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公开(公告)号：US20080021062A1
公开(公告)日：2008-01-24
申请号：US11609166
申请日：2006-12-11
申请人： Thomas Simpson , James Kang , Jeffrey Albert , Cristobal Alhambra , Gerard Koether , James Woods , Yan Li
发明人： Thomas Simpson , James Kang , Jeffrey Albert , Cristobal Alhambra , Gerard Koether , James Woods , Yan Li
CPC分类号： C07D215/38 , C07D215/14 , C07D215/52
摘要： Compounds of Formula II wherein R1, A, R2, R3, R4, R5, R8, n, m and q are as described in the specification, pharmaceutically-acceptable salts, methods of making, pharmaceutical compositions containing and methods for using the same.
摘要翻译： 式II的化合物，其中R 1，A，R 2，R 3，R 4，R 4， R 5，R 8，n，m和q如说明书中所述，药学上可接受的盐，制备方法，药物组合物及其使用方法。
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公开(公告)号：US20060183732A1
公开(公告)日：2006-08-17
申请号：US10549271
申请日：2004-03-10
申请人： Keith Herzog , Robert Jacobs , Jianxing Kang , Thomas Simpson , James Woods
发明人： Keith Herzog , Robert Jacobs , Jianxing Kang , Thomas Simpson , James Woods
IPC分类号： A61K31/55 , C07D223/12
CPC分类号： C07D409/12 , C07D223/12 , C07K5/06026 , C07K5/06043 , C07K5/06191
摘要： This invention relates to novel compounds having formula (I) to their pharmaceutical compositions and to their methods of use. These novel compounds inhibit secretase and thereby inhibit the production of amyloid β protein, thereby acting to prevent the formation of neurological deposits of amyloid protein. The present invention relates to the treatment of neurological disorders related to amyloid β-protein production such as Alzheimer's disease.
摘要翻译： 本发明涉及具有式（I）的新化合物及其药物组合物及其使用方法。 这些新型化合物抑制分泌酶，从而抑制淀粉样蛋白β蛋白的产生，从而起到防止淀粉样蛋白神经沉积的形成的作用。 本发明涉及治疗与淀粉样蛋白β-蛋白生产相关的神经障碍，例如阿尔茨海默病。
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公开(公告)号：US20060089346A1
公开(公告)日：2006-04-27
申请号：US10528640
申请日：2003-10-02
申请人： Christopher Becker , Bruce Dembofsky , Robert Jacobs , James Kang , Cyrus Ohnmacht , James Rosamond , Ashokkumar Shenvi , Thomas Simpson , James Woods
发明人： Christopher Becker , Bruce Dembofsky , Robert Jacobs , James Kang , Cyrus Ohnmacht , James Rosamond , Ashokkumar Shenvi , Thomas Simpson , James Woods
IPC分类号： A61K31/554 , A61K31/55 , A61K31/551
CPC分类号： C07K5/06034 , A61K38/00 , C07D223/16 , C07D267/10 , C07D267/14 , C07D281/06 , C07D281/10 , C07D405/04 , C07D417/12 , C07D417/14 , C07K5/06026 , C07K5/06191
摘要： Compounds having the formula (1) pharmaceutical compositions containing them and their methods of use for the treatment of neurological disorders related to amyloid B protein production and neurological disorders such as Alzheimer's disease. These compounds inhibit γ secretase and thereby inhibit the production of amyloid β protein, thereby acting to prevent the formation of neurological deposits of amyloid protein.
摘要翻译： 具有式（1）的药物组合物及其用于治疗与淀粉样蛋白B蛋白质产生和神经障碍如阿尔茨海默病相关的神经障碍的方法。 这些化合物抑制γ分泌酶，从而抑制淀粉样蛋白β蛋白的产生，从而起到防止淀粉样蛋白的神经沉积的形成的作用。
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公开(公告)号：US08014714B2
公开(公告)日：2011-09-06
申请号：US12200328
申请日：2008-08-28
IPC分类号： G03G15/20
CPC分类号： G03G15/2057
摘要： Fusers, printing apparatuses and methods of fusing toner on media are disclosed. An embodiment of a fuser for heating media includes a fuser roll including an outer portion having a first outer surface; a voltage source connected to the outer portion and adapted to supply voltage to the outer portion to heat the first outer surface; a pressure roll having a second outer surface; and a nip between the first and second outer surfaces. The first and second outer surfaces are adapted to contact a medium at the nip.
