公开(公告)号：US4579747A

公开(公告)日：1986-04-01

申请号：US589005

申请日：1984-03-13

申请人： Katsumi Sugiyama ,  Toshiyuki Ozawa ,  Nobuya Nagashima ,  Yoshinobu Uchida

发明人： Katsumi Sugiyama ,  Toshiyuki Ozawa ,  Nobuya Nagashima ,  Yoshinobu Uchida

IPC分类号： A23L27/00 ,  A23L27/30 ,  C07C67/00 ,  C07C231/00 ,  C07K1/00 ,  C07K1/14 ,  C07K5/072 ,  C07K5/075 ,  A23L1/236

CPC分类号： C07K5/0613 ,  A23L27/31 ,  A23L27/32

摘要： .alpha.-L-aspartyl-L-phenylalanine methyl ester II type crystals consisting of two types of crystals, II.sub.A and II.sub.B type, which interconvert from one to the other depending upon the equilibrium moisture content of the crystals, wherein one type of crystal, II.sub.a, exhibits X-ray diffraction peaks at angles of diffraction of at least 20.6.degree., 21.2.degree., 5.0.degree. and 11.1.degree., and the other type of crystal, II.sub.B, exhibits X-ray diffraction peaks at angles of diffraction of at least 15.2.degree., 11.1.degree., 19.6.degree. and 4.5.degree., as measured by X-ray diffractometer using CuK.sub..alpha. radiation and wherein the equilibrium moisture content of either of the crystals at a relative humidity of 78% is not higher than about 3%.

摘要翻译： 由两种晶体组成的α-L-天冬氨酰基-L-苯丙氨酸甲酯II型晶体，IIA和IIB型晶体，根据晶体的平衡水分含量从一个到另一个相互转变，其中一种晶体IIa 在衍射角至少为20.6°，21.2°，5.0°和11.1°的X射线衍射峰，其他类型的晶体IIB在衍射角呈现至少15.2°的X射线衍射峰 ，11.1°，19.6°和4.5°，通过使用CuKα辐射的X射线衍射仪测量，并且其中任一晶体在相对湿度78％下的平衡水分含量不高于约3％。

公开(公告)号：US20080008773A1

公开(公告)日：2008-01-10

申请号：US11819441

申请日：2007-06-27

申请人： Hiromu Ohnogi ,  Katsumi Sugiyama ,  Nobuko Muraki ,  Hiroaki Sagawa ,  Ikunoshin Kato

发明人： Hiromu Ohnogi ,  Katsumi Sugiyama ,  Nobuko Muraki ,  Hiroaki Sagawa ,  Ikunoshin Kato

IPC分类号： A61K36/886 ,  A61K36/00 ,  A61P19/00 ,  A61K36/28

CPC分类号： C07D311/80 ,  A23K20/121 ,  A23L33/105 ,  A23V2002/00 ,  A61K31/353 ,  A61K36/23 ,  A61K36/232 ,  A61K36/282 ,  A61K36/8967 ,  A23V2200/306 ,  A23V2250/21

摘要： The present invention relates to a therapeutic agent or prophylactic agent for a disease requiring promotion of osteogenesis or enhancement of bone morphogenetic protein production, an agent for promotion of osteogenesis or an agent for enhancement of bone morphogenetic protein production, and a food, beverage or feed for promotion of osteogenesis or enhancement of bone morphogenetic protein production, characterized in that each comprises as an effective ingredient a processed product derived from a plant. Also, the present invention relates to a method for measuring an enhancing action for bone morphogenetic protein production, a method for screening a substance having an enhancing action for bone morphogenetic protein production, and a method for preparing a substance having an enhancing action for bone morphogenetic protein production, each method using a specified cell.

