公开(公告)号：US4259893A

公开(公告)日：1981-04-07

申请号：US961022

申请日：1978-11-15

申请人： Hiromi Ando ,  Kiyoshi Tateoka ,  Yoshihiro Hayashida

发明人： Hiromi Ando ,  Kiyoshi Tateoka ,  Yoshihiro Hayashida

IPC分类号： B60T13/573 ,  B60T13/577 ,  F15B9/10

CPC分类号： B60T13/577

摘要： A fluid pressure operated servomotor such as a vacuum booster including a power piston having a differential pressure acting thereacross, an input rod for actuating a valve mechanism mounted in the power piston, a reaction lever disposed between the power piston and an output rod for transmitting a force to the output rod and transmitting a reaction force to the input rod. A return spring for urging the power piston in the return direction acts through the reaction lever on the power piston, whereby the reaction force is not transmitted to the input rod until the force transmitted to the output rod exceeds a predetermined value.

摘要翻译： 一种流体压力操作的伺服电动机，例如包括具有作用在其上的压差的动力活塞的真空助力器，用于致动安装在动力活塞中的阀机构的输入杆，设置在动力活塞和输出杆之间的反作用杆， 向输出杆施加力并将反作用力传递到输入杆。 用于在返回方向上推动动力活塞的复位弹簧作用在动力活塞上的反作用杆上，由此反作用力不会传递到输入杆，直到传递到输出杆的力超过预定值。

公开(公告)号：US4085656A

公开(公告)日：1978-04-25

申请号：US704621

申请日：1976-07-12

申请人： Hiromi Ando

发明人： Hiromi Ando

IPC分类号： B60T13/57 ,  F15B9/10

CPC分类号： B60T13/57 ,  Y10T137/86919

摘要： A vacuum booster has a housing the interior of which is divided into a vacuum chamber and a pressure chamber, a plunger connected to an input rod and fitted slidably in a cylinder portion of a valve body, and valve seats defined respectively on adjacent ends of the plunger and the cylinder portion to cooperate with a seating surface of a valve member for controlling respectively the communication between the pressure chamber and the atmosphere and between the two chambers. A surface portion of the seating surface of the valve member with which at least one of the valve seats engages is a curved rotational surface.

摘要翻译： 真空助力器具有壳体，其内部被分成真空室和压力室，连接到输入杆并且可滑动地装配在阀体的气缸部分中的柱塞以及分别限定在阀体的相邻端部上的阀座 柱塞和气缸部分，以与阀构件的就座表面配合，以分别控制压力室和大气之间以及两个室之间的连通。 阀构件的座表面的至少一个阀座与其接合的表面部分是弯曲的旋转表面。

公开(公告)号：US07605272B2

公开(公告)日：2009-10-20

申请号：US11814753

申请日：2006-01-27

申请人： Yutaka Kanda ,  Hiromi Ando ,  Keiko Kawashima ,  Takamasa Sugita ,  Masayo Suzuki ,  Hisashi Tagaya ,  Tomoyuki Nakazato ,  Yoshinori Yamashita ,  Takeshi Takahashi ,  Shinji Nara ,  Hiroaki Nakamura

发明人： Yutaka Kanda ,  Hiromi Ando ,  Keiko Kawashima ,  Takamasa Sugita ,  Masayo Suzuki ,  Hisashi Tagaya ,  Tomoyuki Nakazato ,  Yoshinori Yamashita ,  Takeshi Takahashi ,  Shinji Nara ,  Hiroaki Nakamura

IPC分类号： C07D231/56 ,  C07D211/06 ,  C07D413/10 ,  C07D403/10 ,  A61K31/416 ,  A61K31/4439 ,  A61K31/496 ,  A61K31/5355 ,  A61K31/5377

CPC分类号： C07D231/56 ,  C07D401/12 ,  C07D405/12 ,  C07D409/12 ,  C07D413/12 ,  C07D417/12 ,  C07D491/10 ,  C07D495/04

摘要： The present invention provides a type I insulin-like growth factor receptor (IGF-1R) inhibitor comprising, as an active ingredient, an indazole derivative represented by Formula (I): {wherein R1 represents —NR4R5 [wherein R4 represents a hydrogen atom or the like, R5 represents substituted or unsubstituted lower alkyl, —C(═O)R6 (wherein R6 represents substituted or unsubstituted lower alkyl, substituted or unsubstituted aryl or the like), or the like], or the like, and R2 and R3 may be the same or different and each represents a hydrogen atom, hydroxy, substituted or unsubstituted lower alkoxy, or the like} or a pharmaceutically acceptable salt thereof, and the like.

