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92 条记录 (耗时 0.036 秒)

    Skin external agents and drugs
    11.
    发明授权
    Skin external agents and drugs 失效
    皮肤外用剂和药物

    公开(公告)号：US07037489B2

    公开(公告)日：2006-05-02

    申请号：US10169040

    申请日：2000-12-15

    申请人： Hideyo Uchiwa ,  Sachiyo Hirotsu ,  Akinori Haratake ,  Takeshi Ikemoto ,  Junichi Matsui ,  Shunsuke Yamazaki ,  Masaki Yoshida ,  Motoi Hayase

    发明人： Hideyo Uchiwa ,  Sachiyo Hirotsu ,  Akinori Haratake ,  Takeshi Ikemoto ,  Junichi Matsui ,  Shunsuke Yamazaki ,  Masaki Yoshida ,  Motoi Hayase

    IPC分类号： A61K31/74 ,  A61K6/00

    CPC分类号： C07C69/60 ,  A61K8/39 ,  A61K8/671 ,  A61K31/22 ,  A61K31/225 ,  A61Q17/00 ,  A61Q17/04 ,  A61Q19/00 ,  A61Q19/007 ,  A61Q19/08 ,  A61Q19/10

    摘要： Skin external agent compositions and drugs characterized by containing fumaric acid diester derivatives represented by following general formula (1), wherein R1 represents C1-4 alkylene; R2 and R3 represent each liner or branched C1-8 alkyl; and n is an integer of 2 to 5; which provide epidermal barrier function potentiating agents and skin external agent compositions having a high safety, quickly relieving epidermal permeation barrier function failures and having an effect of maintaining the skin in a cosmetologically healthy state; agents to be used together with HB-EFG expression inducing agents accelerating epidermal turnover, amphiregulin expression inhibitors regulating excessive epidermal proliferation, and retinoic acid or its derivative preventing skin chapping caused by retinoic acid or its derivative; and skin aging relieving agents capable of ameliorating depression in the skin metabolism and thinning in association with aging.

    摘要翻译： 皮肤外用剂组合物和药物，其特征在于含有由以下通式（1）表示的富马酸二酯衍生物，其中R 1表示C 1-4烷基; R 2和R 3代表每个内衬或支链C 1-8烷基; n为2〜5的整数， 其提供表皮屏障功能增强剂和皮肤外用剂组合物，其具有高安全性，快速缓解表皮渗透屏障功能障碍并具有保持皮肤处于美观健康状态的效果; 与HB-EFG表达诱导剂加速表皮转换，调节过度表皮增生的双调蛋白表达抑制剂和视黄酸或其衍生物一起使用的药剂可以防止由视黄酸或其衍生物引起的皮肤裂伤; 以及能够改善皮肤新陈代谢抑制和与老化相关的变薄的皮肤老化缓解剂。

    Apparatus for making nonwoven fabric
    13.
    发明授权
    Apparatus for making nonwoven fabric 失效

    公开(公告)号：US06663373B2

    公开(公告)日：2003-12-16

    申请号：US09885161

    申请日：2001-06-21

    申请人： Masaki Yoshida

    发明人： Masaki Yoshida

    IPC分类号： D01D5092

    CPC分类号： D04H3/03 ,  D01D5/0985 ,  D04H3/16

    摘要： An apparatus for making a nonwoven fabric including, between spinning nozzles and a top surface of an air-permeable endless belt running in one direction, air blow means spaced apart from the nozzles, a duct directly connected to the air blow means and a hood directly connected to the duct so as to cover the vicinity of the top surface of the endless belt so that the interior of the hood may be subjected to a suction effect exerted through the endless belt from below the endless belt.

    Skin Lightening Compositions
    16.
    发明申请
    Skin Lightening Compositions 审中-公开

    公开(公告)号：US20140154190A1

    公开(公告)日：2014-06-05

    申请号：US14175360

    申请日：2014-02-07

    申请人： Yoko Niki ,  Masaki Yoshida ,  Masamitsu Ichihashi ,  Hideya Ando ,  Daniel B. Yarosh ,  Mary S. Matsui

    发明人： Yoko Niki ,  Masaki Yoshida ,  Masamitsu Ichihashi ,  Hideya Ando ,  Daniel B. Yarosh ,  Mary S. Matsui

    IPC分类号： A61K8/49 ,  A61Q17/04 ,  A61Q19/02

    CPC分类号： A61K8/4946 ,  A61K8/49 ,  A61K2800/782 ,  A61Q17/04 ,  A61Q19/02

    摘要： Compositions and methods for lightening and/or depigmenting skin are provided, the compositions comprising compounds having the structure: wherein: R1 and R2 are same or different and are each selected from the group consisting of hydrogen, alkyl, carbomethoxy, carboethoxy, alkoxy, and alkanoyl, any of which may be halogen-substituted, and halogen; R6 is selected from the group consisting of hydrogen, methyl, and ethyl; and R3, R4 and R5 are the same or different and are each selected from the group consisting of hydrogen, methyl, methoxy, ethoxy, methoxyethoxy, ethoxyethoxy, propoxy, propoxymethoxy, and the like, any of which may be halogen-substituted; or having the structure: wherein: R2 is hydrogen, lower alkyl or hydroxy lower alkyl; R3 is lower alkyl, —CH2CN, hydroxy lower alkyl, —NO, —CH2N═C or (wherein R6 and R7 are independently selected from the group consisting of hydrogen and lower alkyl) or hydrogen provided R2 is not hydrogen; R4 is Z-T-W wherein Z represents —O—, —NH— or a single bond; T represents a straight- or branched-chain lower-alkylene group; when Z is a single bond, T also represents an ethenylene or a propenylene group wherein the unsaturated carbon is at the single bond; when Z is —O—, T also represents an allylene group wherein the saturated carbon is at the oxygen; and W represents hydrogen, when T is allylene and Z is —O—, and Ar, wherein Ar is selected from thienyl, pyridinyl, furanyl, phenyl and substituted phenyl wherein there are one or more substituents on the phenyl independently selected from halogen or lower alkyl; and R5 is hydrogen, halogen or lower alkyl; or pharmaceutically-, cosmetically- and dermatologically-acceptable salts, solvates, and bioprecursors, and stereoisomers and enantiomers of these compounds, free from or mixed with other enantiomers or stereoisomers; and such compounds in compositions with a pharmaceutically-, cosmetically- or dermatologically-acceptable carrier thereof comprising a safe and effective amount of the skin lightening or depigmenting compound.