摘要翻译： 本发明涉及需要促进骨形成发生或增强骨形态发生蛋白质生成的疾病的治疗剂或预防剂，促进成骨的药剂或增强骨形态发生蛋白质生产的药剂，以及食品，饮料或饲料 用于促进成骨或增强骨形态发生蛋白质的生成，其特征在于，每种都包含作为有效成分的来自植物的加工产品。 另外，本发明涉及骨形态发生蛋白质生成增强作用的测定方法，骨形态发生蛋白质生成增强作用物质的筛选方法以及骨形态发生增强作用物质的制备方法 蛋白质生产，每种方法使用指定的细胞。

公开(公告)号：US20060039998A1

公开(公告)日：2006-02-23

申请号：US10529860

申请日：2003-09-29

申请人： Hiromu Ohnogi ,  Katsumi Sugiyama ,  Nobuko Muraki ,  Hiroaki Sagawa ,  Ikunoshin Kato

发明人： Hiromu Ohnogi ,  Katsumi Sugiyama ,  Nobuko Muraki ,  Hiroaki Sagawa ,  Ikunoshin Kato

IPC分类号： A61K36/282 ,  A61K36/232 ,  A61K36/896 ,  A61K36/886

CPC分类号： C07D311/80 ,  A23K20/121 ,  A23L33/105 ,  A23V2002/00 ,  A61K31/353 ,  A61K36/23 ,  A61K36/232 ,  A61K36/282 ,  A61K36/8967 ,  A23V2200/306 ,  A23V2250/21

摘要： The present invention relates to a therapeutic agent or prophylactic agent for a disease requiring promotion of osteogenesis or enhancement of bone morphogenetic protein production, an agent for promotion of osteogenesis or an agent for enhancement of bone morphogenetic protein production, and a food, beverage or feed for promotion of osteogenesis or enhancement of bone morphogenetic protein production, characterized in that each comprises as an effective ingredient a processed product derived from a plant. Also, the present invention relates to a method for measuring an enhancing action for bone morphogenetic protein production, a method for screening a substance having an enhancing action for bone morphogenetic protein production, and a method for preparing a substance having an enhancing action for bone morphogenetic protein production, each method using a specified cell.

摘要翻译： 本发明涉及需要促进骨形成发生或增强骨形态发生蛋白质生成的疾病的治疗剂或预防剂，促进成骨的药剂或增强骨形态发生蛋白质生产的药剂，以及食品，饮料或饲料 用于促进成骨或增强骨形态发生蛋白质的生成，其特征在于，每种都包含作为有效成分的来自植物的加工产品。 另外，本发明涉及骨形态发生蛋白质生成增强作用的测定方法，骨形态发生蛋白质生成增强作用物质的筛选方法以及骨形态发生增强作用物质的制备方法 蛋白质生产，每种方法使用指定的细胞。

公开(公告)号：US06979001B2

公开(公告)日：2005-12-27

申请号：US10607198

申请日：2003-06-27

申请人： Hisashi Ohtsuki ,  Takayuki Norimatsu ,  Eiji Funahashi ,  Koji Kametaka ,  Motoharu Niki ,  Katsumi Sugiyama ,  Kenro Adachi

发明人： Hisashi Ohtsuki ,  Takayuki Norimatsu ,  Eiji Funahashi ,  Koji Kametaka ,  Motoharu Niki ,  Katsumi Sugiyama ,  Kenro Adachi

IPC分类号： F16C19/18 ,  F16C19/52 ,  F16C33/78 ,  F16J15/32

CPC分类号： F16J15/3264 ,  F16C19/186 ,  F16C33/64 ,  F16C33/768 ,  F16C33/783 ,  F16C33/7883 ,  F16C41/007 ,  F16C2240/40 ,  F16C2326/02 ,  F16J15/326

摘要： A wheel bearing includes a sealing device 5 positioned between inner and outer members 1 and 2. This sealing device 5 includes an elastic member 14, which eventually forms an encoder grid and is provided on a first annular sealing plate 11. A second annular sealing plate 12 is provided with sealing lips 16a to 16c. An engagement 18 between a cylindrical wall 11a of the first annular sealing plate 11 and the inner member 1 is provided with an elastic member 20 made of a material dissimilar to that for the elastic material 14. This elastic member 20 may be a rubber coated layer, resin paint layer, a thin film of adhesive material or a ring-shaped rubber member. Thereby, any possible ingress of water across an engagement surface of the annular sealing plate is prevented, accompanied by increase of the lifetime of the bearing, with no problem associated with separation and displacement of the annular sealing plates. The magnetic flux density can also be easily secured.