摘要翻译： 本发明提供一种I型胰岛素样生长因子受体（IGF-1R）抑制剂，其包含作为活性成分的由式（I）表示的吲唑衍生物：其中R 1表示-NR 4 R 5 [其中R 4表示氢原子或 R 5表示取代或未取代的低级烷基，-C（-O）R 6（其中R 6表示取代或未取代的低级烷基，取代或未取代的芳基等），R 2和R 3可以相同 或不同的，并且各自表示氢原子，羟基，取代或未取代的低级烷氧基等}或其药学上可接受的盐等。

公开(公告)号：US20070117856A1

公开(公告)日：2007-05-24

申请号：US10548475

申请日：2004-07-30

申请人： Yoshihisa Ohta ,  Fumihiko Kanai ,  Shinji Nara ,  Yutaka Kanda ,  Hiroshi Umehara ,  Yukimasa Shiotsu ,  Tomoki Naoe ,  Hitoshi Kiyoi ,  Keiko Kawashima ,  Hiromi Ando ,  Motoki Miyama

发明人： Yoshihisa Ohta ,  Fumihiko Kanai ,  Shinji Nara ,  Yutaka Kanda ,  Hiroshi Umehara ,  Yukimasa Shiotsu ,  Tomoki Naoe ,  Hitoshi Kiyoi ,  Keiko Kawashima ,  Hiromi Ando ,  Motoki Miyama

IPC分类号： A61K31/416 ,  C07D231/56

CPC分类号： C07D231/56

摘要： The present invention provides a compound represented by Formula (I): [wherein R1 represents CONR1aR1b (wherein R1a and R1b may be the same or different and each represents a hydrogen atom, substituted or unsubstituted lower alkyl, substituted or unsubstituted aryl, substituted or unsubstituted ararkyl or a substituted or unsubstituted heterocyclic group, or R1a and R1b are combined together with the adjacent nitrogen atom thereto to form a substituted or unsubstituted heterocyclic group) or the like, R2 represents a hydrogen atom, CONR2aR2b (wherein R2a and R2b may be the same or different and each represents a hydrogen atom, substituted or unsubstituted lower alkyl, substituted or unsubstituted aryl, substituted or unsubstituted ararkyl or a substituted or unsubstituted heterocyclic group, or R2a and R2b are combined together with the adjacent nitrogen atom thereto to form a substituted or unsubstituted heterocyclic group), NR2cR2d (wherein R2c and R2d may be the same or different and each represents a hydrogen atom, substituted or unsubstituted lower alkyl, substituted or unsubstituted lower alkanoyl, substituted or unsubstituted aroyl, substituted or unsubstituted heteroaroyl, substituted or unsubstituted ararkyl, substituted or unsubstituted lower alkylsulfonyl or substituted or unsubstituted lower arylsulfonyl) or the like].

摘要翻译： 本发明提供由式（I）表示的化合物：[其中R 1表示CONR 1a 1b 1b（其中R 1a） R 1b和R 1b可以相同或不同，各自表示氢原子，取代或未取代的低级烷基，取代或未取代的芳基，取代或未取代的芳烷基或取代或未取代的杂环基， 或R 1a和R 1b与相邻的氮原子一起形成取代或未取代的杂环基）等，R 2 O， >表示氢原子，其中R 2a，R 2b和R 2b可以相同或不同， 各自表示氢原子，取代或未取代的低级烷基，取代或未取代的芳基，取代或未取代的芳烷基或取代或未取代的杂环基，或R 2b和R 2b >与t结合在一起 它与氮原子相邻以形成取代或未取代的杂环基），NR 2c R 2d（其中R 2c和R 2d） 取代或未取代的低级烷酰基，取代或未取代的芳酰基，取代或未取代的杂芳酰基，取代或未取代的芳烷基，取代或未取代的低级烷基磺酰基或 取代或未取代的低级芳基磺酰基等）。

公开(公告)号：US06698202B2

公开(公告)日：2004-03-02

申请号：US10084261

申请日：2002-02-26

申请人： Takato Ogiwara ,  Kenji Sano ,  Naganori Koshimizu ,  Hiromi Ando

发明人： Takato Ogiwara ,  Kenji Sano ,  Naganori Koshimizu ,  Hiromi Ando

IPC分类号： B60T11224

CPC分类号： B60T11/224 ,  B60T11/26

摘要： A master cylinder of the invention supplies a brake fluid from a large diameter pressurizing chamber 56 to a small diameter hydraulic chamber 49 by opening a reverse flow checking opening and closing portion 61 by sliding movement of a stepped piston 16 forwardly, that is, fast fill and when the hydraulic pressure of the large diameter pressurizing chamber 56 rises, a control valve 86 escapes the hydraulic pressure of the large diameter pressurizing chamber 56 to a reservoir 12 to gradually lower in accordance with rise of the hydraulic pressure of the small diameter hydraulic chamber 49, thereby capable of reducing a strange feeling in a pedal feeling caused by sudden pressure release of the large diameter pressuring chamber 56.