    Sealing pump-up device
    17.
    发明授权
    Sealing pump-up device 有权
    密封泵送装置

    公开(公告)号：US08201586B2

    公开(公告)日：2012-06-19

    申请号：US12305580

    申请日：2007-06-13

    申请人： Masaki Yoshida ,  Ryuji Izumoto ,  Shinichi Iwasaki ,  Rieko Iwasaki, legal representative

    发明人： Masaki Yoshida ,  Ryuji Izumoto ,  Shinichi Iwasaki

    IPC分类号： B65B31/00

    CPC分类号： B29C73/166 ,  B29L2030/00

    摘要： To prevent a burr, produced from the joint portion by welding between a liquid agent container and an injection unit, from interfering with a boring member inserted into a jig communication passage when the boring member is inserted into the jig communication passage to prevent the obstruction of the piercing action through a sealing member by the edge of the boring member. In the sealing pump-up device 10, a tubular inner annular member 104 is integrally formed on the inner peripheral side of a joined portion 37 in an injection unit 20 so as to surround, from an outer peripheral side, a boring member 62 held in a jig insertion hole 44, and a burr housing unit 106 consisting of an almost cylindrical space is formed between the outer annular member 28 of a liquid container 18 and the tubular inner annular member 104, whereby it is possible to guide the tip end side of a burr 110, extending from the joint portion between the outer annular member 28 and a joined portion 37 toward the inner peripheral side, from moving toward the boring member 62 side of the burr 110 by means of the tubular inner annular member 104.

    摘要翻译： 为了防止在液体剂容器和注射单元之间通过焊接从接合部分产生的毛刺，当镗孔构件插入夹具连通通道中时妨碍插入到夹具连通通道中的钻孔构件，以防止堵塞 通过钻孔构件的边缘通过密封构件的穿孔作用。 在密封泵送装置10中，管状内环状构件104一体形成在注射单元20的接合部37的内周侧，以从外周侧包围保持在 在液体容器18的外部环形构件28和管状内部环形构件104之间形成有由几乎圆柱形的空间构成的夹具插入孔44和毛刺容纳单元106，由此可以将顶端侧 从外环形构件28和接合部37之间的接合部向内周侧延伸的毛刺110通过管状内环状构件104向毛刺110的镗孔构件62侧移动。

    MAP DATA UPDATE SYSTEM, MAP DATA UPDATE METHOD, COMPUTER-READABLE STORAGE MEDIUM STORING MAP DATA UPDATE PROGRAM
    18.
    发明申请
    MAP DATA UPDATE SYSTEM, MAP DATA UPDATE METHOD, COMPUTER-READABLE STORAGE MEDIUM STORING MAP DATA UPDATE PROGRAM 审中-公开
    地图数据更新系统，地图数据更新方法，计算机可读存储介质存储地图数据更新程序

    公开(公告)号：US20120065811A1

    公开(公告)日：2012-03-15

    申请号：US13255843

    申请日：2010-03-30

    申请人： Masaki Nakamura ,  Masatoshi Takahara ,  Motoki Kanba ,  Masaki Yoshida ,  Takashi Orui ,  Yousuke Wada ,  Noriaki Ito ,  Kiyoshi Tsurumi

    发明人： Masaki Nakamura ,  Masatoshi Takahara ,  Motoki Kanba ,  Masaki Yoshida ,  Takashi Orui ,  Yousuke Wada ,  Noriaki Ito ,  Kiyoshi Tsurumi

    IPC分类号： G06F7/00 ,  G06F17/00 ,  G01C21/26

    CPC分类号： G01C21/30 ,  G01C21/32

    摘要： A map data update system includes a first storage portion that stores road network data that describes a road in terms of a connection relationship between a node and a link; an update portion that receives update data and updates the road network data based on the update data; a data obtaining portion that obtains additional data by a means that differs from a means that receives the update data; a second storage portion that stores the additional data including association information that indicates association between the additional data and the link; and a correcting portion that, when update processing of the road network data is executed by the update portion, the association information in the additional data that is associated with the link that is changed by the update processing.

    摘要翻译： 地图数据更新系统包括第一存储部分，其存储根据节点和链路之间的连接关系描述道路的道路网数据; 更新部分，其接收更新数据并根据更新数据更新道路网数据; 数据获取部分，通过与接收更新数据的手段不同的手段获得附加数据; 存储附加数据的第二存储部分，所述附加数据包括指示所述附加数据与所述链接之间的关联的关联信息; 以及校正部，当由所述更新部执行所述道路网数据的更新处理时，与通过所述更新处理而改变的所述链接相关联的附加数据中的所述关联信息。