公开(公告)号：US10989723B2

公开(公告)日：2021-04-27

申请号：US16258412

申请日：2019-01-25

Applicant: IntegenX Inc.

Inventor： James Ogg ,  David Eberhart ,  William D. Nielsen ,  Helen Franklin ,  Stevan B. Jovanovich

IPC: B01L3/00 ,  G01N35/00 ,  B01L7/00 ,  C12Q1/6818 ,  C12Q1/686 ,  C12Q1/6888

Abstract: Provided herein are instruments and cartridges for processing samples. The cartridges include fluidic circuits in which fluid movement can be regulated by diaphragm valves. In certain cartridges, deformable material providing a diaphragm contacts an interface in the instrument that actuates the diaphragm directly, without intervening actuation layer. Certain cartridges have a plurality of fluidic circuits and fluid distribution channels or pneumatic distribution channels configured to deliver fluids or pneumatic pressure to any of the fluidic circuits, selectively. Certain cartridges have compartments containing on-board reagents. Compartments can be closed by a film attached to a body the cartridge through a heat seal.

公开(公告)号：US10961561B2

公开(公告)日：2021-03-30

申请号：US16250646

申请日：2019-01-17

Applicant: IntegenX, Inc.

Inventor： David Eberhart ,  William D. Nielsen ,  Helen Franklin ,  Stevan B. Jovanovich ,  Dennis Lehto ,  Kaiwan Chear ,  James Klevenberg ,  Chungsoo Charles Park ,  Corey M. Smith ,  Philip Justus Wunderle ,  David King

IPC: B01L3/00 ,  G01N1/10 ,  C12Q1/6806 ,  C12Q1/686 ,  G01N27/447

Abstract: Provided herein is a fluidic cartridge having a body comprising a malleable material and a layer comprising a deformable material bonded to a surface of the body that seals one or more fluidic channels that communicate with one or more valve bodies formed in a surface of the body. The valve can be closed by applying pressure to the deformable material sufficient to crush and close off a fluidic channel in the body. Also provided are a cartridge interface configured to engage the cartridge. Also provided is a system including a cartridge interface and methods of using the cartridge and system.

公开(公告)号：US20190242917A1

公开(公告)日：2019-08-08

申请号：US16258412

申请日：2019-01-25

Applicant: IntegenX Inc.

Inventor： James Ogg ,  David Eberhart ,  William D. Nielsen ,  Helen Franklin ,  Stevan B. Jovanovich

IPC: G01N35/00 ,  C12Q1/6818 ,  B01L7/00 ,  B01L3/00 ,  C12Q1/6888 ,  C12Q1/686

CPC classification number: G01N35/00663 ,  B01L3/502 ,  B01L3/502715 ,  B01L3/50273 ,  B01L3/502738 ,  B01L3/502746 ,  B01L7/52 ,  B01L2200/026 ,  B01L2200/027 ,  B01L2200/04 ,  B01L2200/0689 ,  B01L2200/10 ,  B01L2200/16 ,  B01L2300/044 ,  B01L2300/0627 ,  B01L2300/0645 ,  B01L2300/0672 ,  B01L2300/0816 ,  B01L2300/0864 ,  B01L2300/0867 ,  B01L2300/087 ,  B01L2300/0887 ,  B01L2300/12 ,  B01L2300/123 ,  B01L2300/18 ,  B01L2300/1827 ,  B01L2400/0421 ,  B01L2400/0478 ,  B01L2400/0487 ,  B01L2400/0622 ,  B01L2400/0638 ,  B01L2400/0644 ,  B01L2400/0655 ,  C12Q1/6818 ,  C12Q1/686 ,  C12Q1/6888 ,  G01N2035/00673

Abstract: Provided herein are instruments and cartridges for processing samples. The cartridges include fluidic circuits in which fluid movement can be regulated by diaphragm valves. In certain cartridges, deformable material providing a diaphragm contacts an interface in the instrument that actuates the diaphragm directly, without intervening actuation layer. Certain cartridges have a plurality of fluidic circuits and fluid distribution channels or pneumatic distribution channels configured to deliver fluids or pneumatic pressure to any of the fluidic circuits, selectively. Certain cartridges have compartments containing on-board reagents. Compartments can be closed by a film attached to a body the cartridge through a heat seal.