摘要翻译： 本发明的主缸通过向前倾斜阶梯式活塞16的滑动打开反向流动检查开闭部61来将制动液从大直径加压室56供给到小直径液压室49，即快速填充 并且当大直径加压室56的液压上升时，控制阀86将大直径加压室56的液压从储存器12排出，以便随着小直径液压室的液压升高逐渐降低 从而能够减小由大直径加压室56的突然的压力释放引起的踏板感觉的奇怪的感觉。

公开(公告)号：US06625981B2

公开(公告)日：2003-09-30

申请号：US10050100

申请日：2002-01-18

申请人： Junichi Ikeda ,  Hiromi Ando ,  Atsuya Koshu

发明人： Junichi Ikeda ,  Hiromi Ando ,  Atsuya Koshu

IPC分类号： F16D3102

CPC分类号： F02M35/10229 ,  B60T13/52 ,  F02M35/10

摘要： There is disclosed a pneumatic booster having a vacuum chamber connected to an intake pipe of an engine. An air outlet of an ejector is connected to the intake pipe through a vacuum control valve, and an air inlet of the ejector is connected to an air cleaner. A vacuum pick-up port of the ejector is connected to the vacuum chamber of a booster body. The vacuum control valve comprises a control chamber and a control piston, and the negative pressure in the booster is introduced into the control chamber and acts on the control piston. When the negative pressure in the booster is insufficient, the control piston acts to open the control valve and a negative pressure is supplied from the ejector to the vacuum chamber. When the negative pressure in the booster is sufficiently high, the control piston acts to close the control valve and stops the operation of the ejector, thus reducing an effect of the ejector with respect to an air/fuel ratio of the engine.

公开(公告)号：US5884548A

公开(公告)日：1999-03-23

申请号：US831143

申请日：1997-04-01

申请人： Hiromi Ando ,  Kiyoshi Shirahata ,  Mitsuhiro Endo ,  Atsuya Koshu

发明人： Hiromi Ando ,  Kiyoshi Shirahata ,  Mitsuhiro Endo ,  Atsuya Koshu

IPC分类号： B60T8/32 ,  B60T13/563 ,  F15B9/10

CPC分类号： B60T13/563 ,  B60T8/3275

摘要： A brake booster includes a housing, a partition adapted to divide the interior of the housing into two chambers, and two diaphragms adapted to divide the two chambers into constant and variable pressure chambers. A control valve includes a valve body carried by the diaphragms, and a plunger slidably received in the valve body. The control valve is operatively connected to the variable pressure chambers to develop a pressure differential across the diaphragms to cause the diaphragms to move in response to actuation of an input rod. A reaction disk is disposed between an output rod and the valve body to transmit the reaction of movement of the output rod to the input rod. An adjusting mechanism is disposed between the plunger and the reaction disk and compressible so as to develop a greater degree of pressure differential when a force applied by the input rod exceeds a predetermined level. The reaction disk is caused to make contact with the contact disk and held out of contact with the spring and the plunger when the plunger is actuated.

摘要翻译： 制动助力器包括壳体，适于将壳体的内部分成两个腔室的隔板以及适于将两个腔室分成恒定和可变压力腔室的两个隔膜。 控制阀包括由隔膜承载的阀体和可滑动地容纳在阀体中的柱塞。 控制阀可操作地连接到可变压力室，以跨越隔膜形成压力差，以响应于输入杆的致动而使隔膜移动。 反作用盘设置在输出杆和阀体之间，以将输出杆的运动反应传递到输入杆。 调节机构设置在柱塞和反作用盘之间并且可压缩，以便当由输入杆施加的力超过预定水平时产生更大程度的压力差。 当活塞被致动时，使反作用盘与接触盘接触并与弹簧和柱塞保持不接触。

公开(公告)号：US4245845A

公开(公告)日：1981-01-20

申请号：US860322

申请日：1977-12-14

申请人： Hiromi Ando ,  Tomizo Azuma

发明人： Hiromi Ando ,  Tomizo Azuma

IPC分类号： B60T13/569 ,  F16J15/12

CPC分类号： B60T13/569

摘要： A vacuum booster device having a diaphragm the inner peripheral portion of which is rigidly clamped between the outer peripheral portion of a valve body and the central portion of a piston plate, wherein a rigid annular ring is attached to the diaphragm for preventing the radial outward movement of the material of the inner peripheral portion of the diaphragm when the diaphragm is compressed axially between the valve body and the piston plate.