摘要翻译： 车轮轴承包括定位在内部构件1和外部构件2之间的密封装置5。 该密封装置5包括最终形成编码器格栅并设置在第一环形密封板11上的弹性构件14。 第二环形密封板12设置有密封唇部16a至16c。 在第一环形密封板11的圆柱形壁11a和内部构件1之间的接合部18设置有由与弹性材料14不同的材料制成的弹性构件20。 该弹性构件20可以是橡胶涂覆层，树脂涂料层，粘合剂材料的薄膜或环形橡胶构件。 因此，防止了环形密封板的接合表面的任何可能的进入水流，伴随着轴承寿命的增加，并没有与环形密封板的分离和移位有关的问题。 也可以容易地确保磁通密度。

公开(公告)号：US20050272809A1

公开(公告)日：2005-12-08

申请号：US10529859

申请日：2003-09-29

申请人： Hiromu Ohnogi ,  Katsumi Sugiyama ,  Nobuko Muraki ,  Tatsuji Enoki ,  Hiroaki Sagawa ,  Ikunoshin Kato

发明人： Hiromu Ohnogi ,  Katsumi Sugiyama ,  Nobuko Muraki ,  Tatsuji Enoki ,  Hiroaki Sagawa ,  Ikunoshin Kato

IPC分类号： A23K1/16 ,  A23L1/30 ,  A61P25/00 ,  A61P43/00 ,  C07D311/58 ,  C07D311/80 ,  A61K31/353 ,  C07D311/76

CPC分类号： C07D311/80 ,  A23K20/121 ,  A23L33/10 ,  C07D311/58

摘要： The present invention relates to a novel chalcone compound represented by the following general formula: wherein R1 and R2 are taken together with the carbon atom to which they are bound, respectively, to form a hydroxydimethyl hexane ring, or where R1 is a hydroxyl group, R2 is an isohexenyl group, a derivative thereof, or a salt thereof. Also, the present invention relates to a therapeutic agent or prophylactic agent for a disease requiring neuronal protection, suppression for nitrogen monoxide (NO) production, inhibition for aldose reductase or suppression for interleukin production, and a food, beverage or feed for treatment or prevention of the above-mentioned disease, characterized in that each comprises the above-mentioned compound as an effective ingredient.

摘要翻译： 本发明涉及由以下通式表示的新型查耳酮化合物：其中R 1和R 2分别与它们所结合的碳原子一起连接 ，以形成羟基二甲基己烷环，或其中R 1是羟基，R 2是异己烯基，其衍生物或其盐。 此外，本发明涉及需要神经元保护，抑制一氧化氮（NO）产生，抑制醛糖还原酶或抑制白介素产生的疾病的治疗剂或预防剂，以及用于治疗或预防的食品，饮料或饲料 的上述疾病，其特征在于，每种都包含上述化合物作为有效成分。

公开(公告)号：US20050250715A1

公开(公告)日：2005-11-10

申请号：US10521447

申请日：2003-07-17

申请人： Hiromu Ohnogi ,  Katsumi Sugiyama ,  Hiroaki Sagawa ,  Ikunoshin Kato

发明人： Hiromu Ohnogi ,  Katsumi Sugiyama ,  Hiroaki Sagawa ,  Ikunoshin Kato

IPC分类号： A23L1/30 ,  A61K31/56 ,  A61K31/704 ,  A61P9/00 ,  A61P25/00 ,  A61P27/02 ,  A61P35/00 ,  A61P43/00 ,  C07H15/256 ,  C07J63/00

CPC分类号： C07J63/00 ,  A23L33/10 ,  A61K31/56 ,  A61K31/704 ,  C07H15/256 ,  A61K2300/00

摘要： The present invention relates to a therapeutic agent or prophylactic agent for a disease requiring enhancement of nerve growth factor (NGF) production upon treatment or prevention, an enhancing agent for nerve growth factor production, and a food, beverage or feed for enhancing nerve growth factor production, characterized in that each comprises as an effective ingredient a compound selected from the group consisting of soyasaponin compounds, soyasapogenin compounds, glycyrrhizin and salts thereof. In addition, the present invention relates to a novel soyasaponin compound and a novel soyasapogenin compound, having an action for enhancement of NGF production.