摘要翻译： 公开了将介质上的调色剂熔合，印刷设备和定影方法。 用于加热介质的定影器的实施例包括定影辊，该定影辊包括具有第一外表面的外部部分; 连接到所述外部部分并适于向所述外部部分供电以加热所述第一外表面的电压源; 具有第二外表面的压力辊; 以及第一和第二外表面之间的辊隙。 第一和第二外表面适于在辊隙处接触介质。
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公开(公告)号：US20100054784A1
公开(公告)日：2010-03-04
申请号：US12200328
申请日：2008-08-28
IPC分类号： G03G15/20
CPC分类号： G03G15/2057
摘要： Fusers, printing apparatuses and methods of fusing toner on media are disclosed. An embodiment of a fuser for heating media includes a fuser roll including an outer portion having a first outer surface; a voltage source connected to the outer portion and adapted to supply voltage to the outer portion to heat the first outer surface; a pressure roll having a second outer surface; and a nip between the first and second outer surfaces. The first and second outer surfaces are adapted to contact a medium at the nip.
摘要翻译： 公开了将介质上的调色剂熔合，印刷设备和定影方法。 用于加热介质的定影器的实施例包括定影辊，该定影辊包括具有第一外表面的外部部分; 连接到所述外部部分并适于向所述外部部分供电以加热所述第一外表面的电压源; 具有第二外表面的压力辊; 以及第一和第二外表面之间的辊隙。 第一和第二外表面适于在辊隙处接触介质。
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16.发明申请公开(公告)号：US20070146702A1
公开(公告)日：2007-06-28
申请号：US11298958
申请日：2005-12-09
申请人： Robert Canning , Scott Mehr , Barry Rubin , Thomas Simpson , Douglas Stilwell
发明人： Robert Canning , Scott Mehr , Barry Rubin , Thomas Simpson , Douglas Stilwell
IPC分类号： G01N15/02
CPC分类号： G01N21/94 , G01N1/2813 , G01N33/32 , G01N2015/0092 , G01N2015/1486 , G06T7/0004 , G06T2207/30108
摘要： An automated computer-controlled method and apparatus for measuring the quality or fineness of a pigment dispersion sample, comprising placing the pigment dispersion at the deep end of the tapered path of a Hegman gage block, placing the Hegman gage block in a holder in a motorized drawdown device that draws the scraper along the length of the tapered path at an angle and to at a contact pressure and at a controlled rate, thereby creating a tapered film sample of paint whose thickness tapers from a maximum thickness of 100 micrometers to a minimum thickness of zero. An illuminator assembly illuminates the sample with a substantially collimated light source at an intensity level and the light reflected from the sample is collected by a lens onto a photodetector array in a digital camera. After a time interval the camera acquires an image of the sample. The image is digitized and stored in a memory in the computer and then a portion of the image within a region of interest corresponding to the sample in the tapered path is analyzed to detect and count pigment agglomerates that protrude above the surface of the sample.
摘要翻译： 一种用于测量颜料分散体样品的质量或细度的自动计算机控制方法和装置，包括将颜料分散体放置在Hegman量具块的锥形路径的深端，将Hegman量具块放置在机动化的 牵引装置沿着锥形路径的长度以一定角度并以接触压力和受控速率牵引刮刀，从而形成一个厚度从100微米的最大厚度变薄到最小厚度的涂料的锥形膜样品 零。 照明器组件以强度水平的基本上准直的光源照亮样品，并且从样品反射的光被透镜收集到数字照相机中的光电检测器阵列上。 在一段时间间隔后，相机获取样品的图像。 将图像数字化并存储在计算机中的存储器中，然后分析与锥形路径中的样品相对应的感兴趣区域内的图像的一部分，以检测并计数突出在样品表面上方的颜料附聚物。
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17.发明申请Novel Pyrazole Derivatives And Their Use As Modulators Of Nicotinic Acetylcholine Receptors 审中-公开新型吡唑衍生物及其作为烟酸乙酰胆碱受体调节剂的用途公开(公告)号：US20080081833A1
公开(公告)日：2008-04-03
申请号：US11722118
申请日：2005-12-16
申请人： Glen Ernst , William Frietze , Thomas Simpson
发明人： Glen Ernst , William Frietze , Thomas Simpson
IPC分类号： A61K31/415 , A61P25/28 , C07D231/00 , C07D231/02
CPC分类号： C07D491/04 , C07D231/40 , C07D495/04
摘要： Compounds of Formula I: wherein A1, A2, D and E are as described in the specification, pharmaceutically-acceptable salts thereof, processes for preparing them, pharmaceutical compositions containing them and their use in therapy, especially for treatment of conditions associated with reductions in nicotinic transmission.