摘要翻译： 一种真空增压装置，其具有其内周部刚性地夹紧在阀体的外周部分与活塞板的中心部分之间的隔膜，其中刚性环形环安装在隔膜上以防止径向向外移动 当隔膜在阀体和活塞板之间轴向压缩时，隔膜的内周部分的材料。

公开(公告)号：US4100838A

公开(公告)日：1978-07-18

申请号：US748321

申请日：1976-12-07

申请人： Kiyoshi Tateoka ,  Hiromi Ando ,  Tomizo Azuma

发明人： Kiyoshi Tateoka ,  Hiromi Ando ,  Tomizo Azuma

IPC分类号： B60T13/573 ,  B60T13/577 ,  F15B9/10 ,  F01B31/12

CPC分类号： B60T13/577

摘要： A vacuum augmentation device for use with a vehicle braking system and of the type having a body, a diaphragm-piston mechanism providing a pair of fluid chambers in the body, valving for isolating or communicating the chambers, a push rod actuated plunger assembly for operating the valving, an output rod shiftably mounted in the body and carrying a fulcrum plate, and a number of reaction levers for effecting a lever type coupling between the diaphragm-piston mechanism, the shiftable plunger assembly and the fulcrum plate on the output rod is provided with improved structure for coupling the reaction levers with the diaphragm-piston mechanism, which structure employs a mounting plate member engaged with the mechanism and carrying on the opposite side thereof an elongate fulcrum pin for each reaction lever which is longitudinally engageable with the latter in line contacting relationship to provide a radially fixed fulcrum for each of the reaction levers. The improved structure facilitates assembly of the device, provides for retention of the fulcrum pins against dropping out, and establishes the kind of radially fixed, line contact fulcrums necessary to prevent material change in the augmentation ratio with wear.

摘要翻译： 一种与车辆制动系统一起使用的真空增压装置，具有本体的类型的真空增强装置，在主体中提供一对流体室的隔膜活塞机构，用于隔离或连通腔室的阀，用于操作的推杆致动柱塞组件 阀，输出杆可移动地安装在主体中并承载支点板，并且提供多个用于在隔膜活塞机构，可移动柱塞组件和输出杆上的支点板之间进行杠杆式联接的反作用杆 具有改进的结构，用于将反作用杆与隔膜 - 活塞机构联接，该结构采用与机构接合的安装板构件，并在其相对侧上承载用于每个​​反作用杆的细长支点销，该支撑销可纵向与后者成直线接合 接触关系以为每个反应杆提供径向固定的支点。 改进的结构便于装置的组装，提供支撑销的保持以防止掉落，并且建立了防止材料随着磨损增加比例变化所必需的径向固定的线接触支点的种类。

公开(公告)号：US06578360B2

公开(公告)日：2003-06-17

申请号：US09984794

申请日：2001-10-31

申请人： Tomonori Mouri ,  Takato Ogiwara ,  Hiromi Ando ,  Naganori Koshimizu

发明人： Tomonori Mouri ,  Takato Ogiwara ,  Hiromi Ando ,  Naganori Koshimizu

IPC分类号： B60T1120

CPC分类号： B60T11/20

摘要： A master cylinder including a cylinder having one end open to the outside. A secondary piston guide ring, a sleeve and a primary piston guide ring are adapted to be fitted in this order into the cylinder from the one open end. A piston is slidably fitted in an axial direction of the cylinder, into each of the secondary piston guide ring, the sleeve and the primary piston guide ring. A retainer is provided at the open end of the cylinder, and adapted to abut against the primary piston guide ring so as to prevent escape of the primary piston guide ring from the cylinder. An elastic member is provided between a rearward end portion of the sleeve and a forward end portion of the primary piston guide ring.

摘要翻译： 主缸，其具有一端向外敞开的气缸。 次级活塞导向环，套筒和主活塞导向环适于从一个开口端顺次安装到气缸中。 活塞在气缸的轴向方向可滑动地装配到每个次级活塞导向环，套筒和主活塞导向环中。 保持器设置在气缸的开口端处，并且适于抵靠主活塞导向环，以防止主活塞导向环从气缸逸出。 弹性构件设置在套筒的后端部和主活塞导向环的前端部之间。