. Richards
CPC classification number: B05C5/02 , B41J2/1404 , B41J2/14201 , B41J2/175 , B41J2/17563 , B41J2/17596 , B41J2002/14403 , B41J2002/14467 , B41J2202/12
Abstract: A fluid ejection apparatus may include a drop generator to eject fluid droplets in a vertical direction and a fluid channel containing the drop generator. The fluid channel may include a vertical inlet through which fluid is to enter the fluid channel and a vertical outlet through which fluid not ejected by the drop generator is to be circulated out of the fluid channel.
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公开(公告)号：US11698149B2
公开(公告)日：2023-07-11
申请号：US16477807
申请日：2017-02-15
Applicant: Hewlett-Packard Development Company, L.P.
Inventor： Pavel Kornilovich , Alexander N. Govyadinov , Viktor Shkolnikov
CPC classification number: F16K99/0017 , B01L3/502738 , B01L3/502784 , B01L2300/06 , B01L2300/0627 , B01L2300/1827 , B01L2400/0688
Abstract: A microfluidic valve may include a first portion of a liquid conduit to contain a gas, a second portion of a liquid conduit to contain a liquid, and a constriction between the first portion and the second portion and across which a capillary meniscus is to form between the gas and the liquid. The microfluidic valve may further include a drop jetting device within the second portion to open the valve by breaking the capillary meniscus across the constriction.
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公开(公告)号：US11680957B2
公开(公告)日：2023-06-20
申请号：US16772390
申请日：2018-02-12
Applicant: HEWLETT-PACKARD DEVELOPMENT COMPANY, L.P.
Inventor： Alexander N. Govyadinov , Pavel Kornilovich , Diane R. Hammerstad
IPC: G05D7/06 , G01P5/20 , B01L3/00 , G01F1/7082 , G01F1/7084 , G01F1/7086
CPC classification number: G01P5/20 , B01L3/502715 , G01F1/7082 , G05D7/0676 , B01L2300/0627 , G01F1/7084 , G01F1/7086
Abstract: A microfluidic flow sensor may include a substrate having a microfluidic channel, an inert particle source to supply a fluid carrying an inert particle to the microfluidic channel and a sensor element along the microfluidic channel and spaced from the inert particle source. The sensor element outputs a signal based upon a sensed passage of the inert particle with respect to the sensor element. Portions of the microfluidic channel proximate the sensor element have a first size and wherein the inert particle provided by the inert particle source is to have a second size greater than one half the first size.
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