摘要翻译： 式I化合物：其中A 1，A 2，D和E如说明书中所述，其药学上可接受的盐，其制备方法，含有 他们及其在治疗中的应用，特别是用于治疗与烟碱传播减少有关的病症。
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公开(公告)号：US20070131018A1
公开(公告)日：2007-06-14
申请号：US11634581
申请日：2006-12-05
IPC分类号： G01F25/00
CPC分类号： G01N21/05 , G01N21/0317 , G01N2021/0346
摘要： A flow cell for measuring the color properties of a liquid flowing therethrough using interrogating radiation at a predetermined wavelength has a thin partition mounted in spaced relationship between both a window and a base of the cell. The partition and the window define an air cavity therebetween. The spacing between the partition and the window is such that evanescent coupling of radiation reflected from the liquid into the material of the window is prevented. The cell has a pressurized fluid inflow channel and a pressurized fluid outflow channel formed therein. Each of the inflow and outflow channels communicates with the air cavity. The inflow and outflow channels are sized to pass a pressurized fluid, such as pressurized air, through the air cavity such that, in use, the spaced relationship between the partition and the window is maintained by pressurized fluid in the air cavity. The pressure of the pressurized fluid in the air cavity is determined in accordance with the pressure of the liquid flowing through the cell.
摘要翻译： 用于测量以预定波长的询问辐射流过其中的液体的颜色特性的流通池具有以隔开的关系安装在电池单元的窗口和基座之间的薄隔板。 分隔件和窗口在其间限定一个空气腔。 分隔件和窗口之间的间隔使得防止从液体反射到窗口的材料中的辐射的消逝耦合。 电池具有形成在其中的加压流体流入通道和加压流体流出通道。 每个流入和流出通道与气腔连通。 流入和流出通道的尺寸设定为使加压流体（例如加压空气）通过空气腔，使得在使用中，分隔件和窗口之间的间隔关系由空气腔中的加压流体维持。 根据流过电池的液体的压力来确定空气腔中的加压流体的压力。
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公开(公告)号：US20050082251A1
公开(公告)日：2005-04-21
申请号：US10762778
申请日：2004-01-22
申请人： Richard Darr , James Miller , Richard Lovelace , Thomas Simpson
发明人： Richard Darr , James Miller , Richard Lovelace , Thomas Simpson
CPC分类号： B65D23/106 , B65D2501/0027 , B65D2501/0036
摘要： The container includes a hollow body of plastic material having a lower supporting base, a sidewall extending upwardly from the base, a shoulder portion extending upwardly from the sidewall and an upper neck portion with an opening therein extending upwardly from the shoulder portion. The neck portion includes at least one engagement surface which fits together with at least one engagement surface on a separately formed handle to form at least one projection seated in at least one groove.
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20.发明申请Treatments for reduction of cytotoxicity and viral contamination of implantable medical devices 审中-公开用于减少可植入医疗器械的细胞毒性和病毒污染的治疗公开(公告)号：US20060110370A1
公开(公告)日：2006-05-25
申请号：US10996156
申请日：2004-11-23
CPC分类号： A61L27/24 , A01N1/0231 , A01N63/00 , A61L2/0088 , A61L27/3687 , A61L27/56
摘要： A method for treating biomaterial is provided in which a biological tissue, typically after being cross-linked, is contacted with an anticalcification treatment solution under condition effective to render the biomaterial resistant to in vivo calcification upon implantation in a host animal. The anticalcification treatment solutions comprise higher alcohol solutions, a polyol solutions and/or a polar aprotic organic solvent solutions. Methods of reducing cytotoxicity to host tissue of bioprostheses that comprise fixed animal tissues, and treatments to reduce viral contamination of implantable medical devices are disclosed herein.
摘要翻译： 提供了一种治疗生物材料的方法，其中通常在交联后的生物组织在有效使得生物材料在植入宿主动物体内抵抗体内钙化的条件下与抗细胞治疗溶液接触。 抗化学处理溶液包含高级醇溶液，多元醇溶液和/或极性非质子有机溶剂溶液。 本文公开了减少包含固定动物组织的生物假体的宿主组织的细胞毒性的方法以及用于减少可植入医疗装置的病毒污染的治疗方法。
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