摘要翻译： 本发明涉及治疗或预防需要增强神经生长因子（NGF）产生的疾病的治疗剂或预防剂，用于神经生长因子产生的增强剂，以及用于增强神经生长因子的食品，饮料或饲料 其特征在于，各自包含选自由大豆皂角苷化合物，大豆皂草苷化合物，甘草甜素及其盐组成的组的有效成分。 此外，本发明涉及一种新的大豆皂草素化合物和具有增强NGF产生作用的新型大豆皂草配基化合物。

公开(公告)号：US4610827A

公开(公告)日：1986-09-09

申请号：US629468

申请日：1984-07-10

申请人： Toshihide Yukawa ,  Toru Ikeda ,  Shinichi Kishimoto ,  Katsumi Sugiyama

发明人： Toshihide Yukawa ,  Toru Ikeda ,  Shinichi Kishimoto ,  Katsumi Sugiyama

IPC分类号： C07B57/00 ,  C07C67/00 ,  C07C227/34 ,  C07C229/02 ,  C07C229/36 ,  C07C239/00 ,  C07C271/22 ,  C07C301/00 ,  C07C323/58 ,  C07D209/20 ,  C07C103/50

CPC分类号： C07C271/22

摘要： A method for optical resolution of a DL-amino acid comprising reacting the DL-amino acid with an optically active N-acyl aspartic acid in a solvent or mixture of solvents, and separating the resulting two diasteromeric salts by way of the difference between their solubilities in the solvent or mixture of solvents. The difference in solubility may be enhanced by cooling, concentration, addition of a solubility-decreasing organic solvent, pH adjustment or salting out.

摘要翻译： 一种DL-氨基酸的光学拆分方法，包括将DL-氨基酸与光学活性N-酰基天冬氨酸在溶剂或溶剂混合物中反应，并通过其溶解度之间的差异分离得到的两种非对映异构体盐 在溶剂或溶剂混合物中。 通过冷却，浓缩，添加溶解度降低的有机溶剂，pH调节或盐析可以提高溶解度的差异。

公开(公告)号：US07498357B2

公开(公告)日：2009-03-03

申请号：US10581034

申请日：2004-12-01

申请人： Hiromu Ohnogi ,  Katsumi Sugiyama ,  Tatsuji Enoki ,  Eiji Kobayashi ,  Hiroaki Sagawa ,  Ikunoshin Kato

发明人： Hiromu Ohnogi ,  Katsumi Sugiyama ,  Tatsuji Enoki ,  Eiji Kobayashi ,  Hiroaki Sagawa ,  Ikunoshin Kato

IPC分类号： A61K31/343 ,  C07D307/80

CPC分类号： C07D493/08 ,  A23K20/121 ,  A23L33/10 ,  C07C49/835 ,  C07C49/84 ,  C07C409/08 ,  C07D307/80

摘要： The present invention provides a novel chalcone compound, its derivative or a salt thereof, each having a suppressive action of NO production or an inhibitory action of aldose reductase. In addition, the present invention provides a medicament, a food, a beverage or a feed having a therapeutic or prophylactic effect for a disease showing sensitivity to the compound, by utilizing the physiological actions of the compound.

摘要翻译： 本发明提供了具有NO产生抑制作用或醛糖还原酶抑制作用的新型查耳酮化合物及其衍生物或其盐。 此外，本发明通过利用化合物的生理作用，提供对化合物显示敏感性的疾病具有治疗或预防作用的药物，食品，饮料或饲料。

公开(公告)号：US20090053383A1

公开(公告)日：2009-02-26

申请号：US12176088

申请日：2008-07-18

申请人： Hiroshi ENDO ,  Yasushi Hattori ,  Hitoshi Sakakibara ,  Katsumi Sugiyama ,  Yuko Asai ,  Satoko Motomura ,  Ikunoshin Kato

发明人： Hiroshi ENDO ,  Yasushi Hattori ,  Hitoshi Sakakibara ,  Katsumi Sugiyama ,  Yuko Asai ,  Satoko Motomura ,  Ikunoshin Kato

IPC分类号： A23F3/06 ,  A23F3/22

CPC分类号： A23F3/34

摘要： According to the present invention, there are provided kneading-free Angelica keiskei tea leaves obtainable by a treatment comprising a step for roast-heating a dried material of Angelica keiskei; an Angelica keiskei tea beverage produced by using the kneading-free Angelica keiskei tea leaves; and a process for producing thereof. The Angelica keiskei tea leaves are preferably heated at a heating temperature of 100° C. to 150° C. in the roast-heating treatment, and the dried material of Angelica keiskei to be subjected to the roast-heating is preferably obtained by drying in a dried system after blanching and has a moisture content of 20% or less. Further, according to the present invention, there is also provided an Angelica keiskei chalcone function-formulated beverage comprising formulated Angelica keiskei chalcones that are components specific to Angelica keiskei.

摘要翻译： 根据本发明，提供了通过包括用于对当归keiskei的干燥材料进行烘烤的步骤的处理而获得的无捏合当归keiskei茶叶; 通过使用揉捏的当归keiskei茶叶生产的当归keiskei茶饮料; 及其制造方法。 本发明的茶叶优选在烘烤加热处理中在100℃〜150℃的加热温度下进行加热，优选通过将烘烤后的干燥物干燥， 漂白后的干燥体系，水分含量为20％以下。 此外，根据本发明，还提供了包含作为当归keiskei特异性成分的配方的当归keiskei chalcones的当归keiskei查耳酮功能配方饮料。

公开(公告)号：US20070092587A1

公开(公告)日：2007-04-26

申请号：US10561431

申请日：2004-06-18

申请人： Hiromu Ohnogi ,  Katsumi Sugiyama ,  Nobuko Muraki ,  Tatsuji Enoki ,  Hiroaki Sagawa ,  Ikunoshin Kato

发明人： Hiromu Ohnogi ,  Katsumi Sugiyama ,  Nobuko Muraki ,  Tatsuji Enoki ,  Hiroaki Sagawa ,  Ikunoshin Kato

IPC分类号： A61K36/232

CPC分类号： A61K36/232 ,  A23L2/02 ,  A23V2002/00 ,  A23V2250/21 ,  A23V2200/328

摘要： The present invention provides an extract obtainable by extracting a plant belonging to Umbelliferae, or a processed product thereof, with a water-containing alcohol; a process for preparing the extract; a therapeutic agent or prophylactic agent for a disease accompanying an abnormality in an amount of insulin or insulin response and/or diabetic complications, characterized in that the therapeutic agent or prophylactic agent comprises as an effective ingredient the extract as defined above; an agent for an insulin-mimetic action, characterized in that the agent comprises as an effective ingredient the extract as defined above; a food, beverage or feed, comprising the extract as defined above; an agent for enhancing glucose uptake into a cell, characterized in that the agent comprises as an effective ingredient the extract as defined above; to an agent for inducing differentiation into an adipocyte, characterized in that the agent comprises as an effective ingredient the extract as defined above; and an inhibitory agent for aldose reductase, characterized in that the agent comprises as an effective ingredient the extract as define above.

摘要翻译： 本发明提供通过用含水醇提取属于伞形赤霉属的植物或其加工产物而获得的提取物; 一种制备提取物的方法; 用于伴随胰岛素或胰岛素反应量和/或糖尿病并发症的异常的疾病的治疗剂或预防剂，其特征在于所述治疗剂或预防剂包含作为有效成分的上述提取物; 用于胰岛素模拟作用的药剂，其特征在于所述药剂包含如上所定义的提取物作为有效成分; 包含上述提取物的食品，饮料或饲料; 用于增强葡萄糖摄入细胞的药剂，其特征在于所述药剂包含如上所定义的提取物作为有效成分; 涉及诱导分化为脂肪细胞的药剂，其特征在于所述药剂包含如上所定义的提取物作为有效成分; 以及醛糖还原酶抑制剂，其特征在于，所述药剂含有作为有效成分的上述定义的提